Target Carcinogenic Risk Research Articles

Concentrations, source apportionment and potential health risk of toxic metals in foodstuffs of Bangladesh

Toxic metal contamination in foodstuff is a major concern for public health and human beings are continuously exposed to toxic metals through consumption of cereals, pulses, vegetables, fruits, and other crops grown in the metals contaminated soil. The present study was conducted to investigate the concentrations of chromium (Cr), nickel (Ni), copper (Cu), arsenic (As), cadmium (Cd), and lead (Pb) in foodstuffs and their possible human health risks in Jhenaidah and Kushtia districts, Bangladesh. The range of Cr, Ni, Cu, As, Cd, and Pb in the studied foodstuffs were 1.57–12.52, 1.71–37.78, 1.97–16.67, 0.36–3.72, 0.00–4.02, and 1.04–10.88 mg/kg dw, respectively. Multivariate principal component analysis revealed significant anthropogenic contributions of Cr, Cu, As, and Pb in the studied foodstuffs. The estimated daily intake (EDI) values of all the metals except Cu were higher than the maximum tolerable daily intake (MTDI). The target hazard quotients (THQs) of the studied metals, excluding Cr, from all foodstuffs were higher than 1, indicating that if people consume these types of foods in their diet, they might pose risk to these metals. The estimated target carcinogenic risk of As was higher than USEPA standard (10−4), indicating increased risk of cancer for adults and children in the study area.

Concentrations, source apportionment and potential health risk of toxic metals in foodstuffs of Bangladesh

Toxic metal contamination in foodstuff is a major concern for public health and human beings are continuously exposed to toxic metals through consumption of cereals, pulses, vegetables, fruits, and other crops grown in the metals contaminated soil. The present study was conducted to investigate the concentrations of chromium (Cr), nickel (Ni), copper (Cu), arsenic (As), cadmium (Cd), and lead (Pb) in foodstuffs and their possible human health risks in Jhenaidah and Kushtia districts, Bangladesh. The range of Cr, Ni, Cu, As, Cd, and Pb in the studied foodstuffs were 1.57–12.52, 1.71–37.78, 1.97–16.67, 0.36–3.72, 0.00–4.02, and 1.04–10.88 mg/kg dw, respectively. Multivariate principal component analysis revealed significant anthropogenic contributions of Cr, Cu, As, and Pb in the studied foodstuffs. The estimated daily intake (EDI) values of all the metals except Cu were higher than the maximum tolerable daily intake (MTDI). The target hazard quotients (THQs) of the studied metals, excluding Cr, from all foodstuffs were higher than 1, indicating that if people consume these types of foods in their diet, they might pose risk to these metals. The estimated target carcinogenic risk of As was higher than USEPA standard (10−4), indicating increased risk of cancer for adults and children in the study area.

Assessment of Essential and Potentially Toxic Elements and Possible Health Risks in Hylocereus undatus and Punica granatum.

This study evaluates essential and toxic element contents in dragon (Hylocereus undatus (Haworth) Britton and Rose) and pomegranate (Punica granatum L.) and possible health risks through the consumption of these fruits. Total concentrations of 15 chemical elements (Al, Br, Ca, Cd, Cl, Cr, Cu, Fe, Hg, K, Mn, Na, Ni, Pb, and Zn) were determined by instrumental neutron activation analysis (INAA) and atomic absorption spectrometry (AAS) techniques. This study indicates that these fruits are a vital source of essential elements for human health. It is observed that Pb concentrations were higher in both fruits whereas Cd concentrations were slightly higher than WHO/FAO tolerable levels only in pomegranate. The estimated daily intake (EDI) of the chemical elements was within the maximum tolerable daily intake (MTDI) values. Furthermore, target hazard quotient (THQ) values were also within the safe level (THQ < 1). However, the calculated target carcinogenic risk (TCR) values of Cd for pomegranate and Cr for dragon fruit were higher than the maximum limit (1.0 × 10-4) for children. Finally, this study will create public awareness about micronutrient contents as well as metal contaminations of the studied fruits.

