Features Of System Research Articles

Photonic generation and transmission of dual-band double-TBWP chirped microwave waveforms with frequency multiplication and immunity to dispersion-induced power fading

A novel photonic approach for generating and transmitting dual-band double-time bandwidth product (TBWP) chirped microwave waveforms with frequency multiplication and immunity to dispersion-induced power fading is proposed. Utilizing an integrated dual-drive dual-parallel Mach-Zehnder modulator (DD-DPMZM), single-sideband modulation of the RF input and suppression of odd-order optical sidebands are achieved. By adjusting the RF input's centre frequency and the DD-DPMZM's bias voltages, dual-band waveforms with frequency multiplication are realized, enabling transmission through optical fibres without dispersion-induced power fading. Experimental validation demonstrates successful transmission over dispersion compensation modules equivalent to 60 km or 20 km of single-mode fibre. The proposed system features a simplified architecture, reconfigurability, and robust anti-dispersion capabilities, making it highly suitable for distributed multi-band radar networks over optical fibre links.

Characterization of Silica Sand-Based Pervious Bricks and Their Performance under Stormwater Treatment

The acceleration of urbanization has disrupted natural water cycles, resulting in increased impervious urban surfaces and non-point source pollution from stormwater runoff. Addressing urban stormwater recharge has become crucial. This study introduces a novel silica sand-based permeable filtration material, investigating its surface characteristics, pore structure, permeability, and pollutant interception capabilities. The results demonstrate that hydrophilic binder coating modification of the permeable surface sand aggregate, combined with hydrophilic inorganic additives, having a porous structure with an average pore size of less than 50 μm and a porosity between 15% and 35%, significantly enhances surface hydrophilicity, achieving a permeation rate of up to 6.8 mL/(min·cm²). Moreover, it shows exceptional filtration and anti-clogging properties, achieving over 98% suspended solids interception and strong resistance to fouling. Dynamic biofilm formation experiments using simulated rain and domestic wastewater explore biofilm morphology and function on silica sand filtration well surfaces. Mature biofilms sustain COD removal efficiency exceeding 70%, with levels consistently below 50 mg/L, NH4+ decreasing to 2 mg N/L, and total nitrogen maintained below 10 mg N/L. The system features anoxic, anoxic, and aerobic zones, fostering synergistic organic matter and nitrogen removal by diverse microorganisms, enhancing pollutant mitigation. Silica sand-based permeable filtration material effectively mitigates urban stormwater runoff pollutants—suspended solids, organic matter, and nitrogen—offering an innovative solution for sponge city development and rainwater resource management.

3D printed Ti3C2@Polymer based artificial forest for autonomous water harvesting system

The escalating scarcity of freshwater resources presents significant challenges to global sustainability, demanding innovative solutions by integrating cutting-edge materials and technologies. Here we introduce an autonomous artificial forest (3D AF) for continuous freshwater acquisition. This system features a three-dimensional (3D) architecture incorporating a carbon nanofiber (CNF) network and MXene@polypyrrole (Ti3C2@PPy), enhancing surface area, light absorption, heat distribution, and surface wettability to improve solar vapor generation and fog collection efficiency. The autonomous operation is facilitated by an integrated photothermal actuator that adjusts to the day and night conditions. During daylight, the 3D AF tilts downward to maximize solar exposure for water evaporation, while at night, it self-adjusts to optimize fog particle collection. Notably, our device demonstrates the ability to harvest over 5.5 L m−2 of freshwater daily outdoors. This study showcases the potential of integrating advanced materials and technologies to address pressing global freshwater challenges, paving the way for future innovations in water harvesting.

Experimental research on chemisorption energy storage performance for industrial waste heat recovery and conversion

This study investigates a solid chemisorption energy storage system utilizing a multi-component chloride salt composite adsorbent with a mass ratio of NH4Cl, CaCl2, MnCl2, and expanded natural graphite treated with sulfuric acid (ENG-TSA). The system features a shell-and-tube heat exchanger and analyzes refrigeration and heat storage performance under varying industrial low-temperature waste heat (60–110 °C) conditions, with condensation and evaporation temperatures of 0–25 °C and discharging temperatures of 40–60 °C. The results indicate that the multi-salt composite adsorbent reduces hysteresis between adsorption and desorption stages. The highest coefficient of performance (COP) and specific cooling power (SCP) were 0.461 and 328 W/kg, respectively, at an evaporation temperature of 25 °C and a charging temperature of 110 °C. Excessively long cycle times negatively affect system efficiency, with optimal performance achieved at a 40-min cycle. The findings highlight the system's effectiveness for industrial low-grade waste heat recovery, providing a solid foundation for future reactor design and material selection.

