Linear Discriminant Analysis Technique Research Articles

Student’s Health Exercise Recognition Tool for E-Learning Education

Due to the recently increased requirements of e-learning systems, multiple educational institutes such as kindergarten have transformed their learning towards virtual education. Automated student health exercise is a difficult task but an important one due to the physical education needs especially in young learners. The proposed system focuses on the necessary implementation of student health exercise recognition (SHER) using a modified Quaternion-based filter for inertial data refining and data fusion as the pre-processing steps. Further, cleansed data has been segmented using an overlapping windowing approach followed by patterns identification in the form of static and kinematic signal patterns. Furthermore, these patterns have been utilized to extract cues for both patterned signals, which are further optimized using Fisher’s linear discriminant analysis (FLDA) technique. Finally, the physical exercise activities have been categorized using extended Kalman filter (EKF)-based neural networks. This system can be implemented in multiple educational establishments including intelligent training systems, virtual mentors, smart simulations, and interactive learning management methods.

Condition-Based Health Monitoring of Electrical Machines Using DWT and LDA Classifier

In the industry, continuous health monitoring of electric motors is considered as an essential requirement. The continuous operation of the electric motor may cause malfunctions and addressing them timely is a critical challenge. The development of an efficient health monitoring system based on the identification of electrical motor faults is on great demand. This paper addresses the fault detection technique using discrete wavelet transform (DWT) algorithm for continuous health monitoring of electric motor-based systems. The faults have been detected through Motor Current Signature Analysis (MCSA) series procedures using the proposed method. Concurrently, the wavelet transform algorithm produces frequency-based spectrum related to the stator current parameters to accomplish the fault classification. This study provides an analysis of three motor faults of Phase imbalance, Rotor misalignment, and High contact resistance (HCR). DWT has the ability to categorize the input signals into approximate coefficient state for low frequency signals and detailed coefficient state for high frequency signals. In this research, this technique is used to detect faults because it is able of processing signals of very low frequency, and effectively deal with intermittent sharp signals that appear frequently during processing. DWT technique based on conditional monitoring of an induction motor with precise detailed coefficients and more skilled at light loads given on a motor-shaft with relatively fast execution time compared to FFT. Furthermore, the comparison of healthy and faulty induction motors has been compiled by Linear Discriminant Analysis (LDA) technique, a sub-application of MATLAB, and used for faults management purposes. LDA in comparison with PCA gives more perfect results. In this research, different faults have been detected with 100% accuracy using LDA classifier. The implementation of the proposed scheme will be beneficial in avoiding faults by ensuring that preemptive measures are taken timely against these faults, and the production of industries is protected from revenue losses.

Dimensionality Reduction with Weighted Voting Ensemble Classification Model Using Speech Data Based Parkinson’s Disease Diagnosis

Parkinson’s disease (PD) is a progressive neurodegenerative illness that frequently affects phonation, articulation, fluency, and prosody of speech. Speech impairment is a major sign of PD which can be employed for the earlier identification of the disease and provide proper treatment. Besides, the machine learning (ML) models can be commonly employed for PD detection and classification by the use of speech data. Since the speech data has the features of maximum data redundancy, high aliasing, and small sample sizes, dimensionality reduction (DR) techniques become essential for effective PD diagnosis. Therefore, this paper presents a new DR with weighted voting ensemble classification (DR-WVEC) model for PD diagnosis. The presented DR-WVEC model operates on different stages such as pre-processing, DR, classification, and voting process. Primarily, the speech data undergoes min–max normalization process in order to normalize the speech data. Besides, linear discriminant analysis (LDA) technique is applied for reducing the dimensionality of the features. In addition, an ensemble of two ML models, namely extreme learning machine (ELM) and Adaboost models, is employed for classification. Finally, a weighted voting-based classification process is carried out where the integration of two ML models takes place and the highest outcome is chosen as the final results. In order to assess the effective PR diagnostic outcome, an extensive set of simulations were carried out on Parkinson’s telemonitoring dataset. The obtained experimental results reported the betterment of the DR-VWEC technique over the other compared methods in terms of different aspects.

