Taishan Medical University Research Articles

Prevention of dementia using mobile phone applications (PRODEMOS): protocol for an international randomised controlled trial

IntroductionProfiles of high risk for future dementia are well understood and are likely to concern mostly those in low-income and middle-income countries and people at greater disadvantage in high-income countries....

Efficacy and safety of intrathecal meropenem and vancomycin in the treatment of postoperative intracranial infection in patients with severe traumatic brain injury.

This study investigated the improvement and safety of intrathecal meropenem and vancomycin in the treatment of postoperative intracranial infection in patients with severe traumatic brain injury (STBI). A retrospective analysis was performed on 86 patients with intracranial infections after cranial trauma operation in Tai'an Traditional Chinese Medicine Hospital and Affiliated Hospital of Taishan Medical University from May 2004 to June 2017. The patients were divided into the control group (43 patients) and the experimental group (43 patients) according to the treatment. Patients in the control group were intravenously infused with vancomycin hydrochloride (1.0 g, Q12H) and meropenem (2.0 g, Q8H). After lumbar cistern drainage was performed for the release of cerebrospinal fluid (CSF), patients in the experimental group were slowly given vancomycin 20 mg. After the tube was flushed with 2 ml of 0.9% sodium chloride injection, the patients were slowly given meropenem 20 mg, bid. The clinical efficacy, cure time and treatment cost of patients in the two groups were observed. The adverse reactions and sequelae after 6 months of treatment were recorded. The response rate (RR) of patients in the experimental group was significantly higher than that in the control group (P<0.05). The cure time of patients in the experimental group was significantly lower than that in the control group (P<0.05). The treatment cost of patients in the experimental group was significantly lower than that in the control group (P<0.05). The incidence of adverse reactions of patients, incidence of sequelae of patients in the experimental group was significantly lower than that in the control group (P<0.05). Intrathecal meropenem and vancomycin is more effective than intravenous administration in the treatment of intracranial infection after craniotomy. It can significantly shorten the treatment time and reduce the treatment cost, with better safety.

Soluble Myeloid Triggering Receptor Expressed on Myeloid Cell 1 Might Have More Diagnostic Value for Bacterial Ascites than C-reactive Protein.

The timely and accurate diagnosis of ascites is of great significance for early treatment and prognostication. This study explored the value of soluble myeloid triggering receptor expressed on myeloid cell 1 (sTREM-1) and C-reactive protein (CRP) for assessing ascites. A total of 133 patients with ascites who received treatment at the Affiliated Hospital of Taishan Medical University between September 2015 and September 2017 were retrospectively analyzed. The ascites in 22, 45, 33 and 33 patients were tuberculous, bacterial, tumorous, and transudative, respectively. Healthy volunteers (n=30) who received a health examination at the same hospital during the same period constituted the control group. Before treatment, both ascitic sTREM-1 and CRP showed significant differences among the ascites subgroups (P<0.001), with the highest levels in the bacterial subgroup. Serum sTREM-1 and CRP also showed significant differences among the groups. A correlation analysis showed a positive correlation between sTREM-1 and CRP. ROC curves of the bacterial subgroup showed that when the optimal cutoff point was set to 20.2, the sensitivity, specificity, positive predictive value, and negative predictive value of the serum sTREM-1 index were 0.933, 0.955, 0.914, and 0.965, respectively. sTREM-1 may provide more diagnostic value than CRP for the diagnosis of bacterial ascites.

Blended learning in medical physiology improves nursing students' study efficiency.

The rapid development of mobile phones and communication networks is profoundly changing the lives of people in China. With the gradual growth of Wi-Fi on college and university campuses, Chinese schools are setting off a wave of teaching reform combining online material with traditional classroom instruction. We adapted a Chinese University massive open online course physiology course into a private university online course, specifically designed for second-semester bachelor's level nursing students at Taishan Medical University. This online course blended with classroom teaching was offered to 108 freshmen from two parallel reform classes. A third class of 55 students was offered the traditional classroom lecture-based course as a control. Impressive teaching effects were achieved in reform classes, as indicated by significant improvement in student performance on the final examination and positive student feedback. The student surveys showed that 68% of students preferred the blended course over traditional classroom courses. The most highly rated advantages of the blended course were flexible learning time (84%) and improvement of independent study skills (75%). As higher education enters the internet era, exploiting the high-quality cyber resources may be the fastest and most economical way to improve teaching efficiency and enhance students' study experience.

