Abstract Background Inflammatory Bowel Disease (IBD) most commonly affects women of reproductive age. While considered effective, there are limited data concerning IBD and pregnancy-related outcomes in patients receiving in vitro fertilization (IVF). This study compares the characteristics and outcomes of pregnant women with IBD who conceived spontaneously with those who required IVF. Methods This retrospective study included pregnant women with IBD who visited the IBD Mom Clinic at the Tel Aviv Sourasky Medical Center (TLVMC). The cohort consists of two groups - women who conceived spontaneously (IBD-spon) or through IVF therapy (IBD-IVF). Demographics, clinical characteristics, as well as pregnancy and IBD-related outcomes were collected from electronic medical records. Results A total of 269 IBD pregnancies from September 2017 to December 2023 were reviewed; 53 women (19.7%) conceived via IVF. Among the IBD-IVF group, there was a lower rate of Crohn’s disease (54.7% vs 67%, P=0.02), similar rate of ulcerative colitis (35.8% vs 31%, p=0.347) and lower rate of patients with pouch (9.4% vs 1.9%, p=0.005). Disease duration was longer in IBD-IVF (10.5 ± 6.9 vs. 8.3 ± 6.0 years, p<0.05) and the IBD-IVF group was significantly older (mean 34.5 ± 5.4 years vs. 31.6 ± 4.4 years, p<0.001) and independently associated with a 10% increase in IVF conception likelihood per additional year of age (OR=1.10, p<0.001). Patients with CD who received IVF had higher rates of peri-anal involvement compared to those who conceived spontaneously (37.9% vs. 19.5% p<0.05). Table 1 summarizes these findings. First-trimester fecal calprotectin levels were elevated in the IBD-IVF group (684.1 ± 1003.5 vs. 373.8 ± 529.6 μg/g, p<0.001). Despite that, no significant differences in IBD exacerbations, advanced therapy adjustments, or hospitalizations were observed. Adverse pregnancy outcomes were more frequent in the IBD-IVF group. These includes lower mean fetal weight (2999.7 ± 493 vs. 3185.6 ± 524.6 g, p=0.05), spontaneous abortions (9.4% vs. 1.9%, p=0.03), and pregnancy losses before 20 weeks (7.5% vs. 1.5%, p=0.03), as detailed in Table 2. Conclusion In this study, significantly higher rates of adverse pregnancy outcomes were observed in patients conceiving through IVF. Older age was independently associated with IVF conception. No increased adverse IBD-related outcomes were observed. These data suggest that the complications in the IVF group, are more related to underlying maternal risk factors and emphasize the importance of close monitoring and follow-up in this population.
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