This paper deals with the asynchronous distributed event-triggered control of continuous-time nonlinear interconnected systems. The nonlinear dynamics of the subsystems are represented by Takagi–Sugeno fuzzy models via the sector nonlinearity approach. Moreover, the nonlinear interconnections among the subsystems are assumed to be known and sector-bounded. In the event-triggered control setup, where the state information is asynchronously available to the local controllers only in specific time instants, it is necessary to deal with the asynchronous premise variables because they introduce extra difficulties to derive suitable co-design conditions. To deal with this issue, we propose a new triggering strategy such that the local event-triggering mechanisms (ETMs) counteract the effects of asynchronous premise variables. With this new distributed ETM, a co-design condition is proposed, and the existence of a strictly positive minimum inter-event time is proved to exclude Zeno behaviour. Moreover, a multi-objective optimization procedure is introduced to enlarge the estimate of the domain of attraction of the closed-loop equilibrium and minimize the number of transmissions provided by the ETMs. Finally, the approach is validated through the synchronization of interconnected oscillators.