This analysis deals with the effect of mixed convection and thermal radiation on steady three-dimensional (3D) flow of Williamson fluid near an irregular surface. The phenomenon is examined in semi-infinite domain and the flow is produced by means of non-linear stretching. The mass transfer analysis is carried out by means of activation energy and binary chemical reaction. The governing equations are initially reformed into ODES by applying applicable variables and then solutions are calculated for the flow field, mass transfer rate, skin frictions, temperature, heat transfer rate and concentration via shooting. New characteristics of dimensionless variables are illustrated by means of graphs and tables. The detailed analysis anticipates that velocity declines by the elevation of Weissenberg number and accelerates with the increase of mixed convection parameters. Further, the temperature enhances with the increase of temperature ratio and radiation parameters and behaved oppositely analogous to development in Prandtl number.