Systematic Series Research Articles

States of Low Energy on Bianchi I spacetimes

States of Low Energy are a class of exact Hadamard states for free quantum fields on cosmological spacetimes whose structure is fixed at all scales by a minimization principle. The original construction was for Friedmann–Lemaître geometries and is here generalized to anisotropic Bianchi I geometries relevant to primordial cosmology. In addition to proving the Hadamard property, systematic series expansions in the infrared and ultraviolet are developed. The infrared expansion is convergent and induces in the massless case a leading spatial long distance decay that is always Minkowski-like but anisotropy modulated. The ultraviolet expansion is shown to be equivalent to the Hadamard property, and a non-recursive formula for its coefficients is presented.

Computer vision application for industrial Li-ion battery module disassembly

Automated robot-assisted disassembly is essential for the flexible disassembly of Li-ion battery modules for economic and safety reasons. In such a case, a CAD model for the planning process is of immense benefit. The geometric uncertainties due to the breathing of the Li-ion cells as well as the presence of component tolerances underline the importance of a sensor-based detection approach to determine the actual state of the battery module, which is crucial to ensure an automated and reliable disassembly process. In this paper, we present a method for 3D camera-based localization of points on deformed battery modules, aiding in identifying support points for milling operations in robot-assisted disassembly cells. This separation operation planning employs a CAD model, and our introduced computer vision “data processing pipeline”—a systematic series of processing steps—bridges the gap between the CAD model and the actual battery module. This involves capturing the module using a 3D camera and subsequently registering its points with the CAD model’s points. Central to this process are two algorithms: The Bayesian Coherent Point Drift (BCPD) algorithm ensures accurate non-rigid registration, while TEASER++ aids in reducing computational time. We demonstrate the effectiveness of these combined algorithms in our pipeline through rigorous testing and metrics, evidencing that a balance between accuracy and computational speed can be attained by adjusting point density.

Comparative Outcomes of the Transareolar Approach: Systematic Review And Case Series

Comparative Outcomes of the Transareolar Approach: Systematic Review And Case Series

Complications of Medical Tourism in Aesthetic Surgery: A Systematic Review and Case Series

Complications of Medical Tourism in Aesthetic Surgery: A Systematic Review and Case Series

Preventable deaths involving falls in England and Wales, 2013-22: a systematic case series of coroners' reports.

Falls in older people are common, leading to significant harm including death. Coroners have a duty to report cases where action should be taken to prevent future deaths, but dissemination of their findings remains poor. To identify preventable fall-related deaths, classify coroner concerns and explore organisational responses. A retrospective systematic case series of coroners' Prevention of Future Deaths (PFD) reports, from July 2013 (inception) to November 2022. England and Wales. Reproducible data collection methods were used to web-scrape and read PFD reports. Demographic information, coroner concerns and responses from organisations were extracted and descriptive statistics used to synthesise data. Five hundred and twenty-seven PFDs (12.5% of PFDs) involved a fall that contributed to death. These deaths predominantly affected older people (median 82years) in the community (72%), with subsequent death in hospital (70.8%). A high proportion of cases experienced fractures (51.6%), major bleeding (35.9%) or head injury (38.7%). Coroners frequently raised concerns regarding falls risks assessments (20.9%), failures in communication (20.3%) and documentation issues (17.5%). Only 56.7% of PFDs received a response from organisations to whom they were addressed. Organisations tended to produce new protocols (58.5%), improve training (44.6%) and commence audits (34.3%) in response to PFDs. One in eight preventable deaths in England and Wales involved a fall. Addressing concerns raised by coroners should improve falls prevention and care following falls especially for older adults, but the poor response rate may indicate that lessons are not being learned. Wider dissemination of PFD findings may help reduce preventable fall-related deaths in the future.

Honesty-humility negatively correlates with dishonesty in romantic relationships.

