Interactive Technology Research Articles

Innovations in blood pressure measurement and reporting technology: International Society of Hypertension position paper endorsed by the World Hypertension League, European Society of Hypertension, Asian Pacific Society of Hypertension, and Latin American Society of Hypertension.

Blood pressure (BP) is a key contributor to the lifetime risk of preclinical organ damage and cardiovascular disease. Traditional clinic-based BP readings are typically measured infrequently and under standardized/resting conditions and therefore do not capture BP values during normal everyday activity. Therefore, current hypertension guidelines emphasize the importance of incorporating out-of-office BP measurement into strategies for hypertension diagnosis and management. However, conventional home and ambulatory BP monitoring devices use the upper-arm cuff oscillometric method and only provide intermittent BP readings under static conditions or in a limited number of situations. New innovations include technologies for BP estimation based on processing of sensor signals supported by artificial intelligence tools, technologies for remote monitoring, reporting and storage of BP data, and technologies for BP data interpretation and patient interaction designed to improve hypertension management ("digital therapeutics"). The number and volume of data relating to new devices/technologies is increasing rapidly and will continue to grow. This International Society of Hypertension position paper describes the new devices/technologies, presents evidence relating to new BP measurement techniques and related indices, highlights standard for the validation of new devices/technologies, discusses the reliability and utility of novel BP monitoring devices, the association of these metrics with clinical outcomes, and the use of digital therapeutics. It also highlights the challenges and evidence gaps that need to be overcome before these new technologies can be considered as a user-friendly and accurate source of novel BP data to inform clinical hypertension management strategies.

Efficacy and safety of fedratinib in patients with myelofibrosis previously treated with ruxolitinib (FREEDOM2): results from a multicentre, open-label, randomised, controlled, phase 3 trial

Most patients with myelofibrosis develop ruxolitinib intolerance or disease that is relapsed or refractory, and survival rates after ruxolitinib discontinuation are poor. We aimed to evaluate the safety and efficacy of fedratinib versus best available therapy (BAT) in patients with myelofibrosis previously treated with ruxolitinib. FREEDOM2 was a multicentre, open-label, randomised, controlled, phase 3 trial in 86 clinics in 16 countries, in which patients aged at least 18 years with intermediate-2 or high-risk myelofibrosis that was relapsed or refractory or intolerant to ruxolitinib with Eastern Cooperative Oncology Group performance status 0-2 were stratified by spleen size by palpation, platelet count, and previous ruxolitinib treatment, and randomly assigned 2:1 by interactive response technology to receive fedratinib 400 mg per day (4 × 100 mg capsules orally once daily, open-label) or BAT. Patients received prophylactic antiemetics and thiamine supplementation, and symptomatic antidiarrhoeals as required. Primary endpoint was proportion of patients reaching spleen volume reduction (SVR) of at least 35% (SVR35) at end of cycle 6 in the intention-to-treat population. This manuscript reports the primary analysis of the trial; follow-up is ongoing. This trial is registered at clinicaltrials.gov, NCT03952039. Between Sept 9, 2019 and June 24, 2022, of 316 patients screened, 201 were randomly assigned and treated (134 to fedratinib, 67 to BAT [including 52 receiving ruxolitinib]); 46 patients from the BAT group crossed over to fedratinib. Approximately half of enrolled patients were male (fedratinib 75 [56%] of 134; BAT 30 [45%] of 67) and most were White (fedratinib 106 [79%] of 134; BAT 58 [87%] of 67). At data cutoff (Dec 27, 2022), median survival follow-up was 64·5 weeks (IQR 37·9-104·9). SVR35 at end of cycle 6 was seen in 48 (36%) of 134 patients receiving fedratinib versus four (6%) of 67 patients receiving BAT (30% difference; 95% CI 20-39; one-sided p-value <0·0001). During the first six cycles 53 (40%) of 134 patients in the fedratinib group and 8 (12%) of 67 patients in the BAT group had grade 3 or greater treatment-related adverse events, most frequently anaemia (fedratinib 12 [9%] of 134; BAT 6 [9%] of 67) and thrombocytopenia (fedratinib 16 [12%] of 134; BAT 2 [3%] of 67); one patient in the fedratinib group died from acute kidney injury suspected to be related to study drug (no treatment-related deaths in the BAT group). Gastrointestinal adverse events occurred more frequently in the fedratinib group compared with the BAT group, but were mostly grade 1-2 in severity and more frequent in early cycles, and were less frequent than in prior clinical trials. A total of 28 (21%) of 134 patients in the fedratinib group and 3 (4%) of 67 patients in the BAT group had thiamine levels below lower limit of normal per central laboratory assessment, with only one case of low thiamine in the fedratinib arm after the introduction of prophylactic thiamine supplementation. Findings from FREEDOM2 support fedratinib as a second-line Janus kinase inhibitor option to reduce spleen size after ruxolitinib failure or intolerance in patients with myelofibrosis, and shows effective strategies for management of gastrointestinal adverse events and low thiamine concentrations through prophylaxis, monitoring, and treatment. Bristol Myers Squibb.

