Abstract
In this issue, Unis et al., 2002 Unis AS Munson JA Rogers SJ et al. A randomized, double-blind, placebo-controlled trial of porcine versus synthetic secretin for reducing symptoms of autism. J Am Acad Child Adolesc Psychiatry. 2002; 41: 1315-1321 Abstract Full Text Full Text PDF PubMed Scopus (45) Google Scholar report that neither biologic nor synthetic secretin improves symptoms in autism. The autistic subjects were studied in three groups: biologic secretin, synthetic secretin, and placebo, and symptoms were rated using reliable, standardized measures. Parents reported symptom improvement for all three groups, as did a teacher-reported measure. Statistical analysis confirmed the parent and teacher reports and established (with a 1 in 20 chance of error) that there were no differences between secretin and placebo groups. These results can be added to the negative results of five previous placebo-controlled trails of secretin in autism. One trial with a 5% chance of error might be considered persuasive; six trials should be considered conclusive.
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