Scope Of Technology Research Articles

Impact of Internet Hospital Consultations on Outpatient Visits and Expenses: Quasi-Experimental Study

Background Internet hospital consultations are emerging in China as a new channel for patients to access health care services. Unlike third-party health care platforms such as Haodf, Teladoc Health, and MDLive, internet hospitals seamlessly integrate patients’ offline medical records with online consultations, offering a cohesive online and offline health care experience. However, its impact on outpatient visits remains ambiguous. While it may encourage outpatient visits due to better continuity of care, it could also reduce face-to-face visits because of the convenience of online consultations. Given that patients in China have the autonomy to freely choose their health care providers, it is critical for hospitals to understand the effect of this telehealth technology on outpatient visits. Objective This study aimed to analyze the impact of patients’ adoption of internet hospital consultations on their outpatient frequency and expenses, and whether these impacts vary between urban and rural patients. Methods The data used in this study were collected from a public tertiary hospital situated in a southeastern county of China, covering internet hospital consultations from January 2021 to October 2022, and offline outpatient records from January 2020 to October 2022. The dataset also includes patient demographic information. To estimate the causal effect, we used a quasi-experimental design, combining the difference-in-differences (DiD) analysis with the propensity score matching (PSM). After performing PSM, 2065 pairs of patients (4130 patients) were obtained for data analysis. Results Our findings highlight 3 key results. First, patients’ adoption of internet hospital consultations increases their frequency of outpatient visits by 2.4% per month (P<.001), and the associated expenses by 15.5% per month (P<.001). Second, such positive effects are more pronounced for patients residing in rural areas. Specifically, for every 1% increase in the distance between patients’ residences and the county government (an urban center), the positive effect on monthly outpatient visits increases by 0.3% (P=.06), and the positive effect on monthly outpatient expenses increases by 2.4% (P=.03). Third, our post hoc analysis shows that rural patients living in areas with higher local health care quality experience a mitigated positive effect of internet hospital consultations, compared with those in areas with lower health care quality. Conclusions This study extends the research scope of telehealth technologies by investigating internet hospitals, which are characterized by the integration of online and offline services. Our findings suggest that patients’ adoption of internet hospital consultations is associated with an increase in both the frequency and expenses of outpatient visits. In addition, these effects vary based on patients’ urban-rural status and local health care quality. These insights offer valuable guidance for policy makers and health care providers in promoting and optimizing the development and operation of internet hospitals.

Strategizing Originality for Technology Convergence: An Engineering Management Approach

This study examines how the integration of internal expertise with external research partnerships influences the confluence of technologies. Analyzing a decade’s patents, it clarifies the efficacy of varied knowledge acquisition strategies on innovation. The research quantifies the contribution of such synergies to innovation across technological, industrial, and geographic realms. Methodologically, it employs patent analytics to dissect originality into technology scope, assignee variety, industry diversity, and country-specific innovation trends from 2010 to 2019. Findings reveal a positive link between comprehensive technological and industrial knowledge and enhanced technological convergence. Significantly, it accentuates the role of global collaboration in unifying new technologies and industries. This interdisciplinary approach and in-depth organizational learning understanding are vital for spurring innovation. The results offer pivotal insights for academia and policy formulation in technology governance, advocating for integrated knowledge strategies to drive sector-spanning technology unification. The study provides a blueprint for fostering innovation through inter-sectoral and interdisciplinary exchange.

Kimberly Bryant’s Black Girls Code: closing the opportunity gap in technology for black women and girls

