Systemic Component Research Articles

Systemic Component of Legal Mechanisms

Systemic Component of Legal Mechanisms

A catalogue of low-mass X-ray binaries in the Galaxy: From the INTEGRAL to the Gaia era

Context. Low-mass X-ray binaries (LMXBs) are high-energy sources that require multi-wavelength follow-up campaigns to be fully characterised. New transients associated with LMXBs are regularly discovered, and previously known systems are often revisited by astronomers to constrain their intrinsic parameters. All of this information compiled into a catalogue may build a useful tool for subsequent studies on LMXBs and their population. Aims. We aim to provide an update on past LMXB catalogues dating back 16 yr and propose to the community a database on Galactic LMXBs with the most complete, manually curated set of parameters and their original references. On top of a fixed version accessible through Vizier, we propose hosting the catalogue independently on our GitHub collaboration, side-by-side with our previous catalogue on high-mass X-ray binaries. The database will be regularly updated based on new publications and community inputs. Methods. We built a working base by cross-matching previous LMXB catalogues and supplementing them with lists of hard X-ray sources detected over the past 20 yr. We compiled information from Simbad on LMXBs as a starting point for a thorough, manual search in the literature to retrieve important parameters that characterize LMXBs. We retrieved newly detected LMXBs and candidates directly from literature searches. Counterparts to these LMXBs are compiled from hard X-ray to infrared and radio domains. Every piece of information presented on the LMXBs is curated and backed by accurate references. Results. We present a catalogue of 339 Galactic LMXBs listing their coordinates, companion star spectral type, systemic radial velocity, component masses and compact object nature, the presence of type I X-ray bursts, as well as orbital data. Coordinates and identifiers of counterparts at various wavelengths are given, including 140 LMXBs detected in Gaia DR3.

A systems approach to assist policy action to prevent falls among community-dwelling older people in Australia.

While systems thinking has gained recognition as an important approach in health policy and prevention research, its application in the context of fall prevention among community-dwelling older adults has been underutilised. Here, we build on the guiding principles of the systemic lens component of the Prevention System Change Framework to assess and identify potential changes that are required to facilitate policy action in the field of falls prevention. We conducted a desktop search to identify policy documents encompassing falls prevention among community-dwelling older adults in Australia. Documents were considered eligible if they were published in the last 10 years and were authored or endorsed by federal or state government bodies. We collaboratively examined eligible documents to gain insights into the current policy landscape in falls prevention and to illustrate opportunities for action and the potential for strengthening partnerships. There is no current national policy on preventing falls in older adults in Australia. While we identified eight policy documents, none focused exclusively on falls prevention, indicating that falls are currently not perceived as a public health issue that warrants a dedicated policy framework. We identified a need for a comprehensive national policy that draws upon insights from various disciplines, suggests intersectoral collaboration, addresses health inequities and involves meaningful engagement with key stakeholders. Future falls prevention policies may benefit from clear governance structures and specific targets, along with mechanisms for monitoring and evaluating outcomes. Falls prevention is a pressing public health concern that requires dedicated policy resources. Adopting a systems-oriented approach can help reduce falls and their associated burdens on individuals and the healthcare system. Acknowledging the urgency and complexity of this challenge is a first, essential step toward crafting a comprehensive national falls prevention policy.

Systemic component of foreign policy decision

Systemic component of foreign policy decision

Multimorbidities in COPD are Associated With Increased Exacerbations and Health Care Resource Utilization in Real-World Patients from a U.S. Database.