Trends and determinants of the use of episiotomy in a prospective population-based registry from central India

BackgroundFindings from research and recommendations from the World Health Organization favor restrictive use of episiotomy, but whether this guidance is being followed in India, and factors associated with its use, are not known. This study sought to document trends in use of episiotomy over a five-year period (2014–2018); to examine its relationship to maternal, pregnancy, and health-system characteristics; and to investigate its association with other obstetric interventions.MethodsWe conducted a secondary analysis of data collected by the Maternal Newborn Health Registry, a prospective population-based pregnancy registry established in Central India (Nagpur, Eastern Maharashtra). We examined type of birth and use of episiotomy in vaginal deliveries from 2014 to 2018, as well as maternal and birth characteristics, health systems factors, and concurrent obstetric interventions associations with its use with multivariable Poisson regression models.ResultsDuring the five-year interval, the rate of episiotomy in vaginal birth rose from 13 to 31% despite a decline in assisted vaginal birth. Associations with episiotomy were found for the following factors: prior birth, multiple gestations, seven or more years of maternal education, higher gestational age, higher birthweight, delivery by an obstetrician (as compared to midwife or general physician), and birth in hospital (as compared to clinic or health center). After adjusting for these factors, year over year rise in episiotomy was significant with an adjusted incidence rate ratio (AIRR) of 1.10 [95% confidence interval (CI) 1.08–1.12; p = 0.002]. We found an association between episiotomy and several other obstetric interventions, with the strongest relationship for maternal treatment with antibiotics (AIRR 4.23, 95% CI 3.12–5.73; p = 0.001).ConclusionsEpisiotomy in this population-based sample from central India steadily rose from 2014 to 2018. This increase over time was observed even after adjusting for patient characteristics, obstetric risk factors, and health system features, such as specialty of the birthing provider. Our findings have important implications for maternal-child health and respectful maternity care given that most women prefer to avoid episiotomy; they also highlight a potential target for antibiotic stewardship as part of global efforts to combat antimicrobial resistance.Trial RegistrationThe study was registered at ClinicalTrials.gov under reference number NCT01073475.

Improving preparation in the emergency trauma room: the development and impact of real-time data transfer and dashboard visualization system.

This study examines, with clinical end users, the features of a visualization system in transmitting real-time patient data from the ambulance to the emergency trauma room (ETR) to determine if the real-time data provides the basis for more informed and timely interventions in the ETR before and after patient arrival. We conducted a qualitative in-depth interview study with 32 physicians in six German and Swiss hospitals. A visualization system was developed as prototype to display the transfer of patient data, and it serves as a basis for evaluation by the participating physicians. The prototype demonstrated the potential benefits of improving workflow within the ETR by providing critical patient information in real-time. Physicians highlighted the importance of features such as the ABCDE scheme and vital signs that directly impact patient care. Configurable and mobile versions of the prototype were suggested to meet the specific needs of each clinic or specialist, allowing for the transfer of only essential information. The results highlight on the one hand the potential need for adaptable interfaces in medical communication technologies that balance efficiency with minimizing additional workload for emergency medical services and show that the use of pre-notification systems in communication between ambulance and hospital can be supportive. Further research is recommended to assess practical application and support in clinical practice, including a re-evaluation of the enhanced prototype by professionals.

Exploring the Mechanisms that Allow Incompatible Beliefs to Coexist in the Cognitive System.