Aquaporin CmPIP2; 3 links H2O2 signal and antioxidation to modulate trehalose-induced cold tolerance in melon seedlings.

Cold stress severely restricts the growth and development of cold-sensitive crops. Trehalose (Tre), known as the 'sugar of life', plays key roles in regulating plant cold tolerance by triggering antioxidation. However, the relevant regulatory mechanism remains unclear. Here, we confirmed that Tre triggers apoplastic hydrogen peroxide (H2O2) production and thus plays key roles in improving the cold tolerance of melon (Cucumis melo var. makuwa Makino) seedlings. Moreover, Tre treatment can promote the transport of apoplastic H2O2 to the cytoplasm. This physiological process may depend on aquaporins. Further studies showed that a Tre-responsive plasma membrane intrinsic protein 2; 3 (CmPIP2; 3) had strong H2O2 transport function and that silencing CmPIP2; 3 significantly weakened apoplastic H2O2 transport and reduced the cold tolerance of melon seedlings. Yeast library and protein-DNA interaction technology were then used to screen two Tre-responsive transcription factors, abscisic acid responsive element (ABRE)-binding factor 2 (CmABF2) and abscisic acid responsive element (ABRE)-binding factor 3 (CmABF3), which can bind to the ABRE motif of the CmPIP2; 3 promoter and activate its expression. Silencing of CmABF2 and CmABF3 further dramatically increased the ratio of apoplastic H2O2/cytoplasm H2O2 and reduced the cold tolerance of melon seedlings. This study uncovered that Tre treatment induces CmABF2/3 to positively regulate CmPIP2; 3 expression. CmPIP2; 3 subsequently enhances the cold tolerance of melon seedlings by promoting the transport of apoplastic H2O2 into the cytoplasm for conducting redox signals and stimulating downstream antioxidation.

Safety and immunogenicity of mRNA-based seasonal influenza vaccines formulated to include multiple A/H3N2 strains with or without the B/Yamagata strain in US adults aged 50–75 years: a phase 1/2, open-label, randomised trial

