Autotransplantation Of Teeth Research Articles

Rapid prototyping-assisted tooth autotransplantation is associated with a reduced root canal treatment rate: a retrospective cohort study

BackgroundAutotransplantation is a beneficial treatment with a high success rate for young patients. However, most adult patients require root canal treatment (RCT) of the donor teeth after the autotransplantation procedure, which causes a prolonged treatment time and additional expenses and increases the rate of future tooth fracture. Rapid prototyping (RP)-assisted autotransplantation shortens the extra-alveolar time and enables a superior clinical outcome. However, no cohort studies of the application of this method on adult populations have been reported.MethodsThis study is a retrospective cohort study. All patients underwent autotransplantation from 2012 to 2020 in the Kaohsiung and Chia-Yi branches of Chang Gung Memorial Hospital, and the procedure and clinical outcomes were analysed. Differences in clinical outcomes, age, sex, extra-alveolar time, fixation method, and RCT rate were compared between the two groups.ResultsWe enrolled 21 patients, 13 treated using the conventional method and 8 treated using the RP-based technique. The RCT rates of the conventional group and RP group were 92.3% and 59%, respectively. The mean age of the two groups was significantly different (28.8 ± 10 vs. 21.6 ± 2.1); after performing subgroup analysis by excluding all of the patients aged > 40 years, we found that the RCT rates were still significantly different (91.0% vs. 50%). The mean extra-alveolar time was 43 s in the RP group, and the autotransplantation survival rate in both groups was 100%.ConclusionsRapid prototyping-assisted autotransplantation was successfully adopted for all patients in our study population. By shortening the extra-alveolar time, only 50% of the patients required a root canal treatment with a 100% autotransplantation survival rate.Trial Registration : Retrospectively registered.

Application effect of computer-aided design combined with three-dimensional printing technology in autologous tooth transplantation: a retrospective cohort study

BackgroundThe activity of donor periodontal membrane is the key factor of autologous tooth healing. The application of digital aided design, 3D printing model and guide plate in autotransplantation of tooth (ATT) is expected to reduce the damage of periodontal membrane and preserve the activity of periodontal membrane, so as to improve the success rate of ATT. This study tried to prove the role of digital technology in improving the success rate of ATT, although there are differences in model accuracy in practice.MethodsWe included 41 tooth autotransplantation cases which assisted by 3D-printed donor models and surgical guides and divided them into two groups in accordance with whether the donor tooth could be placed successfully after the preparation of alveolar socket guided by the model tooth. Then, we compared and analyzed the preparation time of alveolar socket, extra-alveolar time, and number of positioning trials of the donor tooth between the two groups. We also included a comparison of the in vitro time of the donor tooth with that of 15 min. The incidence of complications was included in the prognostic evaluation.ResultsThe mean preparation time of the alveolar socket, mean extra-alveolar time of donor tooth, and mean number of positioning trials with donor tooth of 41 cases were 12.73 ± 6.18 min, 5.56 ± 3.11 min, and 2.61 ± 1.00, respectively. The group wherein the donor tooth cannot be placed successfully (15.57 ± 6.14 min, 7.29 ± 2.57 min) spent more preparation time of alveolar socket and extra-alveolar time than the group wherein the donor tooth can be placed successfully (9.75 ± 4.73 min, 3.75 ± 2.57 min). The number of positioning trials with the donor tooth of the group wherein the donor tooth cannot be placed successfully (3.19 ± 0.75) was higher than that of the other group (2.00 ± 0.86). There was no significant difference in survival rates between the two groups.ConclusionsCompared with the traditional tooth autotransplantation, the introduction of computer-aided design combined with 3D printing of the model tooth and surgical guides evidently shortens the preparation time of the alveolar socket and the extra-alveolar time of the donor tooth and reduces the number of positioning trials with the donor tooth regardless of the shape deviation between the model and actual teeth.

Tooth auto-transplantation to close an oro-sinusal communication using a 3D printed model to adapt the alveolar socket: a case report

Introduction: Tooth auto-transplantation has a high success rate therapy when limiting the extra-oral time of the graft. In this way, printing a 3D model of the germ can be a useful tool in order to prepare the receiving site. Observation: We treated a case of post extractional oro-sinusal communication closure using a 3D pattern to adapt the alveolar socket receiving the wisdom tooth auto-transplantation. Comment: Extra-oral time spent by the graft was under 15 seconds improving the chance of success. After one year follow up, the graft is vital, functional and it continued its root formation. Conclusion: 3D printing seems to be an effective technique to minimize surgical time leading to a higher rate of success for auto-transplantation therapies.

