Target Eccentricity Research Articles

Reduced spatial attentional distribution in older adults.

Older adults show decline in visual search performance, but the underlying cause remains unclear. It has been suggested that older adults' altered performance may be related to reduced spatial attention to peripheral visual information compared with younger adults. In this study, 18 younger (M = 21.6 years) and 16 older (M = 69.1 years) participants performed pop-out and serial visual search tasks with variously sized gaze-contingent artificial central scotomas (3°, 5°, or 7° diameter). By occluding central vision, we measured how attention to the periphery was contributing to the search performance. We also tested the effect of target eccentricity on search times and eye movements. We hypothesized that, if attention is reduced primarily in the periphery in older adults, we would observe longer search times for more eccentric targets and with central occlusion. During the pop-out search, older adults showed a steeper decline in search performance with increasing eccentricity and central scotoma size compared with younger adults. In contrast, during the serial search, older adults had longer search times than younger adults overall, independent of target eccentricity and scotoma size. Longer search times were attributed to higher cost-per-item slopes, indicating increased difficulty in simultaneously processing complex symbols made up of separable features in aging, possibly stemming from challenges in spatially binding individual features. Altogether, our findings point to fewer attentional resources of simultaneous visual processing to distribute over space or separable features of objects, consistent with decreased dorsal visual stream functioning in aging.

Benefits of subthalamic nucleus deep brain stimulation on visually-guided saccades depend on stimulation side and classic paradigm in Parkinson’s disease

ObjectiveWe aimed to gain further insight into previously reported beneficial effects of subthalamic nucleus deep brain stimulation (STN-DBS) on visually-guided saccades by examining the effects of unilateral compared to bilateral stimulation, paradigm, and target eccentricity on saccades in individuals with Parkinson’s disease (PD). MethodsEleven participants with PD and STN-DBS completed the visually-guided saccade paradigms with OFF, RIGHT, LEFT, and BOTH stimulation. Rightward saccade performance was evaluated for three paradigms and two target eccentricities. ResultsFirst, we found that BOTH and LEFT increased gain, peak velocity, and duration compared to OFF stimulation. Second, we found that BOTH and LEFT stimulation decreased latency during the gap and step paradigms but had no effect on latency during the overlap paradigm. Third, we found that RIGHT was not different compared to OFF at benefiting rightward saccade performance. ConclusionsLeft unilateral and bilateral stimulation both improve the motor outcomes of rightward visually-guided saccades. Additionally, both improve latency, a cognitive-motor outcome, but only in paradigms when attention does not require disengagement from a present stimulus. SignificanceSTN-DBS primarily benefits motor and cognitive-motor aspects of visually-guided saccades related to reflexive attentional shifting, with the latter only evident when the fixation-related attentional system is not engaged.

The effect of visual rivalry in peripheral head-mounted displays on mobility

Recent head-mounted displays and smart glasses use vision multiplexing, an optical approach where two or more views are superimposed on each other. In vision multiplexing, augmented information is presented over an observer’s natural field of view, providing field expansion and critical information during mobility situations like walking and driving. Yet despite its utility, vision multiplexing may produce visual rivalry, a phenomenon where perception alternates between the augmented information and the background scene for seconds at a time. To investigate, we compared the effect of different peripheral vision multiplexing configurations (unilateral opaque, unilateral see-through and bilateral see-through) on the detection of augmented information, incorporating at the same time real-world characteristics (target eccentricity, depth condition, and gaze movement) for a more realistic assessment. Results showed a persistently lower target detection rate in unilateral configurations than the bilateral configuration, suggesting a larger effect of binocular rivalry on target visibility. Nevertheless, this effect does become attenuated when more naturalistic elements are incorporated, and we discuss recommendations for vision multiplexing design and possible avenues for further research.

A competition framework for fixation-preference in strabismus.

Strabismic subjects often develop the ability to fixate on a target with either eye. Previous studies have shown that fixation-preference behavior varies systematically depending on spatial location of the target. We hypothesized that, when an eccentric target is presented, oculomotor fixation-preference in strabismus may be accounted for in a competitive decision framework wherein the brain must choose between two possible retinal errors to prepare a conjugate saccade that results in one of the eyes acquiring the eccentric target. We tested this framework by recording from visuo-motor neurons in the superior colliculus (SC) of two strabismic rhesus macaque monkeys as they performed a delayed saccade task under binocular viewing conditions. In one experiment, visual targets were presented at one of two locations corresponding to the neuronal receptive field location with respect to either the viewing or the deviated eye. Robust visual sensory responses were observed when targets were presented at either location indicating the presence of competing sensory signals for eye-choice. In a second experiment, a single visual target was placed at the neuronal receptive field location where the animal switched fixation on some trials and did not on other trials. At such target locations where either eye could acquire the target, both visual and build-up activity was greater in trials when the saccade encoded by the neuron "won." These findings provide evidence for the influence of visual suppression within SC sensory activity and support the possible utilization of a competition framework, one that has been previously described for when a binocularly aligned animal chooses from among multiple targets, to drive fixation-preference behavior in strabismus.

