The shape stability of the structure plays a very important role in deep space exploration engineering. This paper presents 3D novel zero Poisson’s ratio metamaterial (ZPRM) with programmable thermal expansion and Young's modulus through the combination of bi-material triangles and re-entrant hexagonal structures. The coefficient of thermal expansion (CTE) and Young's modulus of the ZPRM-1 are predicted by establishing theoretical analysis models based on the classical beam theory. The mechanical response behavior of the ZPRM −1 under small deformation is simulated by finite element analysis (FEA). 3D printing is adopted to design and prepare experimental specimens, and compression experiments are carried out to certify the accuracy of the theories and FEA of Young's modulus. The results of parameter analysis show that the ZPRM-1 can tune the CTE and Young's modulus in a wide range when the geometric parameters and material combination are changed. In addition, the mechanical properties of the ZPRM-1 under the combined field of temperature and mechanical loads are investigated to achieve the tunable Young's modulus from positive to negative. This study provides a feasible reference for temperature and mechanical sensitivity instruments.