The advancement of rubberized concrete technology and its application in engineering can significantly promote the complete recycling and safe disposal of waste tire rubber. Integrating crumb rubber into concrete alters its compressive stress–strain behavior. This study investigated the stress–strain characteristics of rubberized concrete containing waste tire crumb rubber, addressing the absence of standard guidelines for the design of rubberized concrete. By examining the complete stress–strain curves of rubberized concrete, key parameters such as peak stress, initial elastic modulus, peak strain and secant modulus were meticulously evaluated. The study delved into the mechanisms through which crumb rubber influences the stress–strain behavior of concrete, considering factors including variations in rubber content and pretreatment methods. The experimental data were analyzed using conventional concrete constitutive theories to quantify the impact of crumb rubber on rubberized concrete's stress–strain relationship. Significant variations were observed, including a notable decline in strength with increasing rubber content. For instance, increasing the rubber content from 0.0% to 5.0% led to reductions of 44.2% in peak stress and 47.0% in secant modulus compared to the reference concrete. In addition, pretreating the crumb rubber markedly improved rubberized concrete strength, and the peak stress of concrete with 1.0%–5.0% pretreated crumb rubber increased by an average of 7.0% compared to that with untreated crumb rubber. The study identified that crumb rubber's inclusion significantly altered the coordination of stress and strain in concrete, thereby affecting its stress–strain behavior. A set of evaluation equations for the stress–strain relationship of rubberized concrete was developed, offering a reliable method for predicting its behavior. This research fills a critical gap in the analytical assessment of rubberized concrete and marks a significant stride towards its broader use in sustainable construction practices.