Systematic Overview Of Literature Research Articles

GANs for Image Security Applications: A Literature Review

Generative Adversarial Networks (GANs) have earned significant attention in various domains due to their generative model’s compelling ability to generate realistic examples probably drawn from sample distribution. Image security indicates the process of protecting digital images from unauthorized access, modification, or distribution. This requires a guarantee of image privacy, integrity, and authenticity to prohibit them from being exploited by malicious attacks. GANs can also be utilized for improving image security by exploiting its generation ability in encryption, steganography, and privacy-preserving tech-niques. This paper reviews GANs-based image security techniques providing a systematic overview of current literature and comparing the role of GANs in image encryption, image steganography, and priva-cy preserving from multiple dimensions. Additionally, it outlines future research directions to further explore the potential of GANs in addressing privacy and image security concerns

Platelet-Rich Plasma in Pediatric Surgery: A Comprehensive Review.

Platelet-Rich Plasma (PRP) therapy has become a promising treatment option in pediatric surgery, offering a novel approach to tissue repair and regeneration. Obtained from the patient's own blood or umbilical cord blood (CB), PRP is a concentrated form of plasma enriched with platelets, growth factors, and cytokines essential for stimulating tissue healing. This systematic review explores the applications of PRP therapy in pediatric surgical procedures, focusing on its role in promoting wound healing, reducing postoperative complications, and enhancing patient outcomes. A systematic literature overview was conducted in accordance with PRISMA guidelines, encompassing studies published between 2004 and 2024. The research has identified different fields of application for PRP therapy in pediatric surgery, including treatment of pilonidal sinus and hypospadias repair. Key findings from clinical studies and randomized controlled trials are summarized, highlighting the efficacy of PRP therapy in accelerating wound healing, reducing pain, and improving patient recovery. Despite promising results, challenges and controversies surrounding PRP therapy persist, including variability in preparation protocols and optimal dosing regimens. The safety of PRP therapy in pediatric patients is also discussed, emphasizing its autologous nature and minimal risk of adverse reactions. In summary, this review highlights the role of PRP therapy as a safe and effective therapeutic approach in pediatric surgery, while further research to standardize protocols and elucidate optimal treatment strategies are still necessary.

Does non-financial information matter? Mapping and clustering literature on the value relevance of comprehensive disclosure

The paper aims to contribute to understanding the value relevance of compre-hensive disclosure, covering different types of information provided in addi-tion to traditional financial reporting. This research is based on an initial sam-ple of 361 documents available on the Scopus database as of December 2022. The study adopts a bibliometric analysis based on the similarity visualization technique on a final sample of 179 articles using the VOSViewer software, and it also performs a content analysis on a subsample of 49 articles. The study mapped and clustered research networks, providing a systematic literature overview. A steady increase of interest in the topic investigated has been observed in re-cent years, driven by the growing attention investors and other users deserve on the role of extended information in disclosing how the firm creates value. The network analysis reveals the existence of four main research streams re-ferring to the following topics: Intangibles, Intellectual Capital Disclosure (ICD) and corporate reputation; ESG and Sustainability disclosure; Environ-mental disclosure and capital market effects; Integrated Reporting and Value Creation. Results highlight prominent research fields and emerging trends, which calls for in-depth consideration of the value relevance of comprehen-sive disclosure within the academic and political space. This article adds to prior research on the topic investigated, combining quantitative and qualita-tive methods to systematize literature. In contrast to other review publications that rely primarily on specific reporting tools, our study refers to different types of reports, providing a systematic picture of the state of the art and fu-ture directions of literature on the value relevance of non-financial infor-mation.

Academic insight for approaching the sustainability of the textile industry

Objective: Sustainability is gaining importance in the textile sector, but there is a lack of literature reviews using bibliometric techniques to provide a quantitative and comprehensive assessment of scientific output. This article aims to provide a current and systematic overview of previous literature on sustainability in the textile sector. To achieve this, a literature review on this topic is done and a model of analysis of the issues studied is presented.Methodology: A mixed-method approach combining bibliometric analysis and qualitative reflection was employed on a sample of 580 papers. Co-word analysis identified thematic clusters in the literature.Results: A general analytical model has been presented to provide a comprehensive and up-to-date review creating five key thematic research domains: Sustainable Development, Value Chain - Cellulose and Textile, Design Process, Circular Economy, and Sustainability. The model has also made it possible to evaluate the relationship of these areas with each other and identify other emerging themes.Limitations: The main limitations come from the methodology used. Future studies can complement the results obtained using additional techniques such as event analysis or case studies.Practical implications: This approach allows companies to focus their strategic decisionson sustainability practices. The findings provide insights for industry stakeholders to prioritise sustainability-related investments and initiatives and enhance operational efficiency.