Inclusion of additional influenza A/H3N2 strains in seasonal influenza vaccines could expand coverage against multiple, antigenically distinct, cocirculating A/H3N2 clades and potentially replace the no longer circulating B/Yamagata strain. We aimed to evaluate the safety and immunogenicity of three next-generation seasonal influenza mRNA vaccines with different compositions that encode for haemagglutinins of multiple A/H3N2 strains, with or without the B/Yamagata strain, in adults. This randomised, open-label, phase 1/2 trial enrolled healthy adults aged 50-75 years across 22 sites in the USA. Participants were randomly assigned (1:1:1:1:1:1:1) via interactive response technology to receive a single dose of mRNA-1011.1 (pentavalent; containing one additional A/H3N2 strain [Newcastle]), mRNA-1011.2 (quadrivalent; B/Yamagata replaced with one additional A/H3N2 strain [Newcastle]), mRNA-1012 at one of two dose levels (pentavalent; B/Yamagata replaced with two additional A/H3N2 strains [Newcastle and Hong Kong]), or one of three quadrivalent mRNA-1010 controls each encoding one of the A/H3N2 study strains. The primary outcomes were safety, evaluated in all randomly assigned participants who received a study vaccination (safety population), and reactogenicity, evaluated in all participants from the safety population who contributed any solicited adverse reaction data (solicited safety population). The secondary outcome was humoral immunogenicity of investigational mRNA vaccines at day 29 versus mRNA-1010 control vaccines based on haemagglutination inhibition antibody (HAI) assay in the per-protocol population. Here, we summarise findings from the planned interim analysis after participants had completed day 29. The study is registered with ClinicalTrials.gov, NCT05827068, and is ongoing. Between March 27 and May 9, 2023, 1183 participants were screened for eligibility, 699 (59·1%) were randomly assigned, and 696 (58·8%) received vaccination (safety population, n=696; solicited safety population, n=694; per-protocol population, n=646). 382 (55%) of the 696 participants in the safety population self-reported as female and 314 (45%) as male. Frequencies of solicited adverse reactions were similar across vaccine groups; 551 (79%) of 694 participants reported at least one solicited adverse reaction within 7 days after vaccination and 83 (12%) of 696 participants reported at least one unsolicited adverse event within 28 days after vaccination. No vaccine-related serious adverse events or deaths were reported. All three next-generation influenza vaccines elicited robust antibody responses against vaccine-matched influenza A and B strains at day 29 that were generally similar to mRNA-1010 controls, and higher responses against additional A/H3N2 strains that were not included within respective mRNA-1010 controls. Day 29 geometric mean fold rises in HAI titres from day 1 against vaccine-matched A/H3N2 strains were 3·0 (95% CI 2·6-3·6; Darwin) and 3·1 (2·6-3·8; Newcastle) for mRNA-1011.1; 3·3 (2·7-4·1; Darwin) and 4·2 (3·4-5·2; Newcastle) for mRNA-1011.2; 3·4 (2·9-4·0; Darwin), 4·5 (3·6-5·5; Newcastle), and 5·1 (4·2-6·2; Hong Kong) for mRNA-1012 50·0 μg; and 2·6 (2·2-3·1; Darwin), 3·7 (3·0-4·6; Newcastle), and 4·1 (3·3-5·1; Hong Kong) for mRNA-1012 62·5 μg. Inclusion of additional A/H3N2 strains did not reduce responses against influenza A/H1N1 or influenza B strains, and removal of B/Yamagata did not affect responses to B/Victoria. These data support the continued clinical development of mRNA-based next-generation seasonal influenza vaccines with broadened influenza A/H3N2 strain coverage. Moderna.

Virtual Reality Software: empowering tourism marketing through technology

ABSTRACT The dynamic evolution of consumer demands in the tourism sector necessitates continual adaptation and innovation in marketing strategies to counter increasing competitiveness. To address these shifts, emerging technologies play a pivotal role. This study focuses on the investigation of Information and Communication Technologies (ICTs) in shaping tourism marketing, culminating in the development of Tour View 360° software. Employing qualitative research methods, including bibliographical analysis and technological prospecting, the study identified prerequisites for the software's creation. Leveraging the Scrum framework for its adaptability, the software was meticulously designed using C# programming language with Unity 3D software. Findings reveal the early-stage adoption of interactive virtual reality technologies for promoting tourism. Nonetheless, Tour View 360° emerges as an innovative tool. The study comprehensively details the software's attributes, functionalities, interfaces, requirements, usability configurations, and final modeling, offering insights into ICT integration in enhancing tourism marketing strategies.

Optimalisasi Proses Pembelajaran Mahasiswa PPG Seni Budaya Melalui Implementasi Edukit Berbasis Interactive Surface

This research aims to optimize the learning process of PPG Arts and Culture students through the implementation of Interactive Surface-based education. The methodology used includes needs analysis, design and development of education, as well as evaluation of the effectiveness of its implementation. This education is designed to provide a more interactive and immersive learning experience, using Interactive Surface technology that allows direct manipulation of learning content. The research results showed a significant increase in student engagement and understanding of the learning material. Evaluation through surveys and in-depth interviews confirms that this education is effective in supporting more adaptive and innovative learning strategies. This research makes an important contribution to the development of modern learning tools that are relevant to today's educational needs.

Revitalisasi Produk Tempe dalam Wisata Edukasi Keberlanjutan Melalui Hilirisasi Karpet Interaktif Muatan Pembelajaran Berbasis Game dan Model Pembelajaran Problem Based Learning

The revitalization of tempe products in sustainable educational tourism through the downstreaming of interactive carpets with game-based learning content and Problem Based Learning (PBL) models aims to enhance attractiveness and learning effectiveness. This program integrates interactive technology and problem-based learning approaches to create enjoyable and immersive educational experiences. Methods include developing game-based interactive carpets, providing technical training for tourism managers, and evaluating effectiveness through user feedback. Results indicate increased learning interest and visitor understanding of tempe production processes and sustainability concepts. The implementation of this program is expected to support the development of innovative educational tourism and promote environmental sustainability.

