Due to the shortage of funds for local universities, the investment in laboratory safety cannot be fully guaranteed, and the construction of safety protection supporting facilities and safety management is lagging behind, so safety is seriously challenged. In recent years, labs have been opened and shared more, and the potential safety risk factors have increased. Laboratory safety accidents occur from time to time, which seriously threaten the lives of teachers and students. Therefore, the safety management of laboratories in local universities needs to be strengthened. By summarizing the current situation of laboratory safety management in local universities, this study analyzes the obvious shortcomings of laboratory safety management in terms of system and regulations, site planning, team building and informationization level from physical and human factors. For example, unclear authority and responsibility between departments, there is insufficient safety management front in laboratory planning and construction, and the safety awareness of personnel is weak. In view of the risks in safety management work, suggestions are made in four aspects: laboratory management system, laboratory technical team construction, regularization of safety education, and optimization of safety management information platform, with a view to providing reference for the effective operation of laboratory safety work in local universities.