Trifarotene: a new chapter in the treatment of acne. An overview of the data on efficacy and safety profile of a fourth-generation retinoid

Vulgar acne is a chronic inflammatory skin disease that has a significant impact on patients' quality of life. The search for new highly effective and treatments with favorable safety profile remains relevant due to the high incidence in the population. The launch of a 4th generation retinoid, trifarotene, which has a selective mechanism of action on RAR-γ (γ-retinoic acid receptors agonist), represents a new era in topical therapy of acne vulgaris and is of particular interest to practical healthcare. A systematic literature overview in PubMed, Google Scholar, and ClinicalTrials.Gov databases was conducted to evaluate the mechanism of action, efficacy, and safety profile of the selective 4th generation retinoid, trifarotene 50 µg/g (0,005%) in dosage form topical cream. In a systematic overview, 12 contemporary studies (2015–2023) were selected confirming the high efficacy of trifarotene in protocols for the treatment of acne vulgaris with localization on both facial and truncal skin. The drug demonstrates a unique ability to modulate cell adhesion, optimize transepidermal water loss and reduce the activity of membrane metalloendopeptidases, which determines its proven efficacy. Trifarotene, an innovative 4th generation topical retinoid approved by the FDA in 2019 for the treatment of acne in patients over 9 years of age, opens new possibilities in the treatment of acne vulgaris. Its selective activity to RAR-γ receptors, proven efficacy and favorable safety profile make it a promising agent in therapeutic practice.

Genetic outcomes in children with developmental language disorder: a systematic review.

Developmental language disorder (DLD) is a common childhood condition negatively influencing communication and psychosocial development. An increasing number of pathogenic variants or chromosomal anomalies possibly related to DLD have been identified. To provide a base for accurate clinical genetic diagnostic work-up for DLD patients, understanding the specific genetic background is crucial. This study aims to give a systematic literature overview of pathogenic variants or chromosomal anomalies causative for DLD in children. We conducted a systematic search in PubMed and Embase on available literature related to the genetic background of diagnosed DLD in children. Included papers were critically appraised before data extraction. An additional search in OMIM was performed to see if the described DLD genes are associated with a broader clinical spectrum. The search resulted in 15,842 papers. After assessing eligibility, 47 studies remained, of which 25 studies related to sex chromosome aneuploidies and 15 papers concerned other chromosomal anomalies (SCAs) and/or Copy Number Variants (CNVs), including del15q13.1-13.3 and del16p11.2. The remaining 7 studies displayed a variety of gene variants. 45 (candidate) genes related to language development, including FOXP2, GRIN2A, ERC1, and ATP2C2. After an additional search in the OMIM database, 22 of these genes were associated with a genetic disorder with a broader clinical spectrum, including intellectual disability, epilepsy, and/or autism. Our study illustrates that DLD can be related to SCAs and specific CNV's. The reported (candidate) genes (n = 45) in the latter category reflect the genetic heterogeneity and support DLD without any comorbidities and syndromic language disorder have an overlapping genetic etiology.

Roles of circular RNAs in osteogenic/osteoclastogenic differentiation.

The process of bone remodeling occurs and is regulated through interactions between osteoclasts, which resorb bone, and osteoblasts, which generate bone tissue. When the homeostatic balance between these two cell types is dysregulated, this can contribute to abnormal bone remodeling resulting in a loss of bone mass as is observed in osteoporosis (OP) and other forms of degenerative bone metabolic diseases. At present, details of molecular mechanism underlying the development of bone metabolic diseases such as OP remain to be elucidated. Circular RNAs (circRNAs) are small non-coding RNA molecules with a closed-loop structure that can regulate the differentiation of osteoclasts and osteoblasts. The present review provides a systematic overview of recent literature on the processes through which circRNAs regulate the dynamic balance between osteoblasts and osteoclasts that ultimately preserve bone homeostasis. It will also give insight that can shape current understanding of the pathogenesis of OP and other bone metabolic diseases to better guide diagnostic and treatment strategies for affected patients.

