Systemic Component Research Articles

The Good Lives Model among detained female adolescents

Abstract Female adolescents constitute a very vulnerable and challenging, yet understudied, minority within the criminal justice system. Up to now, problem-oriented risk management approaches, such as the Risk-Need-Responsivity (RNR) model, are still the most widely used rehabilitation frameworks. More recently, strength-based rehabilitation frameworks, such as the Good Lives Model (GLM), have received increased attention in guiding treatment of detained female adolescents. In the current paper, we explore the relevance and applicability of the GLM in the particular population of detained female adolescents, based on a critical reflection on the theoretical, empirical and clinical evidence available in the scientific literature. First, we argue that the GLM can help to overcome the RNR model's ethical, etiological and clinical limitations, thereby improving rehabilitation theory and effective practice for detained female adolescents. Second, we believe this model, given its holistic and person-centred approach, can be easily extended to this population, however not without taking into account particular developmental and gender issues. Third, we believe the GLM, as a rehabilitation framework, can easily “wrap around” existing evidence-based treatment programs for detained female adolescents, which, overall, are recommended to include a multidimensional, systemic and gender-responsive component. In addition, we think that the different phases of GLM-informed rehabilitation can be easily applied to this particular population. Finally, the application of the GLM among detained female adolescents entails some important research-related, practice-related and normative challenges.

PROFESSIONAL SUBJECTIVITY OF PRIMARY SCHOOL TEACHERS: THE METHODOLOGY SUBSTANTIATION OF AN EXPERIMENTAL FORMATION

The article is devoted to the methodological soundness of the experimental formation of professional subjectivity of future elementary school teachers as a systemic problem of their training because they work with special categories of pupils - students of primary classes. The main methodological approach for its experimental formation is a subject-active approach as a primary school teacher is an educator, the professional and the subject of educational activities in elementary school and, accordingly, the indecated problems should be investigated in the leading ideas and positions of this approach. The leading ideas of the system, competency and other methodological approaches should be taken into account. Particular attention is paid to the methodological aspects of the disclosure of the content of professional subjectivity as its integrated professionally important quality, pedagogical activity which makes it possible to actualize the professional competence in teaching. The content of professional subjectivity structurally includes value-motivated, emotional and volitional, intellectual-cognitive, behavioral-activate, reflexively - evaluative and in individual components. Among them systemic component is individually subjective one, which provides updating and implementation of professional of primary school teachers in general.

Verb Processes in Kurdish Language

This paper presents a descriptive analysis of the processes underlying the usage of transitivity in Kurdish Language. Paul Simpson’s Transitivity model has been adopted in this work. Language use involves both systemic and functional components, the former comprising language grammar system requirements and the latter embracing cognitive/ functional processes underlying the use of a specific systemic component: namely, Material, Mental, Verbal and Relational.
 In a descriptive analysis of transitivity usage in Kurdish language, this paper examines participants’ roles and circumstances in identifying each process. The paper demonstrates that there is a correlation between the speakers’ worldviews and their choice of the processes in using transitivity to generate sentences.
 An adequate and different explanation of the verb concept has been presented on the basis of the semantic organization of a speaker’s experience rather than on viewing transitivity in terms of a grammatical requirement of direct objects. The originality of this paper lies in the various dimensions that such processes provide for analyzing Kurdish sentence structure. The paper can be of benefit as an entry point for studying and understanding the Kurdish verb lexicon and for the program of learning Kurdish language.

What Drives Systemic Credit Risk? Evidence from the US State CDS Market

The root cause of systemic risk is an issue of on-going debate. We document evidence that common shocks of macroeconomic fundamentals are key driver of US state systemic credit risk. A structure model is developed to show importance of economic fundamentals. We find that macroeconomic variables have higher explanatory power for the temporal variation in state credit spreads and its systemic component than do financial market variables. Empirical evidence points to the macroeconomic linkages, not financial linkages, as the dominating source of systemic credit risk, and suggests that state credit risk is mainly driven by the weakness in economic fundamentals.