Silencing miR-21 Induces Polarization of Astrocytes to the A2 Phenotype and Improves the Formation of Synapses by Targeting gpc6 via the STAT3 Pathway After Acute Ischemic Spinal Cord Injury

Background: Ischemic spinal cord injury (ISCI) results in the motor sensory dysfunction of the limbs below the injury site. In response to the injury, astrocytes develop into neuroprotective astrocytes (A2s) to mitigate the damage. Methods: We used the abdominal aortic occlusion model in vivo. Immunohistochemistry was used to detect the distribution of A2s in the spinal cord. We used an Oxygen Glucose Deprivation(OGD) method to model astrocytes ischemia in vitro, and tested proliferation, migration, and excitability of A2 astrocytes using an Edu, wound scratch assay, and a calcium-ion probe. After adjustment miR-21, we detected the model and target genes of A2s using polymerase chain reaction, Western blot, immunofluorescence, and chromatin immunoprecipitation. Findings: These results showed that miR-21 could regulate the conversion between A1s and A2s and that A2s mediated synapsis by targeting gpc6 and neurite growth by means of gdnf via the STAT3 pathway. Interpretation: miR-21 is a switch to regulate the polarization of reactive astrocyte, and promoted synapsis formation and nerites growth after acute ISCI. Funding Statement: Grant support was provided by the National Natural Science Funds of China (Nos. 81401014, 81771346), the Chinese Postdoctoral Science Foundation (No. 2014M561935), and the Chinese Postdoctoral Science Foundation (No. 2015T80725), Technology Research and Development Program of Jinan City(No. 201704133). Declaration of Interests: All authors: No reported conflicts. Ethics Approval Statement: All procedures were performed in accordance with the animal care standards of the Chinese National Institute of Health(CNIH) and regulations of the Taishan medical university Committee for the Care and Use of Laboratory Animals.

Suboptimal health status and psychological symptoms among Chinese college students: a perspective of predictive, preventive and personalised health.

Suboptimal health status (SHS) is an intermediate health status between health and illness, a syndrome characterised by the perception of health complaints, general weakness and low energy. This study aimed to investigate the prevalence of SHS and the correlation between SHS and psychological symptoms among Chinese college students and to identify the SHS-related risk factors from the perspective of predictive, preventive and personalised medicine (PPPM). A cross-sectional study was conducted among 4119 college students who were enrolled from Taishan Medical University and Baoji Vocational and Technical College in the eastern and western areas of China. SHS levels of the participants were measured by an established self-reporting Suboptimal Health Status Questionnaire-25 (SHSQ-25). Psychosomatic conditions were estimated by the self-rating Symptom Checklist-90 (SCL-90) scale. Spearman correlation analysis was applied to analyse the relationship between SHSQ-25 scores and SCL-90 estimates. Logistic regression analysis was applied for multivariate analysis. The prevalence of SHS was 21.0% (864/4119), with 23.3% (701/3005) for female students and 14.6% (163/1114) for male students. The prevalence of general positive psychological symptom was 14.2% (586/4119), with 15.6% (470/3005) for female students and 10.4% (116/1114) for male students. A strong correlation was identified between SHS score and SCL-90 estimates, with the correlation coefficient (r) of 0.719. Logistic regression showed that variables significantly associated with SHS were somatisation (adjusted odds ratio (aOR) = 3.185, 95% confidence interval [CI] = 2.048-4.953), obsessive-compulsive (aOR = 3.518, 95% CI = 2.834-4.368), interpersonal sensitivity (aOR = 1.883, 95% CI = 1.439-2.463) and depression (aOR = 1.847, 95% CI = 1.335-2.554). Our findings confirm that there is a high prevalence of SHS among college students and there is a strong association between SHS and psychological symptoms among Chinese college students. High susceptibility of SHS occurs particularly in vulnerable groups: female students, sophomore students, medical students and students from rural area. Identification of SHS and prompt application of personalised psychological health-supporting activities will promote college students' health status.