Policy responses to real world challenges associated with NEET youth: a scoping review

In the last decades, young people not in education or employment have become the focus of policy-makers worldwide, and there are high political expectations for various intervention initiatives. Despite the global focus, there is currently a lack of systemic knowledge of the factors supporting policy-making. Therefore, using scoping review methodology, a systematic literature overview of research findings in 2013–2021 on young people not in education or employment will be provided. The research revealed five categories to consider from a policy-making perspective: “NEET” as a concept, the heterogeneity of the target group, the impact of policies for young people, possible interventions, and factors influencing young people's coping strategies. Based on analysis, the target group requires applying the holistic principle where the young person is a unique person whose involvement in service creation supports the service's compliance with the actual needs of young people. To support young people, it is important to consider differences within a single social group; the interaction between the different site-based policies; young people's sense of self-perception and autonomy in entering support services; possible coping strategies and the need to provide support in a time and place-based flexible and caring environment through multidisciplinary teams. The study's results support the importance of implementation and the identification of existing opportunities of the EU's reinforced Youth Guarantee guidelines and point to possible future research topics related to the target group.

Vulnerability analysis in complex networks under a flood risk reduction point of view

The measurement and mapping of transportation network vulnerability to natural hazards constitute subjects of global interest for a sustainable development agenda and as means of adaptation to climate change. During a flood, some elements of a transportation network can be affected, causing the loss of lives. Furthermore, impacts include damage to vehicles, streets/roads, and other logistics services - sometimes with severe economic consequences. The Network Science approach may offer a valuable perspective considering one type of vulnerability related to network-type critical infrastructures: the topological vulnerability. The topological vulnerability index associated with an element is defined as reducing the network’s average efficiency due to removing the set of edges related to that element. In this paper, we present the results of a systematic literature overview and a case study applying the topological vulnerability index for the highways in Santa Catarina (Brazil). We produce a map considering that index and areas susceptible to urban floods and landslides. Risk knowledge, combining hazard and vulnerability, is the first pillar of an Early Warning System and represents an important tool for stakeholders of the transportation sector in a disaster risk reduction agenda.

Data mining techniques on astronomical spectra data – II. Classification analysis

ABSTRACT Classification is valuable and necessary in spectral analysis, especially for data-driven mining. Along with the rapid development of spectral surveys, a variety of classification techniques have been successfully applied to astronomical data processing. However, it is difficult to select an appropriate classification method in practical scenarios due to the different algorithmic ideas and data characteristics. Here, we present the second work in the data mining series – a review of spectral classification techniques. This work also consists of three parts: a systematic overview of current literature, experimental analyses of commonly used classification algorithms, and source codes used in this paper. First, we carefully investigate the current classification methods in astronomical literature and organize these methods into ten types based on their algorithmic ideas. For each type of algorithm, the analysis is organized from the following three perspectives. (1) their current applications and usage frequencies in spectral classification are summarized; (2) their basic ideas are introduced and preliminarily analysed; (3) the advantages and caveats of each type of algorithm are discussed. Secondly, the classification performance of different algorithms on the unified data sets is analysed. Experimental data are selected from the LAMOST survey and SDSS survey. Six groups of spectral data sets are designed from data characteristics, data qualities, and data volumes to examine the performance of these algorithms. Then the scores of nine basic algorithms are shown and discussed in the experimental analysis. Finally, nine basic algorithms source codes written in python and manuals for usage and improvement are provided.

Mesoporous Silica Nanoparticle-Based Drug Delivery Systems for the Treatment of Pancreatic Cancer: A Systematic Literature Overview.

Pancreatic cancer is a devastating disease with the worst outcome of any human cancer. Despite significant improvements in cancer treatment in general, little progress has been made in pancreatic cancer (PDAC), resulting in an overall 5-year survival rate of less than 10%. This dismal prognosis can be attributed to the limited clinical efficacy of systemic chemotherapy due to its high toxicity and consequent dose reductions. Targeted delivery of chemotherapeutic drugs to PDAC cells without affecting healthy non-tumor cells will largely reduce collateral toxicity leading to reduced morbidity and an increased number of PDAC patients eligible for chemotherapy treatment. To achieve targeted delivery in PDAC, several strategies have been explored over the last years, and especially the use of mesoporous silica nanoparticles (MSNs) seem an attractive approach. MSNs show high biocompatibility, are relatively easy to surface modify, and the porous structure of MSNs enables high drug-loading capacity. In the current systematic review, we explore the suitability of MSN-based targeted therapies in the setting of PDAC. We provide an extensive overview of MSN-formulations employed in preclinical PDAC models and conclude that MSN-based tumor-targeting strategies may indeed hold therapeutic potential for PDAC, although true clinical translation has lagged behind.