A Preprocessing Perspective for Quantum Machine Learning Classification Advantage in Finance Using NISQ Algorithms.

Quantum Machine Learning (QML) has not yet demonstrated extensively and clearly its advantages compared to the classical machine learning approach. So far, there are only specific cases where some quantum-inspired techniques have achieved small incremental advantages, and a few experimental cases in hybrid quantum computing are promising, considering a mid-term future (not taking into account the achievements purely associated with optimization using quantum-classical algorithms). The current quantum computers are noisy and have few qubits to test, making it difficult to demonstrate the current and potential quantum advantage of QML methods. This study shows that we can achieve better classical encoding and performance of quantum classifiers by using Linear Discriminant Analysis (LDA) during the data preprocessing step. As a result, the Variational Quantum Algorithm (VQA) shows a gain of performance in balanced accuracy with the LDA technique and outperforms baseline classical classifiers.

Decoding EEG rhythms offline and online during motor imagery for standing and sitting based on a brain-computer interface.

Motor imagery (MI)-based brain-computer interface (BCI) systems have shown promising advances for lower limb motor rehabilitation. The purpose of this study was to develop an MI-based BCI for the actions of standing and sitting. Thirty-two healthy subjects participated in the study using 17 active EEG electrodes. We used a combination of the filter bank common spatial pattern (FBCSP) method and the regularized linear discriminant analysis (RLDA) technique for decoding EEG rhythms offline and online during motor imagery for standing and sitting. The offline analysis indicated the classification of motor imagery and idle state provided a mean accuracy of 88.51 ± 1.43% and 85.29 ± 1.83% for the sit-to-stand and stand-to-sit transitions, respectively. The mean accuracies of the sit-to-stand and stand-to-sit online experiments were 94.69 ± 1.29% and 96.56 ± 0.83%, respectively. From these results, we believe that the MI-based BCI may be useful to future brain-controlled standing systems.

Water Quality Prediction and Classification based on Linear Discriminant Analysis and Light Gradient Boosting Machine Classifier Approach

Estimating water quality has existed as one of the vital factors embarked on the planet in the present eons. This paper illustrates a water quality estimate based on the Linear Discriminant Analysis (LDA) technique. Weighted arithmetic index technique is used in the computation of the Water Quality Index (WQI). At that moment, the LDA is linked to the dataset, and the ultimate principal WQI dynamics have been determined. Subsequently after predicting the WQI, Light Gradient Boosted Machine (LGBM) classification is performed in the LDA. Lastly, the LGBM classifier is activated to label the water quality. This proposed LGBM with LDA technique is demonstrated and evaluated on a Gulshan Lake-related dataset. The results show 96% forecast accuracy for the LDA and 100% categorization accuracy for the Light Gradient Boosted Machine classifier system that indicate consistent interpretation linked over the futuristic prototypes. This innovative model LDA-LGBM is aimed at enhancing the prediction of water quality and its classification through AI - ML approach.

Detection of Uniform Gearbox Wear in Induction Motors Based on the Analysis of Stray Flux Signals Through Statistical Time-Domain Features and Dimensionality Reduction Techniques

Gearboxes are core elements in power transmission systems. Although gearboxes are reliable and high-efficiency components, the occurrence of different faults is frequent since they are often subjected to adverse operating conditions. Classical gearbox condition monitoring approaches are based on the analysis of vibration and current motor signals and rely on the identification of specific fault-related frequency patterns. In this regard, this article proposes a novel diagnosis methodology based on the analysis of stray flux signals for detecting uniform wear in the gear teeth. The proposed methodology is based on the processing of the stray flux signals through feature calculation and extraction stages that lead to a high-performance signal characterization by estimating a set of statistical time domain-based features and then reducing the dimensionally by means of the principal component analysis and linear discriminant analysis techniques. Additionally, an automatic fault diagnosis is achieved through a neural network-based classifier for the detection and identification of uniform wear in a gearbox. The obtained results prove the potential of the proposal for its incorporation in condition maintenance programs in the industry, becoming an excellent alternative to classical approaches.