Despite assumptions that people strive for consistency between their beliefs, endorsement of mutually incompatible ones is not rare - a tendency we have previously labelled doublethink, by borrowing from Orwell. In an attempt to understand the nature of doublethink and the underlying mechanism that enables incompatible beliefs to coexist, we conducted two preregistered studies (total N = 691). To do so, in Study 1, we first explored how doublethink relates to (1) thinking styles (rational/intuitive, actively open-minded thinking, and need for cognitive closure), (2) a set of irrational beliefs (magical health, conspiratorial, superstitious, and paranormal beliefs) and (3) its predictiveness for questionable health practices (non-adherence to medical recommendations and use of traditional, complementary and alternative medicine). We then additionally expanded the set of health behaviors in Study 2, and related doublethink to trust in two epistemic authorities - science and the wisdom of the common man. Finally, in both studies, we explored whether those prone to inconsistent beliefs are also more likely to simultaneously rely on conventional and alternative medicine, despite their apparent incompatibility. While doublethink was positively related to need for cognitive closure and different irrational beliefs that easily incorporate contradictions, as well as negatively to actively open-minded thinking, we did not find it to be predictive of the use of non-evidence-based medicine nor of its simultaneous use with official medicine. It seems that this novel construct can be best understood as a feature of the cognitive system that allows incompatible claims to enter it. However, once beliefs are within the system, they are compartmentalized, without any cross-referencing between them. This is further reflected in non-evidence-based beliefs persisting within the belief system, irrespective of their content.

The system of radiological protection and the UN sustainable development goals.

In 2015 the United Nations issued 17 Sustainable Development Goals (SDGs) addressing a wide range of global social, economic, and environmental challenges. The main goal of this paper is to provide an understanding of how the current System of Radiological Protection relates to these SDGs. In the first part it is proposed that the current System of Radiological Protection is implicitly linked to sustainable development. This is substantiated by analysing the features of the current System as set out by the International Commission on Radiological Protection (ICRP) in its publications. In the second part it is proposed that sustainability should be considered and more explicitly addressed in the next ICRP general recommendations, as part of the currently ongoing review and revision of the current System. A few examples are given of how this could be realised, and it is proposed that this issue should be discussed and developed together with the international community interested in radiological protection.

Exploring the potential of nanoparticles as a drug delivery system for cancer therapy: A review

In this review, we discuss the use of organic nanoparticles such as liposomes, polymeric nanoparticles, dendrimers, and inorganic nanoparticles such as gold nanoparticles and mesoporous silica nanoparticles in drug delivery in chemotherapy for cancer therapy. Another strategy is the use of nanoparticle vehicles for drug delivery through the natural openings on tumor vessels called fenestrations. Both of these can be functionalized to attach angiotensin to lymphocytes or any certain part of the cancer cell membrane, microenvironment, or cytoplasmic or nuclear receptor sites, and therefore a high concentration of drug delivery to targeted cancer cells is achieved, but with less or no toxicity to normal tissue. The potential advantages evident in this technology are useful approaches to established high-concentration drug treatment of cancer tissues without harming normal cells. Some features of a nanoparticle-based drug delivery system include the durability of the vehicle, biocompatibility, permeation, and ability to target specific types of cells. Organic and inorganic nanoparticles have developed this kind of drug-carrier system. Particulate systems are also still being explored for cancer drug resistance mechanisms, and their function in immunotherapy is expanding.

Evaluation of the mpox surveillance system in Cameroon from 2018 to 2022: a laboratory cross-sectional study

BackgroundFormal assessment of a surveillance system’s features and its ability to achieve objectives is crucial for disease control and prevention. Since the implementation of the mpox surveillance system in Cameroon, no evaluation has been conducted.MethodsIn a cross-sectional study, we assessed the performance of the mpox surveillance system in accordance with the Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) guidelines. We collected mpox surveillance data from 2018 to 2022 and conducted a survey with key stakeholders of the surveillance program. The survey results were summarized. The rates of complete reporting and mpox detection, as well as the time lag between the different stages of surveillance were analyzed using R version 4.1.ResultsThe mpox detection rate was 21.6% (29/134) over the five years under review. Surveillance indicators revealed that a combination of sample types, including vesicles, crust, and blood, was associated with higher case confirmation. Overall, the mpox surveillance system was effective. Weaknesses in terms of simplicity were identified. Most components of the assessed system failed to meet the timeliness and data quality goals, except for the laboratory component, which was commendable. The lack of a computerized shared database and the system’s non-sustainability were a course of concern.ConclusionsDespite all identified bottlenecks in the mpox surveillance system in Cameroon, it was found to meet it stipulated goals. Recommendations are made for training on surveillance system features, particularly at the facility/field level. Therefore, there is a crucial need to globally improve the mpox surveillance system in Cameroon for better disease control.

Motion Sensing by a Highly Sensitive Nanogold Strain Sensor in a Biomimetic 3D Environment.