Presence of toxic metals in rice with human health hazards in Tangail district of Bangladesh

ABSTRACT Rice is the staple food of Bangladeshi people and is consumed at least twice a day. Thus, the presence of toxic metals in rice grains has become a major public health concern in Bangladesh. The present research was conducted to investigate the concentrations of toxic metals in rice grains and their possible human health risks in the Tangail district of Bangladesh. Toxic metals were measured by using an inductively coupled plasma mass spectrometer (ICP-MS), and the mean concentrations of toxic metals in rice samples were found in order of Cr > Pb > Ni > As > Cu > Cd. The concentrations of Cr, Pb, As, and Cd in the studied rice grain samples exceeded the FAO/WHO standard values for food samples by 100%, whereas the Ni concentrations by 10%. The principal component analysis (PCA) revealed significant anthropogenic contributions of Cr, Ni, As, and Pb concentrations in rice grains. The metal concentrations in rice grain samples showed strong significant correlations by forming primary clusters with each other. The estimated daily intake (EDI) values of Cr, Ni, As, Cd, and Pb from all samples were higher than the maximum tolerable daily intake (MTDI) allowed. The total targeted hazard quotient (TTHQ) values of Cu, Ni, As, Cd, and Pb also exceeded the threshold value of 1.00, indicating a potential non-carcinogenic risk. The estimated target carcinogenic risk of As was higher than the USEPA threshold level 10−4 (0.0001) indicating increased risk of cancer for adults and children in the study area.

Elemental Distribution and Health Risk Assessment of the Edible Fruits of Two Ficus Species, Ficus sycomorus L. and Ficus burtt-davyi Hutch.

Edible fruits of two indigenous medicinal Ficus species (Ficus sycomorus L. and Ficus burtt-davyi Hutch) collected from eight different sites in South Africa were assessed for nutritional value, elemental concentration, and the possible risk associated with their consumption. The metal concentrations in the fruits and growth soil were determined by inductively coupled plasma-optical emission spectrometry (ICP-OES). The results showed elemental concentrations in the fruits to contribute significantly to recommended dietary allowances and were found to be in decreasing order of Ca > Mg > Fe > Zn > Mn > Cu > Cr and Ca˃Mg˃Fe˃Mn˃Zn˃Cu for both F. sycomorus and F. burtt-davyi fruits. The results for proximate composition of F. sycomorus fruits were (in %) 55.8 for moisture, 25.3 for carbohydrates, 5.6 for protein, 8.9 for fats, 55.8 for crude fiber, and 4.4 for ash; for F. burtt-davyi fruits, it was (in %) 78.9 for carbohydrates, 5.0 for protein, 8.4 for lipids, 4.0 for crude fiber, and 3.7 for ash. The health risk assessment showed target hazard quotient, and hazard indices for all the studied heavy metals in the fruits for all the sites were to be less than one and the target carcinogenic risk values to be within the acceptable regulatory cancer risk range. This study confirms that the fruits of F. sycomorus and F. burtt-davyi are safe for human consumption due to low non-carcinogenic and carcinogenic adverse health effects.

Risk assessment of using fish from different types of reservoirs as human food – A study on European perch (Perca fluviatilis)