Genotoxicity of Mercury and Its Derivatives Demonstrated In Vitro and In Vivo in Human Populations Studies. Systematic Review.

Beside partial coverage in three reviews so far (1994, 2009, 2019), there is no review on genotoxic studies dealing with mercury (Hg) and human exposure using the most usual genotoxic assays: sister chromatid exchanges (SCE), chromosomal aberrations (CA), cytochalasin B blocked micronucleus assay (CBMN), and single-cell gel electrophoresis (SCGE or alkaline comet assay). Fifty years from the first Hg genotoxicity study and with the Minamata Convention in force, the genotoxic potential of Hg and its derivatives is still controversial. Considering these antecedents, we present this first systematic literature overview of genotoxic studies dealing with Hg and human exposure that used the standard genotoxic assays. To date, there is not sufficient evidence for Hg human carcinogen classification, so the new data collections can be of great help. A review was made of the studies available (those published before the end of October 2021 on PubMed or Web of Science in English or Spanish language) in the scientific literature dealing with genotoxic assays and human sample exposure ex vivo, in vivo, and in vitro. Results from a total of 66 articles selected are presented. Organic (o)Hg compounds were more toxic than inorganic and/or elemental ones, without ruling out that all represent a risk. The most studied inorganic (i)Hg compounds in populations exposed accidentally, occupationally, or iatrogenically, and/or in human cells, were Hg chloride and Hg nitrate and of the organic compounds, were methylmercury, thimerosal, methylmercury chloride, phenylmercuric acetate, and methylmercury hydroxide.

The Impact of Cannabidiol on Human Brain Function: A Systematic Review.

Background: Accumulating evidence suggests that the non-intoxicating cannabinoid compound cannabidiol (CBD) may have antipsychotic and anxiolytic properties, and thus may be a promising new agent in the treatment of psychotic and anxiety disorders. However, the neurobiological substrates underlying the potential therapeutic effects of CBD are still unclear. The aim of this systematic review is to provide a detailed and up-to-date systematic literature overview of neuroimaging studies that investigated the acute impact of CBD on human brain function. Methods: Papers published until May 2020 were included from PubMed following a comprehensive search strategy and pre-determined set of criteria for article selection. We included studies that examined the effects of CBD on brain function of healthy volunteers and individuals diagnosed with a psychiatric disorder, comprising both the effects of CBD alone as well as in direct comparison to those induced by ∆9-tetrahydrocannabinol (THC), the main psychoactive component of Cannabis. Results: One-ninety four studies were identified, of which 17 met inclusion criteria. All studies investigated the acute effects of CBD on brain function during resting state or in the context of cognitive tasks. In healthy volunteers, acute CBD enhanced fronto-striatal resting state connectivity, both compared to placebo and THC. Furthermore, CBD modulated brain activity and had opposite effects when compared to THC following task-specific patterns during various cognitive paradigms, such as emotional processing (fronto-temporal), verbal memory (fronto-striatal), response inhibition (fronto-limbic-striatal), and auditory/visual processing (temporo-occipital). In individuals at clinical high risk for psychosis and patients with established psychosis, acute CBD showed intermediate brain activity compared to placebo and healthy controls during cognitive task performance. CBD modulated resting limbic activity in subjects with anxiety and metabolite levels in patients with autism spectrum disorders. Conclusion: Neuroimaging studies have shown that acute CBD induces significant alterations in brain activity and connectivity patterns during resting state and performance of cognitive tasks in both healthy volunteers and patients with a psychiatric disorder. This included modulation of functional networks relevant for psychiatric disorders, possibly reflecting CBD’s therapeutic effects. Future studies should consider replication of findings and enlarge the inclusion of psychiatric patients, combining longer-term CBD treatment with neuroimaging assessments.

Corporate social responsibility as an element of good corporate governance a chronology of its historical and contemporary development

Despite many years of dedicated debates on the concepts of corporate social responsibility (CSR) and corporate governance, the question of whether CSR can now be regarded as part of good corporate governance due to underlying changes has not yet been adequately answered. This paper addresses this question by providing a systematic historical literature overview of the concept of CSR before considering it in the context of corporate governance. In this regard, the concept of corporate governance is outlined, and the theoretical basis and corresponding definitions are presented, followed by a comparison of the two concepts. A critical appraisal, predominantly from a European perspective, situates the concepts within the current context and identifies possible problem areas and/or particular challenges that could lead to a new characterisation of CSR as part of good corporate governance.