Patients with chronic obstructive pulmonary disease (COPD) often develop other morbidities, suggesting a systemic component to this disease. This retrospective noninterventional cohort study investigated relationships between multimorbidities in COPD and their impact on COPD exacerbations and COPD-related health care resource utilization (HCRU) using real-world evidence from Optum's de-identified Clinformatics® Data Mart Database. Demographic and clinical characteristics were assessed. Overall comorbidity burden and proportion of individuals with gastroesophageal reflux disease (GERD), diabetes, or osteoporosis/osteopenia were compared in age-matched COPD versus non-COPD cohorts using descriptive statistics. COPD exacerbations and COPD-related HCRU (hospitalizations and emergency department visits) were compared between age-matched cohorts of COPD patients with and without specific common morbidities (GERD, diabetes, and osteoporosis/osteopenia). Additional weight-matching was performed for matched cohorts of COPD patients with and without diabetes, and with and without osteoporosis/osteopenia. The follow-up period was 5 years. Age-matched cohorts with and without COPD each comprised 158,106 patients. Morbidities were more common in the COPD cohort than the cohort without COPD (GERD: 44.9% versus 27.8%; diabetes: 40.8% versus 31.1%; osteoporosis/osteopenia: 18.8% versus 14.1%, respectively). Compared with matched cohorts with COPD only, cohorts of COPD patients with either GERD, diabetes, or osteoporosis/osteopenia experienced increased risk of severe exacerbations (odds ratio [OR]=1.819, OR=1.119, and OR=1.373, respectively), moderate exacerbations (OR=1.699, OR=1.102, and OR=1.322, respectively), or any exacerbations (OR=1.848, OR=1.099, and OR=1.384, respectively, p<0.001 for all comparisons) and increased risk of COPD-related HCRU (emergency department visits: OR=1.983, OR=1.098, and OR=1.343, respectively; hospitalization visits: OR=2.222, OR=1.26, and OR=1.368, respectively; p<0.001 for all comparisons). These real-world data confirm that GERD, diabetes, and osteoporosis are common morbidities in patients with COPD and, moreover, that they affect frequency of exacerbation and HCRU. Determining and addressing the mechanisms behind the systemic effects of COPD may be beneficial for COPD patients and may also help reduce COPD exacerbations.

Preoperative Intensified Chemoradiation with Intensity-Modulated Radiotherapy and Simultaneous Integrated Boost Combined with Capecitabine in Locally Advanced Rectal Cancer: Long-Term Outcomes of a Real-Life Multicenter Study

Background: Despite the feasibility and promising activity data on intensity-modulated RT and simultaneous integrated boost (IMRT-SIB) dose escalation in preoperative chemoradiation (CRT) for locally advanced rectal cancer (LARC), few data are currently available on long-term outcomes. Patients and Methods: A cohort of 288 LARC patients with cT3-T4, cN0-2, cM0 treated with IMRT-SIB and capecitabine from March 2013 to December 2019, followed by a total mesorectal excision (TME) or an organ-preserving strategy, was collected from a prospective database of 10 Italian institutions. A dose of 45 Gy in 25 fractions was prescribed to the tumor and elective nodes, while the SIB dose was prescribed according to the clinical practice of each institution on the gross tumor volume (GTV). Concurrent capecitabine was administered at a dose of 825 mg/m2 twice daily, 7 days a week. The primary objective of the study was to evaluate long-term outcomes in terms of local control (LC), progression-free survival (PFS) and overall survival (OS). The secondary objective was to confirm the previously reported feasibility, safety and efficacy (pCR, TRG1-2 and downstaging rates) of the treatment in a larger patient population. Results: All patients received a dose of 45 Gy to the tumor and elective nodes, while the SIB dose ranged from 52.5 Gy to 57.5 Gy (median 55 Gy). Acute gastrointestinal and hematologic toxicity rates of grade 3–4 were 5.7% and 1.8%, respectively. At preoperative restaging, 36 patients (12.5%) with complete or major clinical responses (cCR or mCR) were offered an organ-preserving approach with local excision (29 patients) or a watch and wait strategy (7 patients). The complete pathologic response rate (pCR) in radically operated patients was 25.8%. In addition, 4 TME patients had pT0N1 and 19 LE patients had pT0Nx, corresponding to an overall pT0 rate of 31.3%. Of the 36 patients selected for organ preservation, 7 (19.5%) required the completion of TME due to unfavorable pathologic features after LE or tumor regrowth during W-W resulting in long-term rectal preservation in 29 of 288 (10.1%) of the total patient population. Major postoperative complications occurred in 14.2% of all operated patients. At a median follow-up of 50 months, the 5-year PFS and OS rates were 72.3% (95% CI: 66.3–77.4) and 85.9% (95% CI: 80.2–90.1), respectively. The 5-year local recurrence (LR) rate was 9.2% (95% CI: 6.0–13.2), while the distant metastasis (DM) rate was 21.3% (95% CI: 16.5–26.5). The DM rate was 24.5% in the high-risk subset compared to 16.2% in the low-intermediate risk group (p = 0.062) with similar LR rates (10% and 8%, respectively). On multivariable analysis, cT4 and TRG3–5 were significantly associated with worse PFS, OS and metastasis-free survival. Conclusions: Preoperative IMRT-SIB with the moderate dose intensification of 52.5–57.5 Gy (median 55 Gy) and the full dose of concurrent capecitabine confirmed to be feasible and effective in our real-life clinical practice. Organ preservation was shown to be feasible in carefully selected, responsive patients. The favorable long-term survival rates highlight the efficacy of this intensified treatment program. The incorporation of IMRT-SIB with a more effective systemic therapy component in high-risk patients could represent a new area of investigational interest.