Discrete region inferred differential evolution feature selection architecture for human face recognition

Face Recognition has received a lot of attention in wide variety of the security application employing face based biometric authentication due to its non intrusive data acquisition. Especially artificial intelligence play important role in face recognition. Numerous researches have been carried out using machine learning technique in order to accuracy of the recognition. In this paper, a novel technique titled as Discrete Differential Evolution (DDE) architecture has been proposed. The proposed architecture will employed after set of the primary image processing steps such as preprocessing, feature extraction and feature selection. Initially preprocessing of the images is performed with image normalization technique and image enhancement technique. Preprocessed image will explored to Linear Discriminant Analysis technique to extract the features of the image. Extracted features will contain some redundant and irrelevant information of the images, it has to eliminate and optimal feature has to be selected to the recognition task. Discrete Region Inferred Differential Evolution architecture is employed to feature selection. Extracted features will be consider as search space, objective function of the DDE generates the optimal features solutions with respect to fitness criteria. Finally recognition task is performed with optimal features using support vector machine.

Assessment of Support Vector Machine performance for default prediction and credit rating

Predicting the creditworthiness of bank customers is a major concern for banking institutions, as modeling the probability of default is a key focus of the Basel regulations. Practitioners propose different default modeling techniques such as linear discriminant analysis, logistic regression, Bayesian approach, and artificial intelligence techniques. The performance of the default prediction is evaluated by the Receiver Operating Characteristic (ROC) curve using three types of kernels, namely, the polynomial kernel, the linear kernel and the Gaussian kernel. To justify the performance of the model, the study compares the prediction of default by the support vector with the logistic regression using data from a portfolio of particular bank customers. The results of this study showed that the model based on the Support Vector Machine approach with the Radial Basis Function kernel, performs better in prediction, compared to the logistic regression model, with a value of the ROC curve equal to 98%, against 71.7% for the logistic regression model. Also, this paper presents the conception of a support vector machine-based rating tool designed to classify bank customers and determine their probability of default. This probability has been computed empirically and represents the proportion of defaulting customers in each class.

Machine Learning for Early Parkinson's Disease Identification within SWEDD Group Using Clinical and DaTSCAN SPECT Imaging Features.

Early Parkinson’s Disease (PD) diagnosis is a critical challenge in the treatment process. Meeting this challenge allows appropriate planning for patients. However, Scan Without Evidence of Dopaminergic Deficit (SWEDD) is a heterogeneous group of PD patients and Healthy Controls (HC) in clinical and imaging features. The application of diagnostic tools based on Machine Learning (ML) comes into play here as they are capable of distinguishing between HC subjects and PD patients within an SWEDD group. In the present study, three ML algorithms were used to separate PD patients from HC within an SWEDD group. Data of 548 subjects were firstly analyzed by Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA) techniques. Using the best reduction technique result, we built the following clustering models: Density-Based Spatial (DBSCAN), K-means and Hierarchical Clustering. According to our findings, LDA performs better than PCA; therefore, LDA was used as input for the clustering models. The different models’ performances were assessed by comparing the clustering algorithms outcomes with the ground truth after a follow-up. Hierarchical Clustering surpassed DBSCAN and K-means algorithms by 64%, 78.13% and 38.89% in terms of accuracy, sensitivity and specificity. The proposed method demonstrated the suitability of ML models to distinguish PD patients from HC subjects within an SWEDD group.