Correlation of self-reported urologic symptoms with systemic health conditions in minority men.

BackgroundTo investigate the correlation between presence and severity of urologic symptoms and self-reported systemic health conditions in minority men.MethodsQuestionnaires were distributed at a Men’s Minority Health Fair. Urologic symptoms were assessed with the International Prostate Symptom Score (IPSS), Sexual Health Inventory for Men (SHIM) and NIH Chronic Prostatitis Symptom Score (CPSI). Each was graded as absent/mild [0], moderate [1] or severe [2] by standard criteria for each and totaled for a urologic score (US). Other questions included age, height/weight and queried heart disease, diabetes, anxiety/stress, sleep apnea and neurologic disease. A systemic score (SS) graded each plus obesity for 6 domains (0–2 for each).ResultsA total of 52 men completed the surveys with a mean age of 58.8 (range, 37–76) years. By symptom score criteria, 17 (33%) had 1 urologic condition, 19 (37%) had 2 and 5 (10%) had all 3. Mean total US was 1.9 (range, 0–6) and mean SS was 2.9 (range, 0–10). There was a strong correlation between US and SS (Spearman Rho =0.73, P<0.0001). The hierarchy of systemic condition impact on US was cardiovascular > anxiety > obesity > diabetes > sleep apnea > neurologic. By multivariable analysis, after adjusting for age, each systemic component strongly correlated with the US. The multivariable model with age plus all of the systemic scores predicted US more accurately than with any one of its components alone.ConclusionsSelf-reported systemic health conditions correlate strongly with presence and severity of urologic symptoms in minority men.

Upper airway and skin symptoms in allergic and non-allergic asthma: Results from the Swedish GA2LEN study

ABSTRACTBackground: Allergic and non-allergic asthma are viewed as separate entities, despite sharing similarities. The aims of this study were to determine differences in symptoms from the upper airways and the skin in allergic and non-allergic asthma. The secondary aims were to identify childhood risk factors and to compare quality of life in the two asthma groups. Methods: This cohort (age 17–76 years) consisted of 575 subjects with allergic or non-allergic asthma and 219 controls. The participants participated in an interview, spirometry, FeNO, skin prick test, and responded to the Mini Asthma Quality of Life Questionnaire. Results: Self-reported allergic rhinitis was significantly more common in both allergic and non-allergic asthma (82.3 and 40.7%) groups compared with the controls. The prevalence of chronic rhinosinusitis (CRS) was similar in both asthma groups. Eczema was significantly more common in both asthmatic groups (72.3 and 59.8%) than controls (47.0%) (p < 0.001 and p = 0.012). Severe respiratory infection in childhood and parental allergy were risk factors for both allergic and non-allergic asthma groups. Quality of life was significantly lower in non-allergic than allergic asthma groups (p = 0.01). Conclusion: Concomitant symptoms from the upper airways and the skin were significantly more common in both allergic and non-allergic asthma. This indicates that non-allergic asthma has a systemic component with similarities to what is found in allergic asthma. There were similarities in the childhood risk factor pattern between the two types of asthma but asthma-related quality of life was lower in the non-allergic asthma group.

Does willingness-to-pay for weather index-based insurance follow covariant shocks?

