Late Jurassic paleogeographic patterns were influenced by the growth of the Pacific plate and the breakup of Pangea, impacting the global paleoclimate during this warm and equable greenhouse period. However, the use of different proxies may introduce bias in seawater temperature reconstructions. In this study, we reconstructed midlatitude Tethyan seawater paleotemperatures in the Northern Hemisphere using carbonate clumped isotopes (Δ47) in well-preserved parts of belemnite rostra from the Upper Jurassic Hongqilafu Formation in the Taxkorgan Basin, southwest Xinjiang, China. Throughout the entire studied section, an increase in the 87Sr/86Sr ratio was observed. Comparison of this ratio with the published global seawater 87Sr/86Sr curve suggests a good correlation with the biostratigraphic and U-Pb age assignments of the Oxfordian−Tithonian interval. The Δ47-derived paleotemperature estimates indicate a long-term, relatively stable, and warm seawater temperature of ∼27 °C within the epipelagic zone of the eastern Tethyan Ocean during the Late Jurassic. Cooler seawater temperatures were recorded at the Oxfordian−Kimmeridgian boundary and in the late Tithonian, likely reflecting changes in paleogeography and paleoceanography resulting from the breakup of Pangea and/or variations in belemnite habitat depth. When compared with global seawater temperature data from different proxies, the results suggest that elevated atmospheric pCO2 levels during the Late Jurassic may have caused warmer conditions in midlatitude and polar regions. The reconstructed δ18Osea values exhibit a remarkably modern midlatitude seawater character and are more positive than values traditionally assumed for the Jurassic ice-free world. Given that the Taxkorgan Basin was located in a semi-enclosed basin and was dominated by evaporation in the Late Jurassic, the reconstructed δ18Osea values may represent regional seawater signals. Consequently, they cannot be used to support the existence of ice sheets in both polar regions. Our results suggest that climatic changes in the Jurassic greenhouse world may have been overprinted by local factors, potentially masking broader climatic trends.