Systemic Concept Research Articles

Towards a Systemic Concept of the Brain Ishemia Stroke: Monte Carlo Driven in silico Model.

The work proposes a new mathematical model of dynamic processes of a typical spatially heterogeneous biological system, and sets and solves a mathematical problem of modeling the dynamics of the system of neurovascular units of the brain in conditions of ischemic stroke. There is a description of only a small number of mathematical models of stroke in the literature. This model is being studied and a numerical and software implementation of the corresponding mathematical problem is proposed. This work is the first attempt ever aiming to employ a Monte Carlo computational approach for In Silico simulation of the most critical parameters in molecular and cellular pathogenesis of the brain ischemic stroke. In this work, a new mathematical model of the development of ischemic stroke is proposed in the form of a discrete model based on neurovascular units (NVU) as elements. As a result of testing the program with the assignment of empirically selected coefficients, data were obtained on the evolution of the states of the lattice of the cellular automaton of the model for the spread of stroke in a region of the brain tissue. A resulting new theoretical model of the particular pathologically altered biosystem might be taken as a promising tool for further studies in neurology; general pathology and cell biology. For the first time, a mathematical model has been constructed that allows us to represent the spatial dynamics of the development of the affected area in ischemic stroke of the brain, taking into account neurovascular units as single morphofunctional structures.

German expert consensus on programmed cell death ligand1 (PD-L1) testing in perioperative systemic therapy of muscle invasive bladder cancer

The risk of recurrence in patients with muscle invasive bladder cancer (MIBC) after radical cystectomy depends on the pathological tumor stage. In particular, patients with lymph node metastasis (pN+), locally advanced (≥pT3), or residual muscle invasive tumor despite neoadjuvant chemotherapy are at high risk. Currently, the importance of adjuvant therapy with immune checkpoint inhibitors is increasing in the context of perioperative systemic therapeutic concepts. The indication for the PD‑1 inhibitor nivolumab currently approved in the European Union requires testing of PD-L1 (programmed cell death ligand1) protein expression by immunochemistry in tumor tissue. Focusing on MIBC patients at high risk of recurrence, new questions arise regarding the implementation and interpretation of PD-L1 testing. An interdisciplinary group of experts from Germany has discussed relevant issues from aclinicopathological point of view and developed practical recommendations to facilitate the implementation of validated and quality-assured PD-L1 testing for the approved indications in daily clinical practice.

E-Government, Proposal of Indicators for Tax Culture with Digital Transformation Support in The Canton of Jipijapa-Ecuador

Technological advancement offers a plethora of benefits, including the potential for novel forms of government management. In recent years, electronic governments have become increasingly relevant due to the numerous advantages they offer, including the convenience of making tax payments and carrying out tax procedures, as well as the opportunities they provide for citizens to actively engage in the decision-making process of a government. Nevertheless, these services are not universally accessible for a number of reasons. The objective of this research is to propose a set of indicators that can contribute to fostering a culture of tax compliance in Canton Jipijapa, Ecuador, through the implementation of an e-government strategy. A procedure that is close to a systemic conception will be applied. To this end, a systemic mapping will be carried out, allowing the proposal of a group of candidate indicators based on the study of the literature. Subsequently, the aforementioned indicators are evaluated by experts within the Ecuadorian context, employing the 2-tuple linguistic model as a methodological approach. The ensuing results facilitate the formulation of actions that foster the tax culture of individuals in Jipijapa Canton, Ecuador, in addition to conducting information surveys that align with the proposed indicators.

THE CONCEPTS OF TEACHING, UPBRINGING, EDUCATION AND THE QUESTION OF THEIR CORRELATION

The concepts of education, teaching and upbringing, as well as the question of their correlation are relevant for modern philosophical research. One of the terminological problems is the use of the word «education» as a synonym for «upbringing» or a synonym for «teaching». The purpose is to provide a logical systematization of the main variants of the definition of the concept of education in its relation to the concepts of teaching and upbringing. The authors identify three main characteristic variants of the correlation between the concepts of education, teaching and upbringing. The first option is a one-component scheme, for which the concepts of teaching, upbringing and education are identical. Education is teaching or upbringing. This scheme is quite common at the everyday and theoretical levels. The authors analyze the historical origins of such identifications. Firstly, it is the New European rationalist interpretation of human nature, which considers the formation of man as a primarily intelligent and knowledgeable being. Secondly, it is the Soviet heritage, which viewed education as a systemic pedagogical concept. The equation of education, teaching, and upbringing also has an etymological basis, as it is similar to the multivalent Greek term paideia and the Latin word discipline. The second option is a two-component scheme. In this scheme, education is a broader concept that includes teaching and upbringing without leveling or identifying them. Teaching reflects the meanings of education in the professional and intellectual sphere, and upbringing in the worldview and moral sphere. The third option is a three-component scheme that includes training, education and development as components of education. This scheme, although interesting, is still in the process of its terminological formation.