Concentrations of As, Cd, Cr, Cu, Hg, Pb, and Zn in sediment samples and muscle tissue of the European perch were analyzed using inductively-coupled plasma optical emission spectrometry (ICP-OES), with the aim to assess the potential ecological (RI) and human health risk, and the degree of contamination (Cd) of three types of reservoirs in Serbia, based on their purpose: electricity generation (Vlasina, Perućac, Zaovine, and Međuvršje), drinking water supply (Garaši), and recreation (Lake Sava). The concentrations of the studied elements were higher in sediments than in fish. However, the levels of Cd in fish caught in Vlasina, Zaovine, and Međuvršje, Hg in Perućac and Garaši, and Pb in Lake Sava exceeded the maximum allowed concentrations. The pollution load index (PLI) indicated that sediments in all six reservoirs were contaminated, but Cd was low; a moderate contamination with Cd was observed in Vlasina, Perućac, and Zaovine, Cr in Zaovine and Međuvršje, and Cu in Međuvršje. A low RI was recorded for all studied reservoirs. Cd was found to be the primary contamination and ecological risk factor. Total target hazard quotient (THQ) and target carcinogenic risk factor (TR) were higher for fishers operating in these reservoirs than for the general population. Higher values of PLI, Cd, RI, and TR were observed in electricity generation reservoirs. Results indicated that this type of reservoirs suffer from higher anthropogenic pressure and/or have a worse pollution management policy compared with other types of reservoirs included in this study, especially the drinking water supply reservoir.

Distribution, Contents, and Health Risk Assessment of Cadmium, Lead, and Nickel in Bananas Produced in Ecuador.

In this study, cadmium (Cd), nickel (Ni), and lead (Pb) contents were analyzed in sixteen banana composite samples from different commercial establishments from eleven Ecuadorian production provinces using graphite furnace atomic absorption spectrophotometry. The concentrations (fresh weight) in the samples collected (9.3–47.3 μg·kg−1 for Cd, 16.1–105.6 μg·kg−1 for Ni, and 36.9–538.0 μg·kg−1 for Pb) were used to calculate the estimated daily intake (EDI), target hazard quotient (THQ), and target carcinogenic risk (CR) associated with dietary exposure to these potentially toxic metals. Cd and Ni results showed that every sample had EDIs lower than the oral reference dose and THQ values lower than 1, demonstrating that there was no non-carcinogenic risk related to the exposure to Cd and Ni. In the case of Pb, two EDIs results were higher than the reference dose, also their corresponding THQ values were higher than 1. The lead CR in all samples was less than 1 × 10−4, the upper limit used for acceptable cancer risk. Thus, there is no significant health risk to the consumer associated with bananas with contamination levels of Cd, Ni, but there is Pb risk for toddlers (12 kg of body weight) intake comparable to the one detected in the present study.

Potential health risk of heavy metals via consumption of rice and vegetables grown in the industrial areas of Bangladesh

Heavy metals are toxic in nature, and their contamination in foodstuff is a matter of concern for human health. The present study was conducted to assess the concentrations of chromium, nickel, copper, arsenic, cadmium, and lead in rice and vegetables and their possible human health risks in Tangail district, Bangladesh. Metals were measured by inductively coupled plasma mass spectrometry (ICP-MS) after microwave digestion system. The average values of Cr, Ni, Cu, As, Cd, and Pb in rice and vegetables were 16.26, 16.11, 13.99, 2.28, 1.86, and 7.93 mg/kg, respectively. The average metal concentration in rice and vegetable species was in the decreasing order of okra > chili > bitter gourd > papaya > brinjal > bean > bottle gourd > rice > cucumber > sponge gourd > Indian spinach. The estimated daily intake (EDI) values of all the metals except Cu were higher than the maximum tolerable daily intake (MTDI). The target hazard quotients (THQs) values of Ni, Cu, As, Cd, and Pb exceeded the threshold value of 1 through consumption of rice and vegetables, indicating significant health risks to both adult and children. The target carcinogenic risk (TR) of As and Pb through consumption of rice and vegetables was higher than the USEPA threshold level (10−4). From the health point of view, this study clearly revealed that consumption of these contaminated rice and vegetables definitely poses carcinogenic and non-carcinogenic risks.

Concentrations and Health Risk Assessment of Trace Elements in Cereals, Fruits, and Vegetables of Bangladesh.