Modeling the diagnosis of coronary artery disease by discriminant analysis and logistic regression: a cross-sectional study

PurposeCoronary artery disease (CAD) is one of the most significant cardiovascular diseases that requires accurate angiography to diagnose. Angiography is an invasive approach involving risks like death, heart attack, and stroke. An appropriate alternative for diagnosis of the disease is to use statistical or data mining methods. The purpose of the study was to predict CAD by using discriminant analysis and compared with the logistic regression.Materials and methodsThis cross-sectional study included 758 cases admitted to Fatemeh Zahra Teaching Hospital (Sari, Iran) for examination and coronary angiography for evaluation of CAD in 2019. A logistics discriminant, Quadratic Discriminant Analysis (QDA) and Linear Discriminant Analysis (LDA) model and K-Nearest Neighbor (KNN) were fitted for prognosis of CAD with the help of clinical and laboratory information of patients.ResultsOut of the 758 examined cases, 250 (32.98%) cases were non-CAD and 508 (67.22%) were diagnosed with CAD disease. The results indicated that the indices of accuracy, sensitivity, specificity and area under the ROC curve (AUC) in the linear discriminant analysis (LDA) were 78.6, 81.3, 71.3, and 81.9%, respectively. The results obtained by the quadratic discriminant analysis were respectively 64.6, 88.2, 47.9, and 81%. The values of the metrics in K-nearest neighbor method were 74, 77.5, 63.7, and 82%, respectively. Finally, the logistic regression reached 77, 87.6, 55.6, and 82%, respectively for the evaluation metrics.ConclusionsThe LDA method is superior to the Quadratic Discriminant Analysis (QDA), K-Nearest Neighbor (KNN) and Logistic Regression (LR) methods in differentiating CAD patients. Therefore, in addition to common non-invasive diagnostic methods, LDA technique is recommended as a predictive model with acceptable accuracy, sensitivity, and specificity for the diagnosis of CAD. However, given that the differences between the models are small, it is recommended to use each model to predict CAD disease.

Disambiguation Enabled Linear Discriminant Analysis for Partial Label Dimensionality Reduction

As an emerging weakly supervised learning framework, partial label learning considers inaccurate supervision where each training example is associated with multiple candidate labels among which only one is valid. In this article, a first attempt toward employing dimensionality reduction to help improve the generalization performance of partial label learning system is investigated. Specifically, the popular linear discriminant analysis (LDA) techniques are endowed with the ability of dealing with partial label training examples. To tackle the challenge of unknown ground-truth labeling information, a novel learning approach named Delin is proposed which alternates between LDA dimensionality reduction and candidate label disambiguation based on estimated labeling confidences over candidate labels. On one hand, the (kernelized) projection matrix of LDA is optimized by utilizing disambiguation-guided labeling confidences. On the other hand, the labeling confidences are disambiguated by resorting to k NN aggregation in the LDA-induced feature space. Extensive experiments over a broad range of partial label datasets clearly validate the effectiveness of Delin in improving the generalization performance of well-established partial label learning algorithms.

Chemical and sensory discrimination of coffee: impacts of the planting altitude and fermentation

Edaphoclimatic conditions, planting altitudes, soil, the microbiome of plants and fruits, genotypes, and postharvest processing are variables that contribute to the chemical and sensory quality of the coffee. Thus, the objective of this study was to evaluate the impacts of planting altitude and fermentation of fruits on the chemical and sensory quality of the coffee using Nuclear Magnetic Resonance (NMR) and Linear Discriminant Analysis (LDA). Cherry coffees were harvested in eight points of altitudes between 826 and 1078.08 m. A completely randomized design with e planting altitudes, five fermentation processes, and five repetitions was performed. Lipids, trigonelline, citrate, and malate were the compounds that most contribute to the chemical discrimination of coffee in the altitudes below 969 m. While, in the high altitudes (> 1000 m), this discrimination was due to the HMF, quinic acid, caffeine, and formic acid, and the global notes of coffee beverages were higher than 80 points. In fermented coffee, the LDA of the chemical data indicates the formation of five clusters, showing how the compounds can suffer changes depending on the form of processing used in coffee. The best score of beverage was observed in samples of 1078.08 m under dry fermentation and only in samples of 969 m was observed a significant difference in the sensory score between spontaneous fermentation and induced fermentation. Thus, coffee sensory scores were dependent on planting and fermentation methods and NMR and LDA techniques proved important in chemical and sensory discrimination of coffees.