Real-Time Hand Gesture Recognition: A Comprehensive Review of Techniques, Applications, and Challenges

Abstract Real-time Hand Gesture Recognition (HGR) has emerged as a vital technology in human-computer interaction, offering intuitive and natural ways for users to interact with computer-vision systems. This comprehensive review explores the advancements, challenges, and future directions in real-time HGR. Various HGR-related technologies have also been investigated, including sensors and vision technologies, which are utilized as a preliminary step in acquiring data in HGR systems. This paper discusses different recognition approaches, from traditional handcrafted feature methods to state-of-the-art deep learning techniques. Learning paradigms have been analyzed such as supervised, unsupervised, transfer, and adaptive learning in the context of HGR. A wide range of applications has been covered, from sign language recognition to healthcare and security systems. Despite significant developments in the computer vision domain, challenges remain in areas such as environmental robustness, gesture complexity, computational efficiency, and user adaptability. Lastly, this paper concludes by highlighting potential solutions and future research directions trying to develop more robust, efficient, and user-friendly real-time HGR systems.

Neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemotherapy alone in patients with early-stage non-small-cell lung cancer (KEYNOTE-671): a randomised, double-blind, placebo-controlled, phase 3 trial

At the first interim analysis of the KEYNOTE-671 trial, adding perioperative pembrolizumab to neoadjuvant chemotherapy significantly improved event-free survival in participants with early-stage non-small-cell lung cancer (NSCLC). We report overall survival and health-related quality of life outcomes from the second interim analysis. KEYNOTE-671 was a global phase 3 trial done at 189 medical centres. Eligible participants (aged ≥18 years) with resectable stage II, IIIA, or IIIB (N2) NSCLC were randomly assigned (1:1) to four cycles of neoadjuvant pembrolizumab (200 mg administered intravenously every 3 weeks) plus cisplatin-based chemotherapy followed by surgery and 13 cycles of adjuvant pembrolizumab (200 mg administered intravenously every 3 weeks) or to four cycles of neoadjuvant placebo (administered intravenously every 3 weeks) plus cisplatin-based chemotherapy followed by surgery and 13 cycles of adjuvant placebo (administered intravenously every 3 weeks). Randomisation was done centrally using an interactive response technology system and was stratified by disease stage, PD-L1 expression, histology, and geographical region in blocks of four. Participants, investigators, and sponsor personnel were masked to treatment assignments; local pharmacists were unmasked to support treatment preparation. The dual primary endpoints were overall survival and event-free survival evaluated in the intention-to-treat population. This study is registered at ClinicalTrials.gov, NCT03425643, and is ongoing but closed to enrolment. Between May 11, 2018, and Dec 15, 2021, 797 participants were randomly assigned to the pembrolizumab group (n=397) or the placebo group (n=400). Median study follow-up at the second interim analysis was 36·6 months (IQR 27·6-47·8). 36-month overall survival estimates were 71% (95% CI 66-76) in the pembrolizumab group and 64% (58-69) in the placebo group (hazard ratio 0·72 [95% CI 0·56-0·93]; one-sided p=0·0052; threshold, one-sided p=0·0054). Median event-free survival was 47·2 months (95% CI 32·9 to not reached) in the pembrolizumab group and 18·3 months (14·8-22·1) in the placebo group (hazard ratio 0·59 [95% CI 0·48-0·72]). In the as-treated population, grade 3-5 treatment-related adverse events occurred in 179 (45%) of 396 participants in the pembrolizumab group and in 151 (38%) of 399 participants in the placebo group. Treatment-related adverse events led to death in four (1%) participants in the pembrolizumab group and three (1%) participants in the placebo group. The significant overall survival benefit of neoadjuvant pembrolizumab plus chemotherapy followed by adjuvant pembrolizumab compared with neoadjuvant chemotherapy alone coupled with a manageable safety profile support the use of perioperative pembrolizumab in patients with resectable, early-stage NSCLC. Merck Sharp & Dohme, a subsidiary of Merck & Co, Rahway, NJ, USA.

