Introduction. Spiritual Intelligence plays a pivotal role in mitigating depression and irrational thoughts, significantly contributing to improved student achievement. This research aims to determine whether or not spiritual intelligence can help college students deal with mental health issues like depression and illogical thinking while simultaneously boosting their academic performance. The sample of the study and methods. The study sample comprised of (62) male and female university students, and they were randomly distributed into two groups: controlling and experimental. Two scales were used: The scale of depression where its items were distributed on four dimensions, are bodily dimension, verbal dimension, the withdrawal dimension, and the psychological dimension, and the scale of irrationality thinking, it had been prepared and joined (60) statements measuring irrational thinking to emphasize the validity of the content. Results. The results show that following the intervention, there were notable improvements in the experimental group's levels of despair and irrational thinking. After the intervention, the average depression score for the experimental group dropped from 90.41 to 67.13, a statistically significant decrease. The control group's decline was less pronounced, falling from 87.85 to 84.26. The average scores for irrational thinking in the experimental group fell from 201.65 to 153.92, while in the control group they were mostly unchanged. It is worth mentioning that there was a more notable decline in depression in females as compared to males. Among college students, the survey found an average spiritual intelligence level of 3.38, with variations noted according to gender and academic performance. Academic success is strongly predicted with critical existential thinking (R2 =5.6%), according to regression research. Practical significance. This study presents important findings regarding the potential of spiritual intelligence to help college students cope with mental health challenges such as sadness and illogical thinking. This study offers important information for mental health practitioners and educators since it shows that spiritual intelligence can lower depression scores and illogical thoughts. Based on the results, student support programs that include interventions focused on spiritual intelligence may help students' mental health and academic performance. For schools, this could mean providing a more all-encompassing plan to ensure their pupils thrive in school.