Astronauts eye-head coordination dysfunction over the course of twenty space shuttle flights.

Coordination of motor activity is adapted to Earth's gravity (1 g). However, during space flight the gravity level changes from Earth gravity to hypergravity during launch, and to microgravity (0 g) in orbit. This transition between gravity levels may alter the coordination between eye and head movements in gaze performance. We explored how weightlessness during space flight altered the astronauts' eye-head coordination (EHC) with respect to flight day and target eccentricity. Thirty-four astronauts of 20 Space Shuttle missions had to acquire visual targets with angular offsets of 20°, 30°, and 49°. Measurements of eye, head, and gaze positions collected before and during flight days 1 to 15 indicated changes during target acquisition that varied as a function of flight days and target eccentricity. The in-flight alterations in EHC were presumably the result of a combination of several factors, including a transfer from allocentric to egocentric reference for spatial orientation in absence of a gravitational reference, the generation of slower head movements to attenuate motion sickness, and a decrease in smooth pursuit and vestibulo-ocular reflex performance. These results confirm that humans have several strategies for gaze behavior, between which they switch depending on the environmental conditions.

A triple distinction of cerebellar function for oculomotor learning and fatigue compensation.

The cerebellum implements error-based motor learning via synaptic gain adaptation of an inverse model, i.e. the mapping of a spatial movement goal onto a motor command. Recently, we modeled the motor and perceptual changes during learning of saccadic eye movements, showing that learning is actually a threefold process. Besides motor recalibration of (1) the inverse model, learning also comprises perceptual recalibration of (2) the visuospatial target map and (3) of a forward dynamics model that estimates the saccade size from corollary discharge. Yet, the site of perceptual recalibration remains unclear. Here we dissociate cerebellar contributions to the three stages of learning by modeling the learning data of eight cerebellar patients and eight healthy controls. Results showed that cerebellar pathology restrains short-term recalibration of the inverse model while the forward dynamics model is well informed about the reduced saccade change. Adaptation of the visuospatial target map trended in learning direction only in control subjects, yet without reaching significance. Moreover, some patients showed a tendency for uncompensated oculomotor fatigue caused by insufficient upregulation of saccade duration. According to our model, this could induce long-term perceptual compensation, consistent with the overestimation of target eccentricity found in the patients' baseline data. We conclude that the cerebellum mediates short-term adaptation of the inverse model, especially by control of saccade duration, while the forward dynamics model was not affected by cerebellar pathology.

Peripheral target detection can be modulated by target distance but not attended distance in 3D space simulated by monocular depth cues

Most studies of visuo-spatial attention present stimuli on a 2D plane, and less is known about how attention varies in 3D space. Previous studies found better peripheral detection performance for targets at a near compared to a far depth, simulated by pictorial cues and optical flow. The current study examined whether target detectability is monotonically related to distance along the depth axis, and whether the attended distance modulates the effect of target distance. We investigated these questions in two experiments that measured how apparent distance and target eccentricity affects peripheral target detection when performed alone during passive simulated self-motion, or during a simultaneous, active central car-following task. Experiment 1 found that targets at an apparent distance of 18.5 virtual meters were detected faster and more accurately than targets at 9.25 and 37 virtual meters, and detectability declined with eccentricity. Experiment 2 examined the effect of the attended location by varying the distance between the viewer and the lead car on which participants were instructed to fixate (i.e. the headway) while equating target distances across headway conditions. Experiment 2 replicated the effects found in Experiment 1, and headway did not modulate the effect of target distance. These results are consistent with the hypothesis that target detection depends non-monotonically on the distance between the viewer and the target, and is not affected by the distance between the target and attended location. However, target detection may also have been affected by stimulus characteristics that co-varied with apparent depth, rather than depth per se.

