Abstract
Chronic inflammation could affect the occurrence and development of malignant tumors. To explore the levels of tumor necrosis factor α (TNF-α) and C-reactive protein (CRP) in patients accompanied by impaired glucose tolerance (IGT) and their clinical significance. A total of 210 patients hospitalized in Affiliated Hospital of Taishan Medical University from Jun., 2013 to Dec., 2014 were selected, in which 92 cases were accompanied by IGT. Meanwhile, 80 randomly-selected healthy people by physical examination were as the control. The levels of routine biochemical indexes, plasma TNF-α and CRP in all subjects were measured. Both systolic and diastolic pressures in hypertension group and hypertension plus IGT group were significantly higher than in control group (p<0.01), but there was no statistical significance between these two groups (p>0.05). The levels of fasting plasma glucose (FPG) and blood glucose 2 h after taking glucose in hypertension plus IGT group were markedly higher than other groups (p<0.01). Homeostasis model assessment-insulin resistance (HOMA-IR), TNF-α and CRP contents were on the progressive increase in control, hypertension and hypertension plus IGT groups, but significant differences were presented among each group (P<0.01). Hypertension accompanied by IGT had a significantly-positive association with CRP, TNF-α, FPG and blood glucose 2h after taking glucose. The levels of plasma TNF-α and CPR in patients with hypertension accompanied by IGT increase significantly, indicating that inflammatory reaction in these patient increases, thus suggesting that these patients should be focused regarding cancer prevention.
Highlights
It is widely known that tumor necrosis factor-α (TNF-α) is important in promoting tumor growth and in the progression of cancers (Charles et al, 2009; Dobrzycka et al, 2009), due to the fact that tumor necrosis factor α (TNF-α) could stimulate cell growth and contribute to metastasis
The levels of fasting plasma glucose (FPG) and blood glucose 2 h after taking glucose in hypertension plus impaired glucose tolerance (IGT) group were markedly higher than other groups (p
Homeostasis model assessment-insulin resistance (HOMA-IR), TNF-α and C-reactive protein (CRP) contents were on the progressive increase in control, hypertension and hypertension plus IGT groups, but significant differences were presented among each group (P
Summary
It is widely known that tumor necrosis factor-α (TNF-α) is important in promoting tumor growth and in the progression of cancers (Charles et al, 2009; Dobrzycka et al, 2009), due to the fact that TNF-α could stimulate cell growth and contribute to metastasis. IR is a phenomenon that hepatocytes, adipocytes and muscular cells trigger an insufficient response to the insulin with normal concentration and an important reason for diabetes mellitus It plays a certain role in the formation of hypertension (Akande et al, 2013). The changes of CRP and TNF-α levels in patients with hypertension accompanied by IGT and their independent risk factors were analyzed to further explore the action of inflammation in occurrence, development and prognosis of hypertension accompanied by IGT and illustrate whether there was mutual promotion between hypertension accompanied by IGT and inflammatory cytokines
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