An assessment of the literature on cause-related marketing: implications for international competitiveness and marketing research

PurposeA substantial, albeit scattered, body of research evidence is accumulating in the cause-related marketing (CRM) research stream. Thus, there is a need of a systematic overview of extant literature to map and holistically understand the CRM domain.Design/methodology/approachTo address this issue and make progress in this important area, the authors systematically review and critically examine the state of academic research on CRM.FindingsBased on a systematic review of 105 journal articles published over the past 30 years, the results reveal that CRM research is a vibrant and rapidly growing domain in the broader marketing field. This assessment exercise also shows that the current state of knowledge about CRM is characterized by persisting knowledge gaps, conflicting empirical results, theoretical inconsistencies, as well as by the absence of international marketing research on the CRM domain.Originality/valueTherefore, the authors critically evaluate the extant CRM research with the aim of increasing its coherence, quality, scope, impact and international dimension. Based on this evaluation, the authors develop an ambitious research agenda that addresses a number of promising research paths embracing different international perspectives. Finally, the authors discuss the contributions to the literature and the implications for both academics and practitioners.

Integral Membrane Fatty Acid Desaturases: A Review of Biochemical, Structural, and Biotechnological Advances

AbstractSustainably produced platform chemicals are increasingly sought after. Fatty acids containing olefinic and hydroxy groups are particularly interesting as platform chemicals for regio‐ and stereo‐selective downstream reactions. Integral membrane fatty acid desaturases can selectively introduce double bonds or catalyze unusual reactions such as acetylenation, conjugation, hydroxylation, and epoxidation. Here, a systematic overview of recent achievements and key literature of integral membrane desaturases is provided in the context of biotechnological potential of the enzyme family.Practical Application: Integral membrane fatty acid desaturases may be the most promising tool to increase the scope of fatty acids as platform chemicals. Plant oil production is well researched and an established sustainable pathway toward high‐yield chemicals. In addition, effort is increasing toward creating microbial high‐yield oil producers. The current bottleneck is the limited fatty acid species that can be produced at high yields. It is envisioned that future enzyme engineering work will enable the targeted design of desaturases to produce modified fatty acids that follow industry needs. This review provides a systematic overview of the natural diversity and complexity of integral membrane fatty acid desaturases to help researchers expand existing fatty acid production beyond currently utilized fatty acid species.

204 - Social Health and Dementia

Mapping the complexity of factors influencing cognitive functioning in dementia with a special focus on social healthKarin Wolf-Ostermann, Prof. Dr., wolf-ostermann@uni-bremen.de, Health Sciences Bremen, University of Bremen, Germany.Henrik Wiegelmann, M.A., Health Sciences Bremen, University of Bremen, Germany, hwiegelmann@uni-bremen.deImke Seifert, M.A, Health Sciences Bremen, University of Bremen, Germany, imke.seifert@uni-bremen.deDorota Szczesniak, PhD, Department of Psychiatry, Wroclaw Medical University, Poland, dorota.szczesniak@umed.wroc.plMarta Lenart, Department of Psychiatry, Wroclaw Medical University, Poland, marta.lenart@umed.wroc.plMateusz Luc, Department of Psychiatry, Wroclaw Medical University, Poland, mateusz.luc@student.umed.wroc.plMarcin Pawlowski, Department of Psychiatry, Wroclaw Medical University, Poland, marcin.pawlowski@student.umed.wroc.plEtienne Rouwette, Prof. Dr., Radboud University, Nijmegen, The Netherlands, e.rouwette@fm.ru.nlAnsgar Gerhardus, Prof. Dr., Health Sciences Bremen, University of Bremen, Germany, ansgar.gerhardus@uni-bremen.deJoanna Rymaszewska, Prof. Dr., Department of Psychiatry, Wroclaw Medical University, Poland, joanna.rymaszewska@umed.wroc.pl and on behalf of the SHARED ConsortiumIntroduction:Over the past years the scientific discourse on health moved beyond unidimensional approaches, focusing on a more complex bio-psycho-social understanding. Regarding dementia and cognitive health, several studies have shown that various multidimensional factors (risk/protective) and their interactions, as well as existing individual and social resources, contribute to the heterogeneity observed for onset and further course of dementia. This presentation will a) give a systematic overview of causal factors in relation to the onset and progression of cognitive functioning and dementia b) show results of a first generic system dynamics model as Causal Loop Diagram (CLD) visualizing how different factors of the system are interrelated.Methods:A mixed methods approach was used. First, we conducted a systematic literature review on factors influencing cognitive health with an emphasis on social factors. Second, the Group Model Building (GMB) approach was used to further elaborate the knowledge base from the literature review and to start building a Causal Loop Diagram as a first comprehensive system dynamics working model. In a final third phase we integrated both strands, agreed on the knowledge base by stepwise discursive consensus and created the CLD.Results:The CLD model includes 73 unique factors directly or indirectly influencing cognitive functioning. Those factors show the basic causal structure of the interplay of variables present in the development and trajectory of dementia. These factors could be grouped into six thematic/disciplinary clusters, such as personal factors, socioeconomic factors, lifestyle factors, neuro -bio-medical factors, environmental factors and social health factors. The model indicates a significant role of social health indicators for cognitive health in dementia.Conclusion:The generic CLD model reflects the knowledge of a multidisciplinary group of researchers, merged with results from a systematic literature overview and supplemented by discussion and iterative feedback processes. The mixed methods approach as well as the integration of system thinking methods turned out to be a reasonable approach to develop and graphically represent the complex structure of factors influencing cognitive functioning in dementia. This model facilitates the development of novel hypotheses about causal relationships between social health and dementia.

