Medical Diagnosis System Research Articles

Robustness in deep learning models for medical diagnostics: security and adversarial challenges towards robust AI applications

The current study investigates the robustness of deep learning models for accurate medical diagnosis systems with a specific focus on their ability to maintain performance in the presence of adversarial or noisy inputs. We examine factors that may influence model reliability, including model complexity, training data quality, and hyperparameters; we also examine security concerns related to adversarial attacks that aim to deceive models along with privacy attacks that seek to extract sensitive information. Researchers have discussed various defenses to these attacks to enhance model robustness, such as adversarial training and input preprocessing, along with mechanisms like data augmentation and uncertainty estimation. Tools and packages that extend the reliability features of deep learning frameworks such as TensorFlow and PyTorch are also being explored and evaluated. Existing evaluation metrics for robustness are additionally being discussed and evaluated. This paper concludes by discussing limitations in the existing literature and possible future research directions to continue enhancing the status of this research topic, particularly in the medical domain, with the aim of ensuring that AI systems are trustworthy, reliable, and stable.

Survey on Adversarial Attack and Defense for Medical Image Analysis: Methods and Challenges

Deep learning techniques have achieved superior performance in computer-aided medical image analysis, yet they are still vulnerable to imperceptible adversarial attacks, resulting in potential misdiagnosis in clinical practice. Oppositely, recent years have also witnessed remarkable progress in defense against these tailored adversarial examples in deep medical diagnosis systems. In this exposition, we present a comprehensive survey on recent advances in adversarial attacks and defenses for medical image analysis with a systematic taxonomy in terms of the application scenario. We also provide a unified framework for different types of adversarial attack and defense methods in the context of medical image analysis. For a fair comparison, we establish a new benchmark for adversarially robust medical diagnosis models obtained by adversarial training under various scenarios. To the best of our knowledge, this is the first survey paper that provides a thorough evaluation of adversarially robust medical diagnosis models. By analyzing qualitative and quantitative results, we conclude this survey with a detailed discussion of current challenges for adversarial attack and defense in medical image analysis systems to shed light on future research directions. Code is available on GitHub.

Multi-resolution visual Mamba with multi-directional selective mechanism for retinal disease detection.

Retinal diseases significantly impact patients' quality of life and increase social medical costs. Optical coherence tomography (OCT) offers high-resolution imaging for precise detection and monitoring of these conditions. While deep learning techniques have been employed to extract features from OCT images for classification, convolutional neural networks (CNNs) often fail to capture global context due to their focus on local receptive fields. Transformer-based methods, on the other hand, suffer from quadratic complexity when handling long-range dependencies. To overcome these limitations, we introduce the Multi-Resolution Visual Mamba (MRVM) model, which addresses long-range dependencies with linear computational complexity for OCT image classification. The MRVM model initially employs convolution to extract local features and subsequently utilizes the retinal Mamba to capture global dependencies. By integrating multi-scale global features, the MRVM enhances classification accuracy and overall performance. Additionally, the multi-directional selection mechanism (MSM) within the retinal Mamba improves feature extraction by concentrating on various directions, thereby better capturing complex, orientation-specific retinal patterns. Experimental results demonstrate that the MRVM model excels in differentiating retinal images with various lesions, achieving superior detection accuracy compared to traditional methods, with overall accuracies of 98.98\% and 96.21\% on two public datasets, respectively. This approach offers a novel perspective for accurately identifying retinal diseases and could contribute to the development of more robust artificial intelligence algorithms and recognition systems for medical image-assisted diagnosis.

An Ensemble Learning Algorithm with Hyperparameter Optimization (ELAHO) Model for Early Detection of Maternal Health Risk (MHR) Level Using Machine Learning

Despite the advancement in the healthcare system, maternal health risk remains high, which is the most challenging aspect nowadays. There is a need to develop an effective model for early detection, monitoring, and prediction of maternal health risk levels during pregnancy. The machine learning intelligence model has proven its effectiveness and robustness in providing accurate and reliable prediction, analysis, and interpretation of medical data, reducing several risk factors for early diagnosis in healthcare. In this research work, we proposed an ensemble learning algorithm with a hyperparameter optimization (ELAHO) model using machine learning algorithms to improve its robustness, effectiveness, and model performance. The proposed method uses a hybrid model of logistic regression and support vector machines (LG-SVM) to predict maternal health risk levels during pregnancy. The method utilized Python software for training, testing, and validation. We evaluated the performance of our proposed model using accuracy, precision, sensitivity, f1-score, and ROC-AUC score. The proposed models outperformed the conventional models and achieved 100% predictive accuracy. The proposed approach has the potential to be adapted as an intelligence-monitoring system for early medical diagnosis during pregnancy. The proposed techniques will help medical professionals make quick decisions accurately and enhance monitoring to improve the level of care offered to pregnant mothers and their unborn children.