PurposeThe purpose of this paper is to investigate the role that weather shocks can play in the livestock mortality microinsurance take-up when the insured risk has a prevalent covariant component.Design/methodology/approachThe sample consists of 360 rural Ethiopian households. Data were collected in a panel-structure at the end of three agricultural seasons (2011-2013). In the questionnaire, a specific section on insurance was meant to collect information on the farmer’s willingness-to-pay (WTP) for a set of insurance products, including livestock mortality insurance. Two OLS regression models and a quantile regression model were employed to estimate the impact of weather anomalies on the WTP for the insurance product.FindingsThe authors find that weather anomalies contribute to changes in the WTP to a large extent. Negative (positive) changes in precipitation (temperature) anomalies can lead to more than a 30 percent reduction in the WTP. This general finding is complemented with the analysis of the conditional distribution of the WTP, which shows that other elements can prevail for low values of the conditional distribution. In this case, the WTP seems to be represented more by the interviewee’s age and basic knowledge of insurance, and village fixed-effects. Basic knowledge of insurance, in particular, can increase WTP by about 60 percent.Practical implicationsThis paper has straightforward implications from a policy perspective. It suggests that farmers would prefer an insurance premium that follows the changes in the systemic component. On the contrary, insurance as well as reinsurance companies are usually reluctant to frequently revise their premiums. Financial education programs, farmer-driven design, trust building, and bundling insurance with other financial and non-financial products can increase the value proposition perceived by the farmers. From a marketing perspective, the overall findings suggest that continuous fine-tuning of the contract, transparency, and targeted information campaigns can contribute to increase and stabilize potential customers’ WTP.Originality/valueTo the best of the authors’ knowledge, this is the first paper that considers the impact of weather shocks on the WTP for a livestock mortality insurance product. Livestock is one of the most strategic assets of poor rural households in Africa. This study contributes to the theoretical and empirical literature on the determinants of weather insurance take-up in developing countries and, in particular, the role of spatiotemporal adverse selection and basis risk (e.g. Jensen et al., 2016).

Contingent Claims Analysis of Sovereign Default Risk in the Eurozone

We study sovereign default risk as measured by credit default swap (CDS) spreads of Eurozone member states between 2008 and 2016. Applying a structural credit risk model we analyze to what extent contingent claims analysis can explain spreads given fundamental balance sheet information. First results confirm that market implied default risk is hardly explainable by available fundamentals. We therefore model the asset value with a jump-diffusion process, which we calibrate to market implied default probabilities. The resulting jump intensities are substantial for both, distressed as well as non-distressed countries. By extending the jump-diffusion model and considering the first-passage time default possibility, our model is able to represent more realistic proportions of jump and pure diffusion risk. Including the first-passage time feature and analyzing conditional default probabilities via correlated jump-diffusion processes further contributes to the analysis of credit contagion and systemic risk. Our approach documents that the largest systemic risk component of the periphery comes from Italy, the smallest from Ireland.

Periodontal profile and radiographic characterization of the jaws in a patient with autosomal dominant osteopetrosis.

Osteopetrosis (OP) comprehends a rare group of conditions, presenting on radiographs increased bone density, deriving from irregularities in osteoclast differentiation or function. In the autosomal dominant osteopetrosis (ADO), some patients stay asymptomatic for some time, or only develop mild symptoms. The dental surgeon is often the first to presuppose the disease during routine imaging examinations, referring the patient to a specialized medical group. Furthermore, osteomyelitis is one of the major OP complications, and should be refrained through frequent dental monitoring. Signals of cortical interruption, sclerotic sequestra or periosteal new bone formation, should be looked for in these patients. Their dental management is complex and procedures encompassing bone tissue, such as implant procedures, tissue regenerations, tooth extractions, maxillofacial surgeries and orthodontic treatments, when elected, should be avoided. This case report describes a case of ADO with a diagnosis of moderate generalized chronic periodontitis, not statistically related to plaque index. This is the first case to describe such a condition, in which the systemic component and the altered bone metabolism seem to be related to the loss of periodontal apparatus, independent of the biofilm. Concerning prevention, we can reinforce the need for frequent dental monitoring to avoid further interventions in those cases.Learning points:This paper reports a case in which the systemic component and the altered bone metabolism seem to have been related to the loss of periodontal attachment apparatus, independent of the biofilm.The periodontal damage observed in the OP patient was not related to the dental plaque, which leads us to suggest that the cases of periodontitis in OP patients should be diagnosed as periodontitis as a manifestation of systemic diseases.The periodontitis prevention should be longed for in OP patients thus, we propose that doctors responsible for patients with OP refer them to a dental service as soon as possible and that dentists should be aware of the preventive dentistry value as well as the most appropriate dental management for those cases.

