The purpose of this study is to present our routine use of high-end ultrasound technique in neurosurgery. Moreover, we present a new technique we introduced into neurosurgery: trans-endoscopic ultrasound for simple navigation and intraoperatively imaging in neuroendoscopy. Neurosurgery has the privilege to benefit from long time experience and evolution of techniques of many neighbour disciplines using ultrasound since several decades. The ALOKA 5000 with four small probes offered a basis to improve minimal invasiveness in our discipline: TCD probe (2.14 to 3.75 MHZ) was used in 508 cases, mainly at ICU; the small part sector probe (3.8 to 7.5 MHZ) was mainly applied intraoperatively in 183 cases and the burr hole probe (3.75 to 7.5 MHZ) was also mainly used intraoperatively in 88 cases. The transendoscopic miniprobe (360°, 6 F + 8 F, 10, 15, 20 MHZ) was used with strictly indication integrated into high-end machine in 21 cases (out of over 100 cases). The complete spectrum of neurosurgical diagnoses presented applicable assistance for therapy in our experience. In 265 intraoperative applications, ultrasound proved to be an excellent neuronavigation system providing the surgeon with real-time imaging and targeting capabilities. Resection control in 43 tumor cases with targeting in 25 small lesions was very satisfying, and in four cases craniotomy correction was possible before opening of dura mater. Compensation of computer-navigation failures was possible in 13 cases, preventing possible disasters. The 482 cases of application at the ICU showed a bedside use, resulting in decrease of risky outdoor examination to reduce stress for our patients and logistic efforts for the professionals. Investigations are running in innovative applications such as brain death diagnosis, bedside-sono-CT, aneurysm-monitoring, bridging-vein monitoring and sono-pupillometry. Intraoperatively, we examine sono-angiography in tumors and for clipping control of aneurysms, compensate computer-navigation pitfalls and navigate endoscopes with our “brain-radar”. The purpose of this study is to present our routine use of high-end ultrasound technique in neurosurgery. Moreover, we present a new technique we introduced into neurosurgery: trans-endoscopic ultrasound for simple navigation and intraoperatively imaging in neuroendoscopy. Neurosurgery has the privilege to benefit from long time experience and evolution of techniques of many neighbour disciplines using ultrasound since several decades. The ALOKA 5000 with four small probes offered a basis to improve minimal invasiveness in our discipline: TCD probe (2.14 to 3.75 MHZ) was used in 508 cases, mainly at ICU; the small part sector probe (3.8 to 7.5 MHZ) was mainly applied intraoperatively in 183 cases and the burr hole probe (3.75 to 7.5 MHZ) was also mainly used intraoperatively in 88 cases. The transendoscopic miniprobe (360°, 6 F + 8 F, 10, 15, 20 MHZ) was used with strictly indication integrated into high-end machine in 21 cases (out of over 100 cases). The complete spectrum of neurosurgical diagnoses presented applicable assistance for therapy in our experience. In 265 intraoperative applications, ultrasound proved to be an excellent neuronavigation system providing the surgeon with real-time imaging and targeting capabilities. Resection control in 43 tumor cases with targeting in 25 small lesions was very satisfying, and in four cases craniotomy correction was possible before opening of dura mater. Compensation of computer-navigation failures was possible in 13 cases, preventing possible disasters. The 482 cases of application at the ICU showed a bedside use, resulting in decrease of risky outdoor examination to reduce stress for our patients and logistic efforts for the professionals. Investigations are running in innovative applications such as brain death diagnosis, bedside-sono-CT, aneurysm-monitoring, bridging-vein monitoring and sono-pupillometry. Intraoperatively, we examine sono-angiography in tumors and for clipping control of aneurysms, compensate computer-navigation pitfalls and navigate endoscopes with our “brain-radar”.