Recent advancements in flexible electronics have highlighted their potential in biomedical applications, primarily due to their human-friendly nature. This study introduces a new flexible electronic system designed for motion sensing in a biomimetic three-dimensional (3D) environment. The system features a self-healing gel matrix (chitosan-based hydrogel) that effectively mimics the dynamics of the extracellular matrix (ECM), and is integrated with a highly sensitive thin-film resistive strain sensor, which is fabricated by incorporating a cross-linked gold nanoparticle (GNP) thin film as the active conductive layer onto a biocompatible microphase-separated polyurethane (PU) substrate through a clean, rapid, and high-precision contact printing method. The GNP-PU strain sensor demonstrates high sensitivity (a gauge factor of ∼50), good stability, and waterproofing properties. The feasibility of detecting small motion was evaluated by sensing the beating of human induced pluripotent stem cell (hiPSC)-derived cardiomyocyte spheroids embedded in the gel matrix. The integration of these components exemplifies a proof-of-concept for using flexible electronics comprising self-healing hydrogel and thin-film nanogold in cardiac sensing and offers promising insights into the development of next-generation biomimetic flexible electronic devices.

Safety of Options to "Boost" (Enhancing Insulin Infusion Rates) and "Ease-Off" (Reducing Insulin Infusion Rates) in CamAPS FX Hybrid Closed-Loop System: A Real-World Analysis.

The usage and safety of the Boost and Ease-off features in the CamAPS FX hybrid closed-loop system were analyzed in a retrospective analysis of real-world data from 7,464 users over a 12-month period. Boost was used more frequently than Ease-off, but for a shorter duration per use. Mean starting glucose was above range for Boost (229 ± 51 mg/dL), and within range for Ease-off (114 ± 29 mg/dL). Time spent below 70 mg/dL was low during Boost periods [median (interquartile range; IQR) 0.0% (0.0, 0.5%)], and lower than during no Boost periods [2.1% (1.2, 3.4%)], while time spent above 180 mg/dL was lower during Ease-off periods (15 ± 14%) compared with no Ease-off periods (25 ± 12%). There were no episodes of severe hypoglycemia or diabetic ketoacidosis attributed to Boost or Ease-off use. Boost and Ease-off allow users to engage safely with CamAPS FX to manage their glucose levels during periods of more-than-usual and less-than-usual insulin needs.

Identification of SNPs and Candidate Genes Associated with Monocyte/Lymphocyte Ratio and Neutrophil/Lymphocyte Ratio in Duroc × Erhualian F2 Population.

Understanding the pig immune function is crucial for disease-resistant breeding and potentially for human health research due to shared immune system features. Immune cell ratios, like monocyte/lymphocyte ratio (MLR) and neutrophil/lymphocyte ratio (NLR), offer a more comprehensive view of immune status compared to individual cell counts. However, research on pig immune cell ratios remains limited. This study investigated MLR and NLR in a Duroc × Erhualian F2 resource population. Heritability analysis revealed high values (0.649 and 0.688 for MLR and NLR, respectively), suggesting a strong genetic component. Furthermore, we employed an ensemble-like GWAS (E-GWAS) strategy and functional annotation analysis to identify 11 MLR-associated and 6 NLR-associated candidate genes. These genes were significantly enriched in immune-related biological processes. These findings provide novel genetic markers and candidate genes associated with porcine immunity, thereby providing valuable insights for addressing biosecurity and animal welfare concerns in the pig industry.

WP1.15 - Advances in remote electronic monitoring of patient-reported outcomes following discharge after surgery: a systematic review

Abstract Aims Standardising post-discharge care is critical to improving surgical recovery. The COVID-19 pandemic caused major changes to in-person visits and surgical follow-up. An earlier review examined the pre-pandemic capture of electronic patient-reported outcomes (ePRO) post-discharge after surgery. This updated review explores how the pandemic has influenced the use of ePRO systems. Methods Databases (Medline/Embase/PsycINFO/CINAHL/Cochrane) were searched from July 2019-August 2023 using terms for ‘patient-reported outcomes’, ‘electronic’, ‘surgery’ and ‘at home’. Primary research studies collecting ePROs in adult surgical patients post-discharge were included. Data extraction/analyses characterised study design, patient characteristics, ePRO system features, the scope within which ePROs are used post-discharge, what PRO data is collected, adherence to ePRO monitoring, impact on primary/secondary outcomes and the patient and clinician experience of using ePRO systems. Results 12,805 articles were identified, of which 81 were included. Emerging findings indicate an increase in research examining ePRO systems in the post-discharge care of surgical patients, with ∼20 articles/year published post-pandemic, compared to ∼3/year in the 5 years pre-pandemic. Usage of ePROs seems to be most prevalent in orthopaedic and gastrointestinal surgery. Full findings will be available for presentation at the conference. Conclusions Interest in using ePROs to support post-discharge care of surgical patients is growing, in response to service provision changes. Important advances in the capabilities of ePRO systems include real-time clinician feedback and integration with hospital electronic records. The findings of this review will highlight important directions for improving the design of ePRO systems and future research examining the effectiveness of ePRO systems at improving post-surgical recovery.