Oil Spills or Look-Alikes? Classification Rank of Surface Ocean Slick Signatures in Satellite Data

Linear discriminant analysis (LDA) is a mathematically robust multivariate data analysis approach that is sometimes used for surface oil slick signature classification. Our goal is to rank the effectiveness of LDAs to differentiate oil spills from look-alike slicks. We explored multiple combinations of (i) variables (size information, Meteorological-Oceanographic (metoc), geo-location parameters) and (ii) data transformations (non-transformed, cube root, log10). Active and passive satellite-based measurements of RADARSAT, QuikSCAT, AVHRR, SeaWiFS, and MODIS were used. Results from two experiments are reported and discussed: (i) an investigation of 60 combinations of several attributes subjected to the same data transformation and (ii) a survey of 54 other data combinations of three selected variables subjected to different data transformations. In Experiment 1, the best discrimination was reached using ten cube-transformed attributes: ~85% overall accuracy using six pieces of size information, three metoc variables, and one geo-location parameter. In Experiment 2, two combinations of three variables tied as the most effective: ~81% of overall accuracy using area (log transformed), length-to-width ratio (log- or cube-transformed), and number of feature parts (non-transformed). After verifying the classification accuracy of 114 algorithms by comparing with expert interpretations, we concluded that applying different data transformations and accounting for metoc and geo-location attributes optimizes the accuracies of binary classifiers (oil spill vs. look-alike slicks) using the simple LDA technique.

P–337 Mid-Infrared spectroscopy as a real time diagnostic tool for chronic endometritis

Abstract Study question Can we develop a real-time diagnostic tool for chronic endometritis (CE) by using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy to evaluate biopsies obtained during hysteroscopy? Summary answer A discrimination model based on the absorbance data was developed by machine learning techniques, differentiating between positive and negative CE histopathology with 97% accuracy. What is known already CE is diagnosed in approximately 15% of infertile women who undergo in vitro fertilization (IVF), in 42% of women with recurrent implantation failure (RIF), and in 57.8% of women with RPL. Diagnosis is done by endometrial biopsy, and the presence of plasma cells in the endometrial stroma is the generally accepted histological diagnostic criterion. However, the histological detection of CE is time-consuming and difficult. ATR-FTIR spectroscopy is a non-destructive method that can provide valuable information on biochemical changes that occur during pathological processes, such as inflammation and cancer. Study design, size, duration We performed a prospective study in which fresh biopsies of endometrium were obtained during standard hysteroscopies. Each biopsy was examined by the spectrophotometer and afterward by histopathological analysis in which multiple myeloma oncogene 1 (MUM–1) staining for plasma cells, a marker of CE, was performed. We planned to investigate 80 samples to develop a discrimination model, and another 40 samples for validation of the model. The study was planned to last two years. Participants/materials, setting, methods Women that underwent hysteroscopy as a part of infertility evaluation were recruited. The hysteroscopies and the biopsy evaluation were performed at the same center. A cut-off of 8 MUM–1 positive cells per 10 high power fields (HPF) was set. We compared the spectroscopy analysis of the positive CE group (≥8) and the negative CE group (<8). Machine learning technique was utilized to build discrimination models. Data analysis was performed using Matlab and Unscrambler software packages. Main results and the role of chance We present preliminary results for our study. Forty-two women were recruited from January 2020 until November 2020. Of the 42 measured spectra, three were discarded due to high measurement noise. Of the 39 biopsies, 33 had MUM–1<8 (CE negative group) and 6 had MUM–1≥8 (CE positive group). Measured spectra of tissue smears from CE negative and positive groups differed from each other in the spectral range of 850–990 [cm–1] (p < 0.05). This wavenumber can be associated with the C-H in-plane bend in the alkene group (CnH2n). A discriminant model was developed between the groups using the Principal Component Analysis and Linear Discriminant Analysis techniques. The accuracy obtained by the model was 97%. We divided the 39 hysteroscopies based on the CE signs into 2 groups: “Negative hysteroscopic-CE” and “Positive hysteroscopic-CE”. Positive hysteroscopic signs were micropolyps, strawberry pattern, hyperemia, punctuation, or pale endometrium. Twenty-three samples were taken in the Negative group and 16 samples were taken in the Positive group. However, measured spectra of tissue smears from negative and positive hysteroscopy groups were not significantly different. The correlation coefficient between hysteroscopy groups and MUM–1 score was r = 0.29, meaning that the characteristic signs of CE in hysteroscopy were not correlated to the histopathology. Limitations, reasons for caution First, these are preliminary results and we need to investigate more samples to validate our model. Second, diagnostic criteria for CE are diverse in the literature and we chose 8 MUM–1 positive cells in 10 HPF, a criterion which may not be accepted by all experts in the field. Wider implications of the findings: ATR-FTIR spectroscopy is highly sensitive to molecular changes and has been utilized as a diagnostic tool in a variety of clinical studies. While histopathological results take about two weeks, ATR-FTIR spectroscopy might give us the possibility to diagnose CE in real-time, allowing an immediate initiation of the appropriate treatment. Trial registration number ClinicalTrials.gov Identifier: NCT04197167