Approaches to enhance the teaching quality of experimental biochemistry for MBBS students in TSMU, China.

With the internationalization of medical education in China, the importance of international students' education in medical schools is also increasing. Except foreign students majoring in Chinese language, English Bachelor of Medicine, Bachelor of Surgery (MBSS) students are the largest group of international students. Based on problems in the teaching process for experimental biochemistry, we designed teaching models adapted to the background of international students and strengthened teachers' teaching ability at Taishan Medical University. Several approaches were used in combination to promote teaching effects and increase the benefit of teaching to teachers. The primary data showed an increased passion for basic medical biochemistry and an improved theoretical background for MBSS students, which will be helpful for their later clinical medicine studies. © 2017 by The International Union of Biochemistry and Molecular Biology, 45(4):360-364, 2017.

Investigation of outpatients with depression disorder in general hospital and related analysis of social support

Objective To investigate the prevalence of depression in outpatients, and discuss the relationship between the prevalence and social support in general hospitals. Methods 468 policlinic internal patients in Affiliated Hospital of Taishan Medical University were selected to perform the assessment on the depression disorder and social support by MINI-International Neuropsychiatric Interview (MINI)(Chinese version), and SPSS18.0 software system was used to process the data. Results The detection rate of depression disorder for policlinic internal patients was 25%(among them, 7.69% suffered from recurrent depressive disorder, 1.26% suffered from dysthymia). The scores of objective support(8.79±2.11), subjective support(21.41±5.22) and exploitability of support(6.54±1.88) for patients with depression were all significantly lower than the scores of patients without depression((11.19±2.55), (24.39±4.38), (7.63±2.07), P<0.01). Recurrent depressive disorder and dysthymia were negatively correlated with subjective support, objective support, and exploitability of support (P<0.05). The regression analysis showed that marriage and disease category and objective support were highly dangerous factors for outpatients with depression disorder. Conclusion The sickness rate of depression disorder among outpatients in general hospitals is high. The exploitability of support by patients with depression disorder is significantly lower than that of patients without depression disorder. Recurrent depressive disorder and dysthymia are negatively correlated with social support. Marriage, disease category and objective suppor are the major influencing factors. Key words: General hospital; Outpatient; Depression disorder; Social support

Correlation between meta cognitive ability and clinical practice ability of college nursing students

Objective To survey the status of the clinical competence and meta-cognitive ability of college nursing students, to explore the correlation between the two factors, and analyze the influencing factors of baccalaureate nursing students' clinical skills, then explore the approach of improving the clinical competence of nursing students. Methods Totally 184 nursing students from Taishan Medical University were investigated by General Information Questionnaire, Clinical Competence Test Scale, University Students Meta Cognitive Ability Scale. Results Nursing students' average score of meta cognition was 80.48±11.97, the average score of clinical competence was 121.22±22.74. The meta cognitive ability and clinical competence of nursing undergraduate students both maintained at the middle level. Meta cognitive ability was positively correlated with clinical competence. To some extent, enhancing the meta cognitive ability could help students improve the clinical competence. Conclusions To understand the status and correlation between meta cognitive ability and clinical competence can guide students to learn effectively, can help teachers play a good role in teaching effectively. Key words: Students, nursing; Clinical competence; Meta cognitive ability

Atherosclerosis is critical in the pathogenesis of erectile dysfunction

a Department of Cardiology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Shandong Province, Liaocheng 252000, PR China b Department of Echocardiography, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Shandong Province, Liaocheng 252000, PR China c Department of Andrology, Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng 252000, PR China

The influence of etiquette training on self efficacy and self confidence in nursing college students

