In order to document quantitatively the cooling and denudation history of the Higher Himalayan granites bordering the Tethyan sedimentary zone, fission-track (FT) apatite and 40Ar39Ar mica ages have been determined on the Gangotri leucogranites and biotite granites in the Garhwal region of India. Gangotri is the source area of the Ganges River and lies in the midst of the highest Himalayan peaks in India. A total of 15 apatite ages from a vertical profile (2580–4370 m) on the Gangotri granites yields FT ages in the range of 1.5 ± 0.6 to 2.4 ± 0.5 Ma, indicating that the rock column with a relief of ∼1800 m cooled through 130 ± 10°C within only ∼1 million years during the Late Pliocene. An average denudation rate of ∼2 mm/yr is estimated for the past 2.4 million years. From the Gangotri granites, we also report a muscovite 40Ar39Ar age of 17.9 ± 0.1 Ma and a biotite age of 18.0 ± 0.1 Ma. These reflect cooling of the rocks through 300–350°C, probably related to an Early Miocene pulse of denudation caused by a basement-cover detachment (the Martoli Normal Fault) above the leucogranites. Time-temperature pathways indicate that the cooling of the rocks in the Late Pliocene-Quaternary was five to six times the magnitude of cooling between 18 and 2 Ma, indicating a distinct pulse of rapid denudation in the Late Pliocene-Quaternary. We interpret these young apatite ages and fast denudation as a geomorphic response (increased erosion and cooling) of the rocks to a major pulse of tectonic uplift in the Higher Himalaya shortly before 2.4 Ma. The effect of climatic cooling on this denudation is considered secondary to the role of tectonic forcing, and indeed produced a positive feedback to the primary cause. Although our study is confined to the Garhwal region, it is probable that other granitic bodies of the Higher Himalaya bordering the Tethyan sedimentary rocks, and forming the loftiest summits in the Himalaya, have also experienced episodic denudation — one major pulse in the Early Miocene, which was mainly tectonic denudation, and another in the Late Pliocene-Quaternary, which was mainly erosional. The latter is well recorded by apatite FT data, and is consistent with the hypothesis that rapid uplift and denudation of the Himalayan rocks may have influenced the initiation of the ice ages in the northern hemisphere.