Questionnaire after autotransplantation of teeth at Osaka Dental University Hospital

Questionnaire after autotransplantation of teeth at Osaka Dental University Hospital

A case report of immediate autotransplanted teeth: 2-year follow-up

A case report of immediate autotransplanted teeth: 2-year follow-up

Autotransplantation of wisdom tooth in the alveolus of extracted first mandibular molar

Dental autotransplantation is a surgical procedure where tooth or dental germ is transffered from one position to another, within the same person. This way an edentulous area after extraction can be successfully restored without the need of other more invasive approaches. This procedure is recommended in young individuals who have lost permanent molars due to caries complications and have an impacted third molar as a potential donor tooth. The aim of this report is to present a successful transplantation of wisdom tooth into the alveolus of the first mandibular molar in a case of a young individual.

Success of a tooth auto-transplant despite delayed endodontic treatment due to COVID-19 pandemic lock-down: a case report

Auto-transplantation has been suggested to be a favourable treatment option in comparison to prosthodonticreplacements. Studies have shown an average survival rate of 89.1% for auto-transplanted teeth. This articleaims to report a successful third molar auto-transplantation, despite delayed endodontic treatment because ofmovement control order (MCO) imposition following COVID-19 out-break in Malaysia. A 22-year-old femalepatient’s impacted lower left third molar (38) was used as a donor to replace her lower left second molar (37),which was deemed non-restorable due to caries and root resorption as a result of impinging pressure from theimpacted adjacent third molar. Successful outcome and uneventful healing were achieved over a period of oneyear, despite delayed endodontic treatment following auto-transplantation. A favourable auto-transplant canbe achieved despite delayed endodontic treatment post-transplantation, if the procedure is performed in a goodaseptic environment and bacterial load is controlled at the site.KEYWORDSCovid-19; Dental pulp; Endodontics; Lockdown; Root canal therapy; Third molars.

Periodontal Tissue Healing After Autologous Tooth Transplantation: A Retrospective Analysis of Case Series.

Tooth transplantation is a treatment that uses non-functional teeth to compensate for defects caused by tooth extractions. Surgical procedures have yielded high success rates in autologous tooth transplantation using a tooth with a complete root. This study aimed to evaluate periodontal tissue healing after transplantation of 14 molar teeth. Fourteen individuals aged 28-53 years who underwent autologous transplantation of third molars with completely developed roots between December 2010 and March 2017 were included in the study. The donor tooth was carefully extracted, placed into the prepared transplant site, and stabilised with an orthodontic wire and 4-0 silk sutures for a few weeks. Endodontic treatment was performed after 3-4 weeks. To evaluate the periodontal tissue healing, clinical measurements of the probing pocket depth (PPD), clinical attachment level (CAL), and keratinised gingival width (KGW) were performed, along with radiographic examinations of bone defect fill (BDF) at baseline and at 6 and 12 months after surgery. Statistical analysis was performed using the Mann-Whitney U test. The changes in PPD and CAL at baseline, 6, and 12 months were statistically significant (P <0.05). KGW did not show a statistically significant decrease. The postoperative-BDF amount at 6 and 12 months was 2.2 ± 1.4 and 4.2 ± 1.4 mm, respectively. Periodontal tissue healing may occur in tooth autotransplantation even in the presence of complete root development in the donor tooth.

A COMPARATIVE MODEL STUDY BETWEEN THE SURVIVABILITY OF DENTAL IMPLANTS VERSUS DENTAL AUTOTRANSPLANTS, LEADING TO A SYSTEMATIC REVIEW

Aim: The aim of this Systematic Review is to compare the survival rate of teeth autotransplantation with immediate implant placement in cases of singular loss of teeth and obtain a clinical recommendation for similar cases. Materials And Methods: The research will be conducted by two independent reviewers in PubMed search and it will include studies from January 2017 to December 2020.The survival rate of both immediate implant placement and tooth autotransplantation will be evaluated in different follow-up times and the information compiled in several metaanalyses.