Preface

Welcome to the Proceedings of the 2024 3rd International Conference on the Energy Internet and Energy Interactive Technology (EIEIT 2024) held via virtual form in Xi’an, China during May 10th to 12th, 2024! EIEIT 2024 builds upon the success of its two previous editions, underscoring the growing importance of energy internet as a cornerstone technology supporting modern power systems. However, despite its promising potential, the development of energy internet in China remains in its nascent stages, necessitating a concerted effort from academia, industry, and government to propel its progress. The conference was organized to provide a comprehensive forum where participants could present their latest research findings, discuss challenges, and explore opportunities for collaboration. The conference attracted about 80 scholars and researchers from all over the world, covering representatives from academia, industry, research institutes, and government organizations. They have a wide range of professional backgrounds related to energy and power engineering. Such a composition of participants not only facilitated interdisciplinary exchanges and cooperation, but also injected a wealth of academic ideas and perspectives into the conference. The program of EIEIT 2024 is rich and diverse, including keynote speeches, oral presentations, poster presentations, academic discussion, etc. The keynote speeches were delivered by internationally renowned scholars including Professor Sanjeevikumar Padmanaban (University of South-Eastern Norway, Norway) and Associate Professor Cristian Paul Chioncel (Universitatea Babeș-Bolyai, Romania) who have in-depth discussions on the cutting-edge dynamics and future development of energy internet and energy interactive technology; the oral presentations provided an extra platform for researchers to showcase their latest research results; and the poster presentations further promoted academic exchanges and collisions of ideas. These conference agendas were designed to promote international academic exchanges and cooperation, and to push forward the researches and applications in the field of energy internet and energy interactive technology. List of Committee Member is available in this Pdf.

POSSIBILITIES OF DEVELOPING STUDENTS' CRITICAL THINKING SKILLS BASED ON THE USE OF INTERACTIVE TECHNOLOGIES IN GEOGRAPHY EDUCATION

The article examines the problem of developing the critical thinking skills of schoolchildren with the help of interactive technologies in the process of teaching geography. Cluster is one of its methods (techniques). A step-by-step technology for developing students’ critical thinking skills based on the use of the “cluster” technique is proposed.

The impact of online interaction and information technology accessibility on academic engagement among international undergraduate students in Chinese universities: The mediating effect of learning interest

Academic engagement was recognized as a crucial predictor to measure the effectiveness of online teaching of international students. Therefore, this study established a mediating model to explore the mechanism underlying of interaction and information technology accessibility on academic engagement of international students, as well as the impact of learning interest on these mechanisms with the context of online teaching. Using a stratified random sampling method, 1895 international students from 32 Chinese universities were selected. These international students had completed the academic engagement scale, interaction scale, information technology accessibility scale, and learning interest scale. The study variables were analyzed in sequence for reliability and validity, common method biases test, correlation analysis, structural equation model testing, and bias-corrected percentile Bootstrap testing. The results revealed that online interaction positively affected the academic engagement of international students in Chinese universities (β= 0.35, p < 0.001), and learning interest played a partial mediating role between online interaction and academic engagement (indirect effect = 0.10, 95 % Boot CI = [0.06, 0.13], p < 0.001). Information technology accessibility did not have a direct impact on academic engagement (β= 0.06, p > 0.05); but learning interest played a complete mediating role between information technology accessibility and academic engagement (indirect effect = 0.09, 95 % Boot CI = [0.05, 0.11], p < 0.001). The results of Bootstrap showed that the mediating effects within the model were significant. The findings of this study explored the potential mechanism underlying the online academic engagement of international students in Chinese universities, and provided empirical evidence for universities and educators to implement differentiated learning support, assist international students in adapting to online learning styles, and stimulate the endogenous motivation of students' learning.

Трансформація готельно-ресторанного обслуговування в умовах цифровізації

The article is dedicated to exploring the unique aspects and primary trends in the digital transformation of hotel and restaurant services. It has been demonstrated that the increasing competition, the drive for operational efficiency, and the enhancement of customer service quality are key drivers for the adoption of digital technologies in the hotel and restaurant industry. Understanding and meeting evolving consumer expectations, such as the preference for online ordering, swift transaction processing, and personalized service, is also crucial in this digital shift. It has been established that under the influence of digitalization processes in all spheres of life, modern restaurants are actively implementing digital technologies, which allow the automation and optimization of most operational processes. Despite the growth of digital activity, domestic restaurants have yet to achieve the same pace of digitalization as other industries or similar enterprises in specific global contexts. This is evidenced by the insufficiently high share of electronic sales (about 12%) and the low implementation of BIG DATA technologies (8.9%) in the management and analytics of hotel and restaurant businesses. Research has revealed that several digitalization tools are being rapidly integrated into restaurant services, including digital marketing, the development of digital food delivery platforms (FoodTech), automated management systems, and interactive technologies. The digital transformation of business processes in food service establishments not only enables swift adaptation to market changes but also significantly enhances the competitiveness of the restaurant business. It is argued that the effectiveness of hotel and restaurant service digitalization processes depends on the choice of the most optimal balance between software tools and digital instruments and the authentic characteristics of each restaurant, the target customer base, their tastes and preferences, and the image strategy of positioning in the food service market. Keywords: digitalization, digital tools, hotel and restaurant business, automated management systems, digital transformation of hotel and restaurant services, digital marketing.