Objective To explore the influence of etiquette training on self efficacy and self confidence in nursing freshmen. Methods 183 nursing freshmen were given 36 class hours of etiquette training from Nursing College of Taishan Medical University. They took general self-efficacy scale (GSES), academic self-efficacy scale (ASES) and self-esteem scale(SES) tests respectively before and after the training. Results Compared with before training((2.32±0.22), (58.34±5.68), respectively), the scores of general self-efficacy and academic self-efficacy ((2.48±0.24), (66.32±6.35), respectively) were significantly increased(P<0.01). The scores of self confidence increased significantly after etiquette training((27.45±2.32), (26.15±2.26), (P<0.01)). Conclusion The etiquette training can improve the self-efficacy and self confidence of nursing college freshmen. Key words: Etiquette training; Nursing college freshmen; Self efficacy; Self confidence

Changes of Plasma Tumor Necrosis Factor α and C-Reactive Protein Levels in Patients with Hypertension Accompanied by Impaired Glucose Tolerance and their Clinical Significance.

Chronic inflammation could affect the occurrence and development of malignant tumors. To explore the levels of tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) in patients accompanied by impaired glucose tolerance (IGT) and their clinical significance. A total of 210 patients hospitalized in Affiliated Hospital of Taishan Medical University from Jun., 2013 to Dec., 2014 were selected, in which 92 cases were accompanied by IGT. Meanwhile, 80 randomly-selected healthy people by physical examination were as the control. The levels of routine biochemical indexes, plasma TNF-α and CRP in all subjects were measured. Both systolic and diastolic pressures in hypertension group and hypertension plus IGT group were significantly higher than in control group (p<0.01), but there was no statistical significance between these two groups (p>0.05). The levels of fasting plasma glucose (FPG) and blood glucose 2 h after taking glucose in hypertension plus IGT group were markedly higher than other groups (p<0.01). Homeostasis model assessment-insulin resistance (HOMA-IR), TNF-α and CRP contents were on the progressive increase in control, hypertension and hypertension plus IGT groups, but significant differences were presented among each group (P<0.01). Hypertension accompanied by IGT had a significantly-positive association with CRP, TNF-α, FPG and blood glucose 2h after taking glucose. The levels of plasma TNF-α and CPR in patients with hypertension accompanied by IGT increase significantly, indicating that inflammatory reaction in these patient increases, thus suggesting that these patients should be focused regarding cancer prevention.

Strategies for Communicating Contraceptive Effectiveness

Public Health NursingVolume 31, Issue 5 p. 438-440 Review Summaries Strategies for Communicating Contraceptive Effectiveness Zhu Jianzhong B.Med., Zhu Jianzhong B.Med. Department of Medical Imaging, Affiliated Hospital of Taishan Medical University, TaiAn City, Shandong, ChinaAll are members of the Cochrane Nursing Care Field (CNCF).Search for more papers by this authorYan Ma B.N., Yan Ma B.N. School of Nursing, Taishan Medical University, TaiAn City, Shandong, ChinaSearch for more papers by this authorLiu Weihua M.Med., R.N., Corresponding Author Liu Weihua M.Med., R.N. School of Nursing, Taishan Medical University, TaiAn City, Shandong, China Correspondence to: Liu Weihua, RN School of Nursing, Taishan Medical University, 2 YingSheng East Rd, TaiAn City, Shandong 271000, China. E-mail: [email protected] This is a summary of a Cochrane Review: The full citation and the names of the researchers who conducted the Review are listed in the Reference section below.Search for more papers by this author Zhu Jianzhong B.Med., Zhu Jianzhong B.Med. Department of Medical Imaging, Affiliated Hospital of Taishan Medical University, TaiAn City, Shandong, ChinaAll are members of the Cochrane Nursing Care Field (CNCF).Search for more papers by this authorYan Ma B.N., Yan Ma B.N. School of Nursing, Taishan Medical University, TaiAn City, Shandong, ChinaSearch for more papers by this authorLiu Weihua M.Med., R.N., Corresponding Author Liu Weihua M.Med., R.N. School of Nursing, Taishan Medical University, TaiAn City, Shandong, China Correspondence to: Liu Weihua, RN School of Nursing, Taishan Medical University, 2 YingSheng East Rd, TaiAn City, Shandong 271000, China. E-mail: [email protected] This is a summary of a Cochrane Review: The full citation and the names of the researchers who conducted the Review are listed in the Reference section below.Search for more papers by this author First published: 10 March 2014 https://doi.org/10.1111/phn.12101Citations: 1 Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume31, Issue5September/October 2014Pages 438-440 RelatedInformation