Safeguarding, uncertainty and new possibilities: an appreciative inquiry into personal adviser’s relational practice with care leavers

Purpose An appreciative inquiry process was collaboratively undertaken with an inner city local authority and personal advisors where systemic social work practice was embedded. The purpose of this study is to explore how systemic social work principles could be integrated into the support of young adults leaving the care system, especially when safeguarding concerns exist. Design/methodology/approach Three fortnightly, reflecting team-style, appreciative inquiry workshops explored the integration into practice of systemic concepts under the themes of safeguarding, uncertainty and new possibilities. Findings Within the contexts of the organisation, other agencies and the relationship, six paired themes emerged: learning and navigating; positioning and risk-taking; and feeling and engaging. Core systemic concepts, such as self-reflexivity and mutual influence, can enable personal advisers to use themselves and their relationship with care leavers as a context for change. Considering responses to risk from different family member positions may support holding greater levels of uncertainty. Seeing resilience as a process rather than a personal attribute enabled personal advisors to think about how they connected with care leavers through shared life experiences, fostering narratives of hopes and dreams where new possibilities abound. Research limitations/implications Appreciative inquiry is generally seen as a defined model for implementing large organisational changes; this study comprised a small sample group, and the model’s application was less defined. Originality/value A gap exists in the extensive care leaver research, addressing safeguarding and working systemically. A conceptual model for practice is offered, with potential utility in developing further systemically informed training and supervision for practitioners. A less structured and more relationally engaged model for appreciative inquiry is presented.

Different facets of addiction from a systemic perspective: a case report

IntroductionMany individuals who suffer from one or multiple substance use disorders often also struggle with another co-morbid psychiatric condition, primarily anxiety disorders. As substance dependency develops, the loss of self-control becomes a pivotal issue, leading to challenges in self-esteem and self-respect. These challenges subsequently give rise to problems in interpersonal communication and close relationships. In addition to the biological model of substance use problems and highly manualized approaches, it is crucial to have a systemic understanding of the patient’s situation and appropriate treatment settings. This understanding allows for the proper consideration of individual differences and requirements, ultimately enabling better treatment and prevention strategies.ObjectivesOur aim is to present a comprehensive case that shows various facets of addiction and introduce a systemic therapy concept of an integrative/systemic day clinic from Germany.MethodsThrough a detailed case presentation, we will introduce a systemic-psychotherapeutic day-clinic concept from a psychiatric training hospital in Wunstorf, Germany.ResultsCase: In the case of a 48-year-old female patient initially diagnosed with recurrent depressive disorder, it was later revealed that she also deals with alcohol addiction and its interconnectedness with sex addiction. Shame and a lack of self-esteem in relationships played a central role in her journey. She does not perceive herself to be loved but to be harmed, which led to many violent sexual acts that increased her feelings of shame. Systemic therapeutic approaches like family constellations were applied, helping her to experience her child-ego states. This profound insight propelled her willingness to change. She began prioritizing self-care, learning to like, accept, and eventually love herself. Aromatherapy aided in calming and maintaining focus. The patient learned to redefine her emotions, aligning them with reality, thereby enabling the adaptive fulfillment of her needs.Conclusions Our interdisciplinary team at the day clinic employs therapeutic approaches like dynamic, cognitive-behavioral, and systemic therapy to thoroughly understand the patients and their conditions. This case underscores the significance of an individually tailored treatment drawing from diverse therapeutic concepts, especially in patients with addiction. The combination of different therapeutic approaches facilitates a profound engagement with the patient, potentially resulting in more intensive therapeutic work and a higher rate of success which should be evaluated in future studies.Disclosure of InterestNone Declared

Looking for a systemic concept and physiological diagnosis of a plant stress state

Looking for a systemic concept and physiological diagnosis of a plant stress state

Intrapreneurial ecosystems in academia and their overlooked outputs: Graduate employability and wellbeing