A privacy-preserving expert system for collaborative medical diagnosis across multiple institutions using federated learning

Expert system recommendation assists the healthcare system to develop in real-time monitoring and diagnosis of patient conditions over several healthcare institutions. Privacy concerns, however, present significant problems since patient data leaks can lead to big effects including financial losses for hospitals and invasions of personal privacy for people. To address these issues, the research introduces a privacy-preserving collaborative medical diagnosis (CMD) method on a federated learning (FL). FL maintains patient privacy and data localization by spreading only model parameters, therefore enabling training models on remote datasets. The combination of Partially Homomorphic Cryptosystem (PHC) and Residual Learning based Deep Belief Network (RDBN) ensures an accurate and safe classification of patient physiological data. Experimental results show that the proposed method is successful in maintaining the diagnostic accuracy over numerous healthcare institutions and protecting privacy. The results show that the RDBN and PHC computations requires around 1000 ms and 150 ms, respectively for classification and privacy; the data transmission from the user to server and from server to user is 5 MB and 4 MB, respectively. Finally with a 30% reduction in overhead, the proposed approach offers an average increase in classification accuracy of 10% over multiple datasets.

A novel CLIPS-based medical expert system for migraine diagnosis and treatment recommendation

Migraines are classified as a neurological disorder defined by recurrent headaches with pain that ranges from mild to severe. Currently, this disorder lacks a permanent cure and definitive diagnostic test. Diagnosis instead requires an assessment of physical and psychological symptoms which differ among patients. To help in the diagnosis process, medical expert systems have been developed and validated since 1960. In this paper, we propose the Migraine Diagnosis and Treatment Expert System (MDATES), a medical expert system for migraine diagnosis and treatment recommendation. The system was designed and implemented using the C Language Integrated Production System (CLIPS) shell. MDATES is able to recognize seven symptoms, two classes of migraines (chronic and episodic), and four subtypes of migraine-classification knowledge (hormonal, aura, hemiplegic, and cluster). A dataset of 300 anonymized patient records with confirmed migraine cases was used to test the system. The diagnoses generated by MDATES were compared against the known diagnoses, and a high level of accuracy was observed, with 67% of the 100 training cases were correctly diagnosed, and 100% of the 200 testing cases were correctly diagnosed. These results highlight the effectiveness and reliability of MDATES and provide valuable assistance to medical professionals in diagnosing migraines. Moreover, we present a literature review that places our proposed system within the broader context of rule-based expert systems for migraine diagnosis and treatment recommendation. This review explores the effectiveness, limitations, and challenges of these systems, and accurately places our system within the current landscape.

Medical image intelligent diagnosis system based on facial emotion recognition and convolutional neural network

The facial emotional information of patients is one of the important indicators of their health status. By combining facial emotion recognition technology, medical imaging intelligent diagnostic systems can more comprehensively understand the psychological and physiological status of patients. This study first selected medical imaging datasets from the publicly available Medical Machine Learning Image Standard database and performed necessary preprocessing, including data cleaning, enhancement, and standardization. Next, a CNN model is constructed to extract key features from medical images and facial expression images through structures such as convolutional layers, activation functions, pooling layers, and fully connected layers. In addition, the system also integrates facial emotion recognition module and medical image analysis module, improving the comprehensiveness of diagnosis through feature fusion. Finally, the diagnostic results are displayed through a user interaction interface. Through comparative experiments, this study verified that the proposed CNN model outperforms traditional LSTM and SVM models in terms of accuracy, recall, and precision. The CNN model has shown significant advantages in medical imaging intelligent diagnosis systems, especially achieving a recall rate of 99%, demonstrating extremely high disease recognition ability. The results of this study not only provide new research directions for the field of intelligent diagnosis in medical imaging, but also lay a solid foundation for future clinical applications.

