Quantitation of sewer inflow and infiltration (I/I) is important for maintaining efficient wastewater transport and treatment. I/I flows can be quantified based on flow rate and water quality measurements. Flow rate-based methods require continuous monitoring of flow rates using flow meters that are costly and prone to fouling. In comparison, conductivity and temperature, as simple water quality parameters, are more easily measurable with more cost-effective and reliable sensors. In this study, a data-driven methodology is developed for estimating I/I flows based on online conductivity and temperature measurements. A Prophet-model-based analytic algorithm is first developed to reconstruct the temperature and conductivity profiles of the base wastewater flow (BWF) from the measured temperature and conductivity time series. The algorithm is shown to be able to reconstruct the BWF temperature and conductivity profiles in two monitored catchments. The reconstructed BWF data are then incorporated into mass/energy balance equations for estimating I/I flows from the measured temperature and conductivity data. The overall I/I quantification method is finally demonstrated using simulation studies of a real-life sewer network and validated against the known I/I flows. This work provides a reliable method for I/I quantification based on simple measurements.