Despite the clear existing theoretical links, ours is the first direct systematic series of studies investigating a potential negative association between Honesty-Humility and general dishonesty in romantic relationships. Eleven preregistered online studies with community samples were run (total N = 5,677). For a first test of our hypothesis, we conducted a series of seven cross-sectional studies based on self-reports; these studies used different methodological approaches to assess relationship-based dishonesty (i.e., closed-ended self-report scales, scenarios, and direct frequency measures). This was followed by one diary study and three studies that base their assessment on more behavioral measurements of relationship-based dishonesty (e.g., a dice roll task and an anagram task). In line with our hypothesis, all studies reliably revealed that participants higher in Honesty-Humility reported less relationship-based dishonesty. The classification of the found results to past research and the general relevance of the Honesty-Humility factor for romantic relationships are discussed. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Design, synthesis, conformational analysis, and biological activity of Cα1-to-Cα6 1,4- and 4,1-disubstituted 1H-[1,2,3]triazol-1-yl-bridged oxytocin analogues

Oxytocin (OT) is a neurohypophyseal peptide hormone containing a disulphide-bridged pseudocyclic conformation. The biomedical use of OT peptides is limited amongst others by disadvantageous pharmacokinetic parameters. To increase the stability of OT by replacing the disulphide bridge with the stable and more rigid [1,2,3]triazol-1-yl moiety, we employed the Cu2+-catalysed side chain-to-side chain azide-alkyne 1,3-cycloaddition. Here we report the design, synthesis, conformational analysis, and in vitro pharmacological activity of a homologous series of Cα1-to-Cα6 side chain-to-side chain [1,2,3]triazol-1-yl-containing OT analogues differing in the length of the bridge, location, and orientation of the linking moiety. Exploiting this macrocyclisation approach, it was possible to generate a systematic series of compounds providing interesting insight into the structure-conformation-function relationship of OT. Most analogues were able to adopt similar conformation to endogenous OT in water, namely, a type I β-turn. This approach may in the future generate stabilised pharmacological peptide tools to advance understanding of OT physiology.

Functional neurological seizures and migraine: A systematic review and case series

BackgroundThe seizure subtype of functional neurological disorder (FND-seizures) is a common neuropsychiatric condition manifesting with episodic epilepsy-like events. Despite the common belief that FND-seizures are precipitated by psychological stressors, neurological disorders may also be triggers. In 1890, Babinski described four cases of FND symptoms associated with migraine attacks. Despite the passing of more than 130 years since this first clinical observation, the relationship between FND-seizures and migraine is not fully elucidated. Objectives(1) To complete a systematic review of the literature that investigated potential associations between FND-seizures and migraine and the response of FND seizures to treatment with migraine prophylactic medications (2). To undertake a retrospective study of patients with FND-seizures and migraine, including response to migraine prophylaxis. Methods(1) Using PRISMA methods, we completed a systematic review of EMBASE and Scopus databases from inception to March 31, 2021, for literature on FND-seizures and migraine. (2) Our multi-disciplinary team, including subspecialists in psychosomatic medicine, epilepsy, and headache disorders, reviewed consecutive patients diagnosed with FND-seizures and migraine to assess potential causal associations and responses to standard migraine prophylactic medications. Results(1) The search yielded seven studies from 126 screened manuscripts (N = 1,186 patients with FND-seizures; mean age 38.7 years; 72.6% female). They varied substantially in design, population, diagnostic measures, and outcomes. Nevertheless, all studies found associations between FND-seizures and migraine, which were stronger than those between epileptic seizures and migraine in comparative investigations, but provided limited information on treatment response. (2) In our case series, investigators reached unanimous consensus that migraine attacks triggered FND-seizures in 28/43 (65.1%) patients reviewed (mean age, 38.8 years; 74% female). In 19/26 (73%) patients with adequate follow-up data, treatment with migraine prophylactic medications alone (no behavioral interventions) concomitantly reduced FND-seizure and headache frequency by >50%. ConclusionOur systematic review and case series indicate that migraine attacks may trigger FND-seizures, perhaps more often that currently understood, and suggest that migraine prophylaxis may reduce FND-seizure frequency in such cases. To validate these observations, fully powered prospective investigations are required.

Controlling Intramolecular Singlet Fission Dynamics via Torsional Modulation of Through-Bond versus Through-Space Couplings.