Research methodology This case study was developed using publicly available published sources like the company’s website, articles, blogs, videos, filings, etc. Multiple sources were used to put together the chronology, quotes and details. This case is not disguised. All the key figures in the case study are identified by their real names. Case overview/synopsis Black Girls Code (BGC) was founded by Kimberly Bryant (Bryant, she) as a nonprofit organization in 2011. BGC conducted workshops and programs to teach young girls of color technology, science, engineering and math and train them in Web design, developing apps and robotics. It aimed to address the lack of diversity in science and technology. The organization has received support from tech giants like Google, Facebook and IBM. In one decade, the organization trained more than 30,000 girls and aimed to teach one million girls by 2040. In 2021, the BGC board ousted Bryant, citing allegations of workplace impropriety. She was put on paid administrative leave by the board. This ousting was done in the aftermath of complaints by several employees who raised concerns about Bryant’s conduct. The former and current employees said that high turnover in the organization was due to Bryant’s leadership, which was rooted in fear, and that she would publicly insult managers. The board formed a special committee to evaluate the concerns and sent Bryant on administrative leave. Cristina Jones, who succeeded Bryant as CEO, brought about several changes in the organization and expanded the scope of science, technology, engineering and math to include arts. She expanded the courses to include design, gaming and others. She was looking forward to launching one million black girls in tech by 2040. But before she could go on, she needed to ensure that the ouster of the founder did not hinder the activities at BGC in any manner and also needed to address the concerns of employees, students and funders. Complexity academic level This case can be used to learn about nonprofits, the role of nonprofits in building an equitable society and nonprofit entrepreneurs. The objective is to understand how passionate entrepreneurs can create organizations that can make a high impact with limited resources but with ambition and vision for radical change. This case also helps in learning the challenges encountered due to the rapid growth of startups and the role of the leader in handling such growth. This case can be integrated into any of the existing courses or taken as a special case study to illustrate the gender and racial disparities that exist even in highly developed countries like the USA.

Mechanism of o-cresol polymerization and its carbon recovery from aqueous solution by a cathode/Fe2+/H2O2 process

Converting organic pollutants into easily recyclable solid polymers has the advantages of saving oxidants and recovering organic carbon, compared to degrading them into smaller organic molecules. Taking o-cresol as a representative phenolic pollutant, this study realizes the dominant reaction of organic polymerization and the recovery of organic carbon from wastewater via a cathode/Fe2+/H2O2 process. With HO• initiation, 53 % of chemical oxygen demand is removed in the form of suspended solid polymers and equivalent organic carbon is recovered. At the same time, the dissolved organic carbon (DOC) removal reaches 64 %, and the H2O2 consumption is only a quarter of that in an ideal degradation process. The recovered solid polymers are oligomers derived from o-cresol and its derivatives, with the molecular weight ranging from 400 to 2500 Da. The polymerization pathway involves repeated HO• oxidation and coupling of intermediate organic radicals. The energy consumption is 26.7 kWh/kg DOC, significantly lower than that of previous Fenton-like processes in the literature. This study broadens the scope of polymerization-based technologies for organic wastewater treatment, and demonstrates that HO• has the potential to simultaneously reduce organic pollution and recover organic carbon by generating suspended solid organic polymers, which may provide new avenues for H2O2-based Fenton processes toward resource recovery and water purification.

Surface Molecularly Engineered Mitochondria Conduct Immunophenotype Repolarization of Tumor-Associated Macrophages to Potentiate Cancer Immunotherapy.

Reprogramming tumor-associated macrophages (TAMs) to an inflammatory phenotype effectively increases the potential of immune checkpoint blockade (ICB) therapy. Artificial mitochondrial transplantation, an emerging and safe strategy, has made brilliant achievements in regulating the function of recipient cells in preclinic and clinic, but its performance in reprogramming the immunophenotype of TAMs has not been reported. Here, the metabolism of M2 TAMs is proposed resetting from oxidative phosphorylation (OXPHOS) to glycolysis for polarizing M1 TAMs through targeted transplantation of mannosylated mitochondria (mPEI/M1mt). Mitochondria isolated from M1 macrophages are coated with mannosylated polyethyleneimine (mPEI) through electrostatic interaction to form mPEI/M1mt, which can be targeted uptake by M2 macrophages expressed a high level of mannose receptors. Mechanistically, mPEI/M1mt accelerates phosphorylation of NF-κB p65, MAPK p38 and JNK by glycolysis-mediated elevation of intracellular ROS, thus prompting M1 macrophage polarization. In vivo, the transplantation of mPEI/M1mt excellently potentiates therapeutic effects of anti-PD-L1 by resetting an antitumor proinflammatory tumor microenvironmentand stimulating CD8 and CD4 T cells dependent immune response. Altogether, this work provides a novel platform for improving cancer immunotherapy, meanwhile, broadens the scope of mitochondrial transplantation technology in clinics in the future.