This study was conducted to determine concentrations of five toxic trace elements (Cr, Ni, As, Cd, and Pb) in cereals, fruits, and vegetables of Bangladesh. The range of mass fractions (mg/kg) of Cr, Ni, As, Cd, and Pb in the foodstuffs was 0.090-2.5, 0.03-2.6, 0.13-1.7, 0.010-0.74, and 0.37-2.2, respectively. This study indicates that concentration of Cr, and Pb in fruits; As, Cd, and Pb in vegetables were higher than WHO/FAO maximum allowable concentration levels. The hazard index (HI) values for adults and children of the toxic elements in studied cereals, fruits and vegetables were higher than 1.0, suggesting non-carcinogenic adverse health hazard to the consumers. The estimated target carcinogenic risk (TCR) values were greater than the threshold level of 1.0 × 10-4 for Cr and Cd in cereals and vegetables indicate potential cancer risk to both adults and children for consumption of the foodstuffs. The present study reveals that trace elements contamination in foodstuffs is a serious issue of concern in Bangladesh.

Characterization of chemical elements in common spices of Bangladesh for dietary intake and possible health risk assessment by INAA and AAS techniques

In this study, total concentrations of seventeen chemical elements (Al, As, Br, Ca, Cd, Cl, Co, Cr, Fe, K, Mn, Na, Ni, Pb, Sc, V and Zn) in Bangladeshi common spices were determined using instrumental neutron activation analysis and atomic absorption spectrometry techniques. This study indicates that spices are a good source of a combination of Ca, Fe, K, Mn, Na and Zn minerals. The concentrations of the elements As, Cd, Cr and Pb in some spices were higher than WHO and FAO permissible levels. However, health risks associated with these elements evaluated by dietary intake, target hazard quotient and target carcinogenic risk indices indicate that people would experience no potential risks due to consumption of the spices.

Spatio-temporal variations in physico-chemical parameters and potentially harmful elements (PHEs) of Uchalli Wetlands Complex (Ramsar site), Pakistan.

Uchalli Wetlands Complex (UWC) is located in District Khushab, Pakistan, which comprised of three lakes named Khabeki, Uchalli, and Jahlar. The UWC Pakistan is one of the Ramsar sites of international importance. However, the information regarding water quality parameters and concentration of potentially harmful elements (PHEs) is relatively short. Present study focused on spatio-temporal variations in the physico-chemical parameters and PHE (Cd, Pb, Ni, Cu, Zn, Cr, As, Mn) concentrations in water and fish samples using inductively coupled plasma. Sampling was done in summer (August 2016) and winter (January 2017) seasons. The overall concentrations of PHEs in water were in the following order: Mn > Zn > Cu > Cr > Ni > Cd > Pb > As for Khabeki; As >Ni > Cr > Mn > Zn > Cu > Cd > Pb for Uchalli; and Mn > Zn > Ni > Cu > As > Cr > Cd > Pb for Jahlar Lake. PHE concentration in fish followed the order Ni > Cd > Mn > Pb > Cu > Zn > Cr > As. PHEs analysis showed that Mn; Ni and As; and Ni and Mn in summer were above the Pakistan Environmental Quality Standards (PEQS) and World Health Organization (WHO) standards in Khabeki, Uchalli, and Jahlar Lakes respectively while in winter, Mn; Cd, Ni, and As; and Ni and Mn were higher than standard values in Khabeki, Uchalli, and Jahlar Lakes respectively. In fish samples, only Cd (0.0942) was higher in summer as compared to winter (0.0512) while other seven PHEs observed were higher in winter. Conclusively, the metal pollution index showed that water quality of UWC is not very fit for human consumption directly. The bioconcentration factor results indicated potential to accumulate PHEs, i.e., Cd (29.4375 and 9.4814), Pb (16.66 and 4.375), and Ni (4.9875 and 6.206), in fish during both sampling campaigns. Target hazard quotient (THQ), target carcinogenic risk (TR), hazard index (HI), estimated daily intake (EDI), and international safe standard limits of PHEs for fish species indicated that fish from UWC is safe for human consumption. Variations in physic-chemical parameters and PHE concentration were observed spatially and temporally that could be caused by precipitation amount or natural geochemistry of the lakes' crust. The water quality was not suitable for direct human consumption. Fish was only found in Khabeki Lake that had potential to accumulate Cd, Pb, and Ni more as compared to other studied PHEs.

