Abstract We previously showed that recent latently tuberculosis infected individuals could be identified by their antibody response against rHspx, an antigen related to latent/early tuberculosis. Here, using different tests we tried to identify latency among individuals with Rheumatoid Arthritis (RA). Twenty-two RA patients were classified by tuberculin skin test (TST) and tested using IgM ELISA to rHspx, specific rHspx TCD4+IFNγ+ quantified by flow cytometry(FC) and Elispot TB (TSPOT.TB). A cut off was established for each test and those who had a positive response were considered possible latently infected individuals. Sixteen healthy controls (HC) were also classified and tested. TST, here considered as a golden standard test for latency, identified 18% of the RA individuals latently infected, while specific TCD4+IFNγ+ recognized 72,7%, ELISA 63,6% and Elispot 27,2%. These results show incongruent identification of TB latency by several tests among RA patients. When combining two tests, the identification of latent tuberculosis among RA individuals changed: FC/ELISA identified 50%, FC/Elispot 18%, ELISA/Elispot 13,6%. The last two associations work the same way as TST. However, FC and ELISA were better than TST in identifying latently infected among RA patients. These results suggest that it may be useful an association of tests (FC and ELISA) to discriminate latently infected individuals among RA patients from an endemic area.