Medication adversely impacts visually-guided eye movements in Parkinson’s disease

ObjectiveWe examined whether previous inconsistent findings about the effect of anti-Parkinsonian medication on visually-guided saccades (VGS) were due to the use of different paradigms, which change the timing of fixation offset and target onset, or different target eccentricities. MethodsThirty-three participants with Parkinson’s disease (PD) completed the VGS tasks OFF and ON medication, along with 13 healthy controls. Performance on 3 paradigms (gap, step, and overlap) and 2 target eccentricities was recorded. We used mixed models to determine the effect of medication, paradigm, and target eccentricity on saccade latency, gain, and peak velocity. ResultsFirst, we confirmed known paradigm effects on latency, and target eccentricity effects on gain and peak velocity in participants with PD. Second, latency was positively associated with OFF medication Movement Disorders Society – Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) motor score in PD. Third, medication prolonged latency for the larger target eccentricity across the 3 paradigms, while decreasing gain and peak velocity in the step paradigm across target eccentricities. ConclusionsMedication adversely affected and was not therapeutically beneficial for VGS. Previous inconsistencies may have resulted from chosen target eccentricity. SignificanceThe negative medication effect on VGS may be clinically significant, as many activities in daily life require oculomotor control, inhibitory control, and visually-guided shifts of attention.

Značilnosti stabilizacij trigonometričnih točk na Primorskem

An analysis of the present-day geodetic marks representing trigonometric points of the 2nd and 3rd order was carried out in the area of Slovenia that was part of the Kingdom of Italy between 1920 and 1947. By reviewing topographies, photographs on hribi.net and sample field surveys, we identified, among the 52 2nd order points, 16 points that had the Italian type of geodetic marks and 6 points with even older types of geodetic marks, dating back to the Austro-Hungarian Monarchy. Among the 407 3rd order points, we identified 68 Italian geodetic marks and 15 even older ones. The so-called Italian type of geodetic mark can be recognised as a concrete pillar with a square or octagonal shape, about 1 m high, with a diameter of 40 to 70 cm. The even older geodetic marks are carved from natural stone. These often have the dual function of being a trigonometric point mark and a land cadastral mark, indicating the boundary of cadastral municipalities. We also investigated the eccentric metal target signals erected in 1996, and those between 1995 and 1997, which were an additional post- consolidation of the existing granite trigonometric marks installed after the Second World War. Finally, we highlight the potential of these old geodetic marks in the design and planning of new measurements in the future.

Visual guidance of locomotor interception is based on nulling changes in target bearing (not egocentric target direction nor target-heading angle).

In two experiments we studied how participants steer to intercept uniformly moving targets in a virtual driving task under hypotheses-differentiating conditions of initial target eccentricity and target motion. In line with our re-analysis of findings from earlier studies, in both experiments the observed interception behavior could not be understood as resulting from reliance on (changes in) egocentric target direction nor from reliance on (changes in) target-heading angle. The overall pattern of results observed was however compatible with a control strategy based on nulling changes in the target's bearing angle. The presence of reversals in movement direction under specific combinations of target eccentricity and motion conditions indicated that the information used was not purely rate-of-change (i.e., first-order) based but carried traces of an influence of initial target position. In Experiment 2 we explicitly tested the potential role of early reliance on perceived egocentric target direction by examining the effects of a 10° rotation of the visual scene (i.e., of both target and environment). While such a rotation gave rise to minor changes in the moment of initiation of the first steering action, contrary to predictions it did not affect the characteristics of the direction-reversal phenomenon. We conclude that the visual guidance of locomotor interception is best understood as resulting from nulling changes in the target's bearing angle, with such nulling perhaps best conceived as being fractional-order (rather integer-order) driven.

Speed-accuracy tradeoffs influence the main sequence of saccadic eye movements

Several studies have proposed that an optimal speed-accuracy tradeoff underlies the stereotyped relationship between amplitude, duration and peak velocity of saccades (main sequence). To test this theory, we asked 8 participants to make saccades to Gaussian-blurred spots and manipulated the task’s accuracy constraints by varying target size (1, 3, and 5°). The largest targets indeed yielded more endpoint scatter (and lower gains) than the smallest targets, although this effect subsided with target eccentricity. The main sequence depended on several interacting factors: saccade latency, saccade gain and target size. Early saccades, which were faster than amplitude-matched late saccades, followed the target-size dependency one would expect from a speed-accuracy tradeoff process. They had higher peak velocities and shorter durations for larger targets than for smaller targets. For late saccades, however, the opposite was found. Deviations from the main sequence also covaried with saccade gain, in line with the idea that motor noise underlies part of the endpoint variability. Thus, our data provide partial evidence that the saccadic system weighs the detrimental effects of motor noise on saccade accuracy against movement duration and speed, but other factors also modulate the kinematics. We discuss the possible involvement of parallel saccade pathways to account for our findings.

