This paper utilizes innovation ecosystem theory to examine how an innovation ecosystem (comprising economic, technological, labor, and institutional subsystems) promotes tourism competitiveness through internal interaction. Employing fuzzy-set qualitative comparative analysis and necessary condition analysis techniques, this study assesses the necessity and sufficiency of an innovation ecosystem for high tourism competitiveness. Findings demonstrate that industrial structure and human capital innovations are requisite for tourism competitiveness, with the former being more universally applicable. Further, this study identifies an earlier innovation-driven mechanism for superior tourism competitiveness: leveraging industrial structure and human capital, and four contemporary innovation-driven mechanisms: leveraging industrial structure, leveraging policy, leveraging technology, and leveraging industrial structure and wages. The rationalization of industrial structure and human capital enhancement serve distinct bottleneck roles. This article contributes to understanding the link between innovation ecosystems and tourism and similarly suggests approaches for enhancing tourism competitiveness through innovation system development.