Technical Stability Research Articles

Realization of advantages of Russian processor architecture KOMDIV64 in technical means of complexes of civil purpose automation

The paper discusses the practical issues of creation cluster-type computing equipment and switching equipment, which are based on Russian technologies and components developed for the segment of high-performance teraflop-class servers. A number of technical solutions are proposed, aimed at forming in the shortest possible time with minimal costs using a limited set of components (clusters), a model range of cluster-type computing equipment. The latter should ensure the creation of technical means of automation systems that have a performance parity with technical means of foreign production, as well as surpass it in a number of important operational and technical parameters, including the duration of the products and technical means life cycle, failure stability and external influencing factors durability.

Stability, Stress and Strain Analysis of Very Slender Pinned Thin-Walled Box Columns according to FEM, Euler and TSTh

In this study, a Finite Element Method (FEM) analysis is presented for the loss of stability in elastic states of very slender pinned without friction box-section thin-walled column axially compressed. From the FEM buckling linear stress analyses are determined the compressing critical forces for 36 cases, presented in tables and as the surface functions in dependence on the slenderness ratio and cross-section. Also are presented graphs obtained from the FEM post-buckling linear stress analysis for the elastic central line, slope, deflection and states of the stresses and strains of the box-section column 20×28×1×2500 mm made of steel, by the assumption that a maximal deflection equals the half of a side dimension. The obtained from the FEM computing function and surface graphs are compared and then discussed with graphs corresponding to Euler’s and Technical Stability Theory (TSTh) results. Finally are compared graphs of the stresses and strains of box-section thin-walled column 20×28×1×2500 obtained from FEM and TSTh, but under compressing critical force determined according to TSTh.

Studying the dynamics of contact interactions during machining based on a system of nonlinear piecewise linear differential equations

When manufacturing parts for thermal control systems for operation in especially difficult conditions of the North and in spacecraft, titanium and complex alloyed alloys are used. They are subject to increased quality requirements. They are achieved through simulation modeling. The solution is based on a dynamic model in which the contact interaction between the tool flank and the workpiece is differentiated. The process of contact interaction is considered as two-phase in the form of a sequence of states of adhesion and sliding. In the space of state variables, a system of nonlinear differential equations of piecewise linear type is constructed based on a set of rheological models. Based on this model, simulation modeling was carried out in the form of a computational experiment. A periodic solution is obtained which is formed as a result of switching the sliding and adhesion phases. In the graphs presented in the paper, the transition from the adhesion phase to the sliding phase is accompanied by a surge in displacement. In this case, in the phase portrait, the phase trajectory reaches the limit cycle with a limited amplitude. At the moment of transition from the adhesion phase to the sliding phase, a characteristic deviation of the phase trajectory from the limit cycle with an increased amplitude is observed, followed by a return to the limit cycle. With a wide variation in cutting speed, the conditions for technical stability are determined. During the simulation, a dynamic manifestation of the formation of chip elements was found, which did not have a serious impact on the nature of dynamic processes. The results obtained make it possible to study the dynamics of contact interactions during cutting in the framework of nonlinear dynamic models. This makes it possible to assess the level of vibration amplitudes and determine the regulated parameters of processing accuracy and surface roughness of manufactured products.

A Study on Technological Dynamics in Structural Health Monitoring Using Intelligent Fault Diagnosis Techniques: A Patent-Based Approach

The performance and reliability of structural components are greatly influenced by the presence of any abnormality in them. To this purpose, structural health monitoring (SHM) is recognized as a necessary tool to ensure the safety precautions and efficiency of both mechanical and civil infrastructures. Till now, most of the previous work has emphasized the functioning of several SHM techniques and systematic changes in SHM execution. However, there exist insufficient data in the literature regarding the patent-based technological developments in the SHM research domain which might be a useful source of detailed information for worldwide research institutes. To address this research gap, a method based on the Co-Operative Patent Classification (CPC) codes is proposed in the current study. The proposed method includes the patent analysis of SHM in terms of its global publication trend and technology-based applications. This analysis is performed using patent database search tools, namely, IncoPat and Espacenet. The period ranging from 2005 to 2019 is selected to retrieve the required patent documents. A new approach termed as Patents’ value is utilized to investigate the technological impact of a patent in the form of forward citations, technical stability, and scope of protection. The identification of emerging SHM techniques and forecasting of vacant technology is also part of current research work. The research results have revealed the increasing trend in the number of published patents each year related to various SHM technologies. In this regard, China, the United States, and South Korea are notified as to the major depositor countries, respectively. Hence, mapping of patent data in this research is an effort to illustrate the effectiveness of the proposed method to demonstrate the development trends and dynamic inventions over the time in SHM research domain to achieve the optimal damage inspections of various mechanical components.

