Large-scale smart floor will be one potential form for a human–machine interface, but is also facing many difficulties and challenges in the materials science and information engineering. Here, we present a straightforward method for fabricating large-scale micro-elastic triboelectric nanogenerator (ME-TENG) arrays, which can be assembled as triboelectric sensing ground for real-time interface interaction and all-weather monitoring. ME-TENG unit of 6 by 6 arrays offers a maximum power density of 5.84 mW·m−2 under a load resistance of 70 MΩ. It displays a sensitivity of 132.48 mV/kPa in the pressure range of 0 to 180 kPa. The electrical output signals have remained stable in the durability tests over 10 days with various weather conditions. Furthermore, successfully demonstrated a regional comprehensive security monitoring (RCSM) system for enabling all-weather monitoring of the features, position, and movement trajectories of an object. Even more gratifying is that the ME-TENG unit of 30 cm by 30 cm prepared by a simple and fast “all-in-one” method, takes costs of 14.84 dollars/m2 and the production period of 2 h, compared with the most cost-effective piezoelectric sensors, the cost and duration were reduced by 98.67 % and 42.86 %, respectively. This work will greatly contribute to the development and implementation of large-scale sensing and the multidimensional security system.