The aim of this paper is dual: a) to elaborate a systemic concept of intrapreneurship in academia which will be reflective of complexities and idiosyncrasies of the University as a multi-mission multi-function organisation; and b) to empirically test this concept in the context of relatively neglected outputs of academic intrapreneurship such as graduate employability and graduate wellbeing. Guided by an intrapreneurial ecosystem framework, our analysis is based on a combination of administrative and survey panel data for 141 UK higher education institutions. We arrive at several contributing findings. These suggest that the intrapreneurial ecosystem within academia is increasingly predisposed towards enhancing the quality of graduate outcomes rather than simply promoting raw measures such as graduate jobs or the number of graduate start-ups. Furthermore, we reveal the critical role of University national stakeholder networks for graduate career satisfaction, start-up generation, and undergraduate employment. Finally, our empirical exercise and its results demonstrate the practical value of the proposed concept of the intrapreneurial ecosystem for University management and practitioners, not least because it systematically identifies areas for an immediate, medium- and long-term action.

INFLUÊNCIAS DE CONCEPÇÕES PARADIGMÁTICAS DA CIÊNCIA EM TEXTOS DE LICENCIANDOS DE CIÊNCIAS BIOLÓGICAS SOBRE ECOLOGIA

ABSTRACT: This article analyzed texts by undergraduates in Biological Sciences on the ecological theme, having as reference the paradigmatic conceptions of contemporary science: complexity, systemic and Cartesian. The research context was the Ecology Practice that is a curricular component of an undergraduate course in Biological Sciences at a public university in the Brazilian Northeast. The investigation employed a qualitative and quantitative approach with the objective of identifying the influence of paradigmatic conceptions of science in the construction of meanings of ecological themes by the undergraduate students participating in the research. The methodology combined the development of conceptual schemes and Statistical Implicit Analysis (SIA), which allowed viewing the implications of complexity and depth of the relationships established between conceptual variables present in the texts. The results indicated that different ecological themes suffer different paradigmatic influences. Systemic and complex conceptions were present in themes with conservationism and environmental impact, while consumerism was linked to the Cartesian paradigm. The research also corroborated the adequacy of mixed research approaches for the science teaching area.

Perioperative and palliative systemic treatments for biliary tract cancer.

Due to the fact biliary tract cancer (BTC) is often diagnosed at an advanced stage, thus, not eligible for resection, and due to the aggressive tumor biology, it is considered as one of the cancer types with the worst prognosis. Advances in diagnosis, surgical techniques, and molecular characterization have led to an improvement of the prognosis of BTC patients, recently. Although neoadjuvant therapy is expected to improve surgical outcomes by reducing tumor size, its routine is not well established. The application of neoadjuvant therapy in locally advanced disease may be indicated, the routine use of systemic therapy prior to surgery for cholangiocarcinoma patients with an upfront resectable disease is less well established, but discussed and performed in selected cases. In advanced disease, only combination chemotherapy regimens have been demonstrated to achieve disease control in untreated patients. Molecular profiling of the tumor has demonstrated that many BTC might bear actionable targets, which might be addressed by biological treatments, thus improving the prognosis of the patients. Furthermore, the addition of the immunotherapy to standard chemotherapy might improve the prognosis in a subset of patients. This review seeks to give a comprehensive overview about the role of neoadjuvant as well as palliative systemic treatment approaches and an outlook about novel systemic treatment concept in BTC.

INTELLIGENCE AND PSYCHOLOGICAL KNOWLEDGE IN POST-NON-CLASSICAL SCIENTIFIC RATIONALITY (REVIEW AND ANALYTICAL NOTES)

Relevance. Intelligence as a complex phenomenon and the mental property of a person is studied in various interpretations, in the social and humanitarian discourse. The works of philosophers, political scientists, sociologists, cult urologists, psychologists, teachers and representatives of other sciences are devoted to the issues of the essence, structure, functional and activity characteristics of intelligence. The interdict capillarity and systemic complexity of the phenomenon of intelligence raises the question of the relationship and conjugation of this concept with the current level of development of psychological knowledge within the framework of modern scientific rationality. The disclosure of the psychological properties of intelligence makes it possible to objectively cognize its social and subjective nature.
 Materials and methods. The correlation and integration of knowledge about intelligence as a subjective quality and the quality of a person is manifested in the conjugation of modern psychological scientific rationality. The study of psychological knowledge about intelligence is carried out through the consistent and complex application of axiological, activity, systemic, subjective approaches and modern concepts in the philosophy of science. To consider and build an objective picture of psychological knowledge about intelligence in modern scientific rationality, a systematic and analytical method, synthetic and analog studies, a deductive method and a method of conceptualization, abstraction and generalization are applied.
 Results. Knowledge of the psychological characteristics and features of the functioning of intelligence as a dynamic, emotional, intellectual and value phenomenon from the standpoint of post-non-classical scientific rationality allows us to consider it as a complex self-developing system inherent in a certain social subject and being a product of the development of culture.
 Discussions and Conclusions. The modern development of psychological knowledge indicates that today psychology considers various phenomena and complex psychosocial systems. As for the phenomenon of intelligence, its characteristics, from the standpoint of post-non-classical scientific rationality, are intellectuality, dynamism, communicativeness, subjectivity, activity and value-semantic properties and qualities that interact and are realized in a complex social environment, functioning in their systemic totality.