Double-edged sword of industrial internet of things: Empirical evidence from green transformation of enterprises

The industrial revolution based on the Internet of Things brings new opportunities and challenges for enterprises' green and sustainable development. Therefore, this study explores the relationship between the Industrial Internet of Things (IIOT) and the Green Transformation of Enterprises (GT) based on the data of China's A-share listed companies from 2009 to 2023 using two-way fixed, mediated effect, and moderated effect models. The results show that for every unit increase in IIOT, the GT increases by 28.89 percent on average, indicating that IIOT can break down information barriers and effectively promote GT. However, after disaggregating the GT, it was found that the IIOT guided companies to implement the Symbolic Green Transformation (SGT) instead of adopting the Realistic Green Transformation (RGT). This strategic choice preference is more pronounced among firms that are larger, in energy-intensive industries, in regions with weaker environmental regulations and higher levels of development. The intermediary mechanism test proved that the IIOT can drive firms to implement comprehensive GT through paths that enhance investment attractiveness, productivity, technological innovation, and pay gaps. In particular, the masking effect reminds us that smart technology is a “double-edged sword”. The negative effects of smart technologies hinder the implementation of RGT. Further analysis reveals an inverted U-shaped relationship between IIOT and RGT preferences. In addition, in companies that focus on Environmental, Social and Governance (ESG) performance and avoid financial speculation, the dark side of intelligent technology is suppressed. The findings of this study enrich the research scope of smart technology, GT, and provide important insights for enterprises in emerging economies to rationally utilize IIOT to seek green and sustainable development under the wave of rapid development of smart technology.

Framework-Induced Electrochemiluminescence Enhancement of an AIEgen-Based MOF Coupled with Heterostructured TiO2@Ag NPs as an Efficient Coreaction Accelerator for Sensitive Biosensing.

In conventional metal-organic framework (MOF) luminophore-involved electrochemiluminescence (ECL) systems, the aggregation-caused quenching commonly exists for the organic luminescent ligands, limiting the ECL efficiency and detection sensitivity. Herein, by employing the aggregation-induced emission luminogen (AIEgen) 1,1,2,2-tetra(4-carboxylbiphenyl)ethylene (H4TCBPE) as a ligand, one high-efficiency ECL emitter (Zr-MOF) was synthesized through a simple hydrothermal reaction. Compared with H4TCBPE monomers and their aggregates, the resultant Zr-MOF possesses the strongest ECL emission, which is mainly attributed to the framework-induced ECL enhancement. Specifically, the heterostructure was prepared by the deposition of silver nanoparticles on TiO2 microflowers and utilized as an efficient coreaction accelerator. Remarkably, the formative heterojunction can increase the interfacial charge transfer efficiency and promote the carrier separation, facilitating the oxidation of coreactant tripropylamine. In this way, a novel aptamer-mediated ECL sensing platform is constructed, achieving the sensitive analysis of adenosine triphosphate with a low detection limit of 0.17 nM. As a proof-of-concept study, this work may enlighten the rational design of new-type MOF-based ECL materials and expand the application scope of the ECL technology.

Enhancing early warning: A DNA biosensor with polyaniline/graphene nanocomposite for label-free voltammetric detection of saxitoxin-producing harmful algae

Yearly reports of detrimental effects resulting from harmful algal blooms (HAB) are still received in Malaysia and other countries, particularly concerning fish mortality and seafood contamination, both of which bear consequences for the fisheries industry. The underlying reason is the absence of a dependable early warning system. Hence, this research aims to develop a single DNA biosensor that can detect a group of HAB species known for producing saxitoxin (SXT), which is commonly found in Malaysian waters. The screen-printed carbon electrode (SPCE)-based DNA biosensor was fabricated by covalent grafting of the 3’ aminated DNA probe of the sxtA4 conserved domain in SXT-producing dinoflagellates on the reverse-phase polymerized polyaniline/graphene (PGN) nanocomposite electrode via carbodiimide linkage. The introduction of a carboxyphenyl layer to the PGN nanotransducing element was essential to augment the carboxylic groups on the graphene (RGO), facilitating attachment with the aminated DNA. The synergistic effect of the asynthesized nanocomposite of PANI and RGO, tremendously enhanced the electron transfer rate of the ferri/ferrocyanide redox probe at the SPCE transducer surface, allowing for the label-free bioanalytical assay of complementary DNA targets. The developed DNA biosensor featuring the capacity to detect a broad range of Alexandrium minutum (A. minutum) cell concentrations, ranging from 10 to 10,000,000 cells L-1. The quantification of A. minutum cells from pure algal culture by the electrochemical DNA biosensor has been well-validated with traditional microscopic techniques. Furthermore, Alexandrium tamiyavanichii, another toxigenic HAB species, exhibited a similar electrochemical characteristic signal to those observed with A. minutum, whilst the biosensor yielded appreciably distinctive results when subjected to a non-toxigenic microalgae species as a negative control, i.e. Isochrysis galbana. A compendium DNA biosensor design and electrochemical detection strategy at laboratory scale serves as a precursor to the potential development of portable device for on-site detection, thus expanding the utility and scope of biosensor technology.