Financial determinants of ensuring the resilience of Ukrainian regions

Financial resilience is the basis of economic development as it determines the ability of the financial system to efficiently perform its functions and ensure optimal resource allocation and the normal course of economic processes under the impact of macroeconomic shocks and endogenous risks. The article aims to assess financial resilience as a systemic component of ensuring the economic development of Ukrainian regions. The research methods include systemic and structural analysis (building an information and analytical model for studying financial resilience), clustering (grouping regions by the criterion of economic development), and risk theory and analysis of variance (identifying potential zones of financial resilience and its components). Data from the regions (oblasts) of Ukraine for 2015–2021 serve as the information and analytical basis of the study. The article reveals that in 2021 regions with better financial resilience (Zhytomyrska, Dnipropetrovska, Kyivska, Lvivska, Odeska, Kharkivska, Cherkaska, and Volynska oblasts) take leading positions in terms of economic development and more efficient use of exogenous and endogenous financial resources than the regions with low financial resilience (Chernivetska, Vinnytska, Khmelnytska, Donetska, Ternopilska, and Ivano-Frankivska oblasts). The study proves that enhancing financial resilience is a trigger and foundation for ensuring economic growth in the regions, especially amid macroeconomic shocks. Balancing the need to use financial resources to restore the economy (growth of production, consumption, and employment) while reducing the dependence of regional economies on external financial sources should become the main vector of policy to ensure the financial resilience of Ukrainian regions. AcknowledgmentsThe study was conducted within the framework of the “Financial Determinants of Ensuring Economic Growth of Regions and Territorial Communities based on Behavioral Economics” project (No. 2020.02/0215) funded by the National Research Foundation of Ukraine (Competition “Support for Research of Leading and Young Scientists”).

Endometriosis in the era of precision medicine and impact on sexual and reproductive health across the lifespan and in diverse populations.

Endometriosis is a common estrogen-dependent disorder wherein uterine lining tissue (endometrium) is found mainly in the pelvis where it causes inflammation, chronic pelvic pain, pain with intercourse and menses, and infertility. Recent evidence also supports a systemic inflammatory component that underlies associated co-morbidities, e.g., migraines and cardiovascular and autoimmune diseases. Genetics and environment contribute significantly to disease risk, and with the explosion of omics technologies, underlying mechanisms of symptoms are increasingly being elucidated, although novel and effective therapeutics for pain and infertility have lagged behind these advances. Moreover, there are stark disparities in diagnosis, access to care, and treatment among persons of color and transgender/nonbinary identity, socioeconomically disadvantaged populations, and adolescents, and a disturbing low awareness among health care providers, policymakers, and the lay public about endometriosis, which, if left undiagnosed and under-treated can lead to significant fibrosis, infertility, depression, and markedly diminished quality of life. This review summarizes endometriosis epidemiology, compelling evidence for its pathogenesis, mechanisms underlying its pathophysiology in the age of precision medicine, recent biomarker discovery, novel therapeutic approaches, and issues around reproductive justice for marginalized populations with this disorder spanning the past 100 years. As we enter the next revolution in health care and biomedical research, with rich molecular and clinical datasets, single-cell omics, and population-level data, endometriosis is well positioned to benefit from data-driven research leveraging computational and artificial intelligence approaches integrating data and predicting disease risk, diagnosis, response to medical and surgical therapies, and prognosis for recurrence.