The Impact Of Systemic Loss Given Default On Economic Capital

Empirical studies have demonstrated that loan default probabilities (PD) and loss given defaults (LGD) are positively correlated because of a common, business cycle, dependency. Regulatory capital requirements demand that banks use downturn LGD estimates because the correlation between PD and LGD is not captured. Economic capital models are not bound by this constraint. We extend and implement a model which captures the PD and LGD correlation by exploring the link between defaults and recoveries from a systemic point of view. We investigate the impact of correlated defaults and resultant loss rates on a portfolio comprising default-sensitive financial instruments. We demonstrate that the systemic component of recovery risk (driven by macroeconomic conditions) exerts greater influence on loss estimation and fair risk pricing than its standalone component.

Coronary heart disease is associated with a worse clinical outcome of hand osteoarthritis: a cross-sectional and longitudinal study

ObjectiveTo determine whether cardiometabolic factors are associated with hand osteoarthritis (HOA) symptoms, radiographic severity and progression in a post hoc analysis of the phase III Strontium ranelate Efficacy in Knee...

MICROBIAL BIODIVERSITY AND ANTIBIOTICS IN PERIODONTAL DISEASES A LITERATURE REVIEW

The Oral cavity is a reservoir of bacteria with high biodiversity, however, not all species can cause invasive diseases. Identification of pathogenic bacteria in the oral lesions is challenging because cultivation of specimens from this non sterile site invariably yields a diversity of bacteria, making associations between cultivated bacteria and particular oral lesions difficult. Periodontitis is a multifactorial disease which might have a systemic or hereditary component in addition to its bacterial aetiology. It is highly prevalent worldwide, affects 30-50% of the population in developed countries, but only ~10% present with severe forms. The microbial aetiology of periodontal disease has been proved since long time ago, approximately 500 species or more have been detected in the gingival sulcus, some of them are widely regarded as major pathogens in periodontitis. Periodontal microbiota are more heterogeneous than earlier believed, in dentistry, gram-negative organisms were considered to be the predominant bacteria in periodontitis; however, gram-positive organisms found in deep, diseased sites are proposed to be the most important pathogens in periodontitis recently. Using antibiotics in controlling periodontal diseases is essential, which either suppress the growth of microorganism or destroy them. Drugs used to treat periodontal disease can be used systemically or locally, however, some periodontopathic bacteria can develop resistance to certain antimicrobials specially in refractory periodontitis and aggressive periodontitis cases.

Is Selective Digestive Decontamination Useful for Critically Ill Patients?

In this study we review the rationale for using selective digestive decontamination (SDD) in critically ill patients, and its effects on clinical outcomes and rates of infection with antimicrobial-resistant microorganisms. SDD consists of the application of nonabsorbable antibiotics to the oropharynx and through a nasogastric or nasoenteral tube, in association with a 4-day course of an intravenous third-generation cephalosporin. The enteral component aims at preventing oral and rectal colonization with potentially pathogenic nosocomial aerobic gram-negative bacilli and yeasts while preserving normal protective anaerobic enteral flora. The short-course systemic component aims at eradicating oral endogenous gram-positive bacteria. SDD decreases the risk of nosocomial infections, and reduces by one-quarter the mortality of patients on mechanical ventilation in settings with low prevalence of antibiotic resistance. Evidence from randomized trials suggests that SDD does not increase rates of antimicrobial-resistant microorganisms, and may reduce resistance rates to some antibiotics. However, several limitations decrease our confidence on these data, particularly for settings with high baseline rates of antimicrobial-resistant microorganisms. Although SDD has a clear potential to improve clinical outcomes of critically patients, its long-term ecologic effects on rates of antimicrobial resistant require appropriate assessment by large multinational cluster randomized trials. Before these results are available, the use of SDD cannot be recommended in most parts of the world, except in settings with very low baseline prevalence of antibiotic resistance.