Covalent dimers, particularly pentacenes, are the dominant platform for developing a mechanistic understanding of intramolecular singlet fission (iSF). Numerous studies have demonstrated that a photoexcited singlet state in these structures can rapidly and efficiently undergo exciton multiplication to form a correlated pair of triplets within a single molecule, with potential applications from photovoltaics to quantum information science. One of the most significant barriers limiting such dimers is the fast recombination of the triplet pair, which prevents spatial separation and the formation of long-lived triplet states. There is an ever-growing need to develop general synthetic strategies to control the evolution of triplets following iSF and enhance their lifetime. Here, we rationally tune the dihedral angle and interchromophore separation between pairs of pentacenes in a systematic series of bridging units to facilitate triplet separation. Through a combination of transient optical and spin-resonance techniques, we demonstrate that torsion within the linker provides a simple synthetic handle to tune the fine balance between through-bond and through-space interchromophore couplings that steer iSF. We show that the full iSF pathway from femtosecond to microsecond timescales is tuned through the static coupling set by molecular design and structural fluctuations that can be biased through steric control. Our approach highlights a straightforward design principle to generate paramagnetic spin pair states with higher yields.

Study of the optical and spectral properties of Phosphor Tellurite Semiconducting Oxide Glasses

A systematic series of binary Phosphor tellurite glasses in the form [(90-X%)TeO2-(X%)V2O5] in mol%, where X = (10,20,25,30,35) have been successfully prepared in standard method (melt quenching), The effect of adding (V2O5) have been discussed. The X-Ray diffraction spectrum shows that the glass composite had no sharp peaks, The absence of abroad hump at (2θ=25-30o) indicates the presence of (L.R.O) long-range structural was disorder. The glass network structure was discussed through IR and Raman spectroscope and that showed the glass network is built of (TeO3 and TeO4) units. From the UV-visible spectrum, the edge of absorption the optical energy gap (Eopt) Urbach energy (Eo), and refractive index (n), have been determined. The results show that (Eopt) decreased with the increase of (V2O5) concentration, and Urbach energy (Eo) decreased with the increase of (V2O5) content, the refractive index (n) increased with the increase of (V2O5) concentration. The thermal parameters such as transition temperature (Tg), thermal stability (S), and thermodynamic fragility (F) are calculated by differential scanning calorimetry (DSC). Structural analysis of the glass system was identified by scanning electron microscopy (SEM).

A method for early-stage design current loads determination on drill-ships

The increasing demand for offshore operations in deep water implies the necessity to predict station-keeping ability of offshore vessels since the early stages of design. To this end, besides developing sufficiently fast and accurate methodologies for the equilibrium resolution of the forces acting on the ship, it is of utmost importance to estimate, in a reliable way, the external forces acting on the vessel. This work focuses on the current loads, aiming at developing a model for fast current load prediction based on high-fidelity Computational Fluid Dynamics (CFD) computations. Selecting the drill-ships as reference vessel-type for the study, starting from the actual fleet operating worldwide, a systematic series of hulls has been generated varying the main hull-form parameters inside the database, according to a Box-Behnken scheme. CFD calculations based on RANS equations have been performed on the whole ship set, for a set of incidence angle varying from 0 to 180 degrees considering the hull symmetric. As numerical analyses are not suitable for fast calculations the results on the systematic series have been used as input for developing a surrogate model based on Multiple Linear Regressions (MLR). The method allows for scaling the results as a function of the Reynolds number, allowing for general and flexible applicability among different vessel dimensions. The results obtained with the developed model are compared with the conventional current loads estimation methods, and the obtained results are compared on the capability plot, highlighting the higher reliability of the proposed model for early-stage predictions.

Surgical treatment of benign subungual tumours—a systematic review and case series

**Background**: Proper surgical technique is critical in the excision of benign subungual tumours to ensure complete tumour removal and prevent nail deformities. A systematic literature review was performed to identify approaches to excision and their clinical outcome. We present a series of rare benign subungual tumours to highlight different approaches and their outcomes.**Methods**: A systematic review of English language literature was conducted using the PubMed database between 1 January 1962 and 31 December 2021 for studies describing surgical approaches to benign subungual tumours. Search terms include ‘glomus tumour’, ‘subungual exostosis’, ‘osteoid osteoma’, ‘fibro-osseous pseudotumour of the digit’, ‘enchondroma’ and ‘implantation dermoid tumour’. We performed a retrospective review of patient records from our institute from 2021–2022. Six patients with subungual tumours were selected.**Results**: Twenty-one studies (with a total of 228 participants) described various techniques for excision of benign subungual tumours. The majority of the studies (n = 18) described the transungual approach, which allows maximum tumour exposure but with risk of nail deformity postoperatively. Other approaches described include lateral subperiosteal (n = 3), periungual (n = 2), nail bed margin (n = 1) and fish mouth (n = 2). Outcomes were measured using the rate of postoperative nail deformity and rate of tumour recurrence. Our series of patients were treated with excision using the transungual (5 of 6) and periungual approach (1 of 6), with good results. **Conclusion**: The available literature demonstrates that the transungual approach is the most widely used technique for removal of subungual tumours. This technique provides excellent tumour exposure; however, it is associated with damage to the nail bed. Our case series suggests that risk of nail dystrophy can be minimised by meticulous nail bed repair.