The [O iii] Profiles of Far-infrared Active and Inactive Optically Selected Green Valley Galaxies

We present a study of the [O iii] λ5007 line profile in a subsample of eight active galactic nuclei (AGNs) and six non-AGNs in the optically selected green valley at z < 0.5 using long-slit spectroscopic observations obtained with the 11 m Southern African Large Telescope. Gaussian decomposition of the line profile was performed to study its different components. We observe that the AGN profiles are more complex than the non-AGN ones. In particular, in most AGNs (5/8) we detect a blue wing of the line. We derive the FWHM velocities of the wing and systemic component, and find that the AGNs show higher FWHM velocities than the non-AGNs in their core component. We also find that the AGNs show blue wings with a median velocity width of approximately 600 km s−1, and a velocity offset from the core component in the range −90 to −350 km s−1, in contrast to the non-AGN galaxies, where we do not detect blue wings in any of their [O iii] λ5007 line profiles. Using the spatial information in our spectra, we show that at least three of the outflow candidate galaxies have centrally driven gas outflows extending across the whole galaxy. Moreover, these are also the galaxies which are located on the main sequence of star formation, raising the possibility that the AGNs in our sample are influencing the star formation of their host galaxies (such as positive feedback). This is in agreement with our previous work where we studied the star formation, morphology, and stellar population properties of a sample of green valley AGNs and non-AGN galaxies.

Abstract 5122: Electrochemotherapy and IL-12 gene electrotransfer in treatment of mast cell tumors in companion dogs

Abstract When cells or tissues are exposed to an electric field, structural changes can be induced in the cell membrane, allowing molecules to flow into the cells. This condition is useful for delivering cytotoxic drugs whose transport into cells is impeded, such as bleomycin and cisplatin. This is referred to as electrochemotherapy (ECT). When DNA or RNA molecules are transported into cells, the approach is called gene electrotransfer (GET). ECT is an effective local treatment for tumors, but it lacks the systemic component of treatment that is essential for fighting metastatic disease. Cancer progression and metastasis are closely related to an inadequate antitumor immune response. Therefore, the antitumor efficacy of interleukin 12 (IL -12), a cytokine that stimulates the innate and adaptive immune response, has been tested in preclinical studies using plasmid DNA encoding IL -12 delivered into the tumor by gene electrotransfer (IL -12 GET). In addition, the combined treatment of ECT and IL -12 GET has already been shown to be effective in the treatment of mouse tumors and has been used in clinical trials in companion dogs to treat various histological types of spontaneous tumors. The results of these studies showed that the treatment is safe and effective. However, in these clinical trials, IL -12 GET was administered by different routes, either intratumorally (i.t.) or peritumorally (peri.t.). Therefore, the aim of this study was to compare the two IL -12 GET routes of administration in combination with ECT and to determine their contribution to the enhanced response to ECT. In the clinical trial, 59 dogs with spontaneous mast cell tumors (MCT) were divided into two groups: one group was treated with the combination of ECT and GET peri.t. (29 dogs) and the other with the combination of ECT + GET i.t. (30 dogs). The efficacy of the treatment was compared with the group of 18 dogs treated with ECT alone. In addition, immunohistochemical studies of tumor samples before treatment and flow cytometric studies of PMBC before and after treatment were performed to determine immunological aspects of the treatment. The results of this study showed that local tumor control was significantly better in the ECT + GET i.t. group (p &amp;lt; 0.05) than in the ECT + GET peri.t. and ECT groups. In addition, the disease-free interval (DFI) and progression-free survival (PFS) were significantly longer in the ECT + GET i.t. group than in the other two groups (p &amp;lt; 0.05). The data on local tumor response, DFI and PFS were consistent with immunological studies, as we detected increased infiltration of antitumor immune cells after treatment in the ECT + GET i.t. group, also suggesting a systemic effect. Citation Format: Maja Cemazar, Ursa Lampreht Tratar, Nina Milevoj, Katarina Znidar, Katja Ursic Valentinuzzi, Andreja Brozic, Gregor Sersa, Natasa Tozon. Electrochemotherapy and IL-12 gene electrotransfer in treatment of mast cell tumors in companion dogs. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 5122.

