Purpose: When trying to establish a diagnosis of chronic pancreatitis (CP) abnormal exocrine function is used as a surrogate for histology as tissue is usually unavailable. The direct stimulated pancreas function tests (PFT) following stimulation have as good or better yield than imaging, EUS and ERCP. Endoscopic PFT (ePFT) have shown similar yields to more complicated and technically challenging PFT. We searched our database to determine if the peak bicarbonate concentration (PBC) varied according to age as this variable could have implications when interpreting test results. Methods: Patients who have ePFT are registered in an unidentifiable database that includes demographics, previous tests such as laboratory, imaging, EUS, ERCP, and histology. Synthetic secretin 0.2 μg/kg (ChiRhoClin, Inc., Burtonsville, MD) was administered IV, and sedation started 30 minutes after. After gastric fluid aspiration, the endoscope was advanced to the level of the major papilla, and 4 duodenal aspirations were done 35 minutes after secretin administration at 5 minute intervals and immediately delivered to the laboratory. An autoanalyzer calibrated to a bicarbonate of 80 meq/L was used, and peak bicarbonate concentration (PBC) of >80 mEq/L was considered normal. The PBC was analyzed according to age groups <30, 30 to 39, 40 to 49, 50 to 59, and >60 years of age to determine if it varied according to age. Results: Sixty-five ePFT have been performed. Indications were chronic abdominal pain (20), suspected chronic pancreatitis (35), idiopathic recurrent acute pancreatitis (3), steatorrhea (5), elevated serum pancreas enzymes (2). There were 44 patients without CP and their median PBC was 104* (range 78.9-135); 21 patients had CP and their median PBC was 74* (27-94) (*p<0.0001). The PBC did not differ in patients without CP regardless of age (Table). The PBC also remained similarly low in the group with CP in all age groups. The PBC remained statistically different between patients with and without CP in all age groups, but the number of patients with CP in the age groups <30 and >60 years was small (two patients in each).Table: [213] PBC according to age groups in pts with and without CPConclusion: In this retrospective database study age did not affect the PBC in patients without or with CP, and it actually remained unaltered suggesting that pancreas function does not decrease with age. The PBC also remained statistically lower in patients with CP regardless of age group compared to patients without CP. The age groups <30 and >60 years old had a small number of patients, thus results need to be interpreted cautiously. The trend suggests that age does not affect the PBC, which remained different in patients with and without chronic pancreatitis.