Human umbilical cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide intoxication

Human umbilical cord blood mononuclear cell transplantation for delayed encephalopathy after carbon monoxide intoxication Dianrong Gong,1 Haiyan Yu,1 Weihua Wang,2 Haixin Yang,1 Fabin Han1,21Department of Neurology, 2Centre for Stem Cells and Regenerative Medicine, Liaocheng People&#39;s Hospital, The Affiliated Liaocheng Hospital, Taishan Medical University, Shandong, People&#39;s Republic of ChinaAbstract: Stem cell transplantation is one of the potential treatments for neurological disorders. Since human umbilical cord stem cells have been shown to provide neuroprotection and promote neural regeneration, we have attempted to transplant the human umbilical cord blood mononuclear cells (hUCB-MNCs) to treat patients with delayed encephalopathy after carbon monoxide intoxication (DEACOI). The hUCB-MNCs were isolated from fresh umbilical cord blood and were given to patients subarachnoidally. Physical examinations, mini-mental state examination scores, and computed tomography scans were used to evaluate the improvement of symptoms, signs, and pathological changes of the patient&#39;s brain before and after hUCB-MNC transplantation. A total of 12 patients with DEACOI were treated with hUCB-MNCs in this study. We found that most of the patients have shown significant improvements in movement, behavior, and cognitive function, and improved brain images in 1&ndash;4 months from the first transplantation of hUCB-MNCs. None of these patients have been observed to have any severe adverse effects. Our study suggests that the hUCB-MNC transplantation may be a safe and effective treatment for DEACOI. Further studies and clinical trials with more cases, using more systematic scoring methods, are needed to evaluate brain structural and functional improvements in patients with DEACOI after hUCB-MNC therapy.Keywords: human umbilical cord blood mononuclear cells, transplantation, delayed encephalopathy after carbon monoxide intoxication, MMSE

Mild Hypothermia Therapy Reduces Blood Glucose and Lactate and Improves Neurologic Outcomes in Patients With Severe Traumatic Brain Injury

*Department of Neurosurgery, Liaocheng People’s Hospital and Liaocheng Clinical School of Taishan Medical University, Shandong Province, People’s Republic of China; and †School of Biomedical Sciences, Charles Sturt University, Wagga Wagga, Australia.

Development and optimization of solid lipid nanoparticle formulation for ophthalmic delivery of chloramphenicol using a Box-Behnken design

The purpose of the present study was to optimize a solid lipid nanoparticle (SLN) of chloramphenicol by investigating the relationship between design factors and experimental data using response surface methodology. A Box-Behnken design was constructed using solid lipid (X1), surfactant (X2), and drug/lipid ratio (X3) level as independent factors. SLN was successfully prepared by a modified method of melt-emulsion ultrasonication and low temperature-solidification technique using glyceryl monostearate as the solid lipid, and poloxamer 188 as the surfactant. The dependent variables were entrapment efficiency (EE), drug loading (DL), and turbidity. Properties of SLN such as the morphology, particle size, zeta potential, EE, DL, and drug release behavior were investigated, respectively. As a result, the nanoparticle designed showed nearly spherical particles with a mean particle size of 248 nm. The polydispersity index of particle size was 0.277 ± 0.058 and zeta potential was −8.74 mV. The EE (%) and DL (%) could reach up to 83.29% ± 1.23% and 10.11% ± 2.02%, respectively. In vitro release studies showed a burst release at the initial stage followed by a prolonged release of chloramphenicol from SLN up to 48 hours. The release kinetics of the optimized formulation best fitted the Peppas–Korsmeyer model. These results indicated that the chloramphenicol-loaded SLN could potentially be exploited as a delivery system with improved drug entrapment efficiency and controlled drug release.