Tc-99m Tetrofosmin SPECT Research Articles

Assessment of reperfusion therapy in acute myocardial infarction by TC-99M tetrofosmin and I-123 BMIPP SPECT imagings

Assessment of reperfusion therapy in acute myocardial infarction by TC-99M tetrofosmin and I-123 BMIPP SPECT imagings

Assessment of regional LV function by gated Tc-99m tetrofosmin SPECT and Fourier analysis

Assessment of regional LV function by gated Tc-99m tetrofosmin SPECT and Fourier analysis

Tc-99m tetrofosmin myocardial perfusion SPECT after dipyridamole combined with low-level exercise in the diagnosis of coronary artery disease.

Tc-99m tetrofosmin is a lipophilic, cationic perfusion imaging agent that changes to Tl-201 in detecting coronary artery disease during exercise testing. The purpose of this study is to evaluate the usefulness of Tc-99m tetrofosmin dipyridamole stress imaging combined with low level exercise for the detection of coronary artery disease. We examined 42 patients and 10 normal volunteers who also underwent coronary angiography. A one-day protocol was used: in the stress study, 296 MBq of tetrofosmin was injected and in the rest study 888 MBq was injected. After intravenous administration of dipyridamole (0.142 mg/kg/min for 4 minutes), the patient was exercised on a bicycle ergometer for 3 min (25 Watts). Tetrofosmin was injected 2 minutes after dipyridamole infusion during the exercise. Single photon emission computed tomographic images were obtained 30 minutes after the tracer injection. Images were interpreted as abnormal in 36 of 42 patients with coronary artery disease, and normal in all of 10 normal volunteers. The overall sensitivity of detection of coronary artery disease was 83.3% and the normalcy rate was 100%. The diagnostic values for the detection of significant stenosis in the three major arteries were: LAD sensitivity 83%, specificity 92%; LCX sensitivity 47%, specificity 91%; RCA sensitivity 75%, specificity 83%. Of the 66 arteries with more than 50% stenosis, 48 arteries were correctly identified. Of the 36 with more than 70% stenosis, 31 were identified. Scintigraphic evidence of multivessel disease was found in only 9 patients (50%). A protocol of Tc-99m tetrofosmin SPECT combined with low level exercise after dipyridamole is therefore useful for the detection of the coronary artery disease.

Tc-99m tetrofosmin lymph node uptake in myocardial perfusion imaging.

A 60-year-old man, who was believed to have angina, underwent Tc-99m Tetrofosmin SPECT imaging during rest myocardial perfusion study, which showed an abnormal uptake with visualization of left axillary lymph nodes. Further Investigation with Tc-99m nanocolloid lymphoscintigraphy and left axillary echography did not show neoplastic axillary lymph node enlargement. Abnormal lymph node uptake was probably due to lymphatic drainage after partial extravasation of radiopharmaceutical during left arm intravenous injection.

Dobutamine Tc-99m Tetrofosmin SPECT in the detection of coronary artery disease (CAD): Evaluation of a same day rest-stress protocole

Dobutamine Tc-99m Tetrofosmin SPECT in the detection of coronary artery disease (CAD): Evaluation of a same day rest-stress protocole

Rest Tc-99m Tetrofosmin SPECT imaging in men with severe coronary artery disease in absence of previous myocardial infarction

Rest Tc-99m Tetrofosmin SPECT imaging in men with severe coronary artery disease in absence of previous myocardial infarction

Planar scintimammography and SPECT in neoadjuvant chemo or hormonotherapy response evaluation in locally advanced primary breast cancer

Conventional imaging procedures have proved of limited value in assessing tumor response to neoadjuvant chemotherapy in locally advanced primary breast cancer (LAPBC). We evaluated the usefulness of radioisotopic procedures comparing planar scintimammography (SM) to SPECT, monitoring pre-surgery neoadjuvant chemo- or hormonotherapy response in 32 LAPBC patients. In all cases, 99mTc-tetrofosmin conventional planar SM and SPECT were acquired by dual-head gamma camera with HR parallel hole collimators. In 15 cases, planar SM with small field of view high resolution dedicated breast camera (DBC) was also acquired. Scintigraphic data always correlated with histopathological findings. At surgery, 4/32 patients had pathological complete remission (pCR), while 28/32 patients had residual tumors. Both conventional planar SM and SPECT were true negative in 4/4 (100%) pCR patients, as was DBC in the only studied case. Conventional planar SM and SPECT detected residual tumors in 23/28 (82%) and in 25/28 (89.2%) cases, respectively. Both procedures missed 2 multifocal, scattered microscopic residues, only evidenced at DBC. Conventional planar SM also missed 3 further macroscopic residues (15-20 mm), while SPECT only one of these, a mucinous BC, in which DBC was not performed. DBC correctly classified all other 12 patients in whom the procedure was performed. Both conventional planar SM and SPECT proved useful diagnostic tools in monitoring neoadjuvant chemo/hormono therapy response in LAPBC with SPECT appearing more sensitive; however, our data, although in a limited number of cases, suggest that sensitivity can further be increased using high resolution DBC, especially in detecting microscopic residual tumor foci.