Medical image intelligent diagnosis system based on facial emotion recognition and convolutional neural network

The facial emotional information of patients is one of the important indicators of their health status. By combining facial emotion recognition technology, medical imaging intelligent diagnostic systems can more comprehensively understand the psychological and physiological status of patients. This study first selected medical imaging datasets from the publicly available Medical Machine Learning Image Standard database and performed necessary preprocessing, including data cleaning, enhancement, and standardization. Next, a CNN model is constructed to extract key features from medical images and facial expression images through structures such as convolutional layers, activation functions, pooling layers, and fully connected layers. In addition, the system also integrates facial emotion recognition module and medical image analysis module, improving the comprehensiveness of diagnosis through feature fusion. Finally, the diagnostic results are displayed through a user interaction interface. Through comparative experiments, this study verified that the proposed CNN model outperforms traditional LSTM and SVM models in terms of accuracy, recall, and precision. The CNN model has shown significant advantages in medical imaging intelligent diagnosis systems, especially achieving a recall rate of 99%, demonstrating extremely high disease recognition ability. The results of this study not only provide new research directions for the field of intelligent diagnosis in medical imaging, but also lay a solid foundation for future clinical applications.

M-XAF: Medical explainable diagnosis system of atrial fibrillation based on medical knowledge and semantic representation fusion

BackgroundElectrocardiogram (ECG) is a critical diagnostic tool used for screening atrial fibrillation (AF). In recent years, several deep learning-based ECG automatic diagnosis methods have been proposed and have yielded satisfactory results. However, the lack of interpretability in these systems limits their clinical usage. MethodsTo address this issue, we propose a medical explainable AF diagnosis system (M-XAF) that not only predicts AF diagnostic results but also generates an analysis report of the ECG medical features that influenced the classification model's decision. Using a novel ECG signal features occlusion analysis method, M-XAF establishes a connection between the medical knowledge space and the representation space from the convolutional neural network (CNN) by extracting understandable semantic sensitive channels (SSCs) via gradient-weighted channel sensitivity. Through the visualization and statistical modeling of SSCs, M-XAF provides multimodal explanations, including ECG feature descriptions, regions of interest (ROI), and class activation mapping (CAM), for AF diagnostic results. ConclusionThe experimental results demonstrate that the M-XAF has achieved satisfactory results in the AF identification task, with accuracy, specificity, PPV, F1, and MCC reaching over 0.9715, 0.9896, 0.9778, 0.9567, and 0.9365 on two public ECG datasets. In addition, M-XAF generates quantitative explainable reports and CAM for each predicted sample from the perspective of classification models. Furthermore, the explainable reports provided by M-XAF can address the high-confidence problem in classification models. Ultimately, the explainable framework in M-XAF can be widely applied in AI-ECG classification scenarios.

Integrated Dataset-Preparation System for ML-Based Medical Image Diagnosis with High Clinical Applicability in Various Modalities and Diagnoses

This study proposed an integrated dataset-preparation system for ML-based medical image diagnosis, offering high clinical applicability in various modalities and diagnostic purposes. With the proliferation of ML-based computer-aided diagnosis using medical images, massive datasets should be prepared. Lacking of a standard procedure, dataset-preparation may become ineffective. Besides, on-demand procedures are locked to a single image-modality and purpose. For these reasons, we introduced a dataset-preparation system applicable for a variety of modalities and purposes. The system consisted of a common part including incremental anonymization and cross annotation for preparing anonymized unprocessed data, followed by modality/subject-dependent parts for subsequent processes. The incremental anonymization was carried out in batch after the image acquisition. Cross annotation enabled collaborative medical specialists to co-generate annotation objects. For quick observation of dataset, thumbnail images were created. With anonymized images, preprocessing was accomplished by complementing manual operations with automatic operations. Finally, feature extraction was automatically performed to obtain data representation. Experimental results on two demonstrative systems dedicated to esthetic outcome evaluation of breast reconstruction surgery from 3D breast images and tumor detection from breast MRI images were provided. The proposed system successfully prepared the 3D breast-mesh closures and their geometric features from 3D breast images, as well as radiomics and likelihood features from breast MRI images. The system also enabled effective voxel-by-voxel prediction of tumor region from breast MRI images using random-forest and k-nearest-neighbors algorithms. The results confirmed the efficiency of the system in preparing dataset with high clinical applicability regardless of the image modality and diagnostic purpose.