The impact of grain size heterogeneity on the performance of low-salinity waterflooding in carbonate formations

Low-salinity waterflooding (LSWF) is a proven enhanced oil recovery method for many target fields. The efficiency of this technique depends on both operational factors as well as reservoir settings such as heterogeneity. Micro-scale rock heterogeneity can critically affect the performance of LSWF as it governs the flow path of the injected water, oil-brine-rock contacts and trapping mechanisms, thus sweep efficiency. However, there exist lack of experimental data and detailed understanding of the effect of grain size heterogeneity on LSWF performance. To address this gap, a systematic series of coreflooding experiments were designed using artificial calcite core plugs to investigate the effect of micro-scale heterogeneity, such as grain size and grain heterogeneity, on oil recovery factor by high-salinity waterflooding (HSWF) and LSWF. High salinity formation water, seawater, and diluted seawater were used as injection brines. For this purpose, two relevant grain size ranges (a) from 38 to 75 µm and (b) from 75 to 125 µm were considered to fabricate homogeneous plugs. Heterogeneous core plugs were made by mixing (a) and (b) grain samples. The artificial cores were initialized with the formation brine and crude oil, and aged to restore wettability. Then a set of coreflooding experiments were performed using the mentioned brine samples, in both secondary and tertiary modes by considering a shut-in period.The results reveal that grains size (or micro-scale) heterogeneity has a significant negative impact on both HSWF and LSWF performance and reduces the oil recovery efficiency of HSWF by approximately 15%. This is primarily attributed to the bypassing and entrapment of oil in heterogeneous cores. Moreover, the results show that regardless of the grain size, LSWF in homogeneous plugs result in almost similar recovery factors. The key finding of this study is that LSWF in heterogeneous plugs is more effective and recovers almost 10% more oil compared to HSWF. This is attributed to wettability alteration as indicated by the reduction of water relative permeability endpoint and delay of breakthrough time. The improvement in oil recovery was consistent with the results obtained from the flotation tests and dynamic IFT measurements. However, although LSWF outperforms HSWF in heterogeneous cores, the ultimate recovery factor becomes less in these plugs. Besides, superior performance of secondary flooding was observed compared to tertiary mode for LSWF, especially in cores with heterogeneous grain sizes, leading to almost 10% higher recovery factor.The novel insights gained through this research help identify the proper targets for LSWF in terms of small-scale heterogeneity and can be potentially applied in other water-based EOR techniques.

Preventable deaths involving opioids in England and Wales, 2013-2022: a systematic case series of coroners' reports.

Opioid deaths have increased in England and Wales. Coroners' Prevention of Future Deaths reports (PFDs) provide important insights that may enable safer use and avert harms, yet reports implicating opioids have not been synthesized. We aimed to identify opioid-related PFDs and explore coroners' concerns to prevent future deaths. In this systematic case series, we screened 3897 coronial PFDs dated between 01 July 2013 and 23 February 2022, obtained by web scraping the UK's Courts and Tribunals Judiciary website. PFDs were included when an opioid was implicated in the death. Included PFDs were descriptively analysed, and content analysis was used to assess concerns reported by coroners. Opioids were involved in 219 deaths reported in PFDs (5·6% of PFDs), equating to 4418years of life lost (median 33years/person). Morphine (29%), methadone (23%) and diamorphine (16%) were the most common implicated opioids. Coroners most frequently raised concerns regarding systems and protocols (52%) or safety issues (15%). These concerns were most often addressed to National Health Service (NHS) organizations (51%), but response rates were low overall (47%). Opioids could be used more safely if coroners' concerns in PFDs were addressed by national organizations such as NHS bodies, government agencies and policymakers, as well as individual prescribing clinicians.