Role of the Dorsal Posterior Parietal Cortex in the Accurate Perception of Object Magnitude in Peripheral Vision.

Following superior parietal lobule and intraparietal sulcus (SPL-IPS) damage, optic ataxia patients underestimate the distance of objects in the ataxic visual field such that they produce hypometric pointing errors. The metrics of these pointing errors relative to visual target eccentricity fit the cortical magnification of central vision. The SPL-IPS would therefore implement an active “peripheral magnification” to match the real metrics of the environment for accurate action. We further hypothesized that this active compensation of the central magnification by the SPL-IPS contributes to actual object’ size perception in peripheral vision. Three optic ataxia patients and 10 age-matched controls were assessed in comparing the thickness of two rectangles flashed simultaneously, one in central and another in peripheral vision. The bilateral optic ataxia patient exhibited exaggerated underestimation bias and uncertainty compared to the control group in both visual fields. The two unilateral optic ataxia patients exhibited a pathological asymmetry between visual fields: size perception performance was affected in their contralesional peripheral visual field compared to their healthy side. These results demonstrate that the SPL-IPS contributes to accurate size perception in peripheral vision.

The generality of the critical spacing for crowded optotypes: From Bouma to the 21st century.

It is rare to find a crowding manuscript that fails to mention “Bouma's law,” the rule of thumb stating that flankers within a distance of about one half of the target eccentricity will induce crowding. Here we investigate the generality of this rule (even for just optotypes), the factors that modulate the critical spacing, and the evidence for the rule in Bouma's own data. We explore these questions by reanalyzing a variety of studies from the literature, running several new control experiments, and by utilizing a model that unifies flanked identification measurements between psychophysical paradigms. Specifically, with minimal assumptions (equivalent psychometric slopes across conditions, for example), crowded acuity can be predicted for arbitrary target sizes and flanker spacings, revealing a performance “landscape” that delineates the critical spacing. Last, we present a compact quantitative summary of the effects of different types of stimulus manipulations on optotype crowding.

Functional coupling between target selection and acquisition in the superior colliculus.

Survival in unpredictable environments requires that animals continuously evaluate their surroundings for behavioral targets, direct their movements toward those targets, and terminate movements once a target is reached. The ability to select, move toward, and acquire spatial targets depends on a network of brain regions, but it remains unknown how these goal-directed processes are linked by neural circuits. Within this network, common circuits in the midbrain superior colliculus (SC) mediate the selection and initiation of movements to spatial targets. However, SC activity often persists throughout movement, suggesting that the same SC circuits underlying target selection and movement initiation may also contribute to "target acquisition": stopping the movement at the selected target. Here, we examine the hypothesis that SC functional circuitry couples target selection and acquisition using a "default motor plan" generated by selection-related neuronal activity. Recordings from intermediate and deep layer SC neurons in mice performing a spatial choice task demonstrate that choice-predictive neurons, including optogenetically identified GABAergic neurons whose activity mediates target selection, exhibit increased activity during movement to the target. By recording from rostral and caudal SC in separate groups of mice, we also revealed higher activity in rostral than caudal neurons during target acquisition. Finally, we used an attractor model to examine how-invoking only SC circuitry-caudal SC activity related to selecting an eccentric target could generate higher rostral than caudal acquisition-related activity. Overall, our results suggest a functional coupling between SC circuits for target selection and acquisition, elucidating a key mechanism for goal-directed behavior.NEW & NOTEWORTHY How do neural circuits ensure that selected targets are successfully acquired? Here, we examine whether choice-related activity in the superior colliculus (SC) promotes a motor plan for target acquisition. By demonstrating that choice-predictive SC neurons-including GABAergic neurons-remain active throughout movement, while the activity of rostral SC neurons increases during acquisition, and by recapitulating these dynamics with an attractor model, our results support a role for SC circuits in coupling target selection and acquisition.

Errors in visuospatial working memory across space and time

Visuospatial working memory (VSWM) involves cortical regions along the dorsal visual pathway, which are topographically organized with respect to the visual space. However, it remains unclear how such functional organization may constrain VSWM behavior across space and time. Here, we systematically mapped VSWM performance across the 2-dimensional (2D) space in various retention intervals in human subjects using the memory-guided and visually guided saccade tasks in two experiments. Relative to visually guided saccades, memory-guided saccades showed significant increases in unsystematic errors, or response variability, with increasing target eccentricity (3°–13° of visual angle). Unsystematic errors also increased with increasing delay (1.5–3 s, Experiment 1; 0.5–5 s, Experiment 2), while there was little or no interaction between delay and eccentricity. Continuous bump attractor modeling suggested neurophysiological and functional organization factors in the increasing unsystematic errors in VSWM across space and time. These findings indicate that: (1) VSWM representation may be limited by the functional topology of the visual pathway for the 2D space; (2) Unsystematic errors may reflect accumulated noise from memory maintenance while systematic errors may originate from non-mnemonic processes such as noisy sensorimotor transformation; (3) There may be independent mechanisms supporting the spatial and temporal processing of VSWM.