Integration of Legacy Industrial Equipment in a Building-Management System Industry 5.0 Scenario

Considering Industry 4.0 directions, followed by recent Industry 5.0 principles, interest in integrating legacy systems in industrial manufacturing has emerged. Due to the continuous evolution of the Internet of Things (IoT) and the Industrial Internet of Things (IIoT), as well as the rapid extension of the scope and adoption of broader technologies, such integration has become feasible. Even though newly developed equipment provides easier interoperability, the replacement of legacy systems highly impacts cost and sustainability, which usually extends to the entire production process, the operators and the maintenance team, and sometimes even the robustness of the production process. Ensuring the interoperability of legacy systems is a problematic task, being dependent on technologies and development techniques and specific industrial domain particularities. This paper considers strategies to ensure the interoperability of legacy systems in a building-management system scenario where local structures are approached using both industrial protocols and web-based contexts. The solution is built following the Industry 5.0 pillars (sustainability, human focus, resilience) and conceives the entire data acquisition and supervisory solution to be flexible, open-source, resilient, and under the control of company engineers. The chosen environment for interfacing and supervision is Node-RED, enabling IoT and IIoT tools, together with a complete orientation toward digital transformation. This way, it is possible to construct a final result that enhances security while bridging outdated protocols and technologies, eliminating compatibility risks in the context of the evolutionary IIoT, ensuring critical process functions are possible, and aiding operators in complying with regulations governing building-management system (BMS) operations, thus solving the challenges that arise in the complex task of adopting the IoT backbone of digital transformation in relation to the integration of legacy equipment. The obtained solution is tested in an automotive industry building-management system, and the results demonstrate its performance, reliability, and high customizability in a context of openness and low cost.

(Energy Technology Division Supramaniam Srinivasan Young Investigator Award) CO2 as a Building Block for Electrosynthetic Coupling to N- and S- Based Reactants

Energy-intensive thermochemical processes within chemical manufacturing are a major contributor to global CO2 emissions. With the increasing push for sustainability, the scientific community is striving to develop renewable energy-powered electrochemical technologies in lieu of CO2-emitting fossil-fuel-driven methods. However, to fully electrify chemical manufacturing, it is imperative to expand the scope of electrosynthetic technologies, particularly through the innovation of reactions involving nitrogen- and sulfur- based reactants as products from water/CO2 electrolysis do not cover the full scope of industrial needs.To this end, this talk focuses on my lab’s efforts not only in CO2 conversion in the use of this molecule as a building block. This entails the co-electrolysis of CO2 with additional small molecule reactants (N2, NO3 -, SO3 2-...) in generating products with C-N and C-S bonds like amides, urea, and sulfonates that are important as commodity and fine chemicals in the chemical industry. In particular, I will discuss several new reaction pathways discovered towards several of the above-mentioned products and the application of operando techniques to understand the key C-N/C-S coupling steps in the reaction process. Figure 1

Research on Piano Program Programming and Creative Optimization Methods Based on Big Data Technology

This study focuses on the programming and creative optimization methods of piano tracks based on big data technology. Through in-depth analysis of the potential application of big data technology in the field of music creation, we propose an innovative framework for piano repertoire programming and creative optimization. This framework fully utilizes the data processing and analysis capabilities of big data technology to mine massive piano repertoire data, extract music elements, style features, and creative patterns. In terms of piano repertoire programming, we use big data technology to quantitatively analyze music elements and construct a data-driven programming model. This model can automatically generate piano repertoire frameworks that match specific styles, emotions, and rhythms based on user creative needs, providing inspiration and direction for creators. In terms of creative optimization, we utilize machine learning algorithms based on big data technology to intelligently evaluate and improve piano tracks. By comparing and analyzing the advantages and disadvantages of different tracks in terms of melody, harmony, structure, etc., we have discovered and extracted the common characteristics of excellent works, providing guidance for creators to optimize their work. This article will focus on the programming and control capabilities of music programming in the design and composition process of big data technology, as well as optimization methods for music creation. Provide precise services for music teaching and research, promote the prosperity and development of music, and accelerate the integration and innovative development of information technology and music education and teaching. In terms of piano repertoire programming, we utilized big data technology to quantitatively analyze music elements and constructed a data-driven programming model. This model can provide creators with rich inspiration and clear direction based on their creative intentions and specific styles. In addition, our study also considered the recognition rates of training models for different instrument types. Through training and optimizing models, we have ensured that piano program programming and creative optimization processes can achieve high recognition rates and accuracy on different instrument types, thereby further expanding the application scope of big data technology in the field of music creation.

