Simultaneous Measurement System Research Articles

Portable six-channel laser speckle system for simultaneous measurement of cerebral blood flow and volume with potential applications in characterization of brain injury.

Cerebral blood flow (CBF) and cerebral blood volume (CBV) are key metrics for regional cerebrovascular monitoring. Simultaneous, non-invasive measurement of CBF and CBV at different brain locations would advance cerebrovascular monitoring and pave the way for brain injury detection as current brain injury diagnostic methods are often constrained by high costs, limited sensitivity, and reliance on subjective symptom reporting. We aim to develop a multi-channel non-invasive optical system for measuring CBF and CBV at different regions of the brain simultaneously with a cost-effective, reliable, and scalable system capable of detecting potential differences in CBF and CBV across different regions of the brain. The system is based on speckle contrast optical spectroscopy and consists of laser diodes and board cameras, which have been both tested and investigated for safe use on the human head. Apart from the universal serial bus connection for the camera, the entire system, including its battery power source, is integrated into a wearable headband and is powered by 9-V batteries. The temporal dynamics of both CBF and CBV in a cohort of five healthy subjects were synchronized and exhibited similar cardiac period waveforms across all six channels. The potential use of our six-channel system for detecting the physiological sequelae of brain injury was explored in two subjects, one with moderate and one with significant structural brain damage, where the six-point CBF and CBV measurements were referenced to structural magnetic resonance imaging (MRI) scans. We pave the way for a viable multi-point optical instrument for measuring CBF and CBV. Its cost-effectiveness allows for baseline metrics to be established prior to injury in populations at risk for brain injury.

A System for Simultaneous Measurement of Hysteresis Loops and Barkhausen Noise in Amorphous Ferromagnetic Ribbons

A System for Simultaneous Measurement of Hysteresis Loops and Barkhausen Noise in Amorphous Ferromagnetic Ribbons

FDM-assisted OA-CEAS system for simultaneous measurements of temperature, CO2, and CO in flames

A system based on off-axis cavity enhanced absorption spectroscopy (OA-CEAS) integrated with frequency division multiplexing (FDM)-assisted wavelength modulation spectroscopy (WMS) was developed for simultaneous measurements of temperature, CO2, and CO in flames by employing two distributed feedback (DFB) diode lasers at 2.0 µm and 2.3 µm. An integrated cavity with an open-path configuration was made up of two cavity mirrors with a reflectivity of 99.8 %, and an effective optical absorption path length of approximately 5.2 m was achieved within a 6 cm diameter flame region. A CO2 line pair at 4990.418 cm−1 and 4990.664 cm−1, along with a CO line at 4300.699 cm−1, were selected as the measurement targets. The system was initially calibrated in a heated static cell and subsequently tested in C2H4/air premixed flat flames for six different equivalence ratios. All concentrations measured by the 1f-normalized 2f signals were compared with the results obtained from both the direct absorption signals and simulations based on adiabatic chemical equilibrium calculations using Chemkin. Additionally, the measured temperatures were compared with the thermocouple readings. According to the measurements conducted at representative C2H4 flames with different equivalence ratios, the accuracies for the measurements of temperature, CO2 concentrations, and CO concentrations were ∼1.062 %, ∼1.082 %, and ∼1.052 %, respectively. All the measurements illustrate the potential of the system for combustion diagnosis.

Simultaneous detection of soot, temperature, and C2H2 in laminar premixed flames using a multi-pass diode laser absorption spectrometer.

We report the development of a multi-pass diode laser absorption spectroscopy system for simultaneous measurements of soot volume fraction (SVF), temperature, and C2H2 concentration using a single diode laser near 1.543 µm. A line-shaped beam spot pattern is chosen for the open-path Herriott multi-pass cavity, enabling sensitive detection at various heights above the burner with an effective optical absorption path length of approximately 1.2 m in a 6 cm diameter flame region. The gas parameters (temperature and C2H2 concentration) and the SVF are determined from the absorption spectra of the target C2H2 line pair and the laser extinction of the soot, which can be extracted from the detected signal, respectively. The performance of the system was confirmed in laminar premixed ethylene and air (C2H4/air) sooting flames produced by a standard bronze plug McKenna burner at four representative equivalence ratios. All the measurement results were compared with the two-dimensional (2D) computational fluid dynamics (CFD) simulations using a skeletal mechanism with the Moss-Brookes model. The good quantitative and qualitative agreement between the TDLAS measurements and 2D CFD simulations confirms the powerful capability of the developed system.

