The purpose of this study was to determine and compare the strategies, challenges faced, and experiences of science teachers and the scientific performance of students among rural and urban schools in Liliw, Laguna. This study aimed to answer the following questions What is the profile of science teachers in terms of Type of School where they teach, Age, Years in Teaching, Teaching Position, and Educational Attainment? What are the Strategies of Science teachers in rural and urban schools? What are the Challenges Faced by Science teachers in rural and urban schools? What are the Experiences of Science teachers in rural and urban schools? What is the level of performance of Grade 6 pupils in Science? Is there a significant difference between strategies, challenges faced, and experiences of Science teachers and the level of pupils performance in Science 6 in rural and urban schools? Is there a significant difference between the level of performance of pupils from rural and from urban schools? Is there a significant effect between the profile of the Science teachers and the level of performance of pupils in Science 6 from rural and urban schools? Is there a significant effect between the strategies of Science teachers and the level of performance of pupils in Science 6 from rural and urban schools? Is there a significant effect between the challenges faced by Science teachers and the level of performance of pupils in Science 6 from rural and urban schools? Is there a significant effect between the experiences of Science teachers and the level of performance of pupils in Science 6 from rural and urban schools? The respondents of the study were the forty-two (42) Science teachers and two hundred and fifty-two (252) students from the different urban and rural schools in the district of Liliw in Laguna. A descriptive survey method was employed in this study. The following were the significant findings of the study There is a significant difference between strategies, challenges faced, and experiences of Science teachers and the level of pupils performance in Science 6 in rural and urban schools There is a significant difference between the level of performance of pupils from rural and urban schools There is a significant effect between the profile of the Science teachers and the level of performance of pupils in Science 6 from rural and from urban schools There is a significant effect between the strategies of Science teachers and the level of performance of pupils in Science 6 from rural and from urban schools There is a significant effect between the challenges faced by Science teachers and the level of performance of pupils in Science 6 from rural and from urban schools and, There is a significant effect between the experiences of Science teachers and the level of performance of pupils in Science 6 from rural and urban schools. Based on the results gathered from the study, the following are being recommended: The strategies, challenges faced, and the experiences of teachers should be brought into consideration in improving the education system in the Philippines since they have an impact or influence on students academic performance, particularly in Science Discrimination between the performances of students from rural and urban is highly discouraged since there is no significant difference between where the school is located, whether rural or urban and, Implementation of such programs for teachers and students that are related to Science is recommended.