IDEOLOGI DAN DOKTRIN MUHAMMADIYAH

Ideology is a set of systemic concepts from the way of thinking of a person or group of people as understanding, theories and ways to achieve goals. Muhammadiyah as a social organization also has an ideology as an organizational identity. The purpose of this article is to explain Muhammadiyah ideology and doctrine and found results namely: 1) Muqaddimah of the Articles of Association, namely the Muqaddimah Concept of the Articles of Association of Muhammadiyah (MADM) and the essence of MADM, the Muqaddimah of the articles of association of Muhammadiyah has 7 main ideas, the framework of the nature of the Muhammadiyah struggle and the definition of the muqaddimah of the ideology of Muhammadiyah. 2) Matan, Beliefs and Life Aspirations of Muhammadiyah, contains the concept and explanation of Matan, Beliefs and Life Aspirations of Muhammadiyah. 3) Muhammadiyah's personality contains 10 points.

Epistemology of synthetic biology: a new theoretical framework based on its potential objects and objectives.

Synthetic biology is a new research field which attempts to understand, modify, and create new biological entities by adopting a modular and systemic conception of the living organisms. The development of synthetic biology has generated a pluralism of different approaches, bringing together a set of heterogeneous practices and conceptualizations from various disciplines, which can lead to confusion within the synthetic biology community as well as with other biological disciplines. I present in this manuscript an epistemological analysis of synthetic biology in order to better define this new discipline in terms of objects of study and specific objectives. First, I present and analyze the principal research projects developed at the foundation of synthetic biology, in order to establish an overview of the practices in this new emerging discipline. Then, I analyze an important scientometric study on synthetic biology to complete this overview. Afterwards, considering this analysis, I suggest a three-level classification of the object of study for synthetic biology (which are different kinds of living entities that can be built in the laboratory), based on three successive criteria: structural hierarchy, structural origin, functional origin. Finally, I propose three successively linked objectives in which synthetic biology can contribute (where the achievement of one objective led to the development of the other): interdisciplinarity collaboration (between natural, artificial, and theoretical sciences), knowledge of natural living entities (past, present, future, and alternative), pragmatic definition of the concept of "living" (that can be used by biologists in different contexts). Considering this new theoretical framework, based on its potential objects and objectives, I take the position that synthetic biology has not only the potential to develop its own new approach (which includes methods, objects, and objectives), distinct from other subdisciplines in biology, but also the ability to develop new knowledge on living entities.

New Perspectives in Innovation Failure Analysis: A taxonomy of general errors and strategic management for reducing risks

In turbulent environments, one of the fundamental problems is the high risk of failure in new innovation projects that affects organizational behaviour and performance of firms and also nations. The study here clarifies the theoretical structure of project-level failure proposing a new definition, based on systems approach (Innovation failure is when organization does not achieve the main goal of project because of a set of errors), and a taxonomy of three general types of error in innovation failures: errors in planning and/or design, in project execution/implementation and in marketization. A case study research clarifies the proposed framework of innovation failures with examples from pharmaceutical sector, aerospace and aircraft industries, and information & communication technology sector. Results suggest that the failure in innovation projects is due to proposed errors associated mainly with bounded rationality of organizations in dealing with goal difficulty, environmental complexity and uncertainty. Different strategies of problem solving to reduce errors and risks leading to innovation failures and improve technological development are proposed, such as learning processes, adaptation perspective, game theory approach, stage-gate method, etc. The proposed systemic concept of innovation failure and related taxonomy of general typologies of error can guide R&D managers, designers, analysts, and policymakers etc. to know main determinants of failure in innovation projects and how appropriate strategies can improve organizational performance and R&D processes of firms for competitive advantage in markets and society.