Tooth autotransplantation of the mandibular third molar: A case report

Autotransplantation is a viable option for treating teeth with severe decay when a donor tooth is available. Our case was a 29-year-old female that her mandibular second molar was non restorable due to extensive root caries. After extraction of mandibular second molar, the mandibular third molar was reimplanted into the recipient site. Root canal therapy was done for the third molar after two weeks.After15 months, clinical and radiographic examination revealed satisfactory outcome with no signs or symptoms suggestive of pathology.

Autotransplantation of the Third Molar: A Therapeutic Alternative to the Rehabilitation of a Missing Tooth: A Scoping Review.

Introduction: Tooth autotransplantation is the repositioning of an erupted, partially erupted, or non-erupted autologous tooth from one site to another within the same individual. Several factors influence the success rate of the autotransplant, such as the stage of root development, the morphology of the tooth, the surgical procedure selected, the extraoral time, the shape of the recipient socket, the vascularity of the recipient bed, and the vitality of the cells of the periodontal ligament. The aim of this scoping review was to provide the most up-to-date information and data on the clinical principles of the third-molar autograft and thus provide clinical considerations for its success. Materials and methods: This review was conducted based on PRISMA-ScR (Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews). The research was conducted by searching for keywords in three databases—PubMed, Scopus and Google Scholar—by two independent reviewers following the PRISMA protocol, from which 599 records were identified. Conclusions: Third-molar autotransplantation is a valid solution to replace missing teeth. The key to the success of this technique is the surgical procedure, which must be as atraumatic as possible to preserve the periodontal ligament of the tooth to be transplanted. The success rate is also linked to the stage of development of the root, with a worse prognosis in the case of a complete root.

Delayed Autotransplantation of Permanent Impacted Maxillary Canine

Tooth autotransplantation is the extraction of a tooth from one location and its replantation in a different location in the same individual. It provides an alternative approach for treating severely impacted tooth when orthodontic treatment is ineffective. This case report presents a patient with buccally impacted left maxillary canine. Alveolar bone grafting (ABG), autotransplantation and orthodontic treatment were carried out. A 4 month review shows good prognosis of the transplanted tooth with no bone resorption.

Aesthetic and functional restoration of the dental arch continuity in difficult cases of impacted teeth within the frontal segment.

Impacted teeth are a fairly common defect with the incidence ranging from 2.9 to 13.7%. Evaluation of the efficacy and safety of various treatment modalities in patients with impacted teeth within the frontal segment of the maxilla. The retrospective evaluation covered treatment outcomes in 81 patients with impacted teeth within the aesthetic segment. The subjects were divided into 3 groups. Patients with the impacted tooth uncovered and orthodontically repositioned in the arch were assigned to group 1. Group 2 consisted of patients with the impacted tooth qualified for extraction and the gap augmented and restored with an implant. Group 3 included subjects, who underwent en-bloc autotransplantation of the impacted tooth. In 38 group 1 subjects 47 teeth were uncovered with a mean efficacy of 58.1% (96.3% and 70% in patients below 18 yoa and adults, respectively). The excellent aesthetic treatment outcome was obtained in 75% and good in 25% of patients. In group 2 twenty-six adult subjects were treated with 100% efficacy. In 65.4% of patients, augmentation with a bone block was performed and in the remaining 34.6%, implantation and augmentation with bone granulate. In 88.3% subjects a satisfying treatment outcome was obtained. In group 3 eighteen teeth in a block were grafted with the efficacy of 88.9%. Excellent aesthetics was obtained in 56.25% of cases and good in 31.25%. Orthodontic repositioning of the impacted teeth in the arch in adult patients bears the risk of failure. Surgical treatment modalities in impacted teeth are effective and provide high aesthetics of the treatment outcome improved by prior orthodontic treatment of the concomitant malocclusion and augmentation of the vertical bone atrophy before implantation.

Effect of donor-specific blood transfusions on allotransplanted teeth in a monkey model: Histoquantification of periodontal healing.