High Mass Transfer Rate in Electrocatalytic Hydrogen Evolution Achieved with Efficient Quasi-Gas Phase System.

The adhesion of H2 bubbles on the electrode surface is one of the main factors limiting the performance of H2 evolution of electrolytic water, especially at high current density. To overcome this problem, here a "quasi-gas phase" electrolytic water reaction system based on capillary effect is proposed for the first time to improve the mass transfer efficiency of H2. The typical feature of this reaction system is that the main site of H2 evolution reaction is transferred from the bulk aqueous solution to the gas phase environment above the bulk aqueous solution, thus effectively inhibiting the aggregation of H2 bubbles and reducing the resistance of their diffusion away. Electrochemical test results show that the proposed quasi-gas phase system can significantly reduce the potential required in H2 evolution reaction process at high current density compared with the conventional electrolytic reaction system. Specifically, the overpotential potential is reduced by 0.31 V when the H2 evolution current density of 250 mA cm-2 is achieved.

High Mass Transfer Rate in Electrocatalytic Hydrogen Evolution Achieved with Efficient Quasi‐Gas Phase System

The adhesion of H2 bubbles on the electrode surface is one of the main factors limiting the performance of H2 evolution of electrolytic water, especially at high current density. To overcome this problem, here a "quasi‐gas phase" electrolytic water reaction system based on capillary effect is proposed for the first time to improve the mass transfer efficiency of H2. The typical feature of this reaction system is that the main site of H2 evolution reaction is transferred from the bulk aqueous solution to the gas phase environment above the bulk aqueous solution, thus effectively inhibiting the aggregation of H2 bubbles and reducing the resistance of their diffusion away. Electrochemical test results show that the proposed quasi‐gas phase system can significantly reduce the potential required in H2 evolution reaction process at high current density compared with the conventional electrolytic reaction system. Specifically, the overpotential potential is reduced by 0.31 V when the H2 evolution current density of 250 mA cm‐2 is achieved.

Patient routing system in rehabilitation after treatment for oncogynecological pathologies

Background. In recent years, oncogynecological diseases have been diagnosed more frequently in women of reproductive age. Despite the high efficiency of treatment measures, significant shortcomings in the rehabilitation system for such patients are noted.Objective: to present the continuity and features of the rehabilitation system for patients of oncogynecological profile.Material and methods. This review included 75 relevant publications from authoritative sources that presented unique findings. The search was conducted in Russian and foreign online libraries, databases and search engines. PRISMA recommendations were used for search and screening.Results. Oncogynecological patients need special attention in providing them medical care at the recovery stage. It is important to adhere to the principle of continuity between all steps of rehabilitation system: immediately after treatment, in rehabilitation department, and on outpatient stage. This system has been developed in Russia, but it needs scaling and solving a number of problems, ranging from a shortage of rehabilitation doctors, limited use of promising rehabilitation tools to insufficient provision of psychological assistance and the absence of generally accepted comprehensive rehabilitation system. At the same time, there is sufficient set of traditional and high-tech rehabilitation methods to provide highly specialized care.Conclusion. Aggressive treatment of oncogynecological diseases has a detrimental effect on the general well-being of women, significantly reducing their quality of life. Previously, proper provision of rehabilitation care encountered the rigidity of the system both at methodological and administrative levels. Recently, there have been positive shifts in solving problems of providing care to oncogynecological patients, however, the presented measures are not enough to qualitatively change the situation.

