The rapid urbanization in Sekondi-Takoradi, Ghana has significantly transformed the land cover, resulting in the proliferation of impervious surfaces and a decline in vegetation. However, the influence of this urban growth on the development of urban heat islands (UHIs) in the metropolis remains understudied. This study aimed to fill this research gap by employing Landsat images to explore the influence of urban growth on urban heat islands in the metropolis from 1991 to 2023. The supervised random forest technique was utilized to map the land cover changes. Furthermore, the computed normalized difference built-up index (NDBI), normalized difference vegetation index (NDVI), land surface temperature (LST), and urban thermal field variance index (UTFVI) were used to analyze the influence of urban expansion on UHIs. The findings revealed a 63.07 km2 increase in built-up areas and a 60.99 km2 decrease in vegetation cover during the study period. This dramatic land use change led to a 3.1°C rise in mean LST and a 19.38 km2 expansion of areas affected by the UHI effect. The UTFVI analysis further indicated a 33.63 km2 increase in the worst ecological zone due to the temperature rise. Statistical analysis between LST, NDVI, and NDBI revealed significant variability in explaining the intensity of LST and UHI in the metropolis over the study period. The study equips city authorities and planners with the fundamental knowledge needed to prepare a sustainable development plan that alleviates adverse effects of urban growth and elevated temperature-related issues. Also, the findings contribute to the global efforts in promoting more livable and climate-resilient urban environments.