Effects of standardization-based coordination mechanisms in project performance

Abstract: Among the coordination mechanisms present in an organization defined by Mintzberg, there are the mechanisms based on standardization of processes, employee skills and outputs. This study intends to investigate, through an exploratory and quantitative approach, the relationship between standardization-based coordination mechanisms, considered essential for project objectives accomplishment, and project performance. In addition, it is proposed to investigate whether project size, project manager power, technical system complexity and external environment stability affect the relationship between standardization mechanisms and project performance. In order to test the proposed model, the structural equation modeling technique was used in an empirical research with 216 professionals that have already worked on projects. The results showed that work processes standardization has a significant effect on the performance of projects and that their effectiveness is greater in smaller projects, when the project manager has power of action, when the external environment is stable and the technical system is not complex. This study also showed evidence that the proper use of standardization-based coordination mechanisms may have its effects enhanced when contingency factors are considered.

Socio-economic model of sustainable development

The article considers the socio-economic model of sustainable development. The study analyzes the conceptual and theoretical foundations of the political, social, economic, spiritual, environmental, scientific, technical and information stability of the state and development of the socioeconomic system. The definition of the concept of the “sustainable state and development” was given, the structural model of the stability of the socioeconomic system was developed. The characteristics of the varieties of the sustainable state and development were defined. The prerequisites for further development of the theoretical foundations of the sustainable development of the socio-economic system were determined.

Technical Buckling, Stress and Strain Simplified Analysis of Semi-Slender Thin-Walled Cylindrical Pinned Column

The stability of load-bearing members is a challenging issue for designers. The avoidance of possible stability troubles is a mandatory step of the overall design process. The paper presents and discusses two simplified methods based on the Technical Stability Theory (TSTh) of loss of stability of lateral buckling in elastic-plastic states of semi-slender columns axially compressed by force. It is assumed that in the critical elastic-plastic transverse cross-section there are the elastic and plastic parts of the area, keeping strength. To simplify the calculations, there are assumed the simplifications that the whole moment of inertia of a cross-section area is taken into account Jz = Jzall, the plastic module equals compress module Epl = Ec taken from experimental researches and as the next bigger simplification, the plastic module equals compressing module Epl = 0. The graphs of functions of the curved axes, their slopes, deflections of the columns, stresses and strains in thin-walled columns and compressing critical stresses depending on the cross-section areas and slenderness ratios are presented as the theoretical examples of thin-walled cylindrical columns and compared to results obtained from experiments with columns made of steel St35.

Sustainable food colours

Sustainable food colours

Enabling Routine MHC-II-Associated Peptide Proteomics for Risk Assessment of Drug-Induced Immunogenicity.

Major histocompatibility complex-II (MHC-II)-Associated Peptide Proteomics (MAPPs) is a mass spectrometry-based approach to identify and relatively quantitate naturally processed and presented MHC-II-associated peptides that can potentially activate T cells and contribute to the immunogenicity of a drug. Acceptance of the MAPPs technology as an appropriate preclinical (and potentially clinical) immunogenicity risk assessment tool depends not only on its technical stability and robustness but also on the ability to compare results across experiments and donors. To this end, we developed a specialized MAPPs data processing pipeline, dataMAPPs, which presents complex mass spectrometric data sets in the form of heat maps (heatMAPPs), enabling rapid and convenient comparison between conditions and donors. A customized normalization procedure based on identified endogenous peptides standardizes signal intensities within and between donors and enables cross-experimental comparison. We evaluated the technical reproducibility of the MAPPs platform using tool compounds with respect to the most prominent experimental factors and found that the systematic biological differences across donors by far outweighed any technical source of variation. We illustrate the capability of the MAPPs platform to generate data that may be used for preclinical risk assessment of drug-induced immunogenicity and discuss its applicability in the clinics.

On Technical Stability for Sets of Trajectories of Discrete Systems

On Technical Stability for Sets of Trajectories of Discrete Systems

The AIDSS Module for Data Acquisition in Crisis Situations and Environmental Protection.