Open Source Data-Based Solutions for Identifying Patterns of Urban Earthquake Systemic Vulnerability in High-Seismicity Areas

Urban settlements located in high-seismicity areas should benefit from comprehensive vulnerability analyses, which are essential for the proper implementation of vulnerability modelling actions. Alas, many developing countries face a shortage of knowledge on seismic vulnerability, particularly concerning its systemic component, as a consequence of a combination of data scarcity and a lack of interest from authorities. This paper aims to identify primary time-independent spatial patterns of earthquake systemic vulnerability based on the accessibility of key emergency management facilities (e.g., medical units, fire stations), focusing on the urban settlements located in the high-seismicity area nearby the Vrancea Seismogenic Zone in Romania. The proposed methodological framework relies on open source data extracted from OpenStreetMap, which are processed via GIS techniques and tools (i.e., Network Analyst, Weighted Overlay Analysis), to compute the service areas of emergency management centres, and to map earthquake systemic vulnerability levels. The analysis shows that accessibility and systemic vulnerability patterns are significantly impacted by a synergy of factors deeply rooted in the urban spatial layout. Although the overall accessibility was estimated to be medium-high, and the overall systemic vulnerability to be low-medium, higher systemic vulnerability levels in certain cities (e.g., Bacău, Onești, Tecuci, Urziceni). The presented findings have multi-scalar utility: they aid in the development of improved, locally tailored seismic vulnerability reduction plans, as well as the allocation of financial and human resources required to manage earthquake-induced crises at regional scale. Further to that, the paper provides a transparent methodological framework that can be replicated to put cities in high-seismicity areas on the map of systemic vulnerability assessments, laying the groundwork for positive change in countries where the challenges associated with high-level seismic risk are often overlooked.

A catalogue of high-mass X-ray binaries in the Galaxy: from the INTEGRAL to theGaiaera

Context.High-mass X-ray binaries (HMXBs) are a particular class of high-energy sources that require multi-wavelength observational efforts to be properly characterised. New identifications and the refinement of previous measurements are regularly published in the literature by independent teams of researchers and might, when they are collected in a catalogue, offer a tool for facilitating further studies of HMXBs.Aims.We update previous instances of HMXB catalogues in the Galaxy and provide the community easy access to the most complete set of observables on Galactic HMXBs. In addition to the fixed version that is available in Vizier, we also aim to host and maintain a dynamic version that can be updated upon request from users. Any modification will be logged in this version.Methods.Using previous HMXB catalogues supplemented by listings of hard X-ray sources detected in the past 20 yr, we produced a base set of HMXBs and candidates by means of identifier and sky coordinate cross matches. We queried in Simbad for unreferenced HMXBs. We searched for as many hard X-ray, soft X-ray, optical, and infrared counterparts to the HMXBs as we could in well-known catalogues and compiled their coordinates. Each HMXB was subjected to a meticulous search in the literature to find relevant measurements and the original reference.Results.We provide a catalogue of 152 HMXBs in the Galaxy with their best known coordinates, the spectral type of the companion star, systemic radial velocities, component masses, orbital period, eccentricity, and spin period when available. We also provide the coordinates and identifiers for each counterpart we found from hard X-rays to the near-infrared, including 111 counterparts from the recentGaiaDR3 catalogue.

Rheumatic disease Risk factors, pathophysiology and management

Rheumatic diseases, because of their systemic inflammatory component, are associated with several shared comorbidities. The high affinity of shared epitope for citrullinated peptides could accelerate the amount of human leukocyte antigen peptide complexes on the surface of antigen-presenting cells, thus leading to a (possible joint-specific) T- cell response. Molecules such as receptor activator of nuclear factor κB ligand, prostaglandins, and matrix metalloproteinases are induced by pro-inflammatory cytokines, involving tumor necrosis factor and interleukin 6, and mediate signs and symptoms of the disease, involving pain and swelling, and degradation of cartilage and bone. Steroids at dosages equivalent to less than 10 mg of prednisone daily are highly effective for relieving symptoms of rheumatoid arthritis and can slow joint injury.