Weber’s syndrome in an HIV positive patient: Revisiting the concentric and eccentric target signs – Question paper

Weber’s syndrome in an HIV positive patient: Revisiting the concentric and eccentric target signs – Question paper

Weber’s syndrome in an HIV positive patient: Revisiting the concentric and eccentric target signs – Answer paper

Weber’s syndrome in an HIV positive patient: Revisiting the concentric and eccentric target signs – Answer paper

Preserved eye movements in adults with spinal muscular atrophy.

Spinal muscular atrophy (SMA) most prominently affects proximal limb and bulbar muscles. Despite older case descriptions, ocular motor neuron palsies or other oculomotor abnormalities are not considered part of the phenotype. We investigated oculomotor function by testing saccadic eye movements of 15 patients with SMA. Their performance was compared with that of age-matched healthy controls. Horizontal rightward and leftward saccades were recorded by means of video-oculography, whereas subjects looked at light-emitting diode targets placed at ±5°, ±10°, and ±15° eccentricities. No differences in saccade amplitude gains, peak velocities, peak velocity-to-amplitude ratios, or durations were observed between controls and patients. More specifically, for 5° target eccentricities, patients had a mean saccadic peak velocity of 153°/s, whereas for 10° and 15° these values were 268°/s and 298°/s, respectively. The corresponding mean peak velocities of the control group were 151°/s, 264°/s, and 291°/s. Our results indicate that patients with SMA perform fast and accurate horizontal saccades without evidence of extraocular muscle weakness. These quantitative oculomotor data corroborate clinical experience that neuro-ophthalmic symptoms in SMA are not common and, if present, should prompt suspicion for an alternative neuromuscular disorder.

Reversals in Movement Direction in Locomotor Interception of Uniformly Moving Targets

Here we studied how participants steer to intercept uniformly moving targets in a virtual driving task. We tested the hypothesis that locomotor interception behavior cannot fully be explained by a strategy of nulling rate of change in pertinent agent-target relations such as the target-heading angle or target’s bearing angle. In line with a previously reported observation and model simulations, we found that, under specific combinations of initial target eccentricity and target motion direction, locomotor paths revealed reversals in movement direction. This phenomenon is not compatible with unique reliance on first-order (i.e., rate-of-change based) information in the case of uniformly moving targets. We also found that, as expected, such reversals in movement direction were not observed consistently over all trials of the same experimental condition: their presence depended on the timing of the first steering action effected by the participant, with only early steering actions leading to reversals in movement direction. These particular characteristics of the direction-reversal phenomenon demonstrated here for a locomotor interception-by-steering task correspond to those reported for lateral manual interception. Together, these findings suggest that control strategies operating in manual and locomotor interception may at least share certain characteristics.

Deciphering the saccade velocity profile of progressive supranuclear palsy: A sign of latent cerebellar/brainstem dysfunction?

ObjectiveTo study whether the velocity profile of horizontal saccades could be used as an indicator of brainstem and cerebellar output dysfunction, depending on progressive supranuclear palsy (PSP) subtype. MethodsWe compared the velocity profiles in 32 PSP patients of various subtypes with 38 age-matched normal subjects, including Richardson syndrome (RS), PSP-parkinsonism (PSPp), and pure akinesia (PAGF), and cerebellar subtypes of PSP (PSPc). ResultsPSP patients showed reduced peak velocity along with increased duration, especially in the deceleration phase. This alteration was more prominent for larger target eccentricities (20–30 degrees), and correlated with disease severity. The changes were most pronounced in PSPc patients, with irregular increases and decreases in velocity profile, followed by RS patients, whereas the change was smaller in PSPp and normal in PAGF patients. ConclusionsSaccade velocity profile can be an indicator of brainstem and/or cerebellar output. Altered velocity profile of PSP patients may reflect the pathology in the brainstem, but may also reflect cerebellar dysfunction, most prominently in PSPc. SignificanceSaccade velocity profile may be used as an indicator of latent cerebellar/brainstem dysfunction.