Assessing the Features of PV System’s Data and the Soiling Effects on PV System’s Performance Based on the Field Data

This paper assesses the features/characteristics of a photovoltaic system’s data, investigates the relationship between the soiling and solar panel performance, and leverages real-world data obtained from a solar site in Shams Solar Facility located at the German University of Technology in Oman. Through an experimental approach, different parameters were scrutinized to unravel the dynamics at play. Due to the lack of studies on how to assess the features of a PV System’s data, and in order to model the PV System’s data, extensive analyses were conducted based on a big dataset containing 36,851 observations of each parameter (environmental factors) of the study. In addition, diverse environmental factors, operational conditions, and the collected data were analyzed by various mathematical/statistical measures, and inferential statistical measures were applied to obtain accurate and significant results that explain the level of each parameter (environmental factors), and are developed to examine the features/characteristics and performance of PV Systems and reveal the influence of soiling accumulation on the energy output. The research findings do not only deepen the understanding of the features of PV Systems data and the impact of soiling on solar panels, but also underscore the significance of considering geographical and climatic variations. This research contributes significantly to advancing knowledge within the realm of solar energy systems and provides actionable insights for optimizing the performance and reliability of PV installations in real-world settings. The discussion, conclusions, limitations, and future directions have been discussed.

The process of strategizing the formation and development of agglomerations in the Kemerovo region – Kuzbass

The article deals with various approaches to interpreting the essence of agglomerations of Kuzbass (geo-urban, legal, managerial and strategic), which ensure finding more effective methods to implement the acceleration of the region’s economic development. The author uses the theory of strategy and methodology of strategizing by Professor V.L. Kvint to analyze the targeted programs of the Kuzbass agglomerations determining the prospects for their development. The peculiar features of economic development are determined by the basic economic indicators of the region such as the volume of investment, budget revenues, and the volume of gross regional product. The author supposes that the drawback of the formation of the agglomerations development programs is the lack of forecast that could reveal global, industry and regional trends directly connected with the prospects for agglomeration. The article contains the definition of the mission and vision essential for developing strategies of agglomerations in Kuzbass; a critical analysis of goal setting has been carried out. In the perspective of development of each goal of the strategy, it is necessary to provide for the measures aimed at supporting agglomerations taking into account their demographic situation and the peculiar features of the settlement system, the level and dynamics of development of municipal bodies and natural and climatic conditions. It is important to provide for financing the reconstruction of the previously lost competitive advantages and the development of technological trends. Intermunicipal coordination development councils of the agglomerations created are recommended to take into account the lack of clear definition of the qualitative characteristics of the tasks set. The implementation of the priority directions of the social and economic transformation of Kuzbass is likely to ensure the new quality of life of the region’s population.

Multidisciplinary hydrogeochemical and isotopic assessment of the Pordenone Plain (Northeastern Italy) for water resources sustainability

This study aims to comprehensively characterize the hydro-geochemical and isotopic features of the complex groundwater system in the Pordenone Plain (northeastern Italy). The area is an important industrial and agricultural area exposed to severe anthropogenic pressure and climate change, which put its water resources at risk in terms of quantity and quality, making it of high scientific and social interest. The hydrogeological setting of the Pordenone Plain has been previously simplified as a phreatic continuous aquifer in the High Plain that changes into a multilayered aquifer system towards the Low Plain. However, this study reveals significant lithological and structural heterogeneities in the High Plain that exert a strong influence on its subsurface hydrodynamics. All waters exhibit a Ca(Mg)–HCO3 composition with relatively high Na–K values in the aquifers of the Low Plain likely related to cation exchange processes. Water stable isotopes (δ2H–H2O and δ18O–H2O) indicate that the deep aquifers in the Low Plain are confined by impermeable geological formations, such as clays and siltstones, which entirely restrict water mixing with shallower aquifers. Concurrently, tritium analysis provides evidence of slow recharge and flow rate. Three primary groundwater flows have been identified within the plain, as follows: 1) a surface flow that affects the unconfined or semi-confined aquifers of the High Plain hosted in gravelly sediments; 2) an intermediate flow fed by the pedemontane zone, which includes unconfined deep aquifers of the High Plain, semi-confined/shallow aquifers (at a depth of 40–50 m) located near the resurgence belt area and karst springs located in eastern pedemontane of the Cansiglio Plateau; 3) a deep flow fed by the mountainous zone that affects the deep confined aquifers of the Low Plain. A reliable hydrogeochemical conceptual model has been developed to explain the compositional variability of the studied waters, providing valuable insights for the sustainable management of groundwater resources in the Pordenone Plain.