Overall Equipment Effectiveness: Systematic Literature Review and Overview of Different Approaches

Overall equipment effectiveness (OEE) is a key performance indicator used to measure equipment productivity. The purpose of this study is to review and analyze the evolution of OEE, present modifications made over the original model and identify future development areas. This paper presents a systematic literature review; a structured and transparent study is performed by establishing procedures and criteria that must be followed for selecting relevant evidences and addressing research questions effectively. In a general search, 862 articles were obtained; after eliminating duplicates and applying certain inclusion and exclusion criteria, 186 articles were used for this review. This research presents three principal results: (1) The academic interest in this topic has increased over the last five years and the keywords have evolved from being related to maintenance and production, to being related to lean manufacturing and optimization; (2) A list of authors who have developed models based on OEE has been created; and (3) OEE is an emerging topic in areas such as logistics and services. To the best of our knowledge, no comparable review has been published recently. This research serves as a basis for future relevant studies.

An integrated framework of factors affecting energy-related user behaviour

ABSTRACT The structure of this paper builds upon current knowledge in the area of energy use and the necessity to develop a holistic conceptual framework as a guide for a variety of energy-related behavior analyses. This research is based on a systematic overview of scientific literature with a focus on energy-related behavior. The main objective of this research was to identify factors affecting energy consumption and energy conservation patterns among users, as well as to reveal energy-related behavior presence in the scientific literature. The contribution of this paper comes from the new observation perspective with a unified and integrated framework of factors affecting energy-related user behavior. Therefore, the framework proposed in this paper combines relevant factors to achieve significant conclusions based on an analytical approach in terms of psychological and energy technology point of view. Lastly, the influencing factors were categorised into four main categories, namely socio-demographic, situational, and individual factors as well as previous experience.

Hyperspectral Imaging and the Retina: Worth the Wave?

PurposeHyperspectral imaging is gaining attention in the biomedical field because it generates additional spectral information to study physiological and clinical processes. Several technologies have been described; however an independent, systematic literature overview is lacking, especially in the field of ophthalmology. This investigation is the first to systematically overview scientific literature specifically regarding retinal hyperspectral imaging.MethodsA systematic literature review was conducted, in accordance with PRISMA Statement 2009 criteria, in four bibliographic databases: Medline, Embase, Cochrane Database of Systematic Reviews, and Web of Science.ResultsFifty-six articles were found that meet the review criteria. A range of techniques was reported: Fourier analysis, liquid crystal tunable filters, tunable laser sources, dual-slit monochromators, dispersive prisms and gratings, computed tomography, fiber optics, and Fabry-Perrot cavity filter covered complementary metal oxide semiconductor. We present a narrative synthesis and summary tables of findings of the included articles, because methodologic heterogeneity and diverse research topics prevented a meta-analysis being conducted.ConclusionsApplication in ophthalmology is still in its infancy. Most previous experiments have been performed in the field of retinal oximetry, providing valuable information in the diagnosis and monitoring of various ocular diseases. To date, none of these applications have graduated to clinical practice owing to the lack of sufficiently large validation studies.Translational RelevanceGiven the promising results that smaller studies show for hyperspectral imaging (e.g., in Alzheimer's disease), advanced research in larger validation studies is warranted to determine its true clinical potential.