The Toolbox implementation for removal of antipersonnel mines, submunitions and unexploded ordnance (TIRAMISU) Advanced Intelligence Decision Support System is an operational system proposed to Mine Action Centres worldwide for conducting non-technical surveys in humanitarian demining. The system consists of three modules, one of which is the module for data acquisition introduced and described in this study. The module has been designed, produced, improved, used and operationally tested and validated on several platforms (helicopters, remotely piloted aircraft systems (RPAS) and a blimp), with various sensors and acquisition units (Global Positioning System (GPS) and inertial measurement unit) in a variety of combinations for additional data acquisition from deep inside a suspected hazardous area. For the purposes of aerial data acquisition over a suspected hazardous area, the use of multiple sensors such as visible digital cameras and multi-spectral visible, near infrared (VNIR), hyperspectral VNIR and thermal infrared sensors are of benefit, because they display the scene in different ways. Off-the-shelf equipment and software were mostly used, but some specific equipment, such as sensor pods, was developed and also some software solutions for data acquisition and pre-processing (transforming hyperspectral line scanner data into hyperspectral images, and producing hyperspectral cubes). The technical stability and robustness of the module were confirmed by operationally testing and evaluating the systems on the aforementioned platforms and missions in several actual suspected hazardous areas in Croatia and Bosnia and Herzegovina, between 2001 and 2015.

Biodegradable and photostable Nb2C MXene quantum dots as promising nanofluorophores for metal ions sensing and fluorescence imaging

Conventional fluorescent probes are either easily photobleached or non-biodegradable, which often leads to the unstable fluorescence signal output and long-term biological toxicity. Therefore, the development of novel fluorescent materials with both excellent photostability and biodegradability is of great significance for further broadening their application in numerous research fields. In this work, Nb2C quantum dots (Nb2C QDs) with pristine crystallographic structures of Nb2C MXene phases and surface oxygen-containing species are synthesized by an ultrasound assisted physicochemical exfoliation in tetrapropylammonium hydroxide. Detailed analyses indicate that the Nb2C QDs not only possess excellent chemical- and photo-stable fluorescence emission but also achieve successful application in fluorescence sensing of heavy metal ions and fluorescence imaging. More importantly, it is confirmed that the Nb2C QDs present high biocompatibility and unique biodegradation property responsive to human myeloperoxidase, implying the application safety of Nb2C QDs in vivo. Under the background of ever-growing and stringent requirements for biosafety and technical stability, the chemical- and photo-stability, biocompatibility, biodegradability, and most importantly the promising fluorescence sensing/imaging characteristic of the obtained Nb2C QDs may argue well for their future applications in environmental monitoring, biomedical diagnosis, visual display, and anti-counterfeiting.

Water-Loss Management under Data Scarcity: Case Study in a Small Municipality in a Developing Country

Urban areas are facing challenges for the provision of public services, with water scarcity arising as one of the main problems. A twin track approach of supply and demand management is essential, and water-loss management contributes to reducing water demand. However, small municipalities from developing countries have technical, information, and financial limitations to locate and monitor water losses. This paper presents the estimation of real and apparent losses in a small municipality from a developing country in a data-scarce situation. For this, several tools were used, allowing data integration that resulted in a water balance, from which water losses were estimated at 46%, and four alternatives for water-loss reduction were developed. A cost-benefit analysis and financial indicators were estimated for the proposed alternatives, resulting in a water savings of 19%, a payback period of 3 years and an internal rate of return of 39%. The proposed strategies have potential to improve water quantity and quality, the technical stability of the system, utility performance, and water security.

О технической устойчивости множеств траекторий дискретных систем

The technical (practical) stability problem for a set of trajectories of discrete systems on a metric space of nonempty convex compact sets in $\Bbb R ^ n$ is considered. On the basis of known results of convex geometry and comparison method, an approach of constructing the auxiliary Lyapunov functionals for the study of technical stability in terms of two measures of evolutionary equations with Hukuhara difference operator is proposed. The problem of estimating the solutions of equations is reduced to the study of finite-dimensional difference equations of comparison. Examples of technical stability study are given to illustrate the constructiveness of this approach.