Enzyme-Modified Microelectrode for Simultaneous Local Measurements of O2 and pH.

The use of miniaturized probes opens a new dimension in the analysis of (bio)chemical processes, enabling the possibility to perform measurements with local resolution. In addition, multiparametric measurements are highly valuable for a holistic understanding of the investigated process. Therefore, different strategies have been suggested for simultaneous local measurements of various parameters. Electroanalytical methods are a powerful strategy in this direction. However, they have been mainly restricted to coupling concurrent independent measurements with different miniaturized probes. Here, we present an enzymatic microbiosensor for the simultaneous detection of O2 and pH. The sensing strategy is based on the pH-dependent bioelectrocatalytic process associated with O2 reduction at a gold microelectrode modified with a multicopper oxidase. After initial investigations of the bioelectrocatalytic reaction over gold macroelectrodes, the fabrication and characterization of micrometer-sized probes are presented. The microbioelectrode exhibits a linear current increase with O2 concentration extending to 17.2 mg L-1, with a sensitivity of (5.56 ± 0.13) nA L mg-1 and a limit of detection of (0.5 ± 0.3) mg L-1. Moreover, a linear response allowing pH detection is obtained between pH 5.2 and 7.5 with a slope of -(47 ± 8) mV per pH unit. In addition, two proof-of-concept analytical examples are shown, demonstrating the capability of the developed sensing system for simultaneous local measurements of O2 and pH. Compared with other miniaturized probes reported before for simultaneous detection, our strategy stands out as the two investigated parameters are acquired from the very same measurement. This strategy greatly simplifies the analytical setup and for the first time provides truly simultaneous local detection in the micrometer scale.

Multi-channel simultaneous emission non-invasive flow measurement system

Multi-channel simultaneous emission non-invasive flow measurement system

Potential multi-parametric OFDR system based on the wavelength-division cross-correlation method

In this study, an optical frequency domain reflectometer (OFDR) system for simultaneous measurement of temperature, strain, and relative humidity (RH) based on the wavelength-division cross-correlation method is proposed and experimentally demonstrated. The Rayleigh scattered spectrum shifts introduced by environmental changes can be demodulated by the cross-correlation operation, and the magnitude of the shifts exhibits variability in distinct wavelength subregions. Leveraging the distinct sensitivity characteristics of different parameters across different wavelength subregions, simultaneous multi-parameter decoupling can be achieved. In the signal processing flow, the frequency domain signals in different wavelength subregions are intercepted, and then the cross-correlation operation is performed separately to obtain the spectrum shift information in different wavelength subregions. The decoupling matrix is constructed to realize the decoupling of the three parameters based on the sensitivity differences of temperature, strain, and RH in different wavelength subregions. This novel and simple multi-parameter sensing system, to the best of our knowledge, has potential applications in engineering monitoring, chemical applications, and environmental measurements.

Upgrade of the ion beam analysis end-station with the wavelength dispersive X-ray spectrometer for use with the focused MeV ion beams

A novel modular end-station has been developed for use with focused MeV ion beams. It supports analysis of micro-samples using simultaneously several ion beam analysis (IBA) techniques, including wavelength dispersive (WD) and energy dispersive (ED) Particle Induced X-ray Emission (PIXE) spectrometry, Elastic Backscattering Spectrometry (EBS and RBS) and Nuclear Reaction Analysis (NRA). The end-station enables quantitative elemental analysis, including the creation of two-dimensional elemental maps based on the ED-PIXE and EBS/RBS/NRA measurements. The in-house developed wavelength dispersive X-ray (WDX) spectrometer can measure high energy resolution spectra on selected sample micro-regions. In this work the description of the modular end-station is presented, highlighting the features of the WDX spectrometer: i) in the complementary analysis of complex ED X-ray spectra with many overlapping peaks measured simultaneously and ii) in chemical speciation studies. An example is presented to demonstrate the capabilities of the modular system for simultaneous analytical measurements of selected heterogeneous micro-samples.

