On the condition that the velocity ratio of compressive wave to shear wave is stable during the propagating process of seismic wave, this paper develops an estimation method for medium quality factor based on single station’s travel time difference between direct S and P waves and the first period signal of direct P wave. 8 774 high SNR wave data altogether recorded by 75 stations are analyzed. The results show that: (1) under the normal regional stress field, the quality factors QmSP in the stable tectonic area are higher than that in the active tectonic area around the Weifang-Jiashan section and its surrounding area in the Tanlu fault zone; (2) in the Juxian-Tancheng section the seismic wave attenuation is relatively quick, and the media is relatively broken, suggesting no tectonic stress accumulation; (3) the Xinyi-Sihong section is currently locking and in accumulating elastic strain energy stage, which has the deep environment and conditions of strong earthquake generation similar to those of the 1668 M8.5 Tancheng strong earthquake.