Technical Stability of Very Slender Rectangular Columns Compressed by Ball-And-Socket Joints without Friction

Stability of load-bearing members, as known, is a challenging issue and several tools are available for designers. Disregarding the material properties in use, the avoidance of possible stability troubles is a mandatory and challenging step of the overall design process. In this study, a theoretical model is presented for the of loss of stability in elastic states of very slender rectangular shell elements axially compressed through ball-and-socket joints without friction. According to this theory, as shown, a loss of carrying capacity of very slender columns in elastic states occurs when the line of force leaves a critical transverse cross-section. The critical transverse cross-section, moreover, progressively moves because of the superposition of bending and pure compression. The theory allows to determine the governing differential equations of curved central lines and their slopes, as well as the critical stresses of columns, in the form of surface function in dependence on slenderness ratios and cross-sectional areas. The graphs for the elastic deflected central line y(x), slope dy/dx, dependence yL/2(P), stresses and strains for a rectangular column made of steel and compressed by ball-and-socket joints without friction, as well as the corresponding surface graphs of critical stress, are presented in this study. The obtained surface graphs of critical stresses are then discussed and compared with Euler’s formulation.

Clinical Validation of the Lymph3Cx Assay to Distinguish Primary Mediastinal Large B-Cell Lymphoma From Diffuse Large B-Cell Lymphoma

Abstract Introduction Primary mediastinal large B-cell lymphoma (PMLBCL) is recognized as a distinct lymphoid neoplasm. However, differentiation from diffuse large B-cell lymphoma (DLBCL) can be difficult due to the need for close clinicopathologic correlation and variability in morphology and immunophenotype. In addition, a recent study identified lymphomas that share molecular and morphological features with PMBCL, yet do not involve the mediastinum. Correct classification of PMBCL may impact therapeutic decision making, increasing the demand for more accurate diagnostic methods. Recent research identified a new gene expression signature that robustly differentiated PMLBCL from DLBCL in both training and independent validation cohorts using RNA isolated from routinely available formalin-fixed, paraffin-embedded (FFPE) tissues. Methods This assay, known as the “Lymph3Cx,” utilizes the nCounter platform (NanoString Technologies, Seattle, WA) and consists of probes for 58 target genes (including both discriminatory and housekeeping genes) that can distinguish PMLBCL cases from DLBCL as well as the “cell-of-origin” subtypes of DLBCL. In the current study reported here, the Molecular Diagnostics–Arizona Laboratory (MDAZL) performed a full validation of the Lymph3Cx assay for use in our clinical diagnostic laboratory. Results Assay performance included accuracy (92.9%), precision (100%), analytical sensitivity (100 ng RNA limit of detection), analytical specificity (measures are in place to prevent interfering substances), reproducibility between technologists and technical replicates (100%), specimen stability (18 months for unstained tissue sections), and RNA Isolation Kit Utility (two kits with equal performance) in order to become the first CLIA-certified, CAP-accredited clinical diagnostics laboratory to offer a molecular assay for distinction of PMLBCL from DLBCL. Conclusion The Lymph3Cx assay will be prospectively used for evaluation of Mayo Clinic patients and for use as an integrated biomarker in clinical trials.

Biological variations, technical stability and elution tactics in dried blood spots specimens: neonatal screening outcomes

For many years, pre-analytical variables were only inappropriately considered in the field of dried blood spots (DBS) testing and even today, with the exception of newborn screening, the entire pre-analytical phase, which comprises the preparation and processing of DBS for their final analysis has not been standardized. (1) compared to conventional venepuncture, less blood volume is required and this fact was most important in paediatric diagnostics; (2) blood collection is simple, non-invasive, and inexpensive; (3) the risk of bacterial contamination or haemolysis is minimal; and (4) DBS can be preserved for long periods with almost no deterioration of the analytes. Advances techniques applied to diagnose the disorders of Inborn errors of metabolism. Dried blood spots (DBSs) have potential use in remote health applications for individual and population diagnosis, and can enable epidemiological surveillance for known and unknown diseases. DBS sampling offers great potential for remote health applications as a cost-effective sample format for large-scale screening and diagnostic purposes, but the DBS samples often need to be transported from remote sampling locations (e.g., tropical or developing countries) to analytical laboratories where the quantitative measurements of different metabolic or disease biomarkers can be carried out. Dried blood spots are commonly method for collecting, storing, transporting, and analysing a variety of human body fluids. Since 2006, however a variety of new and innovative dried blood spots applications, although this pre-analytical approach represents an interesting alternative to classical venous blood sampling, its routine use is limited. Here, we review the application of DBS technology in clinical chemistry, molecular assays, small molecules, and large molecules all are perfectly suited to evaluate its future role supported by new analytical methods such as mass spectrometry.