Plasma-assisted NH3/air flame: Simultaneous LIF measurements of O and OH

In the emerging field of plasma-assisted ammonia (NH3) combustion, the evolution of key intermediate species has rarely been reported. This work establishes a simultaneous measurement system of laser-induced fluorescence (LIF) for hydroxyl (OH) and quantitative two-photon-absorption LIF for atomic oxygen (O), to explore the OH and O dynamics in an NH3/air flame affected by a nanosecond (ns) pulsed plasma discharge. Firstly, with the plasma on, the molar fraction of O is quantified to reach 8.7 × 10–3 in the burnt zone, about two orders of magnitude higher than that without plasma. In addition, the OH LIF signal intensity is four times higher, indicating a significant kinetic enhancement. Then, the spatial characteristics of OH and O are discussed and compared, showing remarkable discrepancy. The discrepancy between them indicates that O production is dominated by plasma kinetics, however, the OH production, primarily stemming from reactions between O and NH3/H2O, still depends on parameters associated with combustion kinetics. We further study the temporal dynamics of O and OH. It is concluded that O and OH peaks at 1.75 μs are mainly attributed to the pathway of quenching of the excited species. After that, O and OH start to decay but show significant differences between unburnt and burnt zones, which are characterized by a single-exponential decay and a bi-exponential decay, respectively. In the unburnt zone, the OH decay is much slower than the O decay due to the diverse pathways for OH production. In the burnt zone, the bi-exponential decay of O and OH can essentially be regarded as a process in which the NH3/air reactive system reaches chemical equilibrium. At this stage, the impacts of the excited species from the plasma gradually diminish and combustion kinetics dominates alone.

Design of a Transformer Oil Viscosity, Density, and Dielectric Constant Simultaneous Measurement System Based on a Quartz Tuning Fork.

Transformer oil, crucial for transformer and power system safety, demands effective monitoring. Aiming to address the problems of expensive and bulky equipment, poor real-time performance, and single parameter detection of traditional measurement methods, this study proposes a quartz tuning fork-based simultaneous measurement system for online monitoring of the density, viscosity, and dielectric constant of transformer oil. Based on the Butterworth-Van Dyke quartz tuning fork equivalent circuit model, a working mechanism of transformer oil density, viscosity, and dielectric constant was analyzed, and a measurement model for oil samples was obtained. A miniaturized simultaneous measurement system was designed based on a dedicated chip for vector current-voltage impedance analysis for data acquisition and a Savitzky-Golay filter for data filtering. A transformer oil test platform was built to verify the simultaneous measurement system. The results showed that the system has good repeatability, and the measurement errors of density, viscosity, and dielectric constant are lower than 2.00%, 5.50%, and 3.20%, respectively. The online and offline results showed that the system meets the requirements of the condition maintenance system for online monitoring accuracy and real-time detection.

A compact detector system for simultaneous measurements of the light yield non-linearity and timing properties of scintillators

This work presents an outline of a detection system that employs the Compton spectrometer method to assess the non-linearity of scintillator light yield. A novel approach is introduced, leading to more accurate measurements through the separate determination of the intrinsic light output parameters and the non-linearity of the scintillators. Key features of this system include the use of a portable scintillation detector with three photomultiplier tubes for precise measurement of the average number of detected photoelectrons and the incorporation of recent advancements in correction techniques for accidental coincidences. The integration of digital acquisition, offline data analysis, and geometric adaptation reduces the time required to perform a measurement. The developed detector can simultaneously measure different timing properties, as well as the relative intensities following ionization excitation in a scintillator. The system’s performance is demonstrated through measurements of the light yield dependence on the deposited energy for commercially available liquid, plastic, and inorganic scintillators. Such instrumentation serves as a valuable tool in the development of novel scintillating materials, including liquid or solid organic scintillators, inorganic scintillators, and composite scintillators for electron detection, in addition to traditional X-ray or γ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\gamma$$\\end{document}-ray detection.