ROBUST DETECTION AND RECOGNITION SYSTEM BASED ON FACIAL EXTRACTION AND DECISION TREE

Automatic face recognition system is suggested in this work on the basis of appearance based features focusing on the whole image as well as local based features focusing on critical face points like eyes, mouth, and nose for generating further details. Face detection is the major phase in face recognition systems, certain method for face detection (Viola-Jones) has the ability to process images efficiently and achieve high rates of detection in real time systems. Dimension reduction and feature extraction approaches are going to be utilized on the cropped image caused by detection. One of the simple, yet effective ways for extracting image features is the Local Binary Pattern Histogram (LBPH), while the technique of Principal Component Analysis (PCA) was majorly utilized in pattern recognition. Also, the technique of Linear Discriminant Analysis (LDA) utilized for overcoming PCA limitations was efficiently used in face recognition. Furthermore, classification is going to be utilized following the feature extraction. The utilized machine learning algorithms are PART and J48. The suggested system is showing high accuracy for detection with Viola-Jones 98.75, whereas the features which are extracted by means of LDA with J48 provided the best results of (F-measure, Recall, and Precision).

Genome-wide selection of discriminant SNP markers for breed assignment in indigenous sheep breeds

Abstract The assignment of an individual to the true population of origin is one of the most important applications of genomic data for practical use in animal breeding. The aim of this study was to develop a statistical method and then, to identify the minimum number of informative SNP markers from high-throughput genotyping data that would be able to trace the true breed of unknown samples in indigenous sheep breeds. The total numbers of 217 animals were genotyped using Illumina OvineSNP50K BeadChip in Zel, Lori-Bakhtiari, Afshari, Moqani, Qezel and a wild-type Iranian sheep breed. After SNP quality check, the principal component analysis (PCA) was used to determine how the animals allocated to the groups using all genotyped markers. The results revealed that the first principal component (PC1) separated out the two domestic and wild sheep breeds, and all domestic breeds were separated from each other for PC2. The genetic distance between different breeds was calculated using FST and Reynold methods and the results showed that the breeds were well differentiated. A statistical method was developed using the stepwise discriminant analysis (SDA) and the linear discriminant analysis (LDA) to reduce the number of SNPs for discriminating 6 different Iranian sheep populations and K-fold cross-validation technique was employed to evaluate the potential of a selected subset of SNPs in assignment success rate. The procedure selected reduced pools of markers into 201 SNPs that were able to exactly discriminate all sheep populations with 100% accuracy. Moreover, a discriminate analysis of principal components (DAPC) developed using 201 linearly independent SNPs revealed that these markers were able to assign all individuals into true breed. Finally, these 201 identified SNPs were successfully used in an independent out-group breed consisting of 96 samples of Baluchi sheep breed and the results indicated that these markers are able to correctly allocate all unknown samples to true population of origin. In general, the results of this study indicated that the combined use of the SDA and LDA techniques represents an efficient strategy for selecting a reduced pool of highly discriminant markers.