Abstract We126: Myocarditis Following mRNA Vaccination for COVID-19 is Mediated by CXCL10 and IFN-γ

Introduction: mRNA vaccines have shown remarkable efficacy against symptomatic COVID-19, reshaping the pandemic's trajectory. Despite a robust safety profile, ongoing monitoring is crucial due to the rare but concerning myocarditis cases, predominantly affecting males under 30. Symptoms appear around 2.6 days post-vaccination, with chest pain, shortness of breath, and palpitations. Elevated cTnI and ST-segment changes are common, along with late gadolinium enhancement in cardiac MRI. Understanding these rare adverse effects is essential for the expanding scope of mRNA technology, spanning infectious disease vaccines and anti-cancer immunotherapies. Hypothesis: Myocarditis linked to COVID-19 mRNA vaccines involves cytokine production from myeloid cells, leading to impaired cardiac function. Methodology: a, Reanalysis of proteomics data of healthy and myocarditis individuals following COVID-19 vaccination; b, Macrophages (N = 7 lines) were exposed to BNT162b2 or mRNA-1273, and analyzed by cytokine array and RNA-seq; c, Cardiomyocytes (N = 4 lines) were treated with CXCL10 (1 and 10 ng/mL) and IFN-γ (0.5 and 5 ng/mL), with or without genistein (10 μM), followed by functional assessment, transcriptomic and proteomic profiling; d, Mice (6 per group) were administered with CXCL10 and IFN-γ, with or without genistein pretreatment (7 days). Myeloid cell infiltration in the heart, serum cTnI levels, RNA-seq, and immunoproteasome activity were analyzed. Results: Examination of post-vaccination plasma revealed a notable rise in CXCL10 and IFN-γ levels in patients. Similarly, macrophages exposed to mRNA vaccines displayed heightened production of these cytokines. When cardiomyocytes were exposed to these cytokines, they exhibited compromised contractility, increased arrhythmogenicity, and gene expression patterns reminiscent of myocarditis. Genistein, an anti-inflammatory phytoestrogen, demonstrated significant alleviation of these effects, preventing cytokine-induced proteasomal activation and preserving contractile function. Mouse model of cytokine-induced myocarditis showed that genistein substantially reduced cardiac injury markers and immune cell infiltration. Conclusion: These findings highlight CXCL10 and IFN-γ as pivotal contributors to myocarditis following mRNA vaccination and suggest genistein as a potential therapeutic intervention to mitigate associated cardiovascular risks.

Pore evolution and reaction mechanism of coal under the combination of chemical activation and autothermal oxidation

Aiming at the limitation problems such as limited scope, high cost and energy consumption of coal bed penetration enhancement technology by traditional physical and chemical methods, a coal seam methane penetration enhancement method based on the combined action of chemical activation and auto thermal oxidation is proposed from the idea of utilizing the in-situ energy of the coal body. In this paper, N2 and CO2 adsorption, XPS and FTIR methods are used to study the pore structure evolution law and the change characteristics of the reactive structure of coal matrix under the effect of chemically activated autothermal oxidation. The synergistic microporous pore volume of chemical activation and auto thermal oxidation was 48.91 cm3/g−1 × 10-3, which was 28.96 % and 22.7 % higher than chemical activation and auto thermal oxidation respectively; The microporous specific surface area was 162.7 m2/g, which was 38 % and 26.6 % higher than chemical activation and auto thermal oxidation respectively. Activated coals expand and merge holes to a deeper degree after oxidative warming, and the complexity of the pore structure in the coal decreases; Highly reactive radicals in coal pores substantially promote the oxidation of coal structure, enhance the aromatic polymerization reaction of activated coal, and improve the maturity and aromaticity of activated coal, and the oxygen-containing functional groups in activated coal are negatively correlated with the oxidation temperature. The results of this study reveal the potential of the auto thermal oxidation-driven penetration enhancement method under chemical activation for coal seam gas penetration enhancement and extraction.