Miniature, multi-dichroic instrument for measuring the concentration of multiple fluorophores.

Identification of tumour margins during resection of the brain is critical for improving the post-operative outcomes. Due to the highly infiltrative nature of glioblastoma multiforme (GBM) and limited intraoperative visualization of the tumour margin, incomplete surgical resection has been observed to occur in up to 80 % of GBM cases, leading to nearly universal tumour recurrence and overall poor prognosis of 14.6 months median survival. This research presents a miniaturized, SiPMT-based optical system for simultaneous measurement of powerful DRS and weak auto-fluorescence for brain tumour detection. The miniaturisation of the optical elements confined the spatial separation of eight select wavelengths into footprint measuring 1.5 × 2 × 16 mm. The small footprint enables this technology to be integrated with existing surgical guidance instruments in the operating room. It's dynamic ability to subtract any background illumination and measure signal intensities across a broad range from pW to mWs make this design much more suitable for clinical environments as compared to spectrometer-based systems with limited dynamic ranges and high integration times. Measurements using optical tissue phantoms containing mixed fluorophores demonstrate correlation coefficients between the fitted response and actual concentration using PLS regression being 0.95, 0.87 and 0.97 for NADH, FAD and PpIX , respectively. These promising results indicate that our proposed miniaturized instrument could serve as an effective alternative in operating rooms, assisting surgeons in identifying brain tumours to achieving positive surgical outcomes for patients.

A triple-imaging-modality system for simultaneous measurements of prompt gamma photons, prompt x-rays, and induced positrons during proton beam irradiation

Objective. Prompt gamma photon, prompt x-ray, and induced positron imaging are possible methods for observing a proton beam’s shape from outside the subject. However, since these three types of images have not been measured simultaneously nor compared using the same subject, their advantages and disadvantages remain unknown for imaging beam shapes in therapy. To clarify these points, we developed a triple-imaging-modality system to simultaneously measure prompt gamma photons, prompt x-rays, and induced positrons during proton beam irradiation to a phantom. Approach. The developed triple-imaging-modality system consists of a gamma camera, an x-ray camera, and a dual-head positron emission tomography (PET) system. During 80 MeV proton beam irradiation to a polymethyl methacrylate (PMMA) phantom, imaging of prompt gamma photons was conducted by the developed gamma camera from one side of the phantom. Imaging of prompt x-rays was conducted by the developed x-ray camera from the other side. Induced positrons were measured by the developed dual-head PET system set on the upper and lower sides of the phantom. Main results. With the proposed triple-imaging-modality system, we could simultaneously image the prompt gamma photons and prompt x-rays during proton beam irradiation. Induced positron distributions could be measured after the irradiation by the PET system and the gamma camera. Among these imaging modalities, image quality was the best for the induced positrons measured by PET. The estimated ranges were actually similar to those imaged with prompt gamma photons, prompt x-rays and induced positrons measured by PET. Significance. The developed triple-imaging-modality system made possible to simultaneously measure the three different beam images. The system will contribute to increasing the data available for imaging in therapy and will contribute to better estimating the shapes or ranges of proton beam.

Pitot Tube Sensor Probe System for Simultaneous Airflow and Pressure Measurement of Expiration Inside Pulmonary Airway

Respiratory diseases, including the cronic obstructive pulmonary disease (COPD) are among the leading causes of death worldwide. To date, there is no physical examination procedure that can quantify important parameters within a specific lesion area inside the lung. In this study, we propose a novel sensor probe system consisting of a basket forceps and 2 pressure sensors to simultaneously measure the expiratory airflow and the static pressure inside the pulmonary airway. A Pitot tube mechanism using 2 pressure sensors is introduced in the system for measuring both the physical quantities. Small fiber‐optic pressure sensors with 0.3 mm diameter were utilized, and both the airflow rate and the static pressure characteristics were evaluated for obtaining the calibration curves. Finally, the proposed sensor system was implemented to measure both the airflow and pressure in an artificial ventilator and an experimental animal. The measurement of expired airflow and static pressure inside the airway of a rat with the diameter of 1.8 mm were demonstrated. © 2024 Institute of Electrical Engineer of Japan and Wiley Periodicals LLC.