Specific premature epigenetic aging of cartilage in osteoarthritis.

Osteoarthritis (OA) is a disease affecting multiple tissues of the joints in the elderly, but most notably articular cartilage. Premature biological aging has been described in this tissue and in blood cells, suggesting a systemic component of premature aging in the pathogenesis of OA. Here, we have explored epigenetic aging in OA at the local (cartilage and bone) and systemic (blood) levels. Two DNA methylation age-measures (DmAM) were used: the multi-tissue age estimator for cartilage and bone; and a blood-specific biomarker for blood. Differences in DmAM between OA patients and controls showed an accelerated aging of 3.7 years in articular cartilage (95 % CI = 1.1 to 6.3, P = 0.008) of OA patients. By contrast, no difference in epigenetic aging was observed in bone (0.04 years; 95 % CI = −1.8 to 1.9, P = 0.3) and in blood (−0.6 years; 95 % CI = −1.5 to 0.3, P = 0.2) between OA patients and controls. Therefore, premature epigenetic aging according to DNA methylation changes was specific of OA cartilage, adding further evidence and insight on premature aging of cartilage as a component of OA pathogenesis that reflects damage and vulnerability.

Comparative Genomics of Campylobacter fetus from Reptiles and Mammals Reveals Divergent Evolution in Host-Associated Lineages.

Campylobacter fetus currently comprises three recognized subspecies, which display distinct host association. Campylobacter fetus subsp. fetus and C. fetus subsp. venerealis are both associated with endothermic mammals, primarily ruminants, whereas C. fetus subsp. testudinum is primarily associated with ectothermic reptiles. Both C. fetus subsp. testudinum and C. fetus subsp. fetus have been associated with severe infections, often with a systemic component, in immunocompromised humans. To study the genetic factors associated with the distinct host dichotomy in C. fetus, whole-genome sequencing and comparison of mammal- and reptile-associated C. fetus was performed. The genomes of C. fetus subsp. testudinum isolated from either reptiles or humans were compared with elucidate the genetic factors associated with pathogenicity in humans. Genomic comparisons showed conservation of gene content and organization among C. fetus subspecies, but a clear distinction between mammal- and reptile-associated C. fetus was observed. Several genomic regions appeared to be subspecies specific, including a putative tricarballylate catabolism pathway, exclusively present in C. fetus subsp. testudinum strains. Within C. fetus subsp. testudinum, sapA, sapB, and sapAB type strains were observed. The recombinant locus iamABC (mlaFED) was exclusively associated with invasive C. fetus subsp. testudinum strains isolated from humans. A phylogenetic reconstruction was consistent with divergent evolution in host-associated strains and the existence of a barrier to lateral gene transfer between mammal- and reptile-associated C. fetus. Overall, this study shows that reptile-associated C. fetus subsp. testudinum is genetically divergent from mammal-associated C. fetus subspecies.

Men’s artistic gymnastics: is the use of elastic surfaces systematic in the training process?

Abstract In Artistic Gymnastics, the area (the apparatus) represents the most relevant systemic component. Thus, when one strives to comprehend the internal logic of this sport, the gymnast-apparatus relationship warrants special attention. A change in the training paradigm was observed, showing that the use of Elastic Surfaces (ES) is an essential resource, due to the contemporary features of this sport, such as the hyper-valorisation of acrobatics and a greater presence of flight elements. Through a case study developed in a men’s artistic gymnastics high-performance gymnasium, this study analysed the use of different ES in the training process. Although coaches recognize the importance of ES in training programs, the record of daily activities showed that this use is still limited to select equipment and is not systematic. Such difficulties are due mainly to the lack of educational programs to the development of certain specific methodologies and the non-existence of national equipment suppliers certified by International Gymnastics Federation.

