The article examines the history of religions of the Turkic past, Islamic Renaissance, Tsarist imperialism, Soviet atheism, and nowadays. The author analyzes constitutional and special laws, describes religious diversity and cultural pluralism, examines the system and institutions of religious education, identifies the main reasons for the radicalization of the two countries. He pays special attention to the specifics of the manifestation of religious radicalism in each of the two countries, their approaches to this problem and ways of countering the terrorist threat, and systematizes the opinions of various scientists. The negative consequences of historical and political events on the religious life of the Uzbek and Kazakh societies are determined. The choice of these states is due to the similarity of their history, culture, and political system. A comparative analysis of the state of interfaith relations in Uzbekistan and Kazakhstan is carried out according to the following criteria: historical stages, legislative and legal framework, religious associations, religious education, the problem of religious extremism and fundamentalism. The purpose of the article is to determine the features of the interaction of the authorities with religious and confessional structures, to identify the main problems of interfaith relations and the religious situation in general. This study contributes to a better understanding of ethno-confessional and inter-confessional politics in modern realities, as well as an analysis of the state and forecast of the prospects for the development of tolerant inter-confessional relations in Uzbekistan and Kazakhstan in the context of religious pluralism, globalism, and actual challenges of the postmodern era. It is necessary to gradually strengthen the legislative, political and socio-economic base, which will be aimed at the secular path of development of our countries, without prejudice to confessions and religious organizations, which are separated from the state by definition. In the Turkic period history of Central Asia, many concrete examples testify to the positive experience of historically peaceful coexistence of various religions in the Central Asian Turkic-Muslim region. These historical facts should and can positively influence the further strengthening of interreligious cooperation and harmony