Decision making for transformative change: exploring model use, structural uncertainty and deep leverage points for change in decision making under deep uncertainty

Moving to a low carbon society requires pro-active decisions to transform social and physical systems and their supporting infrastructure. However, the inherent complexity of these systems leads to uncertainty in their responses to interventions, and their critical societal role means that stakes are high. Techniques for decision making under deep uncertainty (DMDU) have recently begun to be applied in the context of transformation to a low carbon society. Applying DMDU to support transformation necessitates careful attention to uncertainty in system relationships (structural uncertainty), and to actions targeting deep leverage points to transform system relationships. This paper presents outcomes of a structured literature review of 44 case studies in which DMDU is applied to infrastructure decisions. Around half of these studies are found to neglect structural uncertainty entirely, and no study explicitly considers alternative system conceptions. Three quarters of studies consider actions targeting only parameters, a shallow leverage point for system transformation. Where actions targeting deeper leverage points are included, models of system relationships are unable to represent the transformative change these interventions could effect. The lack of attention to structural uncertainty in these studies could lead to misleading results in complex and poorly understood systems. The lack of interventions targeting deep leverage points could lead to neglect of some of the most effective routes to achieving transformative change. This review recommends greater attention to deeper leverage points and structural uncertainty in applications of DMDU targeting transformative change.

The influence of the Milan approach—Part 2. The legacy of Boscolo and Cecchin and their Paduan connection: A conversation with Andrea Mosconi

AbstractThe Milan approach, pioneered by Selvini‐Palazzoli, Boscolo, Cecchin, and Prata, has significantly contributed to the field of psychotherapy, particularly in the realm of systemic and family psychotherapy. While rooted in systemic principles and concepts, over time the original Milan group demonstrated differences in their clinical orientations and practices which led to their regrouping into two teams. The paper explores the divergences in their views and directions on family dynamics and the role of symptoms within the system. It delves into the influence of Boscolo and Cecchin, two of the ‘Milan Four’ on the Centro Padovano di Terapia della Famiglia. Drawing from a conversation with Andrea Mosconi, a mentee and collaborator of Boscolo and Cecchin, the paper examines the reconfiguration of the original ‘Milan Four’ team and its impact on their clinical approach. Key Milan principles and concepts such as hypothesising, circularity, and neutrality are examined with particular emphasis on the work of Boscolo and Cecchin's systemic work. These principles, intertwined and interconnected, provide a fertile ground for the construction of multiple hypotheses and circular questioning. The paper also highlights the concept of reflexivity, which originates from Bateson's work and plays a crucial role in family relations and communication while explaining the birthplace of paradox taking place when two levels of meaning are ‘confused.’ The Milan approach continues to be highly regarded, as its early concepts and ideas have evolved and left a lasting impact on the field of family therapy. By reflecting on the distinct contributions of Boscolo and Cecchin, and using examples, Mosconi offers valuable insights into the rich legacy and ongoing relevance of the Milan approach to contemporary therapeutic practice.

Systemic Conception of the Data Acquisition of Digital Twin Solutions for Use Case-Oriented Development and Its Application to a Gearbox

Digital Twins are being used more and more frequently and provide information from the Real Twin for different applications. Measurements on the Real Twin are required to obtain information, which in many cases requires the installation of supplementary sensors. For their conception and design, it is particularly important that the measuring principles are selected purposefully and the appropriate sensors are integrated at the goal-oriented measuring positions without impairing the functions and other properties of the Real Twin by the integration of these sensors. In this article, a “Design for Digital Twin” approach is discussed for the systematic procedure and demonstrated using a multi-staged gearbox as a concrete example. The approach focuses on the mechanical and hardware side of the Real Twin. For the systematic conception and design of the Digital Twin solution, an understanding of the stakeholder demands and the expected use cases is necessary. Based on the stakeholder demands and use cases, the relevant product properties can be determined. Using the relevant properties, an iterative process of conception, design, and analysis takes place. The conception is carried out by means of target-oriented cause–effect analyses, taking into account systemic interrelations of the Real Twin components and systematics for the selection of measurement principles. Systemic considerations, combined with an effect graph, allow for the analysis and evaluation of disturbing factors.

An Appraisal of Opioid Treatment Agreements for the Podiatric Physician.

