Purpose of the study. The article focuses on the role of disruptive pathological processes and "vicious circles" in improving the teaching of pathophysiology. The specificity of the topic is an analytical approach to the application of the research method - descriptive: comparison - for the analysis, synthesis and generalization of the role of disruption pathological processes and "vicious circles" in the possibility of a significant improvement in the mastering of the leading theoretical discipline with the dominant tension of such spheres of human consciousness as thinking and intellect. Scientific novelty. For the first time, the introduction of an original, innovative approach to practice has been ensured, showing that disregulatory pathological processes inevitably lead to the formation of "vicious circles", which is necessary for the formation of highly professional competences. Conclusion. The introduction of disruptive pathological processes and "vicious circles" into the educational process will make it possible to achieve the leading interests of the pathophysiology of deep knowledge of the general laws of the development of the disease, prebiosis, to provide the leading role of pathophysiology in forming the foundations of clinical thinking in students and to fulfill the function of the methodology of clinical disciplines with the possibility of a significant increase the quality of teaching the leading theoretical discipline.