CTNet: a convolutional transformer network for EEG-based motor imagery classification

Brain-computer interface (BCI) technology bridges the direct communication between the brain and machines, unlocking new possibilities for human interaction and rehabilitation. EEG-based motor imagery (MI) plays a pivotal role in BCI, enabling the translation of thought into actionable commands for interactive and assistive technologies. However, the constrained decoding performance of brain signals poses a limitation to the broader application and development of BCI systems. In this study, we introduce a convolutional Transformer network (CTNet) designed for EEG-based MI classification. Firstly, CTNet employs a convolutional module analogous to EEGNet, dedicated to extracting local and spatial features from EEG time series. Subsequently, it incorporates a Transformer encoder module, leveraging a multi-head attention mechanism to discern the global dependencies of EEG's high-level features. Finally, a straightforward classifier module comprising fully connected layers is followed to categorize EEG signals. In subject-specific evaluations, CTNet achieved remarkable decoding accuracies of 82.52% and 88.49% on the BCI IV-2a and IV-2b datasets, respectively. Furthermore, in the challenging cross-subject assessments, CTNet achieved recognition accuracies of 58.64% on the BCI IV-2a dataset and 76.27% on the BCI IV-2b dataset. In both subject-specific and cross-subject evaluations, CTNet holds a leading position when compared to some of the state-of-the-art methods. This underscores the exceptional efficacy of our approach and its potential to set a new benchmark in EEG decoding.

Research on the mechanism of motor muscle control based on optical EEG images

The study of motor muscle control mechanisms can improve rehabilitation therapy and human-computer interaction technology. The limitations of traditional electroencephalography (EEG) limit the comprehensive understanding of motor muscle control mechanisms. Therefore, this study aims to explore the mechanism of motor muscle control based on optical EEG images, in order to expand the understanding of the process of motor control. The study selected optical EEG imaging technology as the main data acquisition tool. Optical EEG images have higher spatiotemporal resolution and can provide more detailed neural activity information. This technology combines optical imaging with EEG images to obtain spatiotemporal information of brain activity in a short period of time. The device is composed of multiple optical sensors and can measure blood oxygen concentration and neuronal activity in the cerebral cortex. Preprocess EEG image data using image processing and signal processing techniques, then use computational methods and algorithms to detect activated regions, and evaluate their relationships using correlation analysis and statistical methods. By comparing EEG image data and motor muscle activity data under different motor tasks. The research results show that optical EEG imaging technology can provide more detailed information on brain neural activity and accurately capture the activity patterns of different motor muscles. These results provide new perspectives and methods for further studying the control mechanisms of motor muscles.

Digital-Signature Oriented Steganography Approach against Man-in-the-Middle Attack

Nowadays, man-in-the-middle (MITM) attacks have become a large problem due to the advancement of computational power and interactive mobile technologies. Message security is a crucial concern that ought to be managed in order to help protect vital data from unauthorized people, such as MITM. Steganography is the technique of hiding secret data within an ordinary, non-secret file or message in order to avoid detection when communicating through an unsecured network. Steganography applications play a vital role in various fields that involve classified data transfer, such as healthcare, multimedia, and the military. Hence, the application of steganography in those fields attracts MITM attacks. Thus, in an attempt to address the challenge. This study proposes a hybrid approach that integrates an image steganography technique, the Advanced Encryption Standard (AES) for message encryption, and EdDSA (Edward-Curve Digital Signature Algorithm) for signature verification to enhance steganography against MITM attacks. The proposed hybrid approach was tested and measured using image metrics (MSE, PSNR, and SSIM) and histogram visualization and verified through experimentation. The results have proven that the proposed hybrid approach is an enhanced security approach with low execution time, more payload size for hiding messages, and a high invisibility embedded message to MITM compared with other existing approaches. This study has potential limitations. It does not explore tamper resistance or algorithm robustness, and it was not tested on a public image dataset.