Metals and arsenic in sediment and fish from Cau Hai lagoon in Vietnam: Ecological and human health risks

Concentrations of Al, As, Bi, Cd, Co, Cr, Cu, Fe, Mn, Mo, Ni, Pb, U, V and Zn were quantified in surface sediments collected from 13 different sampling sites from Cau Hai lagoon in Central Vietnam, and in 8 wild and farmed-fishes involving both pelagic and benthic species. Multivariate analysis shows that these trace elements are mainly associated with lithogenic matter, and are most likely the result of alteration and erosion processes in the lagoon. Enrichment factors and geo-accumulation indices reveal substantial sediment enrichments for both As and Bi with respect to the mean composition in the upper continental crust. As is enriched in the edible portion of fish tissue with values up to 10 times higher than the allowed limits set up by Health Canada. Target hazard quotient and target carcinogenic risk for As were assessed through fish diet and were greater than 1 and 10−4, respectively, indicating potential health risks for fish consumers in Cau Hai lagoon.

Assessment of toxic metals in vegetables with the health implications in Bangladesh

This study was conducted to investigate the levels of heavy metals in twelve species of vegetables and assessment of health risk. Samples were analyzed using inductively coupled plasma mass spectrometer (ICP-MS). The ranges of Cr, Ni, Cu, As, Cd and Pb in vegetables species were 0.37-5.4, 0.03-17, 0.35-45, 0.01-2.6, 0.001-2.2, and 0.04-8.8 [mg/kg, fresh weight (fw)], respectively. The concentrations of As, Cd and Pb in most vegetable species exceeded the maximum permissible levels, indicating unsafe for human consumption. Health risks associated with the intake of these metals were evaluated in terms of estimated daily intake (EDI), and carcinogenic and non-carcinogenic risks by target hazard quotient (THQ). Total THQ of the studied metals from most of the vegetables species were higher than 1, indicated that these types of vegetables might pose health risk due to metal exposure. The target carcinogenic risk (TR) for As ranged from 0.03 to 0.48 and 0.0004 to 0.025 for Pb which were higher than the USEPA acceptable risk limit (0.000001) indicating that the inhabitants consuming these vegetables are exposed to As and Pb with a lifetime cancer risk. The findings of this study reveal the health risks associated with the consumption of heavy metals through the intake of selected vegetables in adult population of Bangladesh.

Heavy Metal Contamination in Fish (Callinectis amnicola) From an Estuarine Creek in the Niger Delta, Nigeria and Health Risk Evaluation.

Heavy metal bioconcentration in crabs from an estuarine creek in the Niger Delta was examined using atomic absorption spectrophotometry. Health risk via human exposure to metal toxicity was evaluated. Mean metal levels (µg/g) were Cr 2.32 ± 0.71, Ni 2.76 ± 0.48, Cu 12.94 ± 3.53, Pb 5.67 ± 1.03, Ag 1.83 ± 0.71 and Cd 0.73 ± 0.14 with significant difference (p < 0.001) between periods. Ni, Pb and Cd had values above FAO/WHO recommended limits. Estimated daily intake values were below the reference oral doses and the target hazard quotient was <1 for each metal examined while hazard index for all metals was also <1. The target carcinogenic risk value for Ni was 3.4 × 10-3. Based on the evaluations, the study concluded that consumers of crabs from the study area had minimal/moderate metal toxicity exposures of no significant health concern but recommended continuous monitoring to detect anomalies.

