The Asia-Pacific Bioinformatics Network (APBioNet; www.apbionet.org) is a nonprofit, nongovernmental, international organization founded in 1998 that focuses on the promotion of bioinformatics in the Asia-Pacific region. APBioNet's mission, since its inception, has been to pioneer the growth and development of bioinformatics awareness, training, education, infrastructure, resources, and research among member countries and economies. Its work includes technical coordination, liaison, and/or affiliation with other international scientific bodies, such as the European Molecular Biology network (EMBnet) and the International Society for Computational Biology (ISCB). APBioNet has more than 20 organizational and 2,000 individual members from over 12 countries in the region, from industry, academia, research, government, investors, and international organizations. APBioNet is spearheading a number of key bioinformatics initiatives in collaboration with international organizations, such as the Asia-Pacific Advanced Network (APAN), the Association of South-East Asian Nations (ASEAN), the Asia-Pacific Economic Cooperation (APEC), and the Asia-Pacific International Molecular Biology Network (A-IMBN), and industry partners. Many of the initiatives and activities have been initiated through its flagship conference, the International Conference on Bioinformatics (InCoB). In 2012, APBioNet was incorporated in Singapore as a public limited liability company to ensure quality, sustainability, and continuity of its mission to advance bioinformatics across the region and beyond. We describe below the key thrust areas of APBioNet.