THE EFFECT OF HEALTHCARE TECHNOLOGY ON HEALTH EXPENDITURES

This study aimed to determine the effect of Magnetic Resonance Imaging and Computed Tomography imaging services, which are within the scope of health technologies, on Health Expenditures. Panel analyses was used for the analyses. In the study, health expenditures were determined as the dependent variable, and the number of MR imaging and CT imaging within the scope of health technology as the independent variable, and 16 countries with regular data for the years 2007-2018 were included in the analysis. These countries were Australia, Belgium, Canada, Chile, The Czech Republic, Denmark, France, Germany, Iceland, Israel, Korea, Latvia, Lithuania, Luxembourg, Slovak Republic, and Slovenia. As a result of the analyses, it was determined that a one-unit increase in the number of Computed Tomography imaging increased health expenditures by 3.23 units, and a one-unit increase in the number of Magnetic Resonance imaging increased health expenditures by 21.9 units. The results of the study revealed that there was a positive and long-term relationship between health expenditures and the number of Computed Tomography and Magnetic Resonance Imaging, and there was a causal relationship in different directions between the variables. In addition, it has been determined that the number of Magnetic Resonance Imaging has increased more than the number of Computed Tomography imaging over the years, and that the number of Magnetic Resonance Imaging has a higher impact on health expenditures than Computed Tomography. When these two results were evaluated together, it is predicted that evaluating Magnetic Resonance Imaging and developing remedial activities will reduce health expenditures.

Optical Control of TRPV1 Channels In Vitro with Tethered Photopharmacology.

Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is important for nociception and inflammatory pain and is activated by a variety of nociceptive stimuli─including lipids such as capsaicin (CAP) and endocannabinoids. TRPV1's role in physiological systems is often studied by activating it with externally perfused ligands; however, this approach is plagued by poor spatiotemporal resolution. Lipid agonists are insoluble in physiological buffers and can permeate membranes to accumulate nonselectively inside cells, where they can have off-target effects. To increase the spatiotemporal precision with which we can activate lipids on cells and tissues, we previously developed optically cleavable targeted (OCT) ligands, which use protein tags (SNAP-tags) to localize a photocaged ligand on a target cellular membrane. After enrichment, the active ligand is released on a flash of light to activate nearby receptors. In our previous work, we developed an OCT-ligand to control a cannabinoid-sensitive GPCR. Here, we expand the scope of OCT-ligand technology to target TRPV1 ion channels. We synthesize a probe, OCT-CAP, that tethers to membrane-bound SNAP-tags and releases a TRPV1 agonist when triggered by UV-A irradiation. Using Ca2+ imaging and electrophysiology in HEK293T cells expressing TRPV1, we demonstrate that OCT-CAP uncaging activates TRPV1 with superior spatiotemporal precision when compared to standard diffusible ligands or photocages. This study is the first example of an OCT-ligand designed to manipulate an ion-channel target. We anticipate that these tools will find many applications in controlling lipid signaling pathways in various cells and tissues.

Self-regulation strategy of influent dissolved oxygen in ANAMMOX unit of domestic wastewater onsite source-separation and synergistic treatment process

An onsite source-separation and synergistic treatment (O3ST) process has been proposed in a previous study. In the study, it was found that toilet wastewater is characterized by spontaneously realizing and stably maintaining a partial nitritation (PN) without dissolved oxygen (DO) control. On this basis, to realize the goal of practical application of ANAMMOX technology following the PN in the O3ST process, this paper carries out the key research on the self-regulation strategy of DO in the effluent of PN unit to reduce the influent DO of ANAMMOX unit. By adding a buffer unit between the PN and ANAMMOX unit with an effective volume of 50.0 % of the PN unit, an interconnecting area of 0.9 % of the coplanar area of the PN and buffer unit, an overflow length of 35.7 % of the width of the PN unit, the automatic control to reduce the amount of DO diffusion and residual in the buffer unit was realized, and the DO concentration of the influent from the buffer to ANAMMOX unit was guaranteed to be less than 1.00 mg/L. Successful application of ANAMMOX technology can increase the TN removal efficiency of the process from a bottleneck value of 66.0 % to 84.0 %, with 44.0 % of the TN removal occurring in the ANAMMOX unit. This study is expected to apply the ANAMMOX technology in a low-maintenance or even no-maintenance form in the O3ST process, which is both an expansion of the application scope of the ANAMMOX technology and a breakthrough in decentralized wastewater treatment technology.