Mechanistic Insight into Age-Related Macular Degeneration (AMD): Anatomy, Epidemiology, Genetics, Pathogenesis, Prevention, Implications, and Treatment Strategies to Pace AMD Management.

One of the most complicated eye disorders is age-related macular degeneration (AMD) which is the leading cause of irremediable blindness all over the world in the elderly. AMD is classified as early stage to late stage (advanced AMD), in which this stage is divided into the exudative or neovascular form (wet AMD) and the nonexudative or atrophic form (dry AMD). Clinically, AMD primarily influences the central area of retina known as the macula. Importantly, the wet form is generally associated with more severe vision loss. AMD has a systemic component, where many factors, like aging, genetic, environment, autoimmune and non-autoimmune disorders are associated with this disease. Additionally, healthy lifestyles, regular exercise, maintaining a normal lipid profile and weight are crucial to decreasing the risk of AMD. Furthermore, therapeutic strategies for limiting AMD should encompass a variety of factors to avoid and improve drug interventions, and also need to take into account personalized genetic information. In conclusion, with the development of technology and research progress, visual impairment and legal blindness from AMD have been substantially reduced in incidence. This review article is focused on identifying and developing the knowledge about the association between genetics, and etiology with AMD. We hope that this review will encourage researchers and lecturers, open new discussions, and contribute to a better understanding of AMD that improves patients' visual acuity, and upgrades the quality of life of AMD patients.

León (Spain) Health professionals' knowledge and clinical practice towards the relationship between cardiovascular diseases and periodontal disease.

Cardiovascular pathologies have a high prevalence in the geriatric population, with acute myocardial infarction being one of the main causes of death in Spain. These pathologies have a systemic inflammatory component that is of vital importance. We also know in dentistry that the main gingival pathogens are capable of generating a systemic inflammatory response, being indirectly involved in the development of the atherosclerotic lesion, assuming, therefore, that periodontal disease is a cardiovascular risk factor. The objective of this study is to determine the knowledge of health professionals who treat cardiovascular diseases about periodontal disease and its relationship with heart disease. A health survey was carried out on 100 Cardiologists, Internists and General Practitioners in the province of León. Points of interest in this survey: the professional's own oral health, knowledge of the relationship between periodontal and heart disease and, lastly, the training received in medicine on oral health. 60% of professionals reviewed their oral health annually and 20% randomly. 48% of health professionals were unaware of periodontal diseases, 77% claimed to have not received university training in this regard, only 13% of those surveyed acknowledged having received more than 10 hours of training on oral health in their experience and finally, 90% thought that training in both Medicine and Dentistry should be collaborative. The degree of knowledge of health professionals regarding oral health is poor (77%), therefore the number of collaborative consultations with dental professionals is low (<63%). Training projects targeting a correct preventive medicine are shown to be necessary. Key words:Cardiovascular disease, oral-systemic health, periodontitis, knowledge, physicians.

The relationship of chronic odontogenic foci of infection with atherosclerosis

Modern studies have convincingly confirmed the rela-tionship between the state of the oral microflora and the risk of developing diseases with a systemic inflammatory component, including atherosclerosis. One of the media-tors of systemic inflammation is C-reactive protein (CRP), which is of particular interest to internists as a predictor of cardiovascular diseases. Purpose of the study. To study the relationship of chronic odontogenic foci of infection with the pathology of the cardiovascular system. Materials and methods of research. А clinical examination was performed with the determination of the OHI-S (Green-Vermillion) and periodontal index (PI); photo pro-tocol, CBCT analysis with a resolution of 12×8.5 in 30 pa-tients aged 41.1±4.1 years with coronary heart disease (CHD). The first group of patients consisted of 15 peo-ple with chronic periodontitis, the second — 15 people without signs of periodontal pathology. In all patients the levels of CRP and total cholesterol were determined before and 4 months after dental treatment. Results.In the first group of patients, before the start of dental treatment, the level of CRP was 8.63±0.12 mg/l, total cholesterol — 7.43±0.24 mmol/l; in the second group, the level of CRP was 4.44±0.36 mmol/l, total cholesterol — 5.76±0.17. 4 months after the dental treatment, the level of CRP in the first group was 5.41±0.23 mg/l, total cholesterol — 6.41±0.12 mmol/l; in the second group, the level of CRP was 4.21±0.12 mg/l, the level of total cholesterol was 5.34±0.13 mmol/l. Conclusion:chronic focal odontogenic infection contributes to the development of a systemic inflammatory response, ac-companied by an increase in the level of CRP. Timely de-tection and elimination of chronic odontogenic foci of infection is accompanied by normalization of the level of C-reactive protein.