Opioid treatment agreements are written agreements between physicians and patients that represent strategies enumerating the risks associated with opioid medications. These opioid treatment agreements set expectations and obligations, as well as identify responsibilities for both patient and prescriber for opioid therapy. Some critics assert that these agreements are cumbersome and degrade the patient once they enter into these agreements. A systemic literature search and review using the Preferred Reporting Item for Systematic Reviews and Meta-Analyses (PRISMA) tool was used to find citations describing opioid treatment agreements and their use. Then eligible and appropriate citations were dissected and analyzed. Using the available federal and state opioid prescribing policies, best practice guidelines as well as positive aspects of reviewed literature citations and avoiding bias, degrading, or macroaggression language, a non-cumbersome opioid treatment agreement specific to podiatric medicine was created. A balance argument for the use of opioid treatment agreements to avoid opioid use disorder that is grounded in clinical literature and commentaries are presented. A one-page sensible opioid treatment agreement specific to podiatric medicine, which is similar to more complex cumbersome ones that are found in the literature, and that may be used as part of any podiatric procedural or surgical inform consent, was created and is presented for review. The perception of defending opioid treatment agreements as documents of disclosure to assist patients in their autonomy was offered. Building on the systemic review findings and concept of using elements of disclosure, a model for an analgesic treatment as a one-page informational document to enhance podiatric physicians to create a specific individual analgesic treatment agreement mirroring the scope of podiatric practices that can be incorporated into procedural and surgical inform consent documents was offered.

Baseline Assessment of Systemic Racism Education in Pharmacy Curricula

Objective. To determine, by survey, the inclusion of systemic racism education in US Doctor of Pharmacy (PharmD) curricula and identify barriers and facilitators to addressing this content.Methods. A survey was developed and distributed to curricular representatives at US colleges and schools of pharmacy. The survey assessed inclusion of systemic racism education in curricula, faculty involvement in teaching systemic racism content, barriers to adding systemic racism content in curricula, and future curricular plans. Data were analyzed using descriptive statistics for institutional background information, curricular content, and barriers to inclusion. Relationships between the inclusion of systemic racism content at public versus private programs were examined, and associations between traditional and accelerated programs were assessed.Results. Fifty-eight colleges and schools of pharmacy provided usable responses. Of the respondents, 84% indicated that teaching systemic racism content and its impact on health and health care was a low priority. For 24% of respondents, systemic racism content was not currently included in their curriculum, while 34% indicated that systemic racism content was included in one or more courses or modules but was not a focus. Despite systemic racism content being offered in any didactic year, it was rarely included in experiential curricula. Top barriers to inclusion were lack of faculty knowledge and comfort with content and limited curricular space. No significant differences were found between program types.Conclusion. Based on the current level of systemic racism education and barriers to inclusion, faculty need training and resources to teach systemic racism concepts within pharmacy curricula. The inclusion of systemic racism concepts and guidance in the Accreditation Council for Pharmacy Education's Accreditation Standards could help to drive meaningful change and promote health equity.

ESSENCE AND CONTENT OF THE MAIN CONCEPTS THAT MAKE UP THE TERMINOLOGY APPARATUS OF MANAGEMENT OF INNOVATIVE DEVELOPMENT OF THE ENTERPRISE

The article defines the essence of the concept of «innovative» and «development». The definitions of the innovative development of the enterprise were studied and their characteristics and signs were highlighted. The content of the concept of «innovative development of the enterprise» received further development, in which, among the known, attention is focused on the need to highlight the key elements and vectors of innovative changes for the formation of competitive advantages and maintaining the balance of relevant innovations in all structural and functional elements of the enterprise, which ensures the effect of synergy and increasing the development potential of the business entity. Innovations can be grouped into three groups: innovation as a process of qualitative changes; innovation as a result; innovation as a tool for creating new opportunities. That is, «innovative» is the one that is related to the process of qualitative changes, characterizes the result of invention and is aimed at creating new opportunities The main characteristics of the concept of «development» include: irreversibility, purposefulness, balance, manageability, progress, synergism, changes in quality. That is, development is a systemic concept that reflects the irreversibility of purposeful change to a qualitative state and balance. The main signs of innovativeness of development are: innovations (innovations), innovative processes, innovative activities and innovative potential (innovative resources). It should be noted that all scientists agree that the main feature of innovative development is innovation itself, as a certain catalyst, the basis of multifactorial changes. Summarizing the above, it can be stated that the innovative development of the enterprise is a compound and complex concept, which determines the expediency of its consideration from the standpoint of the signs of its innovativeness and actual development.