S-30C8-6 Background/Aims: Metabolic syndrome (MS) has been found to be related to chronic kidney disease (CKD) in normal population. MS was also found to be correlated to dioxin levels in an area of Tainan, Taiwan where residents were exposed to dioxin released from a factory from 1965 to 1979. As CKD was prevalent in this endemic area of dioxin exposure, we conducted a study to assess the association between MS and CKD and its related factors among the residents. Methods: We recruited residents with high levels of dioxin, defined as >64 pg WHO98-TEQDF/g lipid and performed health examination between 1 October 2008 and 31 December 2009. CKD was defined as an estimated glomerular filtration rate <60 mL/min/1.73 m2. MS was defined as meeting 3 of the following criteria: fasting glucose 126 mg/dL, waist circumference >90 cm in men and >80 cm in women, triglycerides >150 mg/dL, HDL <40 mg/dL in men and<50 mg/dL in women, and blood pressures 130/85 mm Hg. The results were compared to a group of residents whose blood dioxin levels were below 64 pg WHO98-TEQDF/g lipid. Results: Of the 2933 participants in this study, 319 had high exposure levels. We observed positive associations between CKD and dioxin exposure, gender, insulin, uric acid, and MS (all with P < 0.01). After adjusting for other factors, we found high dioxin exposure (adjusted odds ratio [AOR] = 2.28, 95% confidence interval [CI]: 1.50–3.46), female gender (AOR = 1.95, 95% CI: 1.36–2.79), high insulin (AOR = 1.74, 95% CI: 1.04–2.79), high uric acid (AOR = 3.41, 95% CI: 2.36–4.95), and MS (AOR = 2.99, 95% CI: 2.12–4.21) were independent predictors of CKD. Conclusion: CKD is correlated with high dioxin levels in southern Taiwan. It is also related to the gender, insulin, uric acid, and MS.