Disobedience a fundamental systemic component in the origins of scientific study

Disobedience a fundamental systemic component in the origins of scientific study

'Disobedience' - a fundamental systemic component in the origins of scientific study

'Disobedience' - a fundamental systemic component in the origins of scientific study

ИСТОРИЧЕСКАЯ ПОЛИТИКА И МЕМОРИАЛЬНАЯ КУЛЬТУРА СОВРЕМЕННОГО ВЕНГЕРСКОГО ОБЩЕСТВА

This study analyzes the current memory policy in modern-day Hungary during the early 2020s. The author studies the role and place of intellectual communities as the main spaces of the genesis of memory and the functioning of memorial cultures and collective historical memory in modern social and political thought of Hungary. The article demonstrates that the intellectual community, as a systemic component of contemporary Hungarian society, plays a vital role in developing and transforming memorial culture. Additionally, Hungarian intellectual agents of historical memory politics and shapers of various memorial cultures engage in a spectrum of memorial practices that range from historical revisionism to attempts to create a liberal memorial canon. Thirdly, the memorial practices of the modern intellectual community are linked to the development of nationalist discourse, represented by ethnic and civic nationalisms. Besides, the participation of intellectuals in memorial politics actualizes the political and ideological heterogeneity of modern Hungarian society, contributing to the simultaneous development and competition of various forms of historical memories, stimulating memorial confrontations and memory wars. It is assumed that the role of society in the historical politics of modern Hungary will increase, and intellectuals as memory activists will remain among the main active participants of memorial politics.

Outcomes in patients with non-invasive breast carcinoma.

Non-invasive breast carcinoma is considered to be localized disease and is distinguished from invasive ductal and lobular carcinomas. The local recurrence of non-invasive carcinoma after surgery may lead to development of invasive carcinoma and promote distant metastasis, which worsens the prognosis for breast cancer mortality. The distant metastasis of non-invasive carcinoma may involve the ductal microvasculature without invasion. The outcomes of non-invasive breast carcinoma were examined in this retrospective cohort study. Of 872 primary breast cancers diagnosed at a single center between May 2008 and March 2022, 93 (10.6%) were found to be non-invasive carcinomas and were examined in this study. The breast cancer recurrence and survival rates of patients with non-invasive carcinoma were analyzed retrospectively. The median follow-up period was 1891 (range, 5-4804) days. All patients underwent surgical treatment [mastectomy with sentinel lymph node biopsy (SLNB) and partial mastectomy with or without SLNB, tumorectomy, and microdochectomy]. Postoperatively, radiation therapy was administered to 73 (78.4%) of the patients and endocrine therapy was administered to 64 (81.0%) of 79 patients with hormone-receptor positivity. Of 26 patients who underwent partial mastectomy with SLNB, 24 (92.3%) showed isolated tumor cells in the SLNs on one-step nucleic acid amplification. Local recurrence was observed in three (0.3%) patients; no distant metastasis was observed. One patient died of a noncancerous disease. The overall survival rate was 98.0% and the breast cancer-specific survival rate was 100.0%. Non-invasive breast carcinoma, like invasive breast carcinoma, causes local recurrence, but has a good prognosis without distant metastasis. The clinical significance of isolated tumor cells in the SLNs as a systemic component of non-invasive breast carcinoma remains to be elucidated.