Oregon’s All Roads Transportation Safety Program: Data-Driven Program to Improve Safety on All Public Roads

Historically, the Oregon Department of Transportation (DOT) has spent the Highway Safety Improvement Program (HSIP) funding only on state highways. However, half of the fatalities and serious injuries occur on nonstate roadways. To address this concern and to comply with the federal requirement that the HSIP funding be spent on all public roads, the Oregon DOT developed a jurisdictionally blind safety program, known as the All Roads Transportation Safety (ARTS) Program, to address safety problems on all public roads in Oregon. The objective of the ARTS Program is the same as that of the HSIP: to reduce fatalities and serious injuries on all public roads using a data-driven approach. The ARTS Program has two components: hot spot and systemic. For the first round of the ARTS Program, safety projects were selected by using a combination of a selection approach and an application-based approach. For the hot spot component, potential safety projects were identified by using crash history, and the projects were prioritized on the basis of benefit–cost ratios. The systemic component—with three emphasis areas: roadway departure, intersection, and pedestrian and bicycle—was an application-based process in which the Oregon DOT and local agencies competed for available safety funding. Systemic projects were prioritized on the basis either of benefit–cost ratios (roadway departure and intersection projects) or cost-effectiveness index (pedestrian and bicycle projects). Through collaboration with various stakeholders, the Oregon DOT was able to select safety projects on all public roads with a data-driven approach. It is expected that these projects will significantly improve safety on all Oregon roads by reducing fatal and serious injury crashes.

The Threats and Challenges of a Multipolar World: A Ukraine Crisis Case Study

IntroductionThe crisis in and around Ukraine has clearly demonstrated that the world has changed. This is not news for the most observant politicians and researchers. The changes accumulated slowly, and many of the consequences were predictable.

Looking for New Herbal Treatments for Metabolic Syndrome.

Diabetes, which is one of the metabolic diseases, is a complex and chronic illness to keep maintaining medical and diet care against abnormal glycemic symptoms such as high blood glucose level and insulin resistance. This diabetes, which is inextricably bound up with obesity, can cause decrease of life expectancy, increase of healthcare cost, and weakening of quality of life by risk of acute or long-term complication. In particular, type 2 diabetes mellitus (T2DM) rate of all diabetes reported about over 90%. Also, prevailing population and increasing healthcare budget of diabetes are conservatively estimated to be as much as 366 million people and be as much as 396 billion international dollars in 2030. Even if many clinical doctors and researchers have developed medical care and found therapeutic agent for T2DM, it is difficult to avoid side effects such as hypoglycemia, hyperinsulinemia, diarrhea, and heart failure. Here, this special issue suggested how we accessed alternative treatment or safe therapy for T2DM patients by introducing several research papers using herbal medicines. Traditional medicine has a history of more than 3000 years in clinical trials including China and Korea. The major use of herbal medicines is for health promotion about diverse disease including T2DM and therapy for chronic, as opposed to life-threatening, conditions. It is the most important reason for which herbal medicines are widely perceived as natural and safe without side effects. The historical factors that the herbal medicine has been prescribed in T2DM patients and evaluated safety against side effects for a long time let our group experimentally test whether hyperglycemia effects by taking herbal medicines are related to glucagon-like peptide-1 (GLP-1) stimulation via taste receptor signaling on enteroendocrine L cells or not. Firstly, our group tested whether prescribed extracts of herbal medicines, Citrus aurantium, Anemarrhena asphodeloides, and Bupleurum falcatum, were responsible for GLP-1 secretion and taste receptor signaling or not in enteroendocrine L cells using GLP-1 assay and microarray. GLP-1 is one of the incretin hormones and is secreted from intestinal enteroendocrine L cells, which existed mainly in the proximal ileum and colon, and GLP-1 is induced through nutrient sensing taste receptor that responds to sweet, bitter, umami, and fatty acids. These herbal medicines stimulated GLP-1 secretion and upregulated the mRNA of taste receptor genes in L cells. Additionally, we tested whether GLP-1 secretion practically affected hyperglycemia effects on diabetic mice model or not. Diabetic mice exhibited more ameliorated hyperglycemia than control group. However, this GLP-1 secretion by herbal medicines lacks biochemical evidence. It is unknown which components on herbal medicines stimulate GLP-1 and which specific taste receptor signaling among sweet, bitter, umami, and fatty acids was activated by herbal medicines. To overcome these limitations, the study supplemented systemic inhibition study and component analysis on herbal medicine, Gentiana scabra extracts. In aspect of systemic inhibition study, pharmacologic inhibitors associated with taste receptor signaling on GLP-1 and calcium imaging study and knockout mice of α-gustducin applied to mechanism definition of taste receptor signaling of Gentiana scabra extracts on in vivo study of plasma GLP-1 and insulin measurements. Furthermore, to confirm components in Gentiana scabra extracts and to evaluate active compound of GLP-1 secretion, the components of Gentiana scabra extractswere analyzed by HPLC-MS and active compound of GLP-1 secretion in L cells was selected by GLP-1 assay. This issue tried to explain safe application for T2DM patients by regulating hyperglycemia via taste receptor signaling. We provide previous study of therapeutic application via taste receptor signaling for T2DM patients and challenging limitation such as structural assessments. To accurately define specific taste receptor of binding difference according to chemical characters or structure, the components derived from herbal medicines of structural assessment binding taste receptor should be reinforced to cooperate with structural biology areas. Also, for GLP-1 secretagogue of discovery of evidence-based complementary and alternative medicine via taste receptor signaling, development of agonistic component with taste receptor from each herbal medicine, structural assessment of specific taste receptor on discovery agonistic component, and its GLP-1 secretagogue of clinical evaluation need to be supported by future researches. Hyeung-Jin Jang Jae-Young Um Hanseok Ko Won-Seok Chung

Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease.

The frequent association of gout with metabolic syndrome and cardiovascular disease (CVD) suggests that it has a systemic component. Our objective was to study whether circulating proinflammatory cytokines are associated with comorbidities in gout patients. We studied 330 gout patients from 3 independent cohorts and compared them with 144 healthy individuals and 276 disease controls. We measured circulating levels of interleukin-8 (IL-8)/CXCL8, IL-1β, IL-6, IL-10, IL-12, and tumor necrosis factor, after which we performed proteome-wide analysis in a selection of samples to identify proteins that were possibly prognostic for the development of comorbidities. Replication analysis was performed specifically for myeloid-related protein 8 (MRP-8)/MRP-14 complex. Compared to healthy controls and disease control patients, patients with gouty arthritis (n = 48) had significantly higher mean levels of CXCL8 (P < 0.001), while other cytokines were almost undetectable. Similarly, patients with intercritical gout showed high levels of CXCL8. CXCL8 was independently associated with diabetes mellitus in patients with intercritical gout (P < 0.0001). Proteome-wide analysis in gouty arthritis (n = 18) and intercritical gout (n = 39) revealed MRP-8 and MRP-14 as the proteins with the greatest differential expression between low and high levels of CXCL8 and also showed a positive correlation of MRP8/MRP14 complex with CXCL8 levels (R(2) = 0.49, P < 0.001). These findings were replicated in an independent cohort. The proteome of gout patients with high levels of CXCL8 was associated with diabetes mellitus (odds ratio 16.5 [95% confidence interval 2.8-96.6]) and CVD (odds ratio 3.9 [95% confidence interval 1.0-15.3]). Circulating levels of CXCL8 are increased during both the acute and intercritical phases of gout, and they coincide with a specific circulating proteome that is associated with risk of diabetes mellitus and CVD. Further research focused on the roles of CXCL8 and MRP8/MRP14 complex in patients with gout is warranted.