Telecare in the Brazilian Unified Health System: where we are and where we are heading.

This article explores telecare from telehealth developments and the recent acceleration of the digital health transformation caused by the COVID-19 pandemic, focusing on the Brazilian Unified Health System (SUS). It addresses terminological issues, the scope of actions, the potential use for healthcare, and constraints and contingencies for telecare in Brazil, focusing on teleconsultations and interactions between health professionals and patients. Finally, it presents a set of propositions for the development of telecare policies and practices in Brazil, considering SUS principles, in two central themes: organizational political guidelines and operational propositions to organise services and healthcare delivery. The importance of clarifying the scope and limits of new technologies is highlighted in the attempt to avoid idealizations with proposed solutions to complex health problems. Telecare solutions should be compatible with SUS principles and with the recommended model of care, with the healthcare network coordinated and organised by primary care, ensuring access to health services and integrated and quality healthcare for the Brazilian society.

Achieving enhanced piezoelectric properties in BiFeO3-PbTiO3 based ceramics by a synergistic effects of texturing and structure engineering in reactive template grain growth-like process

A synergistic strategy of texturing and structure engineering in reactive template grain growth-like process has been validated on fabricating 0.66Bi0.9Sm0.1FeO3-0.34PbTiO3 piezoelectric ceramics with enhanced properties. A considerable texture degree is successfully obtained by optimizing sintering conditions. The template is fully dissolved into the matrix after sintering, driving a structure transformation from rhombohedral to pseudo-cubic phase. In comparison to its non-textured counterpart, the textured ceramics show a 69 % increase on large-signal piezoelectric coefficient d33* and a 43 % increase on small-signal piezoelectric coefficient d33. Good high temperature piezoelectric performance is also revealed. At 225 °C, the maximum strain and calculated d33* are 0.22 % and 436 pm/V, respectively, which increase by 49 % compared with corresponding parameters at room temperature. The study not only signify a promising strategy to design high performance BFO based functional materials, but also broaden the scope of texture technology in the development of piezoelectric ceramics.

Biomimetic Hydrogel Strategies for Cancer Therapy.

Recent developments in biomimetic hydrogel research have expanded the scope of biomedical technologies that can be used to model, diagnose, and treat a wide range of medical conditions. Cancer presents one of the most intractable challenges in this arena due to the surreptitious mechanisms that it employs to evade detection and treatment. In order to address these challenges, biomimetic design principles can be adapted to beat cancer at its own game. Biomimetic design strategies are inspired by natural biological systems and offer promising opportunities for developing life-changing methods to model, detect, diagnose, treat, and cure various types of static and metastatic cancers. In particular, focusing on the cellular and subcellular phenomena that serve as fundamental drivers for the peculiar behavioral traits of cancer can provide rich insights into eradicating cancer in all of its manifestations. This review highlights promising developments in biomimetic nanocomposite hydrogels that contribute to cancer therapies via enhanced drug delivery strategies and modeling cancer mechanobiology phenomena in relation to metastasis and synergistic sensing systems. Creative efforts to amplify biomimetic design research to advance the development of more effective cancer therapies will be discussed in alignment with international collaborative goals to cure cancer.

Analysis on the Integration and Development of Smart Sports and Traditional Martial Arts in the New Era

In the context of the new era, the integration of smart sports and traditional martial arts has broad prospects for development. This article first explores the application scope of smart sports technology in martial arts training and demonstrates its significant effect in improving training efficiency and accuracy through case analysis. Then, the practical significance of the integration of smart sports and traditional martial arts was analyzed, including promoting the modern inheritance of traditional culture, improving training effects and popularity, reducing the risk of injury, and its application value in the fields of health management and rehabilitation therapy. On this basis, specific strategies for the integrated development of smart sports and traditional martial arts in the new era are proposed, including promoting the popularization and application of smart sports technology; building a scientific and efficient education and training system to cultivate compound talents; strengthening technology companies and martial arts experts cooperation to jointly develop intelligent equipment and systems suitable for martial arts training. These practices aim to provide new paths and impetus for the integrated development of smart sports and traditional martial arts and promote the modern inheritance and innovative development of Chinese traditional culture.