Based on the Coulomb stress changes due to the 2013 Nantou, Taiwan, earthquake sequences, the locations of successive earthquake events could be estimated. Based on those results, we further investigated the potential earthquake hazards by simulating the strong motions around central Taiwan. The simulating process included three steps. To start, 30 source models on the fault generated by the k-square dislocation distribution concept were employed. Combining the source models with the strong motion generation technique, we derived the dense strong motions with 30 sets correspond to the source models. Finally, the spectral intensities and were computed using the simulated strong motions for evaluating the seismic damage to buildings with different numbers of floors. To validate the spectral intensities applied to the buildings, we simulated the strong motions of the 1999 Chi-Chi earthquake by using the proposed technique and found strong correlation between the spectral intensities and the damaged buildings. The average values of the 30 simulations were adopted as the spectral intensities distributed around central Taiwan. With this effective method, the seismic hazards from the potential earthquake in central Taiwan can be estimated and applied to improve future disaster prevention and management efforts.