Quantitative ultrasound (QUS) parameters are gaining attention recently as non-invasive biomarkers for soft tissue characterization. In this work, we use two QUS parameters, namely effective scatterer diameter (ESD) and mean scatterer spacing (MSS), for binary classification of breast lesions. To produce improved classification results, we propose a modified frequency-domain technique for ESD estimation of breast tissues from the diffuse component of backscattered radio-frequency (RF) data. Ensemble empirical mode decomposition (EEMD) is performed to separate the diffuse component from the coherent component of the backscattered RF data. A non-parametric Kolmogorov–Smirnov (K-S) test is employed for automatic selection of the intrinsic mode functions (IMFs). A novel multi-step system effect minimization process is also used. The ESD is estimated using a novel nearest neighborhood average regression line fitting (NNARLF) algorithm. Furthermore, we use an ameliorated EEMD domain autoregressive (AR) spectral estimation technique for MSS estimation. On using the ESD for binary classification of 139 lesions, we obtain high sensitivity, specificity, accuracy values of 95.45%, 95.79%, and 95.68%, respectively. The area under the receiver operating characteristics (ROC) curve is 0.95. On combining ESD with MSS we obtain even more improved sensitivity, specificity, and accuracy values of 97.73%, 95.79%, and 96.40%, respectively. The area under the ROC also increases to 0.97. This high classification performance demonstrates the potential of the use of these QUS parameters as non-invasive biomarkers for breast cancer detection.
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