IntroductionIn 2018 Missouri University Psychiatric Center, an inpatient psychiatric hospital established a ketamine infusion team to treat severely depressed and acutely suicidal clients. Over 80 infusions were delivered over three years, with positive outcomes and minimal side effects.ObjectivesTo evaluate outcomes of an inpatient psychiatric intravenous ketamine team to deliver treatment without anesthisia colloabration, which could open the horizon for future intravenous medications in a psychiatric inpatient setting.MethodsA team consisting of a psychiatrist supported by a psychiatric PA, psychiatric pharmacist, and a mental health nurse devloped a protocol including physical and mental health screening, inclusion/exclusion criteria, dosing, and client monitoring. For data collection, the team monitored vital signs and mental status changes for tolerability and depression screening tools for efficacy.ResultsTable 1:Ketamine Infusion DataTotal Clients32Male15Female17Dosing0.5mg/kg adjusted bodyweight infused over 40 minutesAverage Baseline Depression Screening (PHQ or QIDS)*20.8Average Baseline Follow up Screening (PHQ or QIDS)*7.5Average Change in Screening Score (PHQ or QIDS)*-14.1% Change From Baseline in Screening Score (PHQ or QIDS)*65.5%Adverse Events DocumentedDissociation 5 (15.6%); Nausea/Vomiting 3 (.09%), Extreme Euphoria 2 (.06%); sedation 1 (.03%); BP Increase 1 (.03%)ConclusionsOverall, ketamine infusions were tolerated well with limited adverse drugs reactions reported or observed and were easily addressed by the team without any serious adverse events. Given the rapid improvement of symptoms and overall tolerability, intravenous ketamine infusions conducted solely by a psychiatric-based team advances our field for further treament modalities.DisclosureNo significant relationships.