Arsenic in the food chain and assessment of population health risks in Bangladesh

The most consumed food samples of cereals (rice, maize and wheat), vegetables (lentil, brinjal, carrot, bean, potato, tomato, onion and chili), fruits (banana, mango and jackfruit), fish (taki, rui, pangas and tilapia), egg (chicken and duck), milk (cow) and meat (chicken, duck, beef and mutton) were collected from some markets of Bogra district northern part of Bangladesh to evaluate the levels of arsenic (As) and associated health risk to the adult’s and child inhabitants. Arsenic is a highly toxic element, and its presence in food composites is a matter of concern to the world scientists. Target hazard quotients (THQs) and target carcinogenic risk were calculated to evaluate the non-carcinogenic and carcinogenic health risk from ingested arsenic. The highest and the lowest mean concentrations of arsenic were noted in the Tilapia fish [(0.94 mg/kg, wet weight (ww)] and beef (0.012 mg/kg, ww). The daily intakes of arsenic via foodstuffs were 1.92 and 3.30 µg/kg-bw/day for rural adults and children and 1.69 and 3.04 µg/kg-bw/day for urban adults and children, respectively. The result shows the highest THQs of arsenic in cereals and vegetables for both the rural and urban inhabitants which exceed the safe limit (>1) indicating that cereals and vegetables are the main food items contributing to the potential health risk. The estimated target cancer risks from ingesting dietary arsenic all exceeded 10−6, indicating increased risk of cancer for adults and children in the study area.

Heavy metals in sediment and their accumulation in commonly consumed fish species in Bangladesh

ABSTRACTSix heavy metals (chromium [Cr], nickel [Ni], copper [Cu], arsenic [As], cadmium [Cd], and lead [Pb]) were measured in sediments and soft tissues of eleven commonly consumed fish species collected from an urban river in the northern part of Bangladesh. The abundance of heavy metals in sediments varied in the decreasing order of Cr > Ni > Cu > Pb > As > Cd. The ranges of mean metal concentrations in fish species, in mg/kg wet weight (ww), were as follows: Cr, 0.11–0.46; Ni, 0.77–2.6; Cu, 0.57–2.1; As, 0.43–1.7; Cd, 0.020–0.23; and Pb, 0.15–1.1. Target hazard quotients (THQs) and target carcinogenic risk (TR) showed the intake of As and Pb through fish consumption were higher than the recommended values, indicating the consumption of these fish species is associated with noncarcinogenic and carcinogenic health risks.

Health risk assessment of trace elements via dietary intake of 'non-piscine protein source' foodstuffs (meat, milk and egg) in Bangladesh.

Concentrations of six trace elements [chromium (Cr), nickel (Ni), copper (Cu), cadmium (Cd), lead (Pb) and arsenic (As)] were assessed in 'non-piscine protein source' foodstuffs (meat, milk and eggs) to evaluate contamination level and human health risks in Bangladesh. The range of Cr, Ni, Cu, Cd, Pb and As in the investigated foodstuffs was 1.24-2.17, 1.29-2.56, 0.92-2.31, 0.12-0.44, 0.15-0.48 and 0.14-0.57mgkg fresh weight(-1), respectively. The estimated mean levels of most of the elements were higher than the maximum allowable concentration (MAC) for dietary foods. The estimated daily intakes (EDIs) of Cr and Cd were higher than the maximum tolerable daily intake (MTDI) for children, indicating that they are more susceptible to toxic elements through food consumption. The target hazard quotients (THQs) and target carcinogenic risk (TCR) of As (THQ > 1 and TCR > 10(-4)) for both the adults and children suggest that the consumers of non-piscine foodstuffs (especially cow milk and chicken meat) are exposed chronically to metal pollution with carcinogenic and non-carcinogenic health consequences.

The concentration, source and potential human health risk of heavy metals in the commonly consumed foods in Bangladesh

