A simple analytical formulas for estimation of the yield and angular distribution of neutrons from thick targets would be useful for calculating the biological protection of heavy ion accelerators with energy (1–6) MeV/nucleon. The results of the calculation with this formulas were compared with those obtained using the LISE++ and FLUKA programs as well as with the available experimental data. As a result, it can be stated that the proposed calculation method can be used for quick assessment. The deviation of the results of such calculations from more accurate ones does not exceed a factor of two, which is comparable with the deviations in the calculation of biological shielding due to a variety in the protection properties of the materials used or in their thickness.