Post-traumatic Sinus Syndrome, Proposal for a New Clinical Entity (CDR Syndrome) as Variant of the Silent Sinus Syndrome: Systematic Review and Case Series.

The diagnostic criteria for silent sinus syndrome (SSS) are still controversial, especially for the post-traumatic/surgery cases that are, nowadays, excluded from the diagnosis of SSS because lacking of spontaneously. We present a systematic review of the last 10years and our case series of SSS associated to previous trauma/surgery, proposing a new interpretation of SSS. In this work, following the PRISMA guide lines for systematic reviews, we collected 86 articles published on PubMed, Cochrane Library and Medline Plus since 2013 to 2023 about SSS. We divided them in six groups forming the structure of the review: (1) epidemiology, (2) clinical presentation, (3) imaging, (4) etiopathogenesis, (5) sss and craniofacial trauma and (6) treatment. We reported two explicative clinical cases: two men of 34 and 37years old, involved in motorcycle accident in 2020 and 2014, respectively, and underwent surgery. They came back in 2023 referring diplopia documented by Hess-Lancaster test. CT-scan reported two clear cases of SSS. Basing on what is reported in literature, and basing on our experience, the post-traumatic/surgery SSS are more frequent than the idiopathic ones. Our proposal is to considered them as two individual entities. We propose to adopt the name of Post-traumatic sinus syndrome, or CDR syndrome (Catalfamo-De Rinaldis), for all cases that respect four specific diagnostic criteria reported into the text.

The colonial gap: An analysis of income distribution in the Port of Dakar, 1911–1940

ABSTRACT This study presents new empirical evidence on the structure of income of African workers in the Port of Dakar between 1911 and 1940. It provides a systematic series of public wages earned by the African and European workforce in a colonial seaport. This series includes income structure by skill tier of public employees and labourers employed at the port. Did wage structure evolve according to relative increases in human capital accumulation in this major colonial seaport? In this investigation, I use data collected from the annual budgets of the port to seek explanations for the structural differences in income in three consecutive decades between 1911 and 1940. I found that the skill premium between highly skilled and unskilled African workers was 3.8 on average during the period analysed. Moreover, the skill premium between mid-skilled and unskilled workers is estimated to be 2.7. Furthermore, top and senior European staff (less than 10% of the staff) accounted for 36% of the overall income. I provide quantitative evidence on how colonial allowances were the key element that contributed to the increasing income gap between European and African workers in similar job categories.

Chronic pain outcomes of patients receiving electroconvulsive therapy: A systematic review and case series.

The potential benefits of electroconvulsive therapy (ECT) in chronic pain and several theories for its mechanism have been reported in the past, but mixed findings have also been reported. In the current systematic review and case series, our primary aim was to assess whether pain and functional outcomes are improved after ECT in patients with chronic pain. Secondary objectives included examining whether psychiatric improvement, specific pain diagnoses, and demographic or medical characteristics were associated with differences in pain treatment response. We performed a retrospective chart review to identify patients with chronic pain diagnoses for more than 3 months prior to the initiation of ECT and a systematic literature search on electronic databases for studies on chronic pain outcomes after ECT. Eleven patients with various chronic pain diagnoses and comorbid psychiatric conditions were identified in the case series. Six patients reported improvement in pain while 10 patients reported improvement in mood following ECT. Systematic review identified 22 articles reporting a total of 109 cases. Eighty-five (78%) of cases reported reduction in pain while 96.3% of the patients with a comorbid psychiatric diagnosis reported improvement in mood symptoms post-ECT. While there was an association between improvement in mood and pain in studies with numeric ratings in both outcomes (r = 0.61; p < 0.001), some patients reported pain improvement without improvement in mood in both the case series and the pooled analysis of cases in the review. Certain pain diagnoses such as CRPS, phantom limb pain, neuropathic pain, and low back pain have consistently reported benefits and should be further studied in future studies with matched case controls. ECT may be offered to patients with certain pain conditions who have not responded sufficiently to conventional therapies, particularly when comorbid mood symptoms are present. Improved documentation practices on the outcomes in chronic pain patients receiving ECT will help generate more studies that are needed on this topic.

Understanding the co-construction of safety in the paediatric intensive care unit: A meta-ethnography of parents' experiences.

