Being able to use ICT by physics, math, biology and chemistry teacher candidates is important in the Covid- 19 pandemic situation. The purpose of the study was to examine the effects of Technological Knowledge (TK), Pedagogical Knowledge (PK), Content Knowledge (CK), Pedagogical Content Knowledge (PCK), Technological Pedagogical Knowledge (TPK), Technological Content Knowledge (TCK), and Technological Pedagogical Content Knowledge (TPACK) instrument variables on physics, math, biology, and chemistry teacher candidates. This study used a questionnaire consisting of 75 items to collect the data from 400 respondents. The data were analysed by using the Structural Equation Model-Partial Least Square (SEM-PLS). The findings indicated that there were positive relationships among the variables of the TPACK. Of the 18 variables that had been analysed, 12 variables had direct relationships with other variables, and 6 variables had no direct relationships. Of the 12 variables, there were 10 variables that had positive relationships and significant effects.