To accurately forecast the future development trend of vegetation in dry areas, it is crucial to continuously monitor phenology, vegetation health indices, and vegetation drought indices over an extended period. This is because drought caused by high temperatures significantly affects vegetation. This study thoroughly investigated the spatial and temporal variations in phenological characteristics and vegetation health indices in the abdominal part of Maowusu Sandland in China over the past 20 years. Additionally, it established a linear correlation between vegetation health and temperature indices in the arid zone. To address the issue of predicting long-term trends in vegetation drought changes, we have developed a method that combines the Informer deep learning model with seasonal and Seasonal Trend decomposition using Loess (STL) and empirical mode decomposition (EMD). Additionally, we have utilized the linearly correlated indices of vegetation health and meteorological data spanning 20 years to predict the Normalized Difference Vegetation Index (NDVI) and Temperature Vegetation Dryness Index (TVDI). The study’s findings indicate that over the 20-year observation period, there was an upward trend in NDVI, accompanied by a decrease in both the frequency and severity of droughts. Additionally, the STL-EMD-Informer model successfully predicted the mean absolute percentage error (MAPE = 1.16%) of the future trend in vegetation drought changes for the next decade. This suggests that the overall health of vegetation is expected to continue improving during that time. This work examined the plant growth circumstances in dry locations from several angles and developed a complete analytical method for predicting long-term droughts. The findings provide a strong scientific basis for ecological conservation and vegetation management in arid regions.