Children experiencing critical illness or injury may require admission to a paediatric intensive care unit (PICU) to receive life-sustaining or life-saving treatment. Studies have explored the experience of parents with a child in PICU but tend to focus on subgroups of children or specific healthcare systems. Therefore, we aimed to undertake a meta-ethnography to draw together the published research. A systematic search strategy was developed to identify qualitative studies, which had explored the experiences of parents with a critically ill child treated in a PICU. A meta-ethnography was undertaken following the structured steps of identifying the topic; undertaking a systematic search; reading the research; determining how the studies relate and translate into each other; and synthesising and expressing the results. We identified 2989 articles from our search and after a systematic series of exclusions, 15 papers remaining for inclusion. We explored the original parent voices (first order) and the interpretation of the study authors (second order) to identify three third-order concepts (our interpretation of the findings), which related to technical, relational and temporal factors. These factors influenced parents' experiences, providing both barriers and facilitators to how parents and caregivers experienced the time their child was in the PICU. The dynamic and co-constructed nature of safety provided an analytical overarching frame of reference. This synthesis demonstrates novel ways in which parents and caregivers can contribute to the vital role of ensuring a co-created safe healthcare environment for their child when receiving life-saving care within the PICU.

AdpPL: An adaptive phase linking-based distributed scatterer interferometry with emphasis on interferometric pair selection optimization and adaptive regularization

The distributed scatterer (DS) interferometry (DSI) technology is a powerful geodetic tool for measuring the deformation over abundant land covers. As a state-of-the-art DSI technology, the SqueeSAR approach considered the statistical behavior of the decorrelated DS and proposed the phase triangulation algorithm (PTA) as the pioneering implementation of the phase linking (PL) theory to estimate the equivalent single-reference (ESR) phases from all interferometric combinations. Subsequently, many advanced estimators of the systematic phase series have been introduced. Interestingly, this paper has demonstrated that the utilization of weakly coherent interferometric pairs is not conducive to the theoretical accuracy improvement of the PL theory in case of the fast decorrelation scenario. Moreover, the reduction of the small baseline scales will worsen the positive definite degree of the time series coherence matrix, which makes the ill-posed solution problem more serious. Therefore, this paper proposes a novel adaptive PL (AdpPL) method integrating the following two innovations for mapping surface deformation: 1) in terms of the interferometric pair selection optimization (IPSO), this paper performs the homogeneity measure-based IPSO (HoMeIPSO) method to remove the lowly coherent candidate subset progressively and select the moderate interferometric pairs adaptively; 2) in terms of the robust parameter estimation, an adaptive regularization (AdpReg) approach suggests selecting an optimal damping factor according to the minimum fitting error of all interferogram observables. Experimental results demonstrate that the proposed method can restore the systematic phase series more clearly and detect the deformation area with spatially highly dynamic characteristics successfully.

Dedifferentiation and Proliferation of Artery Endothelial Cells Drive Coronary Collateral Development in Mice.

Collateral arteries act as natural bypasses which reroute blood flow to ischemic regions and facilitate tissue regeneration. In an injured heart, neonatal artery endothelial cells orchestrate a systematic series of cellular events, which includes their outward migration, proliferation, and coalescence into fully functional collateral arteries. This process, called artery reassembly, aids complete cardiac regeneration in neonatal hearts but is absent in adults. The reason for this age-dependent disparity in artery cell response is completely unknown. In this study, we investigated if regenerative potential of coronary arteries is dictated by their ability to dedifferentiate. Single-cell RNA sequencing of coronary endothelial cells was performed to identify differences in molecular profiles of neonatal and adult endothelial cells in mice. Findings from this in silico analyses were confirmed with in vivo experiments using genetic lineage tracing, whole organ immunostaining, confocal imaging, and cardiac functional assays in mice. Upon coronary occlusion, neonates showed a significant increase in actively cycling artery cells and expressed prominent dedifferentiation markers. Data from in silico pathway analyses and in vivo experiments suggested that upon myocardial infarction, cell cycle reentry of preexisting neonatal artery cells, the subsequent collateral artery formation, and recovery of cardiac function are dependent on arterial VegfR2 (vascular endothelial growth factor receptor-2). This subpopulation of dedifferentiated and proliferating artery cells was absent in nonregenerative postnatal day 7 or adult hearts. These data indicate that adult artery endothelial cells fail to drive collateral artery development due to their limited ability to dedifferentiate and proliferate.