Accurate classification of fresh and charred grape seeds to the varietal level, using machine learning based classification method

Grapevine (Vitis vinifera L.) currently includes thousands of cultivars. Discrimination between these varieties, historically done by ampelography, is done in recent decades mostly by genetic analysis. However, when aiming to identify archaeobotanical remains, which are mostly charred with extremely low genomic preservation, the application of the genomic approach is rarely successful. As a result, variety-level identification of most grape remains is currently prevented. Because grape pips are highly polymorphic, several attempts were made to utilize their morphological diversity as a classification tool, mostly using 2D image analysis technics. Here, we present a highly accurate varietal classification tool using an innovative and accessible 3D seed scanning approach. The suggested classification methodology is machine-learning-based, applied with the Iterative Closest Point (ICP) registration algorithm and the Linear Discriminant Analysis (LDA) technique. This methodology achieved classification results of 91% to 93% accuracy in average when trained by fresh or charred seeds to test fresh or charred seeds, respectively. We show that when classifying 8 groups, enhanced accuracy levels can be achieved using a "tournament" approach. Future development of this new methodology can lead to an effective seed classification tool, significantly improving the fields of archaeobotany, as well as general taxonomy.

Comparison of different predicting models to assist the diagnosis of spinal lesions

ABSTRACT In neurosurgical or orthopedic clinics, the differential diagnosis of lower back pain is often time-consuming and costly. This is especially true when there are several candidate diagnoses with similar symptoms that might confuse clinic physicians. Therefore, methods for the efficient differential diagnosis can help physicians to implement the most appropriate treatment and achieve the goal of pain reduction for their patients. In this study, we applied data-mining techniques from artificial intelligence technologies, in order to implement a computer-aided auxiliary differential diagnosis for a herniated intervertebral disc, spondylolithesis, and spinal stenosis. We collected questionnaires from 361 patients and analyzed the resulting data by using a linear discriminant analysis, clustering, and artificial neural network techniques to construct a related classification model and to compare the accuracy and implementation efficiency of the different methods. Our results indicate that a linear discriminant analysis has obvious advantages for classification and diagnosis, in terms of accuracy. We concluded that the judgment results from artificial intelligence can be used as a reference for medical personnel in their clinical diagnoses. Our method is expected to facilitate the early detection of symptoms and early treatment, so as to reduce the social resource costs and the huge burden of medical expenses, and to increase the quality of medical care.

Random Lasing Detection of Mutant Huntingtin Expression in Cells.

Huntington’s disease (HD) is an autosomal dominant, incurable neurodegenerative disease caused by mutation in the huntingtin gene (HTT). HTT mutation leads to protein misfolding and aggregation, which affect cells’ functions and structural features. Because these changes might modify the scattering strength of affected cells, we propose that random lasing (RL) is an appropriate technique for detecting cells that express mutated HTT. To explore this hypothesis, we used a cell model of HD based on the expression of two different forms—pathogenic and non-pathogenic—of HTT. The RL signals from both cell profiles were compared. A multivariate statistical analysis of the RL signals based on the principal component analysis (PCA) and linear discriminant analysis (LDA) techniques revealed substantial differences between cells that expressed the pathogenic and the non-pathogenic forms of HTT.