Pre-transplant blood transfusions have previously shown a positive effect on organ allograft survival in humans and various animal species. The aims of this study were, first, to evaluate the effect of pre-transplant donor-specific blood transfusions on periodontal healing of fully developed allotransplanted teeth in monkeys; and second, to investigate the immune response against donor antigens and to determine a possible correlation between alloimmune reactions and histopathological signs of rejection. Twenty monkeys (Cercopithecus aethiops) were divided into ten pairs with similar sizes of incisors. One monkey in each pair gave three transfusions to the other monkey with 1-week intervals. One week after the last transfusion, each pair exchanged simultaneously a central maxillary incisor and a lateral mandibular incisor. The corresponding central maxillary and mandibular lateral incisors were autotransplanted to the contralateral sockets. All teeth were treated endodontically per-operatively. Histocompatibility was evaluated by mixed lymphocyte culture before the first transfusion, while alloantibodies and cell-mediated alloresponses were measured before transfusions and at 2 and 8weeks after transplantation. All animals were sacrificed 8weeks after tooth transplantation. Serial sections of the transplanted teeth were quantified histologically. Mixed lymphocyte cultures showed positive reactions in 19 of 20 cases, indicating incompatibility. The majority of the monkeys developed antibodies towards the tooth donor. Cell-mediated cytotoxicity was negative in all monkeys. Histoquantification revealed a mean score of 70% normal periodontal ligament (PDL) in autotransplanted teeth, with 5% ankylosis. The allografts had a mean score of 17% normal PDL and 63% ankylosis, with no significant influence of transfusion. However, in the mandibular grafts, a tendency towards a positive transfusion effect was seen. Donor-specific blood transfusion did not reduce ankylosis in tooth allografts. The healing of mandibular incisor tooth allografts was improved, but not that of maxillary incisors. Donor-specific antibodies showed no effect on the survival of allograft PDL.

Primary tooth autotransplantation: update and retrospective clinical study

Objective A new technique of primary tooth autotransplantation has recently been published demonstrating reliable replacement of missing permanent incisors in young children due to trauma or agenesis. This retrospective clinical study reports on the longterm success of this new technique in a larger patient group regarding its potential to support bone and soft tissue growth. Study design 40 children (age range: 2.7–17.6 years) received 53 primary tooth autotransplants (49 canines and 4 incisors) due to traumatic tooth loss (73%), agenesis (19%) or dysplasia/displacement (8%). Clinical and radiological follow-up examinations were performed to check up on root resorption, bone and soft tissue growth, survival and success. Results 22 transplants still present in the oral cavity of 18 patients yielded a success rate of 77%. The Kaplan-Meier estimator measured a median survival time of 86 months (7.2 years) for all 53 grafts. In all cases, increasing soft tissue and bone development enabled a successful prosthetic rehabilitation regarding aesthetics and function. Conclusions Primary tooth autotransplantation reliably restores edentulous anterior space in children experiencing traumatic tooth loss or agenesis and acts as an immediate therapy before other therapies such as premolar transplantation or orthodontic space closure can be carried out at a later time. It guarantees the co-development of soft tissue and bone in the teenage jaw which is associated with high patient satisfaction and acceptance of this method.

Use of computer-aided three-dimensional prototyping to surgically assist in tooth autotransplantation

Autotransplantation is a surgical technique in which a donor tooth belonging to the same individual is repositioned into a surgically prepared socket or site of previous tooth extraction. It is beneficial in patients with teeth affected by agenesis, trauma, significant caries, and in teeth in a non-restorable condition or prognostically poor due to other pathology. It is particularly useful in paediatric patients, as properly transplanted teeth have a vital periodontium that allows for continuous growth and functional adaptation leading to preservation of the alveolar ridge. Technological advances in rapid prototyping combined with three-dimensional (3D) computed tomography (CT) have the ability to revolutionise autotransplantation. Preoperative planning for atraumatic extraction of the donor tooth and precise preparation of the recipient site with a rapid prototyped surgical template of the donor tooth considerably reduces the extra-alveolar time, and also reduces manipulation of the root sheath and periodontal ligament, and related trauma. This case series demonstrates the efficient and successful autotransplantation of various types of teeth with the use of a rapid prototyped surgical template produced from 3D CT. The use of this technology is expected to refine the surgical technique and improve treatment outcomes.

Influencing Factors in Autotransplantation of Teeth with Open Apex: A Review of the Literature

Dental autotransplantation is the process by which a tooth located in its natural socket is extracted and relocated to another socket in which the tooth is missing or has been extracted due to various reasons such as trauma, extensive caries or periapical pathology, among other reasons. This proposed technique offers a more conservative alternative for patients in comparison with prosthetic or implant techniques, especially in young patients where implants are contraindicated until their maxillary bone system’s growth ends. Thus, the objective of this review was to present a qualitative synthesis of the risk factors that influence the results of open apex dental autotransplantation in humans. After confirming that there are various factors that influence dental autotransplantation, it was concluded that the extra-alveolar time of the donor tooth and the periodontal damage of the root of the donor tooth are the factors of greatest interest in the literature, both closely linked to the use of 3D replication of the transplanted tooth.

