At present, a clear dependency of the dynamics upon temperature and pH has not been established for many heavy metals (HMs), so making it difficult to project and quantify the impact of ocean warming and acidification on metal biogeochemistry in future scenarios. To understand the responses of HMs to future ocean warming and acidification, we estimated the spatial-temporal variations and pollution status of six dissolved HMs (i.e., Cu, Zn, Pb, Cd, Hg, and As) in surface seawater throughout the Bohai Sea during 2012–2014. The results showed that the average concentrations of Cu, Zn, Pb, Cd, Hg, and As in seawater of the Bohai Sea were between 2.01–3.18, 10.47–15.58, 0.85–2.31, 0.25–0.55, 0.05–0.13, and 1.24–1.98 μg L-1, respectively. Spatially, the average concentrations of the studied HMs generally decreased from the three bays towards the central area, except for Hg which was relatively high in the central Bohai Sea in some cases. This implied that, in addition to continental inputs, there may be other processes affecting the distribution pattern of Hg, such as cyclonic or anticyclonic gyres, benthic fluxes between surface and bottom layers, and some marine planktonic and microbial activities. The pollution assessments of six HMs in seawater revealed that the major risk pollutants were Pb and Hg across the Bohai Sea. Analyses of the local and interactive effects of temperature and pH on HMs showed that the interactive effect of changing temperature and pH on HMs is much more complex than a direct temperature/pH relationship with HMs. Altogether, the results suggested that future ocean warming and acidification will significantly influence the concentrations of dissolved HMs in seawater of the Bohai Sea, but with different relationships.