Machine Learning and Natural Language Processing Algorithms in the Remote Mobile Medical Diagnosis System of Internet Hospitals

In order to alleviate the contradiction between supply and demand of professional pharmacists, integrate medical resources, and ensure the safety of patients’ medication, the telemedicine diagnosis system has played a great role. Today, in this “Internet +” era, all walks of life have begun to integrate with Internet technology. The purpose of this article was to discuss the practical utility of machine learning and natural language processing algorithms in the remote mobile medical diagnosis system of Internet hospitals, for which this article conducted in-depth discussion. This article first introduced the basic concepts, development, and characteristics of machine learning and natural language processing algorithms in detail, and carefully studied and analyzed the development and culture of traditional offline medical diagnosis models. Based on machine learning and natural language processing algorithms, a remote mobile medical diagnosis is designed. By combining with the medical diagnosis system of traditional hospitals, a new type of remote mobile medical diagnosis system for Internet hospitals was designed and developed, and the combination of traditional medical industry and Internet technology was deeply studied. According to each functional requirement, the image module, heart rate measurement module, and user setting module are designed, respectively. Compared to traditional medical diagnosis systems, the accuracy of the remote mobile medical diagnosis system based on machine learning applied in Internet hospital diagnosis in this article reached 80% or even higher. At the same time, it was found through experiments that when the evolution number was 3, the maximum fit value and average fit value were the same, both of which were 0.6. This indicates that the system can accommodate more than 10,000 people at the same time, and patients can receive good treatment plans, with a very broad application prospect

Automated feature selection using improved migrating birds optimization for enhanced medical diagnosis

The feature selection task is a crucial phase in data analysis, aiming to identify a minimized set of relevant features for the target class, thereby eliminating irrelevant and redundant attributes used for model training. While population-based feature selection approaches offer prominent solutions for classification performance, their computational time can be prohibitive. To mitigate delays and optimize resource utilization, this study adopts machine learning operations (MLOps). MLOps involves the seamless transition of experimental Machine Learning models into production, serving them to end users and automating the feature selection phase. This paper introduces a novel feature selection method based on improved migrating bird optimization and its automated variant integrated into MLOps. Experiments conducted on six medical datasets validate the effectiveness of our proposed feature selection method in improving the outcomes of medical diagnosis systems. The results showcase satisfactory performance in terms of classification compared to concurrent feature selection algorithms.

Improved Kepler Optimization Algorithm for enhanced feature selection in liver disease classification

Liver diseases represent a significant healthcare challenge, impacting millions globally and posing complexities in diagnosis. To address this global health concern, this paper introduces a groundbreaking enhancement to the Kepler Optimization Algorithm, termed I-KOA, designed specifically for feature selection in high-dimensional datasets. By harnessing the synergies of Opposition-Based Learning and a Local Escaping Operator grounded in the k-nearest Neighbor (kNN) classifier, I-KOA asserts itself as a potent tool for local exploitation, balanced exploration, and evasion of local optima. To our knowledge, this is the first work to exploit KOA as a feature selection method. Pioneering the utilization of KOA as a feature selection method, the paper rigorously tests I-KOA in two extensive experiments, tackling the complex CEC’22 benchmark suite functions and the intricate landscape of five liver disease datasets. Results underscore I-KOA’s unparalleled performance, validated through the Friedman test, where it surpasses seven rival optimization algorithms. Achieving an outstanding overall classification accuracy of 93.46%, Feature selection size of 0.1042, sensitivity of 97.46%, precision of 94.37%, and F1-score of 90.35% across the liver disease datasets, I-KOA’s randomized algorithm ensures robust feature selection, striking a compelling balance between subset size and classification efficacy. Acknowledging computational demands and generalization nuances, I-KOA is a formidable tool ready to revolutionize medical diagnosis and decision support systems. The open source codes of the proposed I-KOA are available at https://www.mathworks.com/matlabcentral/fileexchange/161376-improved-kepler-optimization-algorithm.