Clinical PDT dose dosimetry for pleural Photofrin-mediated photodynamic therapy.

Photodynamic therapy (PDT) is an established cancer treatment utilizing light-activated photosensitizers (PS). Effective treatment hinges on the PDT dose-dependent on PS concentration and light fluence-delivered over time. We introduce an innovative eight-channel PDT dose dosimetry system capable of concurrently measuring light fluence and PS concentration during treatment. We aim to develop and evaluate an eight-channel PDT dose dosimetry system for simultaneous measurement of light fluence and PS concentration. By addressing uncertainties due to tissue variations, the system enhances accurate PDT dosimetry for improved treatment outcomes. The study positions eight isotropic detectors strategically within the pleural cavity before PDT. These detectors are linked to bifurcated fibers, distributing signals to both a photodiode and a spectrometer. Calibration techniques are applied to counter tissue-related variations and improve measurement accuracy. The fluorescence signal is normalized using the measured light fluence, compensating for variations in tissue properties. Measurements were taken in 78 sites in the pleural cavities of 20 patients. Observations reveal minimal Photofrin concentration variation during PDT at each site, juxtaposed with significant intra- and inter-patient heterogeneities. Across 78 treated sites in 20 patients, the average Photofrin concentration for all 78 sites is , with a median concentration of . The average PDT dose for all 78 sites is , with a median dose of . A significant variation in PDT doses is observed, with a maximum difference of 3.1 times among all sites within one patient and a maximum difference of 9.8 times across all patients. The introduced eight-channel PDT dose dosimetry system serves as a valuable real-time monitoring tool for light fluence and PS concentration during PDT. Its ability to mitigate uncertainties arising from tissue properties enhances dosimetry accuracy, thus optimizing treatment outcomes and bolstering the effectiveness of PDT in cancer therapy.

New System for Simultaneous Measurement of Oxygen Consumption and Changes in Wine Color.

The design, construction and validation of a device for the accurate measurement of the dissolved oxygen content in wine and simultaneously the variation of its spectral fingerprint is presented. The novelty of this system is due to two innovative approaches. First, robustness in measurements is obtained by using cuvettes designed to simultaneously measure the dissolved oxygen and color. Secondly, automatic monitoring is performed to ensure that measurements are always taken at the same cuvette position. The fine-tuning of the device with the study of white and red wines makes it possible, on the one hand, to establish the appropriate measurement conditions and, on the other hand, to determine the amount of oxygen required to cause specific changes in the wine spectrum, information that could not be obtained until now. The preliminary results are very interesting, presenting precise data on the amount of oxygen consumed by the wine and the variations in its visible spectrum, thus reflecting the modification of the responsible phenolic compounds. This information is of great interest, since it helps to optimize the handling of the wine and, if necessary, to moderate the uptake of oxygen in each type of wine to ensure the maintenance of the color during the winemaking and conservation processes of each type of wine. The results of the experiments indicate that this new instrument is feasible and accurate for detecting oxygen changes during wine production.

Multichannel resonant acoustic rheometry system for quantification of coagulation of multiple human plasma samples

Resonant Acoustic Rheometry (RAR), a newly developed ultrasound-based technique for non-contact characterization of soft viscoelastic materials, has shown promise for quantitative viscoelastic assessment of temporally changing soft biomaterials in real time, and may be used to monitor blood coagulation process. Here, we report the development of a novel, multichannel RAR (mRAR) system for simultaneous measurements of multiple temporally evolving samples and demonstration of its use for monitoring the coagulation of multiple small-volume plasma samples. The mRAR system was constructed using an array of 4 custom-designed ultrasound transducers at 5.0 MHz and a novel electronic driving system that controlled the generation of synchronized ultrasound pulses for real time assessment of multiple samples simultaneously. As a proof-of-concept of the operation of the mRAR system, we performed tests using pooled normal human plasma samples and anti-coagulated plasma samples from patients treated with warfarin with a range of International Normalized Ratio (INR) values as well-characterized samples with different coagulation kinetics. Our results show that simultaneous tracking of dynamic changes in 4 plasma samples triggered by either kaolin or tissue factor was achieved for the entire duration of coagulation. The mRAR system captured distinct changes in the samples and identified parameters including the clotting start time and parameters associated with the stiffness of the final clots that were consistent with INR levels. Data from this study demonstrate the feasibility of the mRAR system for efficient characterization of the kinetic coagulation processes of multiple plasma samples.