Gobierno electrónico y accesibilidad: Disponibilidad de servicio en las plataformas online estatales de la Argentina

Este artículo presenta los resultados de un relevamiento anual de calidad de servicio de servidores estatales de la Argentina. Por medio de ello, se busca dar cuenta de la importancia de la evaluación sistemática de la infraestructura pública digital de servicios de gestión e información gubernamental. En el caso de la infraestructura estatal, la importancia de su estabilidad técnica tiene una relevancia especial, en tanto la oferta de servicios estatales representa en muchos casos el acceso o la denegación de derechos tan básicos como la educación, la salud o el trabajo. El monitoreo se realizó durante 12 meses sobre 59 sitios dependientes del estado nacional, pudiendo observarse en ellos un rendimiento deficiente en comparación a los grupos de servicios seleccionados como grupos de referencia. Este peor rendimiento se registró tanto en su nivel de disponibilidad como en el tiempo total de respuesta a las solicitudes. Los sitios dependientes del Estado nacional mostraron a su vez patrones de falla diferenciados según grupo de pertenencia (ministerios nacionales, organismos estatales y Universidades nacionales) sugiriendo la existencia de infraestructuras y formas de trabajo heterogéneas que confluyen en todos los casos en altos niveles de no disponibilidad de las plataformas ofrecidas.

Long-Term Safety of Intraperitoneal Radio Transmitter Implants in Brown Bears (Ursus arctos).

Intraperitoneal radio transmitters have been widely used in free-ranging wild mammals, but there are no long-term studies on their biocompatibility or technical stability within the abdominal cavity of animals. Possible negative health effects may bias results from ecological studies on instrumented animals and raise concerns over animal welfare issues. The aim of this study was to evaluate the long-term technical stability and pathological effects of Telonics intraperitoneal very high frequency (VHF) radio transmitters in brown bears (Ursus arctos). We instrumented 305 individual bears with intraperitoneal VHF radio transmitters during a 19-year period. We surgically removed devices that had been in bears for 1–9 years and collected transmitters from animals that died 1–13 years after implantation. We took biopsies for histopathology from tissue encapsulating implants in live bears. Retrieved transmitters underwent a technical inspection. Of the 125 transmitters removed from live bears, 66 were free-floating in the peritoneal cavity [a mean (SD) of 3.8 (1.5) years after implantation], whereas 59 were encapsulated in the greater omentum [4.0 (1.8) years after implantation]. Histopathology of biopsies of the 1–15 mm thick capsules in 33 individuals showed that it consisted of organized layers of connective tissue. In one third of the bears, the inner part of the capsule was characterized by a foreign body reaction. We inspected 68 implants that had been in bears for 3.9 (2.4) years. The batteries had short-circuited four (5.9%) of these devices. This resulted in the death of two animals 10 and 13 years after implantation. In two other bears that underwent surgery, we found the short-circuited devices to be fully encapsulated within the peritoneal cavity 5 and 6 years after implantation. A significant proportion of the other 64 inspected implants showed serious technical problems, such as corrosion of metal parts or the batteries (50%), detachment of the end cap (11.8%), and erosion (7.4%) or melting (5.9%) of the wax coating. We conclude that the wax coating of the transmitters was not biocompatible, that the technical quality of the devices was poor, and that these implants should not be used in brown bears.

Failures on Historical Buildings as a Result of Deterioration of the Foundations and the Subsoil

Abstract: The paper is focused on a system of investigation of hidden parts of historical buildings as footing masonry and subsoil affecting significantly their technical conditions and stability. These impacts are mostly difficult to identify in time and there are often indirect producing differential settlement resulting in development of systems of cracks in the building masonry. Reliable analysis of the building supporting system shall precede any remedial actions or reconstructions. If the demonstration of the above negative impacts on the building becomes visible, it can indicate our late entry in to solving the problems with deterioration of the foundation system. Investigation boring and instrumentation of boreholes for high accuracy 3D displacement monitoring with local levelling system is presented in the paper illustrated by an example of one baroque church of the Broumov group of churches. This activity was followed by analyses of building stones and determination of degree of the footing masonry and subsoil deterioration together with careful input data for numeric modelling estimation.