A Hybrid Intelligent System Framework for the Prediction of Heart Disease Using Machine Learning

In today’s modern world cardiovascular disease is the most lethal one. This disease attacks a person instantly that might create unexpected consequences for the human life. So diagnosing patients correctly on time is the most challenging task for the medical fraternity. The heart disease treatment is quite high and not affordable by most of the patients particularly in India. The research scope is to develop an early prediction treatment using data mining technologies. Now a day every hospital keeps the periodical medical reports of cardiovascular patients through some hospital management system to manage their healthcare. The data mining techniques namely decision tree and random forest are used to analyze heart attack dataset where classification of more common symptoms related to heart attack is done using c4.5 decision tree algorithm, alongside, random forest is applied to improve the accuracy of the classification result of heart attack prediction. In this system various data mining technologies are applied to make a proactive approach against failures in early predictions diagnosis of the disease. We proposed an automated system for medical diagnosis that would enhance medical care and reduce cost. Our aim is to provide a ubiquitous service that is both feasible, sustainable and which also make people to assess their risk for heart attack at that point of time or later. Keywords: Heart attack prediction, ML, Random Forest, Decision Tree, Java, servlet, etc.

Synergizing Deep Learning-Enabled Preprocessing and Human-AI Integration for Efficient Automatic Ground Truth Generation.

The progress of incorporating deep learning in the field of medical image interpretation has been greatly hindered due to the tremendous cost and time associated with generating ground truth for supervised machine learning, alongside concerns about the inconsistent quality of images acquired. Active learning offers a potential solution to these problems of expanding dataset ground truth by algorithmically choosing the most informative samples for ground truth labeling. Still, this effort incurs the costs of human labeling, which needs minimization. Furthermore, automatic labeling approaches employing active learning often exhibit overfitting tendencies while selecting samples closely aligned with the training set distribution and excluding out-of-distribution samples, which could potentially improve the model's effectiveness. We propose that the majority of out-of-distribution instances can be attributed to inconsistent cross images. Since the FDA approved the first whole-slide image system for medical diagnosis in 2017, whole-slide images have provided enriched critical information to advance the field of automated histopathology. Here, we exemplify the benefits of a novel deep learning strategy that utilizes high-resolution whole-slide microscopic images. We quantitatively assess and visually highlight the inconsistencies within the whole-slide image dataset employed in this study. Accordingly, we introduce a deep learning-based preprocessing algorithm designed to normalize unknown samples to the training set distribution, effectively mitigating the overfitting issue. Consequently, our approach significantly increases the amount of automatic region-of-interest ground truth labeling on high-resolution whole-slide images using active deep learning. We accept 92% of the automatic labels generated for our unlabeled data cohort, expanding the labeled dataset by 845%. Additionally, we demonstrate expert time savings of 96% relative to manual expert ground-truth labeling.

Importance of Patient History in Artificial Intelligence-Assisted Medical Diagnosis: Comparison Study.

Medical history contributes approximately 80% to a diagnosis, although physical examinations and laboratory investigations increase a physician's confidence in the medical diagnosis. The concept of artificial intelligence (AI) was first proposed more than 70 years ago. Recently, its role in various fields of medicine has grown remarkably. However, no studies have evaluated the importance of patient history in AI-assisted medical diagnosis. This study explored the contribution of patient history to AI-assisted medical diagnoses and assessed the accuracy of ChatGPT in reaching a clinical diagnosis based on the medical history provided. Using clinical vignettes of 30 cases identified in The BMJ, we evaluated the accuracy of diagnoses generated by ChatGPT. We compared the diagnoses made by ChatGPT based solely on medical history with the correct diagnoses. We also compared the diagnoses made by ChatGPT after incorporating additional physical examination findings and laboratory data alongside history with the correct diagnoses. ChatGPT accurately diagnosed 76.6% (23/30) of the cases with only the medical history, consistent with previous research targeting physicians. We also found that this rate was 93.3% (28/30) when additional information was included. Although adding additional information improves diagnostic accuracy, patient history remains a significant factor in AI-assisted medical diagnosis. Thus, when using AI in medical diagnosis, it is crucial to include pertinent and correct patient histories for an accurate diagnosis. Our findings emphasize the continued significance of patient history in clinical diagnoses in this age and highlight the need for its integration into AI-assisted medical diagnosis systems.

