By combining model testing and numerical simulation, this paper focuses on the influence of landslides on tunnels in loess-bedrock strata by using the perfect landslide–tunnel system (LTS). A mechanical test and simulation (MTS) system was used to provide thrust for loading and unloading the trailing edge of the slope. A Particle Image Velocimetry (PIV) and 32 cluster strain gauges were adopted to monitor the deformation of the tunnel structure and landslide soil, and the sliding surface, respectively. By means of a numerical simulation, the deformation characteristics of a tunnel crossing loess-bedrock strata are comprehensively described. The influence of a cyclic load on the mechanical behavior and displacement of the tunnel and sliding surface is discussed in detail. The experimental results show that the thrust required for the first landslide is the largest, during multiple loading and unloading. With the increase in loading and unloading time, the sliding thrust gradually decreases and eventually remains stable. The landslide presents a progressive failure mode. There is a stress concentration in the upper part of the tunnel, which causes the secondary sliding phenomenon. The deformation of the sliding surface mainly occurs in the upper soil of the tunnel. The deformation direction of the tunnel is consistent with the sliding direction, and the deformation of the sliding surface mainly occurs in the soil above the tunnel. When disturbed by an external force, the tunnel deforms downward, and, when unloaded, the tunnel has a small rebound deformation. However, with the increase in loading–unloading times, the rebound deformation of the tunnel gradually decreases, and the permanent deformation gradually accumulates until the tunnel fails. The research results can provide reference for the construction and protection of tunnel engineering in loess regions, and have reference value for the control of tunnels crossing landslides.