Treatment for critically impacted maxillary canines: Clinical versus scientific evidence – A systematic review

BackgroundCritically impacted maxillary canines are prone to fail to respond to conventional surgical exposure and orthodontic traction. Correct identification of a critical impaction requires enhanced diagnosis modalities and might lead to incorporating alternative surgical strategies in the treatment plan. Predictability of techniques such as apicotomy or tooth autotransplantation is, however, yet to be determined. The objective of this study was to systematically review treatment perspectives for critically impacted maxillary canines. MethodsA systematic review of the available literature until april 2020 was conducted using an electronic search in Embase, Cochrane Central, Web of Science and PubMed databases. Randomised and non-randomised studies investigating treatment options and treatment outcome for buccally and/or palatally critically impacted maxillary canines were considered for the review. Information recorded concerned study design and setting, participants’ characteristics and details regarding the type of intervention, types of outcomes measured and follow-up time. The included studies received a methodological quality scoring and risk of bias analysis according to a tool suggested by Murad et al (2018). ResultsFive studies were included in the quality analysis, all case series. The included studies enrolled a total of 302 patients and counted 346 critical maxillary canine impactions. Apicotomy and autotransplantation were listed as potential surgical approaches with surgical outcome presented for both surgical strategies. Adequate esthetical and/or functional outcomes were reported in most of the included studies. According to the quality assessment tool used, the reviewed studies scored medium on the proposed scale. DiscussionLiterature featuring protocols for identifying and treating critical maxillary canine impaction only consists of case series and case reports, which provide low level of evidence. The rather good results reported by the reviewed studies must be put into perspective as the methodology of these studies was insufficient and potential bias was identified. Comprehensive clinical research is needed to further investigate treatment options and form a basis for clinical guidelines.

Mid-term outcomes and periodontal prognostic factors of autotransplanted third molars: A retrospective cohort study.

Tooth autotransplantation is a valid method for replacing non-restorable teeth. This study aimed to assess mid-term survival and success of autotransplanted third molars and the clinical periodontal parameters and factors predicting successful periodontal attachment apparatus regeneration. In total, 36 patients who had undergone extraction and subsequent autotransplantation of 36 third molars using virtual planning and computer-aided rapid prototyping models by an oral surgeon and endodontist were eligible. Probing pocket depth (PPD), gingival recession (REC), clinical attachment level (CAL), pulpal and periapical healing, root resorption, and radiographic bone loss (RBL) were evaluated. Additionally, a questionnaire evaluated patient-reported outcomes. The mean age of the participants was 30.2 years with a mean follow-up duration of 29.42 ± 14.56 months. The overall survival and success rates were 97.2% and 91.7%, respectively. No statistically significant differences were found in success and survival rates between open and closed apex groups or between compromised and intact buccal bone groups. No signs of pulp necrosis were found in the open apex group. Progressive replacement resorption was detected in one closed apex case. The mean PPD was 2.7 ± 0.45mm for all transplanted teeth. REC was 0.13mm higher in transplanted teeth than in previous hopeless teeth. CAL changes were neither clinically relevant (-0.17 ± 0.66mm) nor statistically significant. The reported patient satisfaction was high. Autotransplantation of third molars is a predictable treatment method, with a 2.5-year cumulative tooth survival and success of 97.2% and 91.7%, respectively, which were not influenced by recipient site integrity or root development.

European Society of Endodontology position statement: Surgical extrusion, intentional replantation and tooth autotransplantation: European Society of Endodontology developed by.

This European Society of Endodontology (ESE) position statement on surgical extrusion, intentional replantation and tooth autotransplantation represents the consensus of an expert committee, convened by the ESE. A narrative review in the International Endodontic Journal (Plotino et al. 2020, international Endodontic Journal, 53, 1636-52) formed the basis for the position statement. The review provided detailed information on the background, clinical procedures and the outcome of surgical extrusion, intentional replantation and tooth autotransplantation techniques. The aim of the current statement is to summarize the best available evidence on these clinical techniques to provide appropriate clinical guidance to undergraduate and postgraduate students, dental practitioners, clinical teachers and researchers. The current position statement will be updated by the ESE periodically to reflect new evidence as it becomes available to provide the most current treatment guidance for clinical practice.