Research Paper on Diseases Prediction Using Machine Learning

There may be drawbacks to using traditional methods for both diagnosis and treatment, especially in the case of serious disorders. Consequently, it's critical to have accurate and analysis of health issues in a timely manner for efficient treatment and prevention. When developing a medical diagnosis system, machine learning (ML) algorithms can be a useful tool as they can yield more accurate disease predictions than traditional approaches. Our team has effectively created a disease prediction system by utilizing multiple machine learning techniques, such as Decision trees, Naive Bayes, and KNN. We have established a framework that facilitates the creation and utilization of prediction models through the implementation of a rule-based methodology. Because of the system's exceptional accuracy, doctors are better equipped to predict and diagnose illnesses early on and resolve health-related issues more skill fully. Index Terms: Prediction, Symptoms of Disease, Machine Learning, Classification

Learning Evaluation Method Based on Artificial Intelligence Technology and Its Application in Education

Artificial intelligence (AI) is a transformative technology that enables machines to perform tasks that typically require human intelligence. Through algorithms and advanced computing systems, AI enables machines to perceive their environment, reason, learn from experience, and make decisions autonomously. From virtual assistants like Siri and Alexa to self-driving cars and advanced medical diagnosis systems, AI applications are reshaping industries and revolutionizing the way we live and work. With its ability to process vast amounts of data and identify complex patterns, AI has the potential to drive innovation, improve efficiency, and solve some of society's most pressing challenges. This paper introduces a novel learning evaluation method based on artificial intelligence technology, specifically leveraging Mamdani Fuzzy Clustering Middle Order Classification (MFCM-OC), and explores its application in education. The proposed method aims to provide a comprehensive assessment of student learning outcomes by analyzing various factors such as academic performance, engagement, and cognitive development. Through simulated experiments and empirical validations, the efficacy of the MFCM-OC-enhanced learning evaluation method is evaluated. Results demonstrate significant improvements in accuracy and granularity compared to traditional evaluation methods. For instance, the MFCM-OC model achieved an average accuracy rate of 85% in predicting student performance, allowing for targeted interventions and personalized learning plans. Additionally, the method enables educators to identify students' strengths and weaknesses more effectively, facilitating data-driven decision-making and continuous improvement in educational practices. These findings underscore the potential of artificial intelligence with MFCM-OC in revolutionizing learning evaluation and enhancing educational outcomes.

Speckle noise reduction on aligned consecutive ultrasound frames via deep neural network

Despite the benefits of ultrasound (US) imaging systems for medical diagnosis and treatment, US images are prone to low resolution and contrast due to US’s inherent attributes, as well as affected by speckle noise that directly influences their quality. In retrospective studies, diverse filters have been applied to minimize the effects of speckle noise and enhance the quality of US images. In this article, we propose a method of enhancing US images inspired by synthetic aperture imaging, which provides high-resolution images by adding low-resolution images and measuring the probe’s movement. Our proposed method does not involve synthetic aperture imaging but compensates for the motion effect in the temporal dimension, aligns consecutive images, and stacks aligned images to suppress speckle noise and consequently enhance the resolution of US images. We exploited deep neural network (DNN) models to estimate motion parameters between consecutive US images. In a new database of US images, we also collected the images’ position-related information implicitly measured in inertial measurement units, which was exploited as a ground truth for motion parameters between consecutive images. Compared with other image-enhancing techniques involving conventional filters and DNN modalities, our method demonstrated superiority in enhancing the quality of US images. We also found that estimating motion parameters directly influenced the success of the image-stacking process. As in ablation studies in DNNs, we additionally investigated the effect of dropping some images in the temporal dimension, which revealed that contextual differences and excessive rates of movement in successive US images weakens the image-stacking process and thus the potential enhancement of US images.

Extensive Review of Literature on Explainable AI (XAI) in Healthcare Applications

Abstract: Artificial Intelligence (AI) techniques are widely being used in the medical fields or various applications including diagnosis of diseases, prediction and classification of diseases, drug discovery, etc. However, these AI techniques are lacking in the transparency of the predictions or decisions made due to their black box-type operations. The explainable AI (XAI) addresses such issues faced by AI to make better interpretations or decisions by physicians. This article explores XAI techniques in the field of healthcare applications, including the Internet of Medical Things (IoMT). XAI aims to provide transparency, accountability, and traceability in AI-based systems in healthcare applications. It can help in interpreting the predictions or decisions made in medical diagnosis systems, medical decision support systems, smart wearable healthcare devices, etc. Nowadays, XAI methods have been utilized in numerous medical applications over the Internet of Things (IOT), such as medical diagnosis, prognosis, and explanations of the AI models, and hence, XAI in the context of IoMT and healthcare has the potential to enhance the reliability and trustworthiness of AI systems.