Seven food items, namely, meat, egg, fish, milk, vegetables, cereals and fruits were collected from Bogra district, Bangladesh to evaluate the levels of heavy metal and associated health risk to the adults and children. The samples were analyzed for the quantification of selected heavy metals (Cr, Ni, Cu, As, Cd and Pb) on inductively coupled plasma mass spectrometer followed by acid digestion. In general, the highest concentrations of the studied metals were detected in vegetables, cereals, and fruits. The range of Cr, Ni, Cu, As, Cd, and Pb in the foods were 0.058–10, 0.036–25, 0.045–40, 0.005–7.1, 0.001–5.5 and 0.005–13mg/kgfw, respectively. Multivariate principal component analysis (PCA) revealed three major groups of the studied metals and showed significant anthropogenic contributions of the Ni, Cu, and As in foods. Health risk assessment was evaluated in terms of target hazard quotient and target carcinogenic risk (TR) which showed that the intake of some metals through foods were higher than the recommended values, consequently consumption of the foods may be associated with non-carcinogenic health risks. Nonetheless, elevated levels of As and Pb were also found to be associated with lifetime carcinogenic risk to the consumers.

Apportionment of heavy metals in soil and vegetables and associated health risks assessment

This study assessed the concentrations of seven common heavy metals such as chromium (Cr), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), cadmium (Cd) and lead (Pb) in agricultural soils and mostly consumed vegetable species and their possible human health risk in Bogra District, northern Bangladesh. The range of mean concentrations were 20.47–59.09, 20.09–69.13, 20.50–74.99, 47.46–128.06, 5.04–23.14, 1.67–6.90 and 31.81–67.65 mg/kg for Cr, Ni, Cu, Zn, As, Cd and Pb, respectively. Accumulation factors (AFs) of heavy metals from soil to the vegetables exhibited highest values for Cu (0.56 ± 0.16), followed by Zn (0.39 ± 0.16). Multivariate principal component analysis showed significant anthropogenic contributions of Cr, Cu, As and Cd in soil and Cr, Ni, Cu and Pb in vegetables. Target hazard quotients (THQs) for individual metals (except As) were below 1, suggesting that people would not experience significant health hazards if they ingest a single metal from one species of vegetable. However, total metal THQ (1.530–5.575) signifies the potential non-carcinogenic health hazard to the highly-exposed consumers in Bangladesh. The target carcinogenic risk (TR) of As (0.275–1.108) and Pb (0.001–0.026) through consumption of vegetables were higher than the USEPA threshold level. From the health point of view, this study showed that the inhabitants who consume contaminated vegetables are exposed chronically to metal pollution with carcinogenic and non-carcinogenic risks.

Trace elements in two staple cereals (rice and wheat) and associated health risk implications in Bangladesh.

Concentrations of fourteen trace elements (Cd, As, Pb, Cr, Ni, Zn, Se, Cu, Mo, Mn, Sb, Ba, V and Ag) in the composite samples of most frequently consumed two staple foods, i.e. rice and wheat (collected from 30 different agroecological zones for the first time in Bangladesh) were measured by ICP-MS. The mean concentrations (mg/kg fresh weight) of Cd, As, Pb, Cr, Ni, Zn, Se, Cu, Mo, Mn, Sb, Ba, V and Ag were found as 0.088, 0.321, 0.713, 0.183, 0.213, 13.178, 0.0256, 1.985, 0.102, 4.654, 0.0033, 0.144, 0.081 and 0.007 and 0.011, 0.281, 0.221, 0.352, 0.145, 15.472, 0.245, 1.894, 0.209, 22.077, 0.0012, 3.712, 0.023 and 0.0013 in rice and wheat samples, respectively. Dietary risk of human health (non-carcinogenic and carcinogenic risks) was assessed by USEPA deterministic approaches. Total target hazard quotient (THQ) values for As and Pb were higher than 1, suggesting that people would experience significant health risks from consuming rice and wheat. However, the THQ of other metals were all less than 1. Also, the estimation showed that the target carcinogenic risk (TR) of As and Pb exceeded the accepted risk level of 1 × 10(-6). Moreover, concerning the nutritional requirements of essential elements for a sound health, the recommended doses for the daily intake of Mn was conveniently supplied by the studied cereals; however, Cr, Zn, Se, Cu and Mo were below the recommend daily allowances (RDAs). Thus, the carcinogenic and non-carcinogenic risk of As and Pb with lower supplementation of essential elements via staple foods for Bangladeshi people is a matter of concern.