Single-channel system for joint unambiguous measurement of DFS and AOA based on serrodyne modulation.

In this paper, a photonic-assisted system for simultaneous and unambiguous measurement of the Doppler frequency shift (DFS) and angle-of-arrival (AOA) using a dual-parallel dual-drive Mach-Zehnder modulator (DP-DDMZM) is proposed and investigated. The echo signals received by two receiving antennas are applied to the radio frequency ports of one sub-DDMZM of the DP-DDMZM. The bias port of the sub-DDMZM is fed by a binary electrical signal that is used to construct two different mapping curves on the relationship between the phase difference and the power of the output intermediate frequency (IF) signal. Therefore, unambiguous AOA measurement with extended range can be realized. The transmitted signal is input into the other sub-DDMZM to implement single-sideband modulation, which is then frequency shifted based on serrodyne modulation. Both the value and direction of DFS can be derived intuitively from the frequency of the output IF signal. Simulation results show that the measurement error of unambiguous DFS measurement is no more than ±0.008H z in the range of -100k H z to 100kHz, and the measurement error of unambiguous AOA is less than ±0.2∘ in the range of -70.8∘ to 70.8°. Moreover, since the scheme does not involve the construction of multi-channels or use of any filter or polarization dependent device, the system has concise structure, high accuracy, large operating bandwidth, and strong robustness, and can be considered as a very promising solution for actual applications.

Experimental and numerical study on the falling film flow process on the outer wall of dome cylinder

The passive containment cooling system (PCCS) is crucial for ensuring the safety of nuclear power plants, and the thickness and temperature of the falling film on its outer wall are important parameters that determine the heat and mass transfer performances. In this paper, a compact liquid film thickness and temperature simultaneous measurement system was developed to provide a measurement method, which is based on the absorption spectroscopy technology, and then the measurement accuracy was verified by using a calibration tool. The results showed that the mean relative error of the liquid film thickness and temperature measurements from the known values were about 3.4% and 0.4%, respectively. On this basis, this system was used to study the falling film process on the outer wall of the dome cylinder analogous to the containment under different working conditions and combined with numerical simulation for comparison. The results showed that the two methods have good consistency. The variation of the liquid film heat transfer coefficient for various operating conditions was further analyzed. It was found that the average thickness of the falling film is positively correlated with the liquid flow rate, but negatively correlated with the temperature and heat transfer coefficient. In summary, this system can accurately study the falling film process on the outer wall of the dome cylinder, which is expected to accurately analyze the heat and mass transfer process in the PCCS and provide data support for its design and optimization.

Feature-constrained real-time simultaneous monitoring of monocular vision odometry for bridge bearing displacement and rotation

The displacement and rotation are critical indicators of bridge's health, especially for the key components of the bridge such as bridge bearings. This study presents a real-time simultaneous measurement method of bridge bearing displacement and rotation to realize round-the-clock structure monitoring. The main contributions include: (1) A displacement and rotation simultaneous measurement algorithm and system is developed based on feature-constrained monocular visual odometry (VO), which uses image sequences of infrared array lamp targets with multiple feature constraints as visual input to construct the mathematical relationship between displacement and rotation and coordinate system transformation matrix. (2) A two-step parameter optimization strategy is proposed based on adaptive multi-window centroid array tracking and transformation matrix purification and refinement, effectively improving displacement and rotation measurement accuracy and robustness. The effectiveness of the proposed method is verified in the laboratory experiment and the actual bridge bearing monitoring of the Huangpu Pearl River Bridge.