Knowledge-intensive engineering is at the forefront of innovation and technological progress, including the de-velopment and application of advanced technologies, materials and complex systems. These achievements lead to break-throughs in various fields such as information technology, telecommunications, aerospace, healthcare, renewable energy and transportation. Knowledge-intensive engineering pushes the boundaries of what is possible and promotes progress in society. Knowledge-intensive engineering makes a significant contribution to eco-nomic growth both at the state and planet level, creating jobs, attracting investment and contributing to the development of entrepreneurship. Enterprises engaged in knowledge-intensive engineering often manage eco-nomic clusters and ecosystems, supporting a wide range of enterprises and services. The development and commercialization of advanced technologies also leads to the creation of new industries and markets, increasing production volumes. In the Russian Federation, knowledge-development engi-neering with its main centers is an important segment of the national economy, which determines the relevance of the scientific problem of knowledge-intensive engineering enterprises. In the course of the study, the functioning and con-stituent elements of the innovative infrastructure of knowledge-intensive engineering enterprises of Moscow region were considered, in addition, the innovative infrastructure of such knowledge-intensive engineering enterprises as “RI “Platan” with the Plant at RI” JSC, “Design Bureau of Radio Engineering and Electronics” JSC and “Aerosila” PJSC scientific-production enterprise was studied. It was found out that they include various technological and pro-duction departments, laboratories and centers, the joint work of which makes it possible to produce high- tech products of national importance. The further direction of the future research is studying of the innovative infra-structure of other representatives of knowledge-intensive engineering enterprises of the Moscow region.