The possibility of the application of modern vocal music technology in vocal music education / La potencial aplicación de las nuevas tecnologías de la música vocal en la enseñanza de la música vocal

Information technologies in the modern world cover many fields of activity, including education. This contributes to the transformation of the educational process and the development of students’ independence. The main purpose of this paper is to assess the possibilities of using modern vocal music technologies in Chinese music education. To achieve the above purpose, the authors of the manuscript analysed the data obtained and divided the interactive technologies that can be used for vocal music education into the following four groups: software for studying theoretical frameworks, universal software, spectrogram software and audio editing software. The selected applications help learners acquire extensive vocal knowledge. Using the Likert scale, the researchers found that the applications of preference chosen by the respondents in each of the presented groups were Explain Everything (93%), Sing Sharp (87%), Sodaphonic (73%) and MAGIX Music Maker (82%). Sing Sharp provides vocal lessons in the form of a game. Sodaphonic eliminates low-quality performance elements in the process of creation of audio files. MAGIX Music Maker helps users create new songs using virtual musical instruments.

Systematic Review of Web-Based Learning in Enhancing Visualization Skill

In the digital era, visualization skills are critical for academic and professional success. This systematic review examines how web-based learning enhances these skills across various disciplines. This study focuses on addressing the challenges of developing effective visualization capabilities and the role of web-based learning in providing innovative solutions. This research utilized the PRISMA methodology to identify primary data utilizing specific keywords. Through extensive searches on Scopus, Web of Science, and ProQuest, 40 relevant studies were identified. The findings are organized into three themes: (1) Learning Innovations, (2) Digital Visual Education, and (3) Creative Visual Pedagogy. Results highlight web-based learning as a pivotal strategy in applied science and technology education, emphasizing collaborative and interactive technologies in enhancing spatial visualization and contributing to advanced educational practices.

MRehab: A Mixed Reality Rehabilitation System Supporting Integrated Speech and Hand Training

Integrated speech and hand-motor training is an effective post-stroke rehabilitation method. However, few interactive systems and assistive technologies were developed in this field. Driven by this challenge, we leverage Mixed Reality technology, which merges immersive virtual scenarios with physical hands-on tools in the real world, to provide patients with multi-modal interactions and engaging training experiences. Following a user-centered design approach, we first interviewed seven therapists to identify user requirements and design considerations. We further designed MRehab, an interactive rehabilitation system that allows patients to regain speech and hand skills through MR scenarios that depict daily living activities. We conducted a preliminary user test with 12 patients and 5 therapists to validate the feasibility and understand the user experience with MRehab. The results confirmed its feasibility for hand-motor training. Additionally, the patients expressed high motivation, engagement, and a positive attitude toward using MRehab. Our findings demonstrate the potential of MR technology in integrated speech and hand function rehabilitation training.

The Evolution of Digital Cultural Heritage Research: Identifying Key Trends, Hotspots, and Challenges through Bibliometric Analysis

Heritage preservation fundamentally represents an act of communication, with digitization and virtual access driving cultural heritage research development and dissemination. These tools stimulate the creation of cultural heritage content and inspire public engagement in learning about and preserving heritage. Despite substantial academic focus on digital cultural heritage (DCH) research, systematic assessment methods remain lacking. This paper researches the application of digital technologies in cultural heritage studies using CiteSpace 6.2 R4 to analyze the evolution of DCH, identifying research hotspots and predicting future trends. The key findings include the following: (1) Current DCH research focuses on countries with significant national power, but future studies should emphasize regions rich in cultural heritage and promote transnational and interdisciplinary research. (2) DCH research concentrates on three areas: the use of VR, AR, and other interactive digital technologies to enhance cultural heritage experiences; the development of cultural relic databases and digital archives; and the implementation of interactive exhibitions and multimedia guides. (3) Identified research hotspots include user immersion experiences, language and identity, and virtual reality technologies. Digital technologies enhance cultural heritage communication by driving innovations in preservation, information management, and digitization. (4) Future research should focus on practical DCH development, emphasizing innovative virtual technologies, database integration, and standardized assessment methods. These efforts aim to provide valuable insights for the sustainable global preservation and dissemination of cultural heritage. The use of digital technologies in cultural heritage is becoming increasingly important, but there is still a need